5-羟基-1,4-萘二醌合成研究

以萘为原料，经硝化反应制得１，５－二硝基萘，再还原得１，５－萘二胺，由重氮化反应转变为１，５－萘二酚，进而氧化合成５－羟基－１。

1,4-二羟基蒽醌稀释锅防腐施工介绍

介绍了1，4－二羟基醌稀释锅防腐施工过程中应注意的事项以及防腐材料的配比等。

血管生成抑制剂候选物——去甲苔藓蒽噻吩的设计合成

目的设计合成血管生成抑制剂候选物——去甲苔藓蒽噻吩。方法以1,8-二羟基-9,10-蒽醌为原料,5,7-二羟基-1-羧基-6-酮-6H-蒽[1,9-bc]噻吩为关键中间体,脱羧反应为关键步骤,经5步反应合成目标分子。结果以10.1%的总收率合成去甲苔藓蒽噻吩,其结构为MS、IR、UV、1H-NMR、13C-NMR和2D-NMR所证实。结论成功地合成了去甲苔藓蒽噻吩。其合成路线具有原料易得、经济高效等特点。

吡哌酸荷移反应及荧光光谱性质研究

研究了吡哌酸（PPA）与2,5-二羟基-3,6-二氯苯醌（CAA）之间的荷移反应。实验表明,二者在丙酮-甲醇介质中发生荷移反应,在35℃恒温40min即可生成络合比为1∶1的荷移络合物,其荧光发射比吡哌酸（PPA）有显著增强。溶液浓度在0.10-7.0μg·m L^-1范围内荷移络合物的荧光强度与浓度线性关系良好,相关系数r=0.9993,检出限为0.10μg·m L^-1。该方法用于吡哌酸（PPA）胶囊的测定,加标回收率为97.1%-99.0%,相对标准偏差（RSD）为1.2%-2.9%。

Laser Flash Photolysis on Electron Transfer Reactions between 1,8-Dihydroxyanthraquinone with Adenine and Cytosine

Electron transfer （ET） reactions between 1,8-dihydroxyanthraquinone （DHAQ） and two DNA bases, adenine （A） and cytosine （C）, have been investigated in CH3CN/H20 solution with nanosecond time-resolved laser flash photolysis. After irradiation at 355 nm, the triplet DHAQ is produced via intersystem crossing and reacts with two nucleobases. ET processes for both reactions have been definitely identified, in which two bases play a significant role of electron donor. Based on the measured decay dynamics of various intermediates and the corresponding quenching rates, an initial ET process followed by a secondary proton-transfer reaction is suggested for both the overall reactions. By plotting the observed quenching rate against the concentration of two DNA bases, the bimolecular quenching rate constants are determined as 9.0-10s L/（mol.s） for the 3DHAQ＊＋C reaction and 3.3x10^8 L/（mol.s） for the 3DHAQ＊＋A reaction, respectively.