Among the human users of the Internet of Things,the hearing-impaired is a special group of people for whom normal information expression forms,such as voice and video are unaccessible,and most of them have some diffic...Among the human users of the Internet of Things,the hearing-impaired is a special group of people for whom normal information expression forms,such as voice and video are unaccessible,and most of them have some difficulty in understanding information in text form.The hearing-impaired are accustomed to receiving information expressed in sign language.For this situation,a new information expression form for the Internet of Things oriented toward the hearing-impaired is proposed in this paper,and the new expression is based on sign language video synthesis.Under the sign synthesis frame,three modules are necessary:constructing database,searching for appropriate sign language video units and transition units,and generating interpolated frames.With this method,text information could be transformed into sign language expression for the hearing-impaired.展开更多
The social transmission of food preferences （STFP） is a behavioural task of olfactory memory, in which an observer rat learns safe food odours from a demonstrator rat, and shows preference for this odour in a subseq...The social transmission of food preferences （STFP） is a behavioural task of olfactory memory, in which an observer rat learns safe food odours from a demonstrator rat, and shows preference for this odour in a subsequent choice test. However, previous studies have failed to detect the transmission of information about food study, we tested how demonstrators＇ health affects the exchange of of potential danger and food aversion using STFP test. In this odour information and whether observers can learn danger information from an unhealthy demonstrator. As expected, the observer rat formed an odour preference after interacting with a demonstrator rat that had just eaten food containing a new odour, however, odour preference rather than aversion was also formed after interacting with a demonstrator rat injected with LiC1 （used to induce gastric malaise）. Furthermore, anaesthetized demonstrator rats and half-anaesthetized demonstrator rats, which showed obvious motor deficits suggesting an unhealthy state, also socially transmitted food preferences to observers. These results suggest that the social transmission of food preferences task is independent of a demonstrators＇ health, and that information about dangerous foods cannot be transmitted using this behavioural task.展开更多
microRNAs regulate diverse biological processes such as development and aging by promoting degradation or inhibiting translation of their target mRNAs. In this study, we have found that the miR-58 family microRNAs reg...microRNAs regulate diverse biological processes such as development and aging by promoting degradation or inhibiting translation of their target mRNAs. In this study, we have found that the miR-58 family microRNAs regulate lifespan in C.elegans. Intriguingly, members of the miR-58 family affect lifespan differently, sometimes in opposite directions, and have complex genetic interactions. The abundances of the miR-58 family miRNAs are up-regulated in the long-lived daf-2 mutant in a daf-16-dependent manner, indicating that these miRNAs are effectors of insulin signaling in C. elegans. We also found that miR-58 is regulated by insulin signaling and partially required for the lifespan extension mediated by reduced insulin signaling,germline ablation, dietary restriction, and mild mitochondrial dysfunction. We further identified the daf-21, ins-1, and isw-1 mRNAs as endogenous targets of miR-58. Our study shows that miRNAs function in multiple lifespan extension mechanisms,and that the seed sequence is not the dominant factor defining the role of a miRNA in lifespan regulation.展开更多
基金supported by the National Natural Science Foundation of China(Nos.60825203,60973056,60973057,U0935004)National Technology Support Project(2007BAH13B01)+2 种基金Beijing Municipal Natural Science Foundation(4102009)Scientific Research Common Program of Beijing Municipal Commission of Education(KM200710005023)PHR(IHLB)
文摘Among the human users of the Internet of Things,the hearing-impaired is a special group of people for whom normal information expression forms,such as voice and video are unaccessible,and most of them have some difficulty in understanding information in text form.The hearing-impaired are accustomed to receiving information expressed in sign language.For this situation,a new information expression form for the Internet of Things oriented toward the hearing-impaired is proposed in this paper,and the new expression is based on sign language video synthesis.Under the sign synthesis frame,three modules are necessary:constructing database,searching for appropriate sign language video units and transition units,and generating interpolated frames.With this method,text information could be transformed into sign language expression for the hearing-impaired.
基金supported by the 973 Program of the Ministry of Science and Technology of China(2013CB835103)the Strategic Priority Research Program of Chinese Academy of Science(XDB02020200)the National Science Foundation of China(31100775)
文摘The social transmission of food preferences （STFP） is a behavioural task of olfactory memory, in which an observer rat learns safe food odours from a demonstrator rat, and shows preference for this odour in a subsequent choice test. However, previous studies have failed to detect the transmission of information about food study, we tested how demonstrators＇ health affects the exchange of of potential danger and food aversion using STFP test. In this odour information and whether observers can learn danger information from an unhealthy demonstrator. As expected, the observer rat formed an odour preference after interacting with a demonstrator rat that had just eaten food containing a new odour, however, odour preference rather than aversion was also formed after interacting with a demonstrator rat injected with LiC1 （used to induce gastric malaise）. Furthermore, anaesthetized demonstrator rats and half-anaesthetized demonstrator rats, which showed obvious motor deficits suggesting an unhealthy state, also socially transmitted food preferences to observers. These results suggest that the social transmission of food preferences task is independent of a demonstrators＇ health, and that information about dangerous foods cannot be transmitted using this behavioural task.
基金supported by the NIH Office of Infrastructure Programs (P40 OD010440), for providing worm strainssupported by Beijing Municipal Science and Technology Commission (a fund for cultivation and development of innovation base) and the Ministry of Science and Technology of China (2014CB84980001)
文摘microRNAs regulate diverse biological processes such as development and aging by promoting degradation or inhibiting translation of their target mRNAs. In this study, we have found that the miR-58 family microRNAs regulate lifespan in C.elegans. Intriguingly, members of the miR-58 family affect lifespan differently, sometimes in opposite directions, and have complex genetic interactions. The abundances of the miR-58 family miRNAs are up-regulated in the long-lived daf-2 mutant in a daf-16-dependent manner, indicating that these miRNAs are effectors of insulin signaling in C. elegans. We also found that miR-58 is regulated by insulin signaling and partially required for the lifespan extension mediated by reduced insulin signaling,germline ablation, dietary restriction, and mild mitochondrial dysfunction. We further identified the daf-21, ins-1, and isw-1 mRNAs as endogenous targets of miR-58. Our study shows that miRNAs function in multiple lifespan extension mechanisms,and that the seed sequence is not the dominant factor defining the role of a miRNA in lifespan regulation.
