AIM:To compare survival between bile duct segmental resection(BDSR)and pancreaticoduodenectomy(PD) for treating distal bile duct cancers. METHODS:Retrospective analysis was conducted for 45 patients in a BDSR group an...AIM:To compare survival between bile duct segmental resection(BDSR)and pancreaticoduodenectomy(PD) for treating distal bile duct cancers. METHODS:Retrospective analysis was conducted for 45 patients in a BDSR group and for 149 patients in a PD group. RESULTS:The T-stage(P<0.001),lymph node invasion (P=0.010)and tumor differentiation(P=0.005)were significant prognostic factors in the BDSR group.The 3-and 5-year overall survival rates for the BDSR group and PD group were 51.7%and 36.6%,respectively and 46.0%and 38.1%,respectively(P=0.099).The BDSR group and PD group did not show any significant difference in survival when this was adjusted for the TNM stage.The 3-and 5-year survival rates were: stageⅠa[BDSR(100.0%and 100.0%)vs PD(76.9% and 68.4%)(P=0.226)];stageⅠb[BDSR(55.8% and 32.6%)vs PD(59.3%and 59.3%)(P=0.942)]; stageⅡb[BDSR(19.2%and 19.2%)vs PD(31.9%and 14.2%)(P=0.669)]. CONCLUSION:BDSR can be justified as an alternative radical operation for patients with middle bile duct inselected patients with no adjacent organ invasion and resection margin is negative.展开更多
Identifying the driving forces that cause changes in forest ecosystem services related to water conservation is essential for the design of interventions that could enhance positive impacts as well as minimizing negat...Identifying the driving forces that cause changes in forest ecosystem services related to water conservation is essential for the design of interventions that could enhance positive impacts as well as minimizing negative impacts. In this study, we propose an assessment concept framework model for indirect-direct-ecosystem service （IN-DI-ESS） driving forces within this context and method for index construction that considers the selection of a robust and parsimonious variable set. Factor analysis was integrated into two-stage data envelopment analysis （TS-DEA） to determine the driving forces and their effects on water conservation services in forest ecosystems at the provincial scale in China. The results showed the following. 1） Ten indicators with factor scores more than 0.8 were selected as the minimum data set. Four indicators comprising population density, per capita gross domestic product, irrigation efficiency, and per capita food consumption were the indirect driving factors, and six indicators comprising precipitation, farmland into forestry or pasture, forest cover, habitat area, water footprint, and wood extraction were the direct driving forces. 2） Spearman＇s rank correlation test was performed to compare the overall effectiveness in two periods： stage 1 and stage 2. The calculated coefficients were 0.245, 0.136, and 0.579, respectively, whereas the tabulated value was 0.562. This indicates that the driving forces obviously differed in terms of their contribution to the overall effectiveness and they caused changes in water conservation services in different stages. In terms of the variations in different driving force effects in the years 2000 and 2010, the overall, stage 1, and stage 2 variances were 0.020, 0.065, and 0.079 in 2000, respectively, and 0.018, 0.063, and 0.071 in 2010. This also indicates that heterogeneous driving force effects were obvious in the process during the same period. Identifying the driving forces that affect service changes and evaluating their efficiency have significant policy implications for the management of forest ecosystem services. Advanced effectiveness measures for weak regions could be improved in an appropriate manner. In this study, we showed that factor analysis coupled with TS-DEA based on the IN-D1-ESS framework can increase the parsimony of driving force indicators, as well as interpreting the interactions among indirect and direct driving forces with forest ecosystem water conservation services, and reducing the uncertainty related to the internal consistency during data selection.展开更多
The aim of the present study was to investigate the long-term effects of 17l）-estradiol （E2） exposure on gonadal development in the tiger puffer （Taktfugu rubripes）, which has a genetic sex determination system o...The aim of the present study was to investigate the long-term effects of 17l）-estradiol （E2） exposure on gonadal development in the tiger puffer （Taktfugu rubripes）, which has a genetic sex determination system of male homogametic XY-XX. Tiger puffer larvae were exposed to 1, 10 and 100 μg/L E2 from 15 to 100 days post-hatch （dph） and then maintained in clean seawater until 400 dph. Changes in sex ratio, gonadal structure and gonadosomatic index （GSI） were monitored at 100, 160, 270 and 400 dph. Sex-associated single nucleotide polymorphism （SNP） markers were used to analyze the genetic sex of samples, except those at 100 dph. Exposure had a positive effect on the conversion of genetically male gonads into phenotypically female gonads at 100 dph. However, gonads from 60% of genetic XY males in the 1-μg/L E2 group and 100% in the 10-μg/L E2 group developed intersexual gonads at 160 dph; gonads of all genetic XY males in the two treatment groups reverted to testis by 270 dph. While 38%, 57% and 44% of gonads of XY fish in the 100-gg/L E2 group reverted to intersexual gonads at 160, 270 and 400 dph, respectively, none reverted to testis after E2 treatment. In addition, E2 exposure inhibited gonadal growth of both genetic sexes, as indicated by the clear dose-dependent decrease in GSI at 270 and 400 dph. The results showed that exposure to E2 during the early life stages of tiger puffer disrupted gonadal development, but that fish recovered after migration to clean seawater. The study suggests the potential use of tiger puffer as a valuable indicator species to evaluate the effects of environmental estrogens on marine fish, thereby protecting valuable fishery resources.展开更多
基金Supported by Grants from IN-SUNG Foundation for Medical Research(C-A7-803-1)
文摘AIM:To compare survival between bile duct segmental resection(BDSR)and pancreaticoduodenectomy(PD) for treating distal bile duct cancers. METHODS:Retrospective analysis was conducted for 45 patients in a BDSR group and for 149 patients in a PD group. RESULTS:The T-stage(P<0.001),lymph node invasion (P=0.010)and tumor differentiation(P=0.005)were significant prognostic factors in the BDSR group.The 3-and 5-year overall survival rates for the BDSR group and PD group were 51.7%and 36.6%,respectively and 46.0%and 38.1%,respectively(P=0.099).The BDSR group and PD group did not show any significant difference in survival when this was adjusted for the TNM stage.The 3-and 5-year survival rates were: stageⅠa[BDSR(100.0%and 100.0%)vs PD(76.9% and 68.4%)(P=0.226)];stageⅠb[BDSR(55.8% and 32.6%)vs PD(59.3%and 59.3%)(P=0.942)]; stageⅡb[BDSR(19.2%and 19.2%)vs PD(31.9%and 14.2%)(P=0.669)]. CONCLUSION:BDSR can be justified as an alternative radical operation for patients with middle bile duct inselected patients with no adjacent organ invasion and resection margin is negative.
基金Under the auspices of Science and Technology Service Network Initiative Project of the Chinese Academy of Sciences(No.KFJ-EW-STS-002)
文摘Identifying the driving forces that cause changes in forest ecosystem services related to water conservation is essential for the design of interventions that could enhance positive impacts as well as minimizing negative impacts. In this study, we propose an assessment concept framework model for indirect-direct-ecosystem service （IN-DI-ESS） driving forces within this context and method for index construction that considers the selection of a robust and parsimonious variable set. Factor analysis was integrated into two-stage data envelopment analysis （TS-DEA） to determine the driving forces and their effects on water conservation services in forest ecosystems at the provincial scale in China. The results showed the following. 1） Ten indicators with factor scores more than 0.8 were selected as the minimum data set. Four indicators comprising population density, per capita gross domestic product, irrigation efficiency, and per capita food consumption were the indirect driving factors, and six indicators comprising precipitation, farmland into forestry or pasture, forest cover, habitat area, water footprint, and wood extraction were the direct driving forces. 2） Spearman＇s rank correlation test was performed to compare the overall effectiveness in two periods： stage 1 and stage 2. The calculated coefficients were 0.245, 0.136, and 0.579, respectively, whereas the tabulated value was 0.562. This indicates that the driving forces obviously differed in terms of their contribution to the overall effectiveness and they caused changes in water conservation services in different stages. In terms of the variations in different driving force effects in the years 2000 and 2010, the overall, stage 1, and stage 2 variances were 0.020, 0.065, and 0.079 in 2000, respectively, and 0.018, 0.063, and 0.071 in 2010. This also indicates that heterogeneous driving force effects were obvious in the process during the same period. Identifying the driving forces that affect service changes and evaluating their efficiency have significant policy implications for the management of forest ecosystem services. Advanced effectiveness measures for weak regions could be improved in an appropriate manner. In this study, we showed that factor analysis coupled with TS-DEA based on the IN-D1-ESS framework can increase the parsimony of driving force indicators, as well as interpreting the interactions among indirect and direct driving forces with forest ecosystem water conservation services, and reducing the uncertainty related to the internal consistency during data selection.
基金Supported by the China Agriculture Research System(No.CARS-50-G20)the National Natural Science Foundation of China(No.31402284)the National High Technology Research and Development Program of China(863 Program)(No.2012AA10A413-2)
文摘The aim of the present study was to investigate the long-term effects of 17l）-estradiol （E2） exposure on gonadal development in the tiger puffer （Taktfugu rubripes）, which has a genetic sex determination system of male homogametic XY-XX. Tiger puffer larvae were exposed to 1, 10 and 100 μg/L E2 from 15 to 100 days post-hatch （dph） and then maintained in clean seawater until 400 dph. Changes in sex ratio, gonadal structure and gonadosomatic index （GSI） were monitored at 100, 160, 270 and 400 dph. Sex-associated single nucleotide polymorphism （SNP） markers were used to analyze the genetic sex of samples, except those at 100 dph. Exposure had a positive effect on the conversion of genetically male gonads into phenotypically female gonads at 100 dph. However, gonads from 60% of genetic XY males in the 1-μg/L E2 group and 100% in the 10-μg/L E2 group developed intersexual gonads at 160 dph; gonads of all genetic XY males in the two treatment groups reverted to testis by 270 dph. While 38%, 57% and 44% of gonads of XY fish in the 100-gg/L E2 group reverted to intersexual gonads at 160, 270 and 400 dph, respectively, none reverted to testis after E2 treatment. In addition, E2 exposure inhibited gonadal growth of both genetic sexes, as indicated by the clear dose-dependent decrease in GSI at 270 and 400 dph. The results showed that exposure to E2 during the early life stages of tiger puffer disrupted gonadal development, but that fish recovered after migration to clean seawater. The study suggests the potential use of tiger puffer as a valuable indicator species to evaluate the effects of environmental estrogens on marine fish, thereby protecting valuable fishery resources.
