The occurrence of concomitant aortic aneurysm and colorectal cancer is a rare medical entity,and con-troversy surrounds its optimal treatment.We report a case of rectal cancer and concomitant aneurysm from the ascendi...The occurrence of concomitant aortic aneurysm and colorectal cancer is a rare medical entity,and con-troversy surrounds its optimal treatment.We report a case of rectal cancer and concomitant aneurysm from the ascending aorta to the common iliac artery.As with DeBakey typeⅠaortic dissecting aneurysm,our patient was treated by rectal cancer resection,with preservation of the anus(Dixon operation)under controlled hypo-tension.Blood pressure was maintained at 80-90/50-60 mmHg and the pulse at 70-90 beats/min.The pathological examination of the surgical specimen showed a poorly differentiated T3N0 tumor.The patient had an uneventful recovery without aneurysm rupture,and was discharged from hospital on postoperative day 15 after 3 d adjuvant chemotherapy with oxaliplatin combined with calcium folinate and fluorouracil.The patient was given six courses of adjuvant chemotherapy in 6 mo,without recurrence or metastasis,and the aneurysm was still stable after 2 years follow-up.展开更多
Objective:Despite resection with curative intent,a majority of patients with gastric cancer will develop disease recurrence.Postoperative adjuvant chemo-radiotherapy increase the curability of surgery,prevent local re...Objective:Despite resection with curative intent,a majority of patients with gastric cancer will develop disease recurrence.Postoperative adjuvant chemo-radiotherapy increase the curability of surgery,prevent local recurrence and improve survival.Methods:Between December 2005 and February 2010,33 patients were eligible for the study,17 patients were randomly assigned for chemo-radiotherapy (GI) and 16 patients with surgery alone (GII).Patients in GI received chemotherapy (fluorouracil,425 mg/m 2/day,and leucovorin,20 mg/m 2/day,for 5 days) was initiated on day 1 and was followed by chemo-radiotherapy beginning 28 days after the start of the initial cycle of chemotherapy.Chemo-radiotherapy consisted of 4500 cGy of radiation at 180 cGy/day,five days/week for five weeks,with fluorouracil (400 mg/m 2/day) and leucovorin (20 mg/m 2/day) on the first four and the last four days of radiotherapy.One month after the completion of radiotherapy,two five-day cycles of fluorouracil (425 mg/m 2/day) plus leucovorin (20 mg/m 2/day) were given one month apart.Results:Grade 3 gastrointestinal toxicity was more common (23.2%) while grade 3 hematological toxicity were (5.8%).Both 3-year survival (53%) and disease free survival (41%) rates were higher in GI than in GII in which they were 43.7% and 31% respectively.Relapse rate was higher in GII (56.3%) than in GI (35.3%).Conclusion:The present study revealed that chemo-radiotherapy after gastric resection in patients with gastric adenocarcinoma improves survival and relapse rates with manageable toxicities.However,studies with larger number of patients are recommended to confirm our results.展开更多
文摘The occurrence of concomitant aortic aneurysm and colorectal cancer is a rare medical entity,and con-troversy surrounds its optimal treatment.We report a case of rectal cancer and concomitant aneurysm from the ascending aorta to the common iliac artery.As with DeBakey typeⅠaortic dissecting aneurysm,our patient was treated by rectal cancer resection,with preservation of the anus(Dixon operation)under controlled hypo-tension.Blood pressure was maintained at 80-90/50-60 mmHg and the pulse at 70-90 beats/min.The pathological examination of the surgical specimen showed a poorly differentiated T3N0 tumor.The patient had an uneventful recovery without aneurysm rupture,and was discharged from hospital on postoperative day 15 after 3 d adjuvant chemotherapy with oxaliplatin combined with calcium folinate and fluorouracil.The patient was given six courses of adjuvant chemotherapy in 6 mo,without recurrence or metastasis,and the aneurysm was still stable after 2 years follow-up.
文摘Objective:Despite resection with curative intent,a majority of patients with gastric cancer will develop disease recurrence.Postoperative adjuvant chemo-radiotherapy increase the curability of surgery,prevent local recurrence and improve survival.Methods:Between December 2005 and February 2010,33 patients were eligible for the study,17 patients were randomly assigned for chemo-radiotherapy (GI) and 16 patients with surgery alone (GII).Patients in GI received chemotherapy (fluorouracil,425 mg/m 2/day,and leucovorin,20 mg/m 2/day,for 5 days) was initiated on day 1 and was followed by chemo-radiotherapy beginning 28 days after the start of the initial cycle of chemotherapy.Chemo-radiotherapy consisted of 4500 cGy of radiation at 180 cGy/day,five days/week for five weeks,with fluorouracil (400 mg/m 2/day) and leucovorin (20 mg/m 2/day) on the first four and the last four days of radiotherapy.One month after the completion of radiotherapy,two five-day cycles of fluorouracil (425 mg/m 2/day) plus leucovorin (20 mg/m 2/day) were given one month apart.Results:Grade 3 gastrointestinal toxicity was more common (23.2%) while grade 3 hematological toxicity were (5.8%).Both 3-year survival (53%) and disease free survival (41%) rates were higher in GI than in GII in which they were 43.7% and 31% respectively.Relapse rate was higher in GII (56.3%) than in GI (35.3%).Conclusion:The present study revealed that chemo-radiotherapy after gastric resection in patients with gastric adenocarcinoma improves survival and relapse rates with manageable toxicities.However,studies with larger number of patients are recommended to confirm our results.
