To improve the traditional classifying methods, such as vector space model （VSM）-based methods with highly complicated computation and poor scalability, a new classifying method （ called IER） is presented based on...To improve the traditional classifying methods, such as vector space model （VSM）-based methods with highly complicated computation and poor scalability, a new classifying method （ called IER） is presented based on two new concepts： interdependence and equivalent radius. In IER, the attribute is selected according to the value of interdependence, and the classifying rule is based on equivalent radius and center of gravity. The algorithm analysis shows that IER is good at classifying a large number of samples with higher scalability and lower computation complexity. After several experiments in classifying Chinese texts, the conclusion is drawn that IER outperforms k-nearest neighbor （kNN） and classifcation based on the center of classes （CCC） methods, so IER can be used online to automatically classify a large number of samples while keeping higher precision and recall.展开更多
Quantum mechanics and molecular dynamics are used to simulate guanidinium ionic liquids. Results show that the stronger interaction exists between guanidine cation and chlorine anion with interaction energy about 109....Quantum mechanics and molecular dynamics are used to simulate guanidinium ionic liquids. Results show that the stronger interaction exists between guanidine cation and chlorine anion with interaction energy about 109.216 kcal/mol. There are two types of spatial distribution for the title system： middle and top. Middle mode is a more stable conformation according to energy and geometric distribution. It is also verified by radial distribution function. The continuous increase of carbon dioxide （CO2） does not affect the structure of ionic liquids, but CO2 molecules are always captured by the cavity of ionic liquids.展开更多
An improved internetworking approach is proposed to enhance the Internet connectivity which is deteriorated due to unidirectional links and blind rebroadcasting of gateway discovery packets for mobile ad hoc networks....An improved internetworking approach is proposed to enhance the Internet connectivity which is deteriorated due to unidirectional links and blind rebroadcasting of gateway discovery packets for mobile ad hoc networks. The hybrid gateway discovery scheme that combined the advantages of a proactive and reactive gateway discovery approach is used to achieve high connectivity while keeping overhead costs low. By exchanging ad hoc on-demand distance vector （AODV） hello packet which includes additional fields named symmetric neighbor list and asymmetric neighbor list, unidirectional links are removed from route computation and broadcast storm can also be relieved simultaneously. Performance results using ns-2 simulations, under varying numbers of unidirectional links and node speeds, show that this improved Internet connectivity approach can provide better performance than others.展开更多
A γ-TiAl alloy with nominal composition of Ti-47%Al（molar fraction） was directionally solidified in an alumina mould with an Y2O3 protective coating.The effects of processing parameters（melting temperature and int...A γ-TiAl alloy with nominal composition of Ti-47%Al（molar fraction） was directionally solidified in an alumina mould with an Y2O3 protective coating.The effects of processing parameters（melting temperature and interaction time） on the metal-coating interface,microstructure and chemical composition of the alloy were evaluated.The result shows that the Y2O3 protective coating exhibits an effective barrier capability to avoid direct contact between the mould base material and the TiAl melt,although the Y2O3 coating is found to suffer some erosion and be slightly dissolved by the molten TiAl due to the coating-metal interactions.The directionally solidified alloys were contaminated with Y and O,and Y2O3 inclusions were dispersed in the metal matrix.The reason for this metal contamination is the Y2O3 coating dissolution by the TiAl melt.One mode of the interaction between Y2O3 and the TiAl melt is dissolution of yttrium and atomic oxygen in the melt by reaction Y2O3（s）=2Y（in TiAl melt）＋3O（in TiAl melt）.Both the extent of alloy contamination and the volume fractions of Y2O3 inclusions depend on the melting temperature and the interaction time.展开更多
From the organization of animal flocks to the emergence of swarming behaviors in bacterial suspension,populations of motile organisms at all scales display coherent collective motion.Recent studies showed that the ani...From the organization of animal flocks to the emergence of swarming behaviors in bacterial suspension,populations of motile organisms at all scales display coherent collective motion.Recent studies showed that the anisotropic interaction between active particles plays a key role in the phase behaviors.Here we investigate the collective behaviors of based-active Janus particles that experience an anisotropic interaction of which the orientation is opposite to the direction of active force by using Langevin dynamics simulations in two dimensional space.Interestingly,the system shows emergence of collective swarming states upon increasing the total area fraction of particles,which is not observed in systems without anisotropic interaction or activity.The threshold for emergence of swarming states decreases as particle activity or interaction strength increases.We have also performed basic kinetic analysis to reproduce the essential features of the simulation results.Our results demonstrate that anisotropic interactions at the individual level are sufficient to set homogeneous active particles into stable directed motion.展开更多
To develop a colon-targeting bioreversible delivery system for β-boswellic acid (BBA) and explore utility of its prodrugs in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats.METHODSSynthesis of 4 co...To develop a colon-targeting bioreversible delivery system for β-boswellic acid (BBA) and explore utility of its prodrugs in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats.METHODSSynthesis of 4 co-drugs of BBA with essential amino acids was achieved by CDI coupling, followed by their spectral characterization. In vitro kinetics were studied by HPLC in aqueous buffers, homogenates of gastrointestinal tract and fecal matter. In vivo kinetic studies were performed in Wistar rat plasma, urine and feces. The prodrugs were screened in TNBS-induced colitis modeled Wistar rats. Statistical significance was assumed at P < 0.05, P < 0.01, P < 0.001 when compared with disease controls using one-way and two-way ANOVAs.RESULTSProdrugs were stable in 0.05 mol/L HCl buffer (pH 1.2) and stomach homogenates. Negligible hydrolysis was observed in phosphate buffer and intestinal homogenates. Substantial release (55%-72% and 68%-86%) of BBA was achieved in rat fecal matter and homogenates of colon. In vivo studies of BBA with L-tryptophan (BT) authenticated colon-specific release of BBA. But, surprisingly substantial concentration of BBA was seen to reach the systemic circulation due to probable absorption through colonic mucosa. Site-specifically enhanced bioavailability of BBA could be achieved in colon, which resulted in demonstration of significant mitigating effect on TNBS-induced colitis in rats without inducing any adverse effects on stomach, liver and pancreas. Prodrug of BT was found to be 1.7% (P < 0.001) superior than sulfasalazine in reducing the inflammation to colon among all prodrugs tested.CONCLUSIONThe outcome of this study strongly suggests that these prodrugs might have dual applicability to inflammatory bowel disease and chronotherapy of rheumatoid arthritis.展开更多
GIS- or CAD-based technology has been widely used for cartographic maps in coal mines, but structural gaps between such maps make it difficult to provide an integrated map service, for any specific purpose, at higher ...GIS- or CAD-based technology has been widely used for cartographic maps in coal mines, but structural gaps between such maps make it difficult to provide an integrated map service, for any specific purpose, at higher levels. There is no uniform platform that can be used to manage all involved maps. The main reason for this is that datasets are submitted by individual coal mines using their individual, diverse software. No consistent model is used within the software for data abstraction and symbolization. This paper first reviews all the essential specifications concerning OGC (Open Geospatial Consortium) interoperability. Then an OGC standard-oriented architecture is proposed to provide distributed coal mine map services. Within this new architecture the management of spatial data archives, and the integration of coal mine maps, are achieved through the interfaces of geospatial services. Finally an open source geospatial approach is suggested to implement the proposed scheme. A case study of the Huaibei Coal Group is used to demonstrate the proposal.展开更多
基金The National Natural Science Foundation of China(No70501024,70501022)the Humanity & Social Science ResearchProgram of Ministry of Education of China (No05JC870013)
文摘To improve the traditional classifying methods, such as vector space model （VSM）-based methods with highly complicated computation and poor scalability, a new classifying method （ called IER） is presented based on two new concepts： interdependence and equivalent radius. In IER, the attribute is selected according to the value of interdependence, and the classifying rule is based on equivalent radius and center of gravity. The algorithm analysis shows that IER is good at classifying a large number of samples with higher scalability and lower computation complexity. After several experiments in classifying Chinese texts, the conclusion is drawn that IER outperforms k-nearest neighbor （kNN） and classifcation based on the center of classes （CCC） methods, so IER can be used online to automatically classify a large number of samples while keeping higher precision and recall.
基金ACKNOWLEDGMENTS This work was supported by the Open Project Program of Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan University of Science and Technology, China （No.E21104）, the National Natural Science Foundation of China （No.21201062 and No.21172066）, and the International Cooperation Project （No.2013DFG60060）.
文摘Quantum mechanics and molecular dynamics are used to simulate guanidinium ionic liquids. Results show that the stronger interaction exists between guanidine cation and chlorine anion with interaction energy about 109.216 kcal/mol. There are two types of spatial distribution for the title system： middle and top. Middle mode is a more stable conformation according to energy and geometric distribution. It is also verified by radial distribution function. The continuous increase of carbon dioxide （CO2） does not affect the structure of ionic liquids, but CO2 molecules are always captured by the cavity of ionic liquids.
基金The National Natural Science Foundation of China(No60362001)
文摘An improved internetworking approach is proposed to enhance the Internet connectivity which is deteriorated due to unidirectional links and blind rebroadcasting of gateway discovery packets for mobile ad hoc networks. The hybrid gateway discovery scheme that combined the advantages of a proactive and reactive gateway discovery approach is used to achieve high connectivity while keeping overhead costs low. By exchanging ad hoc on-demand distance vector （AODV） hello packet which includes additional fields named symmetric neighbor list and asymmetric neighbor list, unidirectional links are removed from route computation and broadcast storm can also be relieved simultaneously. Performance results using ns-2 simulations, under varying numbers of unidirectional links and node speeds, show that this improved Internet connectivity approach can provide better performance than others.
文摘A γ-TiAl alloy with nominal composition of Ti-47%Al（molar fraction） was directionally solidified in an alumina mould with an Y2O3 protective coating.The effects of processing parameters（melting temperature and interaction time） on the metal-coating interface,microstructure and chemical composition of the alloy were evaluated.The result shows that the Y2O3 protective coating exhibits an effective barrier capability to avoid direct contact between the mould base material and the TiAl melt,although the Y2O3 coating is found to suffer some erosion and be slightly dissolved by the molten TiAl due to the coating-metal interactions.The directionally solidified alloys were contaminated with Y and O,and Y2O3 inclusions were dispersed in the metal matrix.The reason for this metal contamination is the Y2O3 coating dissolution by the TiAl melt.One mode of the interaction between Y2O3 and the TiAl melt is dissolution of yttrium and atomic oxygen in the melt by reaction Y2O3（s）=2Y（in TiAl melt）＋3O（in TiAl melt）.Both the extent of alloy contamination and the volume fractions of Y2O3 inclusions depend on the melting temperature and the interaction time.
基金supported by the Ministry of Science and Technology(2016YFA0400904 and 2018YFA0208702)the National Natural Foundation of China(No.21973085,No.21833007,No.21790350,No.21673212,No.21521001,and No.21473165)+1 种基金the Fundamental Research Funds for the Central Universities(No.WK2340000074)Anhui Initiative in Quantum Information Technologies(No.AHY090200).
文摘From the organization of animal flocks to the emergence of swarming behaviors in bacterial suspension,populations of motile organisms at all scales display coherent collective motion.Recent studies showed that the anisotropic interaction between active particles plays a key role in the phase behaviors.Here we investigate the collective behaviors of based-active Janus particles that experience an anisotropic interaction of which the orientation is opposite to the direction of active force by using Langevin dynamics simulations in two dimensional space.Interestingly,the system shows emergence of collective swarming states upon increasing the total area fraction of particles,which is not observed in systems without anisotropic interaction or activity.The threshold for emergence of swarming states decreases as particle activity or interaction strength increases.We have also performed basic kinetic analysis to reproduce the essential features of the simulation results.Our results demonstrate that anisotropic interactions at the individual level are sufficient to set homogeneous active particles into stable directed motion.
文摘To develop a colon-targeting bioreversible delivery system for β-boswellic acid (BBA) and explore utility of its prodrugs in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats.METHODSSynthesis of 4 co-drugs of BBA with essential amino acids was achieved by CDI coupling, followed by their spectral characterization. In vitro kinetics were studied by HPLC in aqueous buffers, homogenates of gastrointestinal tract and fecal matter. In vivo kinetic studies were performed in Wistar rat plasma, urine and feces. The prodrugs were screened in TNBS-induced colitis modeled Wistar rats. Statistical significance was assumed at P < 0.05, P < 0.01, P < 0.001 when compared with disease controls using one-way and two-way ANOVAs.RESULTSProdrugs were stable in 0.05 mol/L HCl buffer (pH 1.2) and stomach homogenates. Negligible hydrolysis was observed in phosphate buffer and intestinal homogenates. Substantial release (55%-72% and 68%-86%) of BBA was achieved in rat fecal matter and homogenates of colon. In vivo studies of BBA with L-tryptophan (BT) authenticated colon-specific release of BBA. But, surprisingly substantial concentration of BBA was seen to reach the systemic circulation due to probable absorption through colonic mucosa. Site-specifically enhanced bioavailability of BBA could be achieved in colon, which resulted in demonstration of significant mitigating effect on TNBS-induced colitis in rats without inducing any adverse effects on stomach, liver and pancreas. Prodrug of BT was found to be 1.7% (P < 0.001) superior than sulfasalazine in reducing the inflammation to colon among all prodrugs tested.CONCLUSIONThe outcome of this study strongly suggests that these prodrugs might have dual applicability to inflammatory bowel disease and chronotherapy of rheumatoid arthritis.
基金Project 40771167 supported by the National Natural Science Foundation of China
文摘GIS- or CAD-based technology has been widely used for cartographic maps in coal mines, but structural gaps between such maps make it difficult to provide an integrated map service, for any specific purpose, at higher levels. There is no uniform platform that can be used to manage all involved maps. The main reason for this is that datasets are submitted by individual coal mines using their individual, diverse software. No consistent model is used within the software for data abstraction and symbolization. This paper first reviews all the essential specifications concerning OGC (Open Geospatial Consortium) interoperability. Then an OGC standard-oriented architecture is proposed to provide distributed coal mine map services. Within this new architecture the management of spatial data archives, and the integration of coal mine maps, are achieved through the interfaces of geospatial services. Finally an open source geospatial approach is suggested to implement the proposed scheme. A case study of the Huaibei Coal Group is used to demonstrate the proposal.
