AIM: TO investigate colonic endocrine cells in lympho- cytic colitis (LC) patients. METHODS: Fifty-seven patients with LC were in- cluded. These patients were 41 females and 16 males, with an average age of 49 yea...AIM: TO investigate colonic endocrine cells in lympho- cytic colitis (LC) patients. METHODS: Fifty-seven patients with LC were in- cluded. These patients were 41 females and 16 males, with an average age of 49 years (range 19-84 years). Twenty-seven subjects that underwent colonoscopy with biopsies were used as controls. These subjects underwent colonoscopy because of gastrointestinal bleeding or health worries, where the source of bleed- ing was identified as haemorrhoids or angiodysplasia. They were 19 females and 8 males with an average age of 49 years (range 18-67 years). Biopsies from the right and left colon were obtained from both patients and controls during colonoscopy. Biopsies were fixed in 4% buffered paraformaldehyde, embedded in paraffin and cut into 5 μm-thick sections. The sections immunostained by the avidin-biotin-complex method for se- rotonin, peptide YY (PYY), pancreatic polypeptide (PP) enteroglucagon and somatostatin cells. The cell densi- ties were quantified by computerised image analysis using Olympus software. RESULTS: The colon of both the patient and the control subjects were macroscopically normal. Histo- pathological examination of colon biopsies from con- trols revealed normal histology. All patients fulfilled the diagnosis criteria required for of LC: an increase in intraepithelial lymphocytes (〉 20 lymphocytes/100 epithelial cells) and surface epithelial damage with increased lamina propria plasma cells and absent or minimal crypt architectural distribution. In the colon of both patients and control subjects, serotonin-, PYY-, PP-, enteroglucagon- and somatostatin-immunoreac- tive cells were primarily located in the upper part of the crypts of Lieberk0hn. These cells were basket- or flask-shaped. There was no statistically significant dif- ference between the right and left colon in controls with regards to the densities of serotonin- and PYY- immunoreactive cells (P = 0.9 and 0.1, respectively). Serotonin cell density in the right colon in controls was 28.9 ± 1.8 and in LC patients 41.6±2.6 (P = 0.008). In the left colon, the corresponding figures were 28.5± 1.9 and 42.4± 2.9, respectively (P = 0.009). PYY cell density in the right colon of the controls was 10.1 ± 1 and of LC patients 41 ± 4 (P = 0.00006). In the left colon, PYY cell density in controls was 6.6± 1.2 and in LC patients 53.3 ± 4.6 (P = 0.00007). CONCLUSION: The change in serotonin cells could be caused by an interaction between immune cells and serotonin cells, and that of PYY density might be sec- ondary.展开更多
We obtain exact spatiotemporal similaritons to a (3+ l)-dimensional inhomogeneous nonlinear Schrodinger equation, which describes the propagation of optical pulses in a cubic-quintic nonlinearity medium with distri...We obtain exact spatiotemporal similaritons to a (3+ l)-dimensional inhomogeneous nonlinear Schrodinger equation, which describes the propagation of optical pulses in a cubic-quintic nonlinearity medium with distributed dispersion and gain. A one-to-one correspondence between such self-similar waves and solutions of the elliptic equation is found when a certain compatibility condition is satisfied. Based on exact solutions, we discuss evolutional behaviors of self-similar cnoidal waves and chirped similaritons in two kind of typicai soliton control systems. Moreover, the comparison between chirped similaritons and chirp-free solitons is given.展开更多
Objective Tu Jia ethnomedicine is a unique medical system inherited and adhibited by Tu Jia minority living in central-south China. Panax japonicus C. A. Mey.(Bai San Qi,白三七) is recognized as an effective and rare ...Objective Tu Jia ethnomedicine is a unique medical system inherited and adhibited by Tu Jia minority living in central-south China. Panax japonicus C. A. Mey.(Bai San Qi,白三七) is recognized as an effective and rare medicinal plant to treat weakness, fatigue and rheumatism in Tu Jia ethnomedicine. This paper is to discover more substance evidence for the application of Tu Jia ethnomedicine. Methods Column chromatography and preparative high performance liquid chromatography (HPLC) was applied for isolation and purification;1H-NMR, 13C-NMR, 1H-1H COSY, HSQC and HMBC NMR spectra were applied for structure identification;Methyl thiazolyl tetrazolim (MTT) assays were applied for cytotoxicity evaluation. Results Totally 12 known compounds were isolated by column chromatography and preparative HPLC from rhizomes of Panax japonicus C. A. Mey.(Bai San Qi,白三七). Structures of these compounds were identified by their NMR spectra. All the 12 compounds were triterpenoid saponins. Five of them were oleanolic acid type, and the remaining 7 were dammarane type. Eleven compounds were assayed for their cytotoxic activity against Hep G2 human liver cancer cell lines and BGC-823 human gastric cancer cell lines. Three of the 11 showed relatively dominant cytotoxicity against these cell lines. Conclusions A total of 12 known compounds have been identified from Panax japonicus C. A. Mey.(Bai San Qi,白三七);NMR spectra of compounds with similar skeletons showed regular characteristics;3 compounds showed relatively dominant cytotoxicity against Hep G2 and BGC-823 cancer cell lines, and the result can be valued as weak while setting the taxol as a positive control.展开更多
Ride and handling are two paramount factors in design and development of vehicle suspension systems. Conflicting trends in ride and handling characteristics propel engineers toward employing multi-objective optimizati...Ride and handling are two paramount factors in design and development of vehicle suspension systems. Conflicting trends in ride and handling characteristics propel engineers toward employing multi-objective optimization methods capable of providing the best trade-off designs compromising both criteria simultaneously. Although many studies have been performed on multi-objective optimization of vehicle suspension system, only a few of them have used probabilistic approaches considering effects of uncertainties in the design. However, it has been proved that optimum point obtained from deterministic optimization without taking into account the effects of uncertainties may lead to high-risk points instead of optimum ones. In this work, reliability-based robust multi-objective optimization of a 5 degree of freedom (5-DOF) vehicle suspension system is performed using method of non-dominated sorting genetic algorithm-II (NSGA-II) in conjunction with Monte Carlo simulation (MCS) to obtain best designs considering both comfort and handling. Road profile is modeled as a random function using power spectral density (PSD) which is in better accordance with reality. To accommodate the robust approach, the variance of all objective functions is also considered to be minimized. Also, to take into account the reliability criterion, a reliability-based constraint is considered in the optimization. A deterministic optimization has also been performed to compare the results with probabilistic study and some other deterministic studies in the literature. In addition, sensitivity analysis has been performed to reveal the effects of different design variables on objective functions. To introduce the best trade-off points from the obtained Pareto fronts, TOPSIS method has been employed. Results show that optimum design point obtained from probabilistic optimization in this work provides better performance while demonstrating very good reliability and robustness. However, other optimum points from deterministic optimizations violate the regarded constraints in the presence of uncertainties.展开更多
An improved homogeneous balance principle and self-similar solutions to the cubic-quintic nonlinear Schroedinger and impose constraints on the functions describing dispersion, self-similar waves are presented.
Teleportation schemes with a five-atom entangled state are investigated. In the teleportation scheme Bell state measurements (BSMs) are difficult for physical realization, so we investigate another strategy using se...Teleportation schemes with a five-atom entangled state are investigated. In the teleportation scheme Bell state measurements (BSMs) are difficult for physical realization, so we investigate another strategy using separate measurements instead of BSM based on cavity quantum electrodynamics techniques. The scheme of two-atom entangled state teleportation is a controlled and probabilistic one. For the teleportation of the three-atom entangled state, the scheme is a probabilistic one. The fidelity and the probability of the successful teleportation are also obtained.展开更多
A gastric intrinsic factor output under 200 U/h after pentagastrin stimulation (N > 2000 U/h) is specific for pernicious anemia. The other findings are either variable or non specific. Serum intrinsic factor antibo...A gastric intrinsic factor output under 200 U/h after pentagastrin stimulation (N > 2000 U/h) is specific for pernicious anemia. The other findings are either variable or non specific. Serum intrinsic factor antibodies, considered as specific in general practice, are present only in half of the patients with pernicious anemia. In their absence, since the disappearance of the Schilling tests, the gastric tubage currently used for the study of gastric acid secretion, is obligatory for the simultaneous study of intrinsic factor output. This study is important to eliminate another disease much more frequent than pernicious anemia, the protein bound to cobalamin malabsorption was observed in achlorhydric simple atrophic gastritis in the presence of intrinsic factor secretion.展开更多
The authors discovered a new magnetic properties of the phosphorous and carbon with a four and five bond, and stibine, bismuthine in organometallic chemistry. This allows to modify many of classical reactions by repla...The authors discovered a new magnetic properties of the phosphorous and carbon with a four and five bond, and stibine, bismuthine in organometallic chemistry. This allows to modify many of classical reactions by replacing with the nitrogen atoms to atoms of phosphorus, arsenic, antimony and bismuth. The authors have proposed a new mechanism for the possible reactions.展开更多
Afferent and efferent neural elements of the retina and central ganglia in the freshwater snail Planorbarius corneus were labelled using retrograde transport of neurobiotin through the optic nerve.Axons of at least so...Afferent and efferent neural elements of the retina and central ganglia in the freshwater snail Planorbarius corneus were labelled using retrograde transport of neurobiotin through the optic nerve.Axons of at least some photoreceptor cells become direct contributors to the optic nerve as no synaptic junctions could be detected.The processes enter the cerebral ganglion and form a dense bundle of thin afferent fibres,the so-called optical neuropil.Efferent neurons were revealed in all ganglia,except the buccal ones.Some of the ascending axons branch in the cerebral ganglia,cross the cerebro-cerebral commissure,reach the contralateral eye and form arborizations in the eye cup.Some efferent neurons send axons to different peripheral nerves as well:n.n.intestinalis,pallialis dexter,pallialis sinister internus et externus.Serotonin-and FMRF-amide-ergic fibres were revealed in the optic nerve.These fibres belong to those central neurons which send their axons to the ipsilateral eye only.They form abundant varicoses in the eye cup and nuclear layer of the retina,and possibly help to regulate retinal sensitivity to light.展开更多
A theory is presented to predict that a novel type of incoherently coupled spatial soliton families, named anti-dark soliton families, can exist in cubic-quintie nonlinear media. The intensity profiles, associated pha...A theory is presented to predict that a novel type of incoherently coupled spatial soliton families, named anti-dark soliton families, can exist in cubic-quintie nonlinear media. The intensity profiles, associated phase distribution and propagation properties are discussed in detail.展开更多
AIM:To investigate the effects of schisandrin B (Sch B) on free fatty acid (FFA)-induced steatosis in L-02 cells.METHODS:Cellular steatosis was induced by incubating L-02 cells with a FFA mixture (oleate and palmitate...AIM:To investigate the effects of schisandrin B (Sch B) on free fatty acid (FFA)-induced steatosis in L-02 cells.METHODS:Cellular steatosis was induced by incubating L-02 cells with a FFA mixture (oleate and palmitate at the ratio of 2:1) for 24 h.Cytotoxicity and apoptosis were evaluated by 3-(4,5-dmethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and Annexin V/propidium iodide staining,respectively.Cellular total lipid was determined using a photocolorimetric method after Nile red staining,and triglyceride content was measured using an enzymatic kit.To study the effects of Sch B on steatosis,L-02 cells were treated with Sch B (1-100 μmol/L) in the absence or presence of 1 mmol/L FFA for 24 h,and cellular total lipid and triglyceride levels were measured.To explore the mechanisms of action of Sch B in the steatotic L-02 cells,mRNA levels of several regulators of hepatic lipid metabolism including adipose differentiation related protein (ADRP),sterol regulatory element binding protein 1 (SREBP-1),peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ were measured by quantitative real-time polymerase chain reaction (PCR),and protein levels of ADRP and SREBP-1 were measured by immunoblotting.RESULTS:Treatment with 1 mmol/L FFA for 24 h induced intracellular lipid accumulation in L-02 cells comparable to that in human steatotic livers without causing apparent apoptosis and cytotoxicity.Sch B mitigated cellular total lipid and triglyceride accumulations in the steatotic L-02 cells in a dose-dependent manner.Quantitative real-time PCR and Western blot analyses revealed that treatment of L-02 cells with 100 μmol/L Sch B reverted the FFA-stimulated up-regulation of ADRP and SREBP-1.CONCLUSION:Sch B inhibits FFA-induced steatosis in L-02 cells by,at least in part,reversing the up-regulation of ADRP and SREBP-1.展开更多
By constructing appropriate transformations and an extended elliptic sub-equation approach, we find some exact solutions of variable coefficient cubic-quintie nonlinear Schrodinger equation with an external potential,...By constructing appropriate transformations and an extended elliptic sub-equation approach, we find some exact solutions of variable coefficient cubic-quintie nonlinear Schrodinger equation with an external potential, which include bell and kink profile solitary wave solutions, singular solutions, triangular periodic wave solutions and so on.展开更多
Halo-olefinic impurities in 1,1,1,3,3-pentafluoropropane (HFC-245fa) product used as blowing agents, etc. could damage the human body and must be removed. Activated carbon was treated by HCI, HN03 and NaOH, respecti...Halo-olefinic impurities in 1,1,1,3,3-pentafluoropropane (HFC-245fa) product used as blowing agents, etc. could damage the human body and must be removed. Activated carbon was treated by HCI, HN03 and NaOH, respectively. The adsorptive performance of unmodified and modified activated carbons for the removal of a low con- tent of l-chloro-3,3,3-trifluoro-l-propene (HCFC-1233zd), 1,3,3,3-tetrafluoro-l-propene (HFC-1234ze), 1- chloro-l,3,3,3-tetrafluoro-l-propene (HFC-1224zb) and 2-chloro-l,3,3,3-tetrafluoro-l-propene (HFC-1224xe) halo-olefins in the 1,1,1,3,3-pentafluoropropane (HFC-245fa] product was investigated. These halo-olefinic im- purities could be substantially removed from the HFC-245fa product via the adsorption over activated carbon when the adsorption temperature was under 333 K, which can be attributed to the n-n dispersion interactions between the halo-olefins and carbon graphite layer. The basic surface groups of activated carbon could catalyze the decomposition of HFC-245fa to form HFC-1234ze. However, the significant increase in the amount of surface acidic groups of activated carbon led to a distinct decrease of adsorption capacity due to the reduction in the mi- cropore volume of adsorbent and a decrease in the strength of the n-n dispersive interactions between halo- olefin molecules and carbon basal. The breakthrough time of halo-olefinic impurities on activated carbon in- creased with the increase of molecular mass and the decrease of molecular symmetry.展开更多
The 13th Five-year Plan period ushered in a new era of socialism with Chinese characteristics.During this period,China’s economy transitioned from rapid to high-quality growth and weathered the storms of the trade wa...The 13th Five-year Plan period ushered in a new era of socialism with Chinese characteristics.During this period,China’s economy transitioned from rapid to high-quality growth and weathered the storms of the trade war with the United States and the COVID-19 outbreak.Chinese policymakers embraced new development concepts,and fought to cut overcapacity and excess inventory,deleverage,lower costs,and bolster weak areas under the theme of supply-side structural reforms.In fighting the three tough battles of major risk prevention,targeted poverty reduction and pollution abatement,China has largely resolved myriad structural contradictions and maintained rapid domestic economic growth and stability.Most targets for the 13th Five-year Plan period have been achieved ahead of time or are near completion on time.Institutional sophistication has bolstered high-quality development.展开更多
Tolerance of a facultative marine fungus Aspergillus flavus towards As (V) was tested.Luxuriant growth of the test isolate was observed in culture media with As (V) concentrations of 25 mg L-1 and 50 mg L-1,indicating...Tolerance of a facultative marine fungus Aspergillus flavus towards As (V) was tested.Luxuriant growth of the test isolate was observed in culture media with As (V) concentrations of 25 mg L-1 and 50 mg L-1,indicating its tolerance to the metal.Accumulation rate of arsenic was always higher when exposed to As (V) at 50 mg L-1 than at 25 mg L-1.The study reveals Aspergillus flavus as a promising candidate for environmental bioremediation.Arsenic contents (mg g-1) in the fungus when exposed to 50 mg L-1 As (V) were measured as 11.1773,4.0983,and 8.0000 mg g-1 on day 3,6 and 9,respectively.The highest content was observed initially,i.e.on day 3,followed by a decline and a rise again.These results provide baseline information for further explorations regarding the exploitation of the fungus for arsenic removal.展开更多
文摘AIM: TO investigate colonic endocrine cells in lympho- cytic colitis (LC) patients. METHODS: Fifty-seven patients with LC were in- cluded. These patients were 41 females and 16 males, with an average age of 49 years (range 19-84 years). Twenty-seven subjects that underwent colonoscopy with biopsies were used as controls. These subjects underwent colonoscopy because of gastrointestinal bleeding or health worries, where the source of bleed- ing was identified as haemorrhoids or angiodysplasia. They were 19 females and 8 males with an average age of 49 years (range 18-67 years). Biopsies from the right and left colon were obtained from both patients and controls during colonoscopy. Biopsies were fixed in 4% buffered paraformaldehyde, embedded in paraffin and cut into 5 μm-thick sections. The sections immunostained by the avidin-biotin-complex method for se- rotonin, peptide YY (PYY), pancreatic polypeptide (PP) enteroglucagon and somatostatin cells. The cell densi- ties were quantified by computerised image analysis using Olympus software. RESULTS: The colon of both the patient and the control subjects were macroscopically normal. Histo- pathological examination of colon biopsies from con- trols revealed normal histology. All patients fulfilled the diagnosis criteria required for of LC: an increase in intraepithelial lymphocytes (〉 20 lymphocytes/100 epithelial cells) and surface epithelial damage with increased lamina propria plasma cells and absent or minimal crypt architectural distribution. In the colon of both patients and control subjects, serotonin-, PYY-, PP-, enteroglucagon- and somatostatin-immunoreac- tive cells were primarily located in the upper part of the crypts of Lieberk0hn. These cells were basket- or flask-shaped. There was no statistically significant dif- ference between the right and left colon in controls with regards to the densities of serotonin- and PYY- immunoreactive cells (P = 0.9 and 0.1, respectively). Serotonin cell density in the right colon in controls was 28.9 ± 1.8 and in LC patients 41.6±2.6 (P = 0.008). In the left colon, the corresponding figures were 28.5± 1.9 and 42.4± 2.9, respectively (P = 0.009). PYY cell density in the right colon of the controls was 10.1 ± 1 and of LC patients 41 ± 4 (P = 0.00006). In the left colon, PYY cell density in controls was 6.6± 1.2 and in LC patients 53.3 ± 4.6 (P = 0.00007). CONCLUSION: The change in serotonin cells could be caused by an interaction between immune cells and serotonin cells, and that of PYY density might be sec- ondary.
基金Supported by the National Natural Science Foundation of China under Grant No.10974177by the Ministry of Science and Technology of China under Grant No.2010DFA04690
文摘We obtain exact spatiotemporal similaritons to a (3+ l)-dimensional inhomogeneous nonlinear Schrodinger equation, which describes the propagation of optical pulses in a cubic-quintic nonlinearity medium with distributed dispersion and gain. A one-to-one correspondence between such self-similar waves and solutions of the elliptic equation is found when a certain compatibility condition is satisfied. Based on exact solutions, we discuss evolutional behaviors of self-similar cnoidal waves and chirped similaritons in two kind of typicai soliton control systems. Moreover, the comparison between chirped similaritons and chirp-free solitons is given.
基金the funding support from the National Natural Science Foundation of China (No. 81703819 and No. 81874369)Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine (No. 2017-04)+1 种基金Hunan Provincial Key Laboratory of Dong Medicine (No. 2015TP1020-02)Students Research Innovative Program of Hunan Province (No. 2018413)
文摘Objective Tu Jia ethnomedicine is a unique medical system inherited and adhibited by Tu Jia minority living in central-south China. Panax japonicus C. A. Mey.(Bai San Qi,白三七) is recognized as an effective and rare medicinal plant to treat weakness, fatigue and rheumatism in Tu Jia ethnomedicine. This paper is to discover more substance evidence for the application of Tu Jia ethnomedicine. Methods Column chromatography and preparative high performance liquid chromatography (HPLC) was applied for isolation and purification;1H-NMR, 13C-NMR, 1H-1H COSY, HSQC and HMBC NMR spectra were applied for structure identification;Methyl thiazolyl tetrazolim (MTT) assays were applied for cytotoxicity evaluation. Results Totally 12 known compounds were isolated by column chromatography and preparative HPLC from rhizomes of Panax japonicus C. A. Mey.(Bai San Qi,白三七). Structures of these compounds were identified by their NMR spectra. All the 12 compounds were triterpenoid saponins. Five of them were oleanolic acid type, and the remaining 7 were dammarane type. Eleven compounds were assayed for their cytotoxic activity against Hep G2 human liver cancer cell lines and BGC-823 human gastric cancer cell lines. Three of the 11 showed relatively dominant cytotoxicity against these cell lines. Conclusions A total of 12 known compounds have been identified from Panax japonicus C. A. Mey.(Bai San Qi,白三七);NMR spectra of compounds with similar skeletons showed regular characteristics;3 compounds showed relatively dominant cytotoxicity against Hep G2 and BGC-823 cancer cell lines, and the result can be valued as weak while setting the taxol as a positive control.
文摘Ride and handling are two paramount factors in design and development of vehicle suspension systems. Conflicting trends in ride and handling characteristics propel engineers toward employing multi-objective optimization methods capable of providing the best trade-off designs compromising both criteria simultaneously. Although many studies have been performed on multi-objective optimization of vehicle suspension system, only a few of them have used probabilistic approaches considering effects of uncertainties in the design. However, it has been proved that optimum point obtained from deterministic optimization without taking into account the effects of uncertainties may lead to high-risk points instead of optimum ones. In this work, reliability-based robust multi-objective optimization of a 5 degree of freedom (5-DOF) vehicle suspension system is performed using method of non-dominated sorting genetic algorithm-II (NSGA-II) in conjunction with Monte Carlo simulation (MCS) to obtain best designs considering both comfort and handling. Road profile is modeled as a random function using power spectral density (PSD) which is in better accordance with reality. To accommodate the robust approach, the variance of all objective functions is also considered to be minimized. Also, to take into account the reliability criterion, a reliability-based constraint is considered in the optimization. A deterministic optimization has also been performed to compare the results with probabilistic study and some other deterministic studies in the literature. In addition, sensitivity analysis has been performed to reveal the effects of different design variables on objective functions. To introduce the best trade-off points from the obtained Pareto fronts, TOPSIS method has been employed. Results show that optimum design point obtained from probabilistic optimization in this work provides better performance while demonstrating very good reliability and robustness. However, other optimum points from deterministic optimizations violate the regarded constraints in the presence of uncertainties.
基金Supported by Natural Science Foundation of Zhejiang Province of China under Grant Nos.Y604106 and Y606182the Special Foundation of "University Talent Indraught Engineering" of Guangdong Province of China under Grant No.GDU2009109the Key Academic Discipline Foundation of Guangdong Shaoguan University under Gant No.KZ2009001
文摘An improved homogeneous balance principle and self-similar solutions to the cubic-quintic nonlinear Schroedinger and impose constraints on the functions describing dispersion, self-similar waves are presented.
基金The project supported by Natural Science Foundation of Anhui Province of China under Grant No. 03042401, the Key Program of the Education Department of Anhui Province under Grant Nos. 2002kj029zd, 2004kj005zd, and the Talent Foundation of Anhui University
文摘Teleportation schemes with a five-atom entangled state are investigated. In the teleportation scheme Bell state measurements (BSMs) are difficult for physical realization, so we investigate another strategy using separate measurements instead of BSM based on cavity quantum electrodynamics techniques. The scheme of two-atom entangled state teleportation is a controlled and probabilistic one. For the teleportation of the three-atom entangled state, the scheme is a probabilistic one. The fidelity and the probability of the successful teleportation are also obtained.
文摘A gastric intrinsic factor output under 200 U/h after pentagastrin stimulation (N > 2000 U/h) is specific for pernicious anemia. The other findings are either variable or non specific. Serum intrinsic factor antibodies, considered as specific in general practice, are present only in half of the patients with pernicious anemia. In their absence, since the disappearance of the Schilling tests, the gastric tubage currently used for the study of gastric acid secretion, is obligatory for the simultaneous study of intrinsic factor output. This study is important to eliminate another disease much more frequent than pernicious anemia, the protein bound to cobalamin malabsorption was observed in achlorhydric simple atrophic gastritis in the presence of intrinsic factor secretion.
文摘The authors discovered a new magnetic properties of the phosphorous and carbon with a four and five bond, and stibine, bismuthine in organometallic chemistry. This allows to modify many of classical reactions by replacing with the nitrogen atoms to atoms of phosphorus, arsenic, antimony and bismuth. The authors have proposed a new mechanism for the possible reactions.
文摘Afferent and efferent neural elements of the retina and central ganglia in the freshwater snail Planorbarius corneus were labelled using retrograde transport of neurobiotin through the optic nerve.Axons of at least some photoreceptor cells become direct contributors to the optic nerve as no synaptic junctions could be detected.The processes enter the cerebral ganglion and form a dense bundle of thin afferent fibres,the so-called optical neuropil.Efferent neurons were revealed in all ganglia,except the buccal ones.Some of the ascending axons branch in the cerebral ganglia,cross the cerebro-cerebral commissure,reach the contralateral eye and form arborizations in the eye cup.Some efferent neurons send axons to different peripheral nerves as well:n.n.intestinalis,pallialis dexter,pallialis sinister internus et externus.Serotonin-and FMRF-amide-ergic fibres were revealed in the optic nerve.These fibres belong to those central neurons which send their axons to the ipsilateral eye only.They form abundant varicoses in the eye cup and nuclear layer of the retina,and possibly help to regulate retinal sensitivity to light.
文摘A theory is presented to predict that a novel type of incoherently coupled spatial soliton families, named anti-dark soliton families, can exist in cubic-quintie nonlinear media. The intensity profiles, associated phase distribution and propagation properties are discussed in detail.
基金Supported by The Hong Kong Baptist University,No.FRG 08-09/II-30
文摘AIM:To investigate the effects of schisandrin B (Sch B) on free fatty acid (FFA)-induced steatosis in L-02 cells.METHODS:Cellular steatosis was induced by incubating L-02 cells with a FFA mixture (oleate and palmitate at the ratio of 2:1) for 24 h.Cytotoxicity and apoptosis were evaluated by 3-(4,5-dmethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and Annexin V/propidium iodide staining,respectively.Cellular total lipid was determined using a photocolorimetric method after Nile red staining,and triglyceride content was measured using an enzymatic kit.To study the effects of Sch B on steatosis,L-02 cells were treated with Sch B (1-100 μmol/L) in the absence or presence of 1 mmol/L FFA for 24 h,and cellular total lipid and triglyceride levels were measured.To explore the mechanisms of action of Sch B in the steatotic L-02 cells,mRNA levels of several regulators of hepatic lipid metabolism including adipose differentiation related protein (ADRP),sterol regulatory element binding protein 1 (SREBP-1),peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ were measured by quantitative real-time polymerase chain reaction (PCR),and protein levels of ADRP and SREBP-1 were measured by immunoblotting.RESULTS:Treatment with 1 mmol/L FFA for 24 h induced intracellular lipid accumulation in L-02 cells comparable to that in human steatotic livers without causing apparent apoptosis and cytotoxicity.Sch B mitigated cellular total lipid and triglyceride accumulations in the steatotic L-02 cells in a dose-dependent manner.Quantitative real-time PCR and Western blot analyses revealed that treatment of L-02 cells with 100 μmol/L Sch B reverted the FFA-stimulated up-regulation of ADRP and SREBP-1.CONCLUSION:Sch B inhibits FFA-induced steatosis in L-02 cells by,at least in part,reversing the up-regulation of ADRP and SREBP-1.
基金supported by National Natural Science Foundation of China under Grant No.10172056
文摘By constructing appropriate transformations and an extended elliptic sub-equation approach, we find some exact solutions of variable coefficient cubic-quintie nonlinear Schrodinger equation with an external potential, which include bell and kink profile solitary wave solutions, singular solutions, triangular periodic wave solutions and so on.
基金Supported by the Major Project of Green Chemical Industry of Zhejiang Province(2007C11043)
文摘Halo-olefinic impurities in 1,1,1,3,3-pentafluoropropane (HFC-245fa) product used as blowing agents, etc. could damage the human body and must be removed. Activated carbon was treated by HCI, HN03 and NaOH, respectively. The adsorptive performance of unmodified and modified activated carbons for the removal of a low con- tent of l-chloro-3,3,3-trifluoro-l-propene (HCFC-1233zd), 1,3,3,3-tetrafluoro-l-propene (HFC-1234ze), 1- chloro-l,3,3,3-tetrafluoro-l-propene (HFC-1224zb) and 2-chloro-l,3,3,3-tetrafluoro-l-propene (HFC-1224xe) halo-olefins in the 1,1,1,3,3-pentafluoropropane (HFC-245fa] product was investigated. These halo-olefinic im- purities could be substantially removed from the HFC-245fa product via the adsorption over activated carbon when the adsorption temperature was under 333 K, which can be attributed to the n-n dispersion interactions between the halo-olefins and carbon graphite layer. The basic surface groups of activated carbon could catalyze the decomposition of HFC-245fa to form HFC-1234ze. However, the significant increase in the amount of surface acidic groups of activated carbon led to a distinct decrease of adsorption capacity due to the reduction in the mi- cropore volume of adsorbent and a decrease in the strength of the n-n dispersive interactions between halo- olefin molecules and carbon basal. The breakthrough time of halo-olefinic impurities on activated carbon in- creased with the increase of molecular mass and the decrease of molecular symmetry.
文摘The 13th Five-year Plan period ushered in a new era of socialism with Chinese characteristics.During this period,China’s economy transitioned from rapid to high-quality growth and weathered the storms of the trade war with the United States and the COVID-19 outbreak.Chinese policymakers embraced new development concepts,and fought to cut overcapacity and excess inventory,deleverage,lower costs,and bolster weak areas under the theme of supply-side structural reforms.In fighting the three tough battles of major risk prevention,targeted poverty reduction and pollution abatement,China has largely resolved myriad structural contradictions and maintained rapid domestic economic growth and stability.Most targets for the 13th Five-year Plan period have been achieved ahead of time or are near completion on time.Institutional sophistication has bolstered high-quality development.
基金due to the Department of Science and Technology,Government of India,for financial support sanctioned under SERC Fast Track Proposals for Young Scientists Scheme (No. SR/FT/L-99/2006) to AKV
文摘Tolerance of a facultative marine fungus Aspergillus flavus towards As (V) was tested.Luxuriant growth of the test isolate was observed in culture media with As (V) concentrations of 25 mg L-1 and 50 mg L-1,indicating its tolerance to the metal.Accumulation rate of arsenic was always higher when exposed to As (V) at 50 mg L-1 than at 25 mg L-1.The study reveals Aspergillus flavus as a promising candidate for environmental bioremediation.Arsenic contents (mg g-1) in the fungus when exposed to 50 mg L-1 As (V) were measured as 11.1773,4.0983,and 8.0000 mg g-1 on day 3,6 and 9,respectively.The highest content was observed initially,i.e.on day 3,followed by a decline and a rise again.These results provide baseline information for further explorations regarding the exploitation of the fungus for arsenic removal.