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基因芯片整合方法在预报儿童急性髓性白血病亚型中的应用
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作者 郭景康 朱煜 王健 《生物信息学》 2009年第2期99-103,共5页
对急性髓性白血病(AML)病人进行明确的亚型分类,有助于制定合适的治疗方案并预测其治疗效果。之前研究表明基因芯片技术在白血病亚型分类中已取得了较好效果,但由于儿童AML发病率较低,相应的芯片分析研究较少,因此目前用于构建儿童AML... 对急性髓性白血病(AML)病人进行明确的亚型分类,有助于制定合适的治疗方案并预测其治疗效果。之前研究表明基因芯片技术在白血病亚型分类中已取得了较好效果,但由于儿童AML发病率较低,相应的芯片分析研究较少,因此目前用于构建儿童AML亚型分类模型的数据相对不足,是否可以应用现有的成人分类模型数据来对儿童AML进行预报还有待研究。应用基因芯片整合分析方法,对来自不同实验的研究成人或儿童AML亚型分类的基因芯片数据进行整合,应用支持向量机分析整合后数据集的亚型预报准确率。结果表明整合后的芯片数据在儿童AML亚型分类预报中的准确率达到97.24%,特征基因分析结果也说明在同一种AML亚型中,对于来自不同年龄组的样本,其特征基因有较高的表达相似性。 展开更多
关键词 儿童急性髓性白血病 基因芯片整合 亚型预报 支持向量机 特征基因
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Aerosol Data Assimilation Using Data from Fengyun-3A and MODIS:Application to a Dust Storm over East Asia in 2011 被引量:6
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作者 Xiaoli XIA Jinzhong MIN +2 位作者 Feifei SHEN Yuanbing WANG Chun YANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2019年第1期1-14,共14页
Aerosol optical depth (AOD) is the most basic paxalneter that describes the optical properties of atmospheric aerosols, and it can be used to indicate aerosol content. In this study, we assimilated AOD data from the... Aerosol optical depth (AOD) is the most basic paxalneter that describes the optical properties of atmospheric aerosols, and it can be used to indicate aerosol content. In this study, we assimilated AOD data from the Fengyun-3A (FY-3A) and MODIS meteorological satellite using the Gridpoint Statistical Interpolation three-dimensional variational data assimilation system. Experiments were conducted for a dust storm over East Asia in April 2011. Each 0600 UTC analysis initialized a 24-h Weather Research and Forecasting with Chemistry model forecast. The results generally showed that the assimilation of satellite AOD observational data can significantly improve model aerosol mass prediction skills. The AOD distribution of the analysis field was closer to the observations of the satellite after assimilation of satellite AOD data. In addition, the analysis resulting from the experiment assimilating both FY-3A/MERSI (Medium-resolution Spectral Imager) AOD data and MODIS AOD data had closer agreement with the ground-based values than the individual assimilation of the two datasets for the dust storm over East Asia. These results suggest that the Chinese FY-3A satellite aerosol products can be effectively applied to numerical models and dust weather analysis. 展开更多
关键词 Fengyun-3A satellite aerosol optical depth data assimilation dust storm
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Predicting Business Insolvency: The Latvian Experience
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作者 Ruta Sneidere Inta Bruna 《Journal of Modern Accounting and Auditing》 2011年第5期487-497,共11页
This paper presents investigations of bankruptcy predicting models which can be useful for external users of a financial statement. Only the methods of financial analysis for insolvency prediction, useful on the basis... This paper presents investigations of bankruptcy predicting models which can be useful for external users of a financial statement. Only the methods of financial analysis for insolvency prediction, useful on the basis of financial statements, were investigated. The paper studied the influence of insolvency on the development of the Latvian Economy, including such relevant points: dynamics of number of insolvency cases in Latvia, data of the payment discipline of debts, tax liabilities of the insolvent companies, dynamics of unemployment support payments. Empirical investigations shows that only Altman's Z'" and Fulmer's H models demonstrate accuracy above 80% in all analyzed business sectors and they are applicable for Latvian companies. The other models are useful to some particular business sector. 展开更多
关键词 INSOLVENCY BANKRUPTCY predicting model financial report
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