目的设计合成具有抗菌活性的二硫吡咯酮类衍生物。方法以6-氨基-1,2-二硫杂环戊烯[4,3-b]吡咯-5(4H)-酮环为骨架结构,经过酰胺化、亲核取代等反应合成了14个N-芳基二硫吡咯酮类衍生物。采用纸片扩散法抑制金黄色葡萄球菌实验测定了所有...目的设计合成具有抗菌活性的二硫吡咯酮类衍生物。方法以6-氨基-1,2-二硫杂环戊烯[4,3-b]吡咯-5(4H)-酮环为骨架结构,经过酰胺化、亲核取代等反应合成了14个N-芳基二硫吡咯酮类衍生物。采用纸片扩散法抑制金黄色葡萄球菌实验测定了所有目标化合物体外抗菌活性,对优选化合物进行了最低抑菌浓度测定和大肠埃希菌RNA聚合酶抑制活性测定,并利用分子对接方法对化合物2i的作用机制进行了预测。结果与结论目标化合物均经1H NMR、13 C NMR和ESI-MS谱确证。2i具有较强的抗菌活性,分子对接结果也表明其与RNA聚合酶开关区具有较强的相互作用,值得做进一步研究。展开更多
Improvement of coking properties of sub-bituminous coal （A） and bituminous coal （B） was done using blended organic solvents, namely, n-methyl-2-pyrrolidinone （NMP） and ethylenediamine （EDA）. Various solvent bl...Improvement of coking properties of sub-bituminous coal （A） and bituminous coal （B） was done using blended organic solvents, namely, n-methyl-2-pyrrolidinone （NMP） and ethylenediamine （EDA）. Various solvent blends were employed for the coal extraction under the total reflux condition. A low-cost ceramic membrane was fabricated using industrial waste iron ore slime of M/s TATA steel R＆D, Jamshedpur （India） to separate out the dissolved coking fraction from the solvent-coal mixture. Membrane separations were carried out in a batch cell, and around 75 % recovered NMP was reused. The fractionated coal properties were determined using proximate and ultimate analyses. In the case of bituminous coal, the ash and sulfur contents were decreased by 99.3 % and 79.2 %, respectively, whereas, the carbon content was increased by 23.9 % in the separated coal fraction. Three different cleaning agents, namely deionized water, sodium dodecyl sulphate and NMP were used to regain the original membrane permeability for the reusing.展开更多
The flower-like microsphere Bi2WO6 with an average diameter of 2.5 μm is synthesized by a simple hydrothermal method in the presence of surfactant sodium dodecyl sulfate （SDS） or polyvinylpyrrolidone （PVP）. The c...The flower-like microsphere Bi2WO6 with an average diameter of 2.5 μm is synthesized by a simple hydrothermal method in the presence of surfactant sodium dodecyl sulfate （SDS） or polyvinylpyrrolidone （PVP）. The crystalline phase, compositions, morphology, microstructure, surface area and band gap energy of the Bi2WO6 are characterized by X-ray diffraction, X-ray energy-dispersive spectrum, scanning electron microscopy, transmission electron microscopy and absorption spectra. It is found that surfactant has a significant influence on the microstructure and properties of the samples. The surfaetant SDS en- hances the surface area and photocatalytic activity of Bi2WO6, while the surfactant PVP has an opposite effect. Under Xe lamp irradiation, the Bi2WO6 sample prepared in the presence of SDS can degrade dye Rhodamine B （RhB） effectively.展开更多
文摘目的设计合成具有抗菌活性的二硫吡咯酮类衍生物。方法以6-氨基-1,2-二硫杂环戊烯[4,3-b]吡咯-5(4H)-酮环为骨架结构,经过酰胺化、亲核取代等反应合成了14个N-芳基二硫吡咯酮类衍生物。采用纸片扩散法抑制金黄色葡萄球菌实验测定了所有目标化合物体外抗菌活性,对优选化合物进行了最低抑菌浓度测定和大肠埃希菌RNA聚合酶抑制活性测定,并利用分子对接方法对化合物2i的作用机制进行了预测。结果与结论目标化合物均经1H NMR、13 C NMR和ESI-MS谱确证。2i具有较强的抗菌活性,分子对接结果也表明其与RNA聚合酶开关区具有较强的相互作用,值得做进一步研究。
文摘Improvement of coking properties of sub-bituminous coal （A） and bituminous coal （B） was done using blended organic solvents, namely, n-methyl-2-pyrrolidinone （NMP） and ethylenediamine （EDA）. Various solvent blends were employed for the coal extraction under the total reflux condition. A low-cost ceramic membrane was fabricated using industrial waste iron ore slime of M/s TATA steel R＆D, Jamshedpur （India） to separate out the dissolved coking fraction from the solvent-coal mixture. Membrane separations were carried out in a batch cell, and around 75 % recovered NMP was reused. The fractionated coal properties were determined using proximate and ultimate analyses. In the case of bituminous coal, the ash and sulfur contents were decreased by 99.3 % and 79.2 %, respectively, whereas, the carbon content was increased by 23.9 % in the separated coal fraction. Three different cleaning agents, namely deionized water, sodium dodecyl sulphate and NMP were used to regain the original membrane permeability for the reusing.
基金supported by the National High Technology Research and Development Program of China (2009AA03Z217)the National Natural Science Foundation of China (90922028, 50842027)
文摘The flower-like microsphere Bi2WO6 with an average diameter of 2.5 μm is synthesized by a simple hydrothermal method in the presence of surfactant sodium dodecyl sulfate （SDS） or polyvinylpyrrolidone （PVP）. The crystalline phase, compositions, morphology, microstructure, surface area and band gap energy of the Bi2WO6 are characterized by X-ray diffraction, X-ray energy-dispersive spectrum, scanning electron microscopy, transmission electron microscopy and absorption spectra. It is found that surfactant has a significant influence on the microstructure and properties of the samples. The surfaetant SDS en- hances the surface area and photocatalytic activity of Bi2WO6, while the surfactant PVP has an opposite effect. Under Xe lamp irradiation, the Bi2WO6 sample prepared in the presence of SDS can degrade dye Rhodamine B （RhB） effectively.
