5G sets an ambitious goal of increasing the capacity per area of current 4G network by 1000 fold. Due to the high splitting gain of dense small cells, ultra dense network(UDN) is widely considered as a key component i...5G sets an ambitious goal of increasing the capacity per area of current 4G network by 1000 fold. Due to the high splitting gain of dense small cells, ultra dense network(UDN) is widely considered as a key component in achieving this goal. In this paper, we outline the main challenges that come with dense cell deployment, including interference, mobility, power consumption and backhaul. Technologies designed to tackle these challenges in long term evolution system(LTE) and their deficiencies in UDN context are also analyzed. To combat these challenges more efficiently, a series of technologies are introduced along with some of our initial research results. Moreover, the trends of user-centric and peer-to-peer design in UDN are also elaborated.展开更多
AIM:To understand the complex reaction of gastric inflammation induced by Helicobacter pylori(H pylori) in a systematic manner using a protein interaction network. METHODS:The expression of genes significantly changed...AIM:To understand the complex reaction of gastric inflammation induced by Helicobacter pylori(H pylori) in a systematic manner using a protein interaction network. METHODS:The expression of genes significantly changed on microarray during H pylori infection was scanned from the web literary database and translated into proteins.A network of protein interactions was constructed by searching the primary interactions of selected proteins.The constructed network was mathematically analyzed and its biological function was examined.In addition,the nodes on the network were checked to determine if they had any further functional importance or relation to other proteins by extending them. RESULTS:The scale-free network showing the relationship between inflammation and carcinogenesis was constructed.Mathematical analysis showed hub and bottleneck proteins,and these proteins were mostly related to immune response.The network contained pathways and proteins related to H pylori infection,such as the JAK-STAT pathway triggered by interleukins.Activation of nuclear factor (NF)-κB,TLR4,and other proteins known to function as core proteins of immune response were also found. These immune-related proteins interacted on the network with pathways and proteins related to the cell cycle,cell maintenance and proliferation,andtranscription regulators such as BRCA1,FOS,REL,and zinc finger proteins.The extension of nodes showed interactions of the immune proteins with cancer- related proteins.One extended network,the core network,a summarized form of the extended network, and cell pathway model were constructed. CONCLUSION:Immune-related proteins activated by H pylori infection interact with proto-oncogene proteins.The hub and bottleneck proteins are potential drug targets for gastric inflammation and cancer.展开更多
With the advancements in wireless sensor networks, Internet of Vehicles(IOV) has shown great potential in aiding to ease traffic congestion. In IOV, vehicles can easily exchange information with other vehicles and inf...With the advancements in wireless sensor networks, Internet of Vehicles(IOV) has shown great potential in aiding to ease traffic congestion. In IOV, vehicles can easily exchange information with other vehicles and infrastructures, thus, the development of IOV will greatly improve vehicles safety, promote green information consumption and have a profound impact on many industries. The purpose of this paper is to promote the innovation and development of IOV. Firstly, this paper presents general requirements of IOV such as guidelines, basic principles, and the goal of development. Secondly, we analyze critical applications, crucial support, and business model to promote the industrial development of IOV. Finally, this paper proposes some safeguard measures to further promote the development of IOV.展开更多
文摘5G sets an ambitious goal of increasing the capacity per area of current 4G network by 1000 fold. Due to the high splitting gain of dense small cells, ultra dense network(UDN) is widely considered as a key component in achieving this goal. In this paper, we outline the main challenges that come with dense cell deployment, including interference, mobility, power consumption and backhaul. Technologies designed to tackle these challenges in long term evolution system(LTE) and their deficiencies in UDN context are also analyzed. To combat these challenges more efficiently, a series of technologies are introduced along with some of our initial research results. Moreover, the trends of user-centric and peer-to-peer design in UDN are also elaborated.
文摘AIM:To understand the complex reaction of gastric inflammation induced by Helicobacter pylori(H pylori) in a systematic manner using a protein interaction network. METHODS:The expression of genes significantly changed on microarray during H pylori infection was scanned from the web literary database and translated into proteins.A network of protein interactions was constructed by searching the primary interactions of selected proteins.The constructed network was mathematically analyzed and its biological function was examined.In addition,the nodes on the network were checked to determine if they had any further functional importance or relation to other proteins by extending them. RESULTS:The scale-free network showing the relationship between inflammation and carcinogenesis was constructed.Mathematical analysis showed hub and bottleneck proteins,and these proteins were mostly related to immune response.The network contained pathways and proteins related to H pylori infection,such as the JAK-STAT pathway triggered by interleukins.Activation of nuclear factor (NF)-κB,TLR4,and other proteins known to function as core proteins of immune response were also found. These immune-related proteins interacted on the network with pathways and proteins related to the cell cycle,cell maintenance and proliferation,andtranscription regulators such as BRCA1,FOS,REL,and zinc finger proteins.The extension of nodes showed interactions of the immune proteins with cancer- related proteins.One extended network,the core network,a summarized form of the extended network, and cell pathway model were constructed. CONCLUSION:Immune-related proteins activated by H pylori infection interact with proto-oncogene proteins.The hub and bottleneck proteins are potential drug targets for gastric inflammation and cancer.
文摘With the advancements in wireless sensor networks, Internet of Vehicles(IOV) has shown great potential in aiding to ease traffic congestion. In IOV, vehicles can easily exchange information with other vehicles and infrastructures, thus, the development of IOV will greatly improve vehicles safety, promote green information consumption and have a profound impact on many industries. The purpose of this paper is to promote the innovation and development of IOV. Firstly, this paper presents general requirements of IOV such as guidelines, basic principles, and the goal of development. Secondly, we analyze critical applications, crucial support, and business model to promote the industrial development of IOV. Finally, this paper proposes some safeguard measures to further promote the development of IOV.
