Ferruginol, a phenolic diterpenoid, was isolated from Prumnupitys andina, a Chilean native plant, as the main compound. Ferruginol has displayed an interesting range of biological activities such as in vitro anti-infl...Ferruginol, a phenolic diterpenoid, was isolated from Prumnupitys andina, a Chilean native plant, as the main compound. Ferruginol has displayed an interesting range of biological activities such as in vitro anti-inflammatory activity. Aim of this research is to evaluate the dermal anti-inflammatory activity of ferruginol, using in vivo models at first time. Ferruginol was subjected to topical assays for the inhibition of inflammation elicited by AA （arachidonic acid） or TPA （phorbol ester） in the murine model. The topical anti-inflammatory activity was evaluated in vivo using groups of 8 animals were treated with a single dose of ferruginol, equimolar doses with regard to the reference drugs, indomethacin and nimesulide. We showed a chemical data were consistent with a type-abietane diterpenoid known as ferruginol. Ferruginol showed topical anti-inflammatory activity at 21.0% and 20.5% in AA and TPA models, respectively. Our results provide data to support further investigations about ferruginol, a type-abietane diterpenoid, as a potential anti-inflammatory agent.展开更多
We give a classification of second-order polynomial solutions for the homogeneous k-Hessian equation σ_k[u] = 0. There are only two classes of polynomial solutions: One is convex polynomial; another one must not be(k...We give a classification of second-order polynomial solutions for the homogeneous k-Hessian equation σ_k[u] = 0. There are only two classes of polynomial solutions: One is convex polynomial; another one must not be(k + 1)-convex, and in the second case, the k-Hessian equations are uniformly elliptic with respect to that solution. Based on this classification, we obtain the existence of C∞local solution for nonhomogeneous term f without sign assumptions.展开更多
文摘Ferruginol, a phenolic diterpenoid, was isolated from Prumnupitys andina, a Chilean native plant, as the main compound. Ferruginol has displayed an interesting range of biological activities such as in vitro anti-inflammatory activity. Aim of this research is to evaluate the dermal anti-inflammatory activity of ferruginol, using in vivo models at first time. Ferruginol was subjected to topical assays for the inhibition of inflammation elicited by AA （arachidonic acid） or TPA （phorbol ester） in the murine model. The topical anti-inflammatory activity was evaluated in vivo using groups of 8 animals were treated with a single dose of ferruginol, equimolar doses with regard to the reference drugs, indomethacin and nimesulide. We showed a chemical data were consistent with a type-abietane diterpenoid known as ferruginol. Ferruginol showed topical anti-inflammatory activity at 21.0% and 20.5% in AA and TPA models, respectively. Our results provide data to support further investigations about ferruginol, a type-abietane diterpenoid, as a potential anti-inflammatory agent.
基金supported by National Natural Science Foundation of China (Grant Nos. 11171339 and 11171261)National Center for Mathematics and Interdisciplinary Sciences
文摘We give a classification of second-order polynomial solutions for the homogeneous k-Hessian equation σ_k[u] = 0. There are only two classes of polynomial solutions: One is convex polynomial; another one must not be(k + 1)-convex, and in the second case, the k-Hessian equations are uniformly elliptic with respect to that solution. Based on this classification, we obtain the existence of C∞local solution for nonhomogeneous term f without sign assumptions.
