Idiopathic pulmonary arterial hypertension(IPAH) is a rare disease of unknown etiology.The exact pathogenesis of pulmonary arterial hypertension is still not well known.In the past decades,many protein molecules have ...Idiopathic pulmonary arterial hypertension(IPAH) is a rare disease of unknown etiology.The exact pathogenesis of pulmonary arterial hypertension is still not well known.In the past decades,many protein molecules have been found to be in-volved in the development of IPAH.With proteomic techniques,profiling of human plasma proteome becomes more feasible in searching for disease-related markers.In present study,we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum.Thirteen spots had changed significantly in IPAH com-pared with healthy controls and were identified by LC-MS/MS.Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.展开更多
In order to develop an efficient method about protein extraction which is suitable for apple proteomic analysis, four protocols of total protein extraction from apple leaves, which are trichloroacetic acid/acetone pre...In order to develop an efficient method about protein extraction which is suitable for apple proteomic analysis, four protocols of total protein extraction from apple leaves, which are trichloroacetic acid/acetone precipitation method （TCA）, phenol extraction methanol/ammonium acetate precipitation method, Tris-HCl extraction method and modified Tris-HCl extraction method were compared. The results showed that the modified Tris-HCl extraction method was the most suitable method in protein extraction for two-dimensional electrophoresis （2-DE） from apple leaves based on the highest resolution and more informative spots of 2-DE gels with no apparent vertical or horizontal streaking.展开更多
We analyze the ground-state properties and the excitation spectrum of Bose-Einstein condensates of photons and PPs in a two-dimensional optical microcavity. First, using the variational method, we discuss the ground-s...We analyze the ground-state properties and the excitation spectrum of Bose-Einstein condensates of photons and PPs in a two-dimensional optical microcavity. First, using the variational method, we discuss the ground-state phase transition of the two-component system. We also investigate the energy gap between the ground state and the first excited state. Moreover, by investigating the excitation spectrum, we also illustrate how the superfluid behavior of photons and PPs can be associated with the phase transition of the system.展开更多
Imidazole base was crystallized with different aromatic carboxylic acids 2,4-dihydroxybenzoic acid, 5-chlorosalicylic acid, and 1,8-naphthalic acid, affording three new binary molecular organic salts of [(C 3 H 5 N 2 ...Imidazole base was crystallized with different aromatic carboxylic acids 2,4-dihydroxybenzoic acid, 5-chlorosalicylic acid, and 1,8-naphthalic acid, affording three new binary molecular organic salts of [(C 3 H 5 N 2 + )·(C 7 H 5 O 4 )] (1), [(C 3 H 5 N 2 + )·(C 7 H 4 O 3 Cl )] C 7 H 5 O 3 Cl (2), and [(C 3 H 5 N 2 + ) (C 12 H 7 O 4 )] (3). Proton transfer occurs from the COOH of carboxylic acid to nitrogen of imidazole in all complexes (1-3), leading to the hydrogen bond N-H…O in all structures. To our knowledge, the recognition pattern between the carboxylic acid group and imidazole (acid-imidazole synthon) is less well-studied so far. The cooperation among COOH, COO and imidazolium cation functional groups for the observed hydrogen bond synthons is examined in the three structures. Generally, the strong N-H…O and O-H…O hydrogen bonds define supramolecular architecture and connectivity within chains, while weaker C-H…O hydrogen bonds play the dominant role in controlling the interactions between layers in these novel organic salts. Thermal stability of these compounds has been investigated by thermogravimetric analysis (TGA) of mass loss.展开更多
The system of two-dimensional nonlinear partial differential equations is considered. This system describes the vein formation in meristematic tissues of young leaves. Variable directions difference scheme is construc...The system of two-dimensional nonlinear partial differential equations is considered. This system describes the vein formation in meristematic tissues of young leaves. Variable directions difference scheme is constructed and investigated. Absolute stability regarding space and time steps of scheme is shown. The convergence statement for the constructed scheme is proved. Rate of convergence is given. Various numerical experiments are carried out and results of some of them are considered in this paper. Comparison of numerical experiments with the results of the theoretical investigation is given too.展开更多
In this paper, the Clarkson-Kruskal direct approach is employed to investigate the exact solutions of the 2-dimensionai rotationai Euler equations for the incompressible fluid. The application of the method leads to a...In this paper, the Clarkson-Kruskal direct approach is employed to investigate the exact solutions of the 2-dimensionai rotationai Euler equations for the incompressible fluid. The application of the method leads to a system of completely solvable ordinary differential equations. Several special cases are discussed and novel nonlinear exact solutions with respect to variables x and y are obtained. It is＇of interest to notice that the pressure p is obtained by the second kind of curvilinear integral and the coefficients of the nonlinear solutions are solitary wave type functions like tanh（ kt /2 ） and sech （kt/2） due to the rotational parameter k ≠ O. Such phenomenon never appear in the classical Euler equations wherein the Coriolis force arising from the gravity and Earth＇s rotation is ignored. Finally, illustrative numerical figures are attached to show the behaviors that the exact solutions may exhibit.展开更多
In the present study the thermal model of skin and subdermal tissues （SST） of human breast have been developed. The human breast is assumed to be spherical in shape with upper hemisphere projecting out from the trun...In the present study the thermal model of skin and subdermal tissues （SST） of human breast have been developed. The human breast is assumed to be spherical in shape with upper hemisphere projecting out from the trunk of the body and lower hemisphere is considered to be a part of the body core. The upper hemisphere represents the breast and its SST region is divided into three layers namely epidermis, dermis and subdermal tissues. The inner part of the breast represents the core/shell of the breast. The outer surface of the breast is assumed to be exposed to the environment from where the heat loss takes place by conduction, convection, radiation and evaporation. The heat transfer from core to the surface takes place by thermal conduction and blood perfusion. Also metabolic activity takes place at different rates in different SST layers of the breast. Boundary conditions have been framed on the basis of physical conditions. A finite element model has been developed for a two-dimensional steady state case.展开更多
A technique of coordinate transformation is devised to overcome the computational difficulty associated with the direct transformation between eigenfunctions of three components of the geometric momentum on two-dimens...A technique of coordinate transformation is devised to overcome the computational difficulty associated with the direct transformation between eigenfunctions of three components of the geometric momentum on two-dimensional spherical surface, and the computations are firstly carried out in new coordinates and secondly the results are transformed back into the original coordinates. The eigenfunctions of different components of geometric momentum is explicitly demonstrated to transform under the spatial rotations in the precise way we anticipate.展开更多
基金Project (No. A-007) supported by the Key Medicine Foundation of Zhejiang Province, China
文摘Idiopathic pulmonary arterial hypertension(IPAH) is a rare disease of unknown etiology.The exact pathogenesis of pulmonary arterial hypertension is still not well known.In the past decades,many protein molecules have been found to be in-volved in the development of IPAH.With proteomic techniques,profiling of human plasma proteome becomes more feasible in searching for disease-related markers.In present study,we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum.Thirteen spots had changed significantly in IPAH com-pared with healthy controls and were identified by LC-MS/MS.Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.
文摘In order to develop an efficient method about protein extraction which is suitable for apple proteomic analysis, four protocols of total protein extraction from apple leaves, which are trichloroacetic acid/acetone precipitation method （TCA）, phenol extraction methanol/ammonium acetate precipitation method, Tris-HCl extraction method and modified Tris-HCl extraction method were compared. The results showed that the modified Tris-HCl extraction method was the most suitable method in protein extraction for two-dimensional electrophoresis （2-DE） from apple leaves based on the highest resolution and more informative spots of 2-DE gels with no apparent vertical or horizontal streaking.
文摘We analyze the ground-state properties and the excitation spectrum of Bose-Einstein condensates of photons and PPs in a two-dimensional optical microcavity. First, using the variational method, we discuss the ground-state phase transition of the two-component system. We also investigate the energy gap between the ground state and the first excited state. Moreover, by investigating the excitation spectrum, we also illustrate how the superfluid behavior of photons and PPs can be associated with the phase transition of the system.
基金supported by the National Natural Science Foundation of China (20701023, 20971076)the Natural Science Foundation of Shandong Province, China (BS2010NJ004,2009ZRB019KH)
文摘Imidazole base was crystallized with different aromatic carboxylic acids 2,4-dihydroxybenzoic acid, 5-chlorosalicylic acid, and 1,8-naphthalic acid, affording three new binary molecular organic salts of [(C 3 H 5 N 2 + )·(C 7 H 5 O 4 )] (1), [(C 3 H 5 N 2 + )·(C 7 H 4 O 3 Cl )] C 7 H 5 O 3 Cl (2), and [(C 3 H 5 N 2 + ) (C 12 H 7 O 4 )] (3). Proton transfer occurs from the COOH of carboxylic acid to nitrogen of imidazole in all complexes (1-3), leading to the hydrogen bond N-H…O in all structures. To our knowledge, the recognition pattern between the carboxylic acid group and imidazole (acid-imidazole synthon) is less well-studied so far. The cooperation among COOH, COO and imidazolium cation functional groups for the observed hydrogen bond synthons is examined in the three structures. Generally, the strong N-H…O and O-H…O hydrogen bonds define supramolecular architecture and connectivity within chains, while weaker C-H…O hydrogen bonds play the dominant role in controlling the interactions between layers in these novel organic salts. Thermal stability of these compounds has been investigated by thermogravimetric analysis (TGA) of mass loss.
文摘The system of two-dimensional nonlinear partial differential equations is considered. This system describes the vein formation in meristematic tissues of young leaves. Variable directions difference scheme is constructed and investigated. Absolute stability regarding space and time steps of scheme is shown. The convergence statement for the constructed scheme is proved. Rate of convergence is given. Various numerical experiments are carried out and results of some of them are considered in this paper. Comparison of numerical experiments with the results of the theoretical investigation is given too.
基金Supported by the National Natural Science Foundation of China under Grant No.11301269Jiangsu Provincial Natural Science Foundation of China under Grant No.BK20130665+2 种基金the Fundamental Research Funds KJ2013036 for the Central UniversitiesStudent Research Training under Grant No.1423A02 of Nanjing Agricultural Universitythe Research Grant RG21/2013-2014R from the Hong Kong Institute of Education
文摘In this paper, the Clarkson-Kruskal direct approach is employed to investigate the exact solutions of the 2-dimensionai rotationai Euler equations for the incompressible fluid. The application of the method leads to a system of completely solvable ordinary differential equations. Several special cases are discussed and novel nonlinear exact solutions with respect to variables x and y are obtained. It is＇of interest to notice that the pressure p is obtained by the second kind of curvilinear integral and the coefficients of the nonlinear solutions are solitary wave type functions like tanh（ kt /2 ） and sech （kt/2） due to the rotational parameter k ≠ O. Such phenomenon never appear in the classical Euler equations wherein the Coriolis force arising from the gravity and Earth＇s rotation is ignored. Finally, illustrative numerical figures are attached to show the behaviors that the exact solutions may exhibit.
文摘In the present study the thermal model of skin and subdermal tissues （SST） of human breast have been developed. The human breast is assumed to be spherical in shape with upper hemisphere projecting out from the trunk of the body and lower hemisphere is considered to be a part of the body core. The upper hemisphere represents the breast and its SST region is divided into three layers namely epidermis, dermis and subdermal tissues. The inner part of the breast represents the core/shell of the breast. The outer surface of the breast is assumed to be exposed to the environment from where the heat loss takes place by conduction, convection, radiation and evaporation. The heat transfer from core to the surface takes place by thermal conduction and blood perfusion. Also metabolic activity takes place at different rates in different SST layers of the breast. Boundary conditions have been framed on the basis of physical conditions. A finite element model has been developed for a two-dimensional steady state case.
基金Supported by National Natural Science Foundation of China under Grant No. 11175063
文摘A technique of coordinate transformation is devised to overcome the computational difficulty associated with the direct transformation between eigenfunctions of three components of the geometric momentum on two-dimensional spherical surface, and the computations are firstly carried out in new coordinates and secondly the results are transformed back into the original coordinates. The eigenfunctions of different components of geometric momentum is explicitly demonstrated to transform under the spatial rotations in the precise way we anticipate.
