目的比较纽约心脏病协会分级(New York Heart Association classes,NYHAc)、左室射血分数(LVEF)和N端前B型利钠肽(N-terminal pro B-type natriuretic peptides,NT-proBNP)等对慢性心力衰竭患者(CHF)心血管事件发生的预测价值。方法入...目的比较纽约心脏病协会分级(New York Heart Association classes,NYHAc)、左室射血分数(LVEF)和N端前B型利钠肽(N-terminal pro B-type natriuretic peptides,NT-proBNP)等对慢性心力衰竭患者(CHF)心血管事件发生的预测价值。方法入选慢性心力衰竭患者,分别检测NYHAc、LVEF及NT-proBNP,并根据指南给予常规治疗。每月随访终点事件是否发生,根据不同的预后将病例分为组0、组1和组2。统计不同预后组别之间上述指标的差异。结果共入选106例患者。3个组别NYHAc均值,组0<组1<组2,3组间比较有统计学意义;对预后的预测价值,其ROC曲线下面积再住院3组比较无统计学意义(P>0.05);3个组别LVEF均值为组0<组1<组2。结论NYHAc和NT-proBNP对于慢性心力衰竭患者心血管事件的发生具有一定预测价值。展开更多
Some recent studies presented two existing types of ENSO events, one is the Eastern-Pacific(EP) type and the other the Central-Pacific(CP) type. This study examined the monitoring ability of several current operationa...Some recent studies presented two existing types of ENSO events, one is the Eastern-Pacific(EP) type and the other the Central-Pacific(CP) type. This study examined the monitoring ability of several current operational ENSO indices. The results indicated that a single index could not distinguish the EP and CP in the historical ENSO events during 1950-2009. The Nio 3 index may only be suitable for monitoring the EP-type ENSO, while the Nio 4 index works only for the CP-type ENSO. In order to capture the occurrence of ENSO events and distinguish the type, we considered a new monitoring index group using Nio 3 and Nio 4 indices. Further analysis confirmed that this index group can monitor different types of historical ENSO events with different spatial distribution of sea surface temperature. It has a good performance in determining the characteristics of the ENSO events, including peak intensity, onset,decay, and mature phase.展开更多
Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of mental status and cognitive impairment. Many studies have reported that alcoholics show a sig...Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of mental status and cognitive impairment. Many studies have reported that alcoholics show a significantly lower ERP P300 amplitude than the norm. In the present study, ERP P300 waves were measured to evaluate the effect of citric acid on cognitive function during excessive alcohol consumption in healthy adults. Five volunteers were selected through clinical interview, physical examination, and psychiatric assessment for participation in this study. In a double-blind placebo-controlled before-after design, each subject was treated with 5 ml/kg body weight alcohol, 5 ml/kg body weight alcohol and 1 mg citric acid, or a placebo on three separate occasions, one week apart. ERP P300, blood biochemical indicators, blood alcohol concentrations (BACs) and acetaldehyde concentrations were assessed. Repeated measure analysis of variance (ANOVA) with a within-subjects factor was used to evaluate differences in blood biochemical indicators, BACs, blood acetaldehyde concentrations, and ERP P300 in the three sessions of assessments. Several blood biochemical indicators showed significant differences between treatments, including the levels of cholinesterase (CHE), total bile acid (TBA), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and glycylproline dipeptidyl aminopeptidase (GPDA). BACs after consumption of alcohol alone or citric acid with al- cohol were significantly higher compared to those after placebo treatment (P<0.05). There were no significant dif- ferences in blood acetaldehyde concentrations between the treatments. The P300 amplitudes on the frontal (Fz), central (Cz), and parietal (Pz) regions of the scalp after consumption of alcohol were significantly lower than those after consumption of the placebo or citric acid with alcohol (P<0.05), while there were no significant differences between the latter two treatments. The results of this study suggest that citric acid could reduce the decline in ERP P300 amplitude and cognitive ability induced by acute alcohol consumption. It may also affect some blood biochemical indicators, but the specific mechanisms need further research.展开更多
文摘目的比较纽约心脏病协会分级(New York Heart Association classes,NYHAc)、左室射血分数(LVEF)和N端前B型利钠肽(N-terminal pro B-type natriuretic peptides,NT-proBNP)等对慢性心力衰竭患者(CHF)心血管事件发生的预测价值。方法入选慢性心力衰竭患者,分别检测NYHAc、LVEF及NT-proBNP,并根据指南给予常规治疗。每月随访终点事件是否发生,根据不同的预后将病例分为组0、组1和组2。统计不同预后组别之间上述指标的差异。结果共入选106例患者。3个组别NYHAc均值,组0<组1<组2,3组间比较有统计学意义;对预后的预测价值,其ROC曲线下面积再住院3组比较无统计学意义(P>0.05);3个组别LVEF均值为组0<组1<组2。结论NYHAc和NT-proBNP对于慢性心力衰竭患者心血管事件的发生具有一定预测价值。
基金The Definition of El Nio/La Nia Episodes,a National Standard ProjectSpecialized Project for Public Welfare Industries(GYHY201406018,GYHY200806009)+2 种基金Program 973(2012CB955901)National Science and Technology Support Program(2009BAC51B05)National Youth Foundation for Natural Science(41005038)
文摘Some recent studies presented two existing types of ENSO events, one is the Eastern-Pacific(EP) type and the other the Central-Pacific(CP) type. This study examined the monitoring ability of several current operational ENSO indices. The results indicated that a single index could not distinguish the EP and CP in the historical ENSO events during 1950-2009. The Nio 3 index may only be suitable for monitoring the EP-type ENSO, while the Nio 4 index works only for the CP-type ENSO. In order to capture the occurrence of ENSO events and distinguish the type, we considered a new monitoring index group using Nio 3 and Nio 4 indices. Further analysis confirmed that this index group can monitor different types of historical ENSO events with different spatial distribution of sea surface temperature. It has a good performance in determining the characteristics of the ENSO events, including peak intensity, onset,decay, and mature phase.
基金Project supported by the National Key Technology R&D Program of China(No.2008BAI52B03)the Program of Education Depart-ment of Zhejiang Province (No.20061391),China
文摘Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of mental status and cognitive impairment. Many studies have reported that alcoholics show a significantly lower ERP P300 amplitude than the norm. In the present study, ERP P300 waves were measured to evaluate the effect of citric acid on cognitive function during excessive alcohol consumption in healthy adults. Five volunteers were selected through clinical interview, physical examination, and psychiatric assessment for participation in this study. In a double-blind placebo-controlled before-after design, each subject was treated with 5 ml/kg body weight alcohol, 5 ml/kg body weight alcohol and 1 mg citric acid, or a placebo on three separate occasions, one week apart. ERP P300, blood biochemical indicators, blood alcohol concentrations (BACs) and acetaldehyde concentrations were assessed. Repeated measure analysis of variance (ANOVA) with a within-subjects factor was used to evaluate differences in blood biochemical indicators, BACs, blood acetaldehyde concentrations, and ERP P300 in the three sessions of assessments. Several blood biochemical indicators showed significant differences between treatments, including the levels of cholinesterase (CHE), total bile acid (TBA), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and glycylproline dipeptidyl aminopeptidase (GPDA). BACs after consumption of alcohol alone or citric acid with al- cohol were significantly higher compared to those after placebo treatment (P<0.05). There were no significant dif- ferences in blood acetaldehyde concentrations between the treatments. The P300 amplitudes on the frontal (Fz), central (Cz), and parietal (Pz) regions of the scalp after consumption of alcohol were significantly lower than those after consumption of the placebo or citric acid with alcohol (P<0.05), while there were no significant differences between the latter two treatments. The results of this study suggest that citric acid could reduce the decline in ERP P300 amplitude and cognitive ability induced by acute alcohol consumption. It may also affect some blood biochemical indicators, but the specific mechanisms need further research.
