1,2-二棕榈酰-sn-甘油-3-磷脂酰胆碱(DPPC,1)不仅可作为药用辅料,还可作为外源性肺表面活性剂,治疗新生儿呼吸窘迫综合征(NRDS)。甘油磷脂酰胆碱(GPC,2)在DCM中,在4-二甲氨基吡啶(DMAP)和二环己基碳二亚胺(DCC)的作用下,与棕榈酸(PA,3)...1,2-二棕榈酰-sn-甘油-3-磷脂酰胆碱(DPPC,1)不仅可作为药用辅料,还可作为外源性肺表面活性剂,治疗新生儿呼吸窘迫综合征(NRDS)。甘油磷脂酰胆碱(GPC,2)在DCM中,在4-二甲氨基吡啶(DMAP)和二环己基碳二亚胺(DCC)的作用下,与棕榈酸(PA,3)反应得DPPC。但发现产生了某一杂质,严重影响产物的纯化。分离、纯化后经MS和1 H NMR确证,该杂质为1,1'-亚甲基双(4-二甲氨基吡啶鎓)双氯化物。把反应溶剂改为乙腈,并将DMAP投料时物质的量比例从3降低至1,目标产物1的收率由33.20%提升至49.18%,纯度99.92%。展开更多
The effects of urinary macromolecul e chondroitin sulfate A(C 4 S)and L-glutamic acid(L-Glu)on the crys-tallization of calcium oxalate were studied using Langmuir-Blodgett(LB)film of dipalmitoylphosphatidylch oline(DP...The effects of urinary macromolecul e chondroitin sulfate A(C 4 S)and L-glutamic acid(L-Glu)on the crys-tallization of calcium oxalate were studied using Langmuir-Blodgett(LB)film of dipalmitoylphosphatidylch oline(DPPC)as templet.All the calcium oxalate c rystals induced by the LB film of DPPC were calcium oxalate monohydrate(COM).However,the morphology of COM was i nfluenced by the additives of C 4 S and L-Glu.C 4 S induced thin and long hexagonal COM c rystals;L-Glu made one or two (010)crystal face of COM crystals dis-appeared.The crystallization time had no effect on the morphology of COM crystals,but the concentration of C 4 S and L-Glu changed it.As increasing the co ncentration of C 4 S,the amount of COM crystals with a hexagonal prism decreased and that with a thin hexago nal slice increased.When the concen tration of C 4 S was 0.50mg ·mL -1 ,all the calcium oxalate crystals were th in hexagonal slice COM crystals.How ever,as the concentration of L-Glu in-creased from 0.01to 0.50mmol·L -1 ,the hexagonal prism-like COM crystals gradually transformed to COM crystals with one or two (010)crystal face disappearance.展开更多
文摘1,2-二棕榈酰-sn-甘油-3-磷脂酰胆碱(DPPC,1)不仅可作为药用辅料,还可作为外源性肺表面活性剂,治疗新生儿呼吸窘迫综合征(NRDS)。甘油磷脂酰胆碱(GPC,2)在DCM中,在4-二甲氨基吡啶(DMAP)和二环己基碳二亚胺(DCC)的作用下,与棕榈酸(PA,3)反应得DPPC。但发现产生了某一杂质,严重影响产物的纯化。分离、纯化后经MS和1 H NMR确证,该杂质为1,1'-亚甲基双(4-二甲氨基吡啶鎓)双氯化物。把反应溶剂改为乙腈,并将DMAP投料时物质的量比例从3降低至1,目标产物1的收率由33.20%提升至49.18%,纯度99.92%。
文摘The effects of urinary macromolecul e chondroitin sulfate A(C 4 S)and L-glutamic acid(L-Glu)on the crys-tallization of calcium oxalate were studied using Langmuir-Blodgett(LB)film of dipalmitoylphosphatidylch oline(DPPC)as templet.All the calcium oxalate c rystals induced by the LB film of DPPC were calcium oxalate monohydrate(COM).However,the morphology of COM was i nfluenced by the additives of C 4 S and L-Glu.C 4 S induced thin and long hexagonal COM c rystals;L-Glu made one or two (010)crystal face of COM crystals dis-appeared.The crystallization time had no effect on the morphology of COM crystals,but the concentration of C 4 S and L-Glu changed it.As increasing the co ncentration of C 4 S,the amount of COM crystals with a hexagonal prism decreased and that with a thin hexago nal slice increased.When the concen tration of C 4 S was 0.50mg ·mL -1 ,all the calcium oxalate crystals were th in hexagonal slice COM crystals.How ever,as the concentration of L-Glu in-creased from 0.01to 0.50mmol·L -1 ,the hexagonal prism-like COM crystals gradually transformed to COM crystals with one or two (010)crystal face disappearance.
