Copper alloyed with various compositions of nickel and tin were cast into molds under argon atmosphere.The cast rods were homogenized,solution heat treated,followed by aging for different time duration.The specimens w...Copper alloyed with various compositions of nickel and tin were cast into molds under argon atmosphere.The cast rods were homogenized,solution heat treated,followed by aging for different time duration.The specimens were characterized for microstructure and tested for microhardness and wear rate.A hybrid model with a linear function and radial basis function was developed to analyze the influence of nickel,tin,and aging time on the microhardness and tribological behavior of copper-nickel-sin alloy system.The results indicate that increase in the composition of nickel and tin increases the microhardness and decreases the wear rate of the alloy.The increase in the concentration of nickel and tin decreases the peak aging time of the alloy system.展开更多
Oral exposure to toxic metals such as cadmium （Cd）, lead （Pb）, copper （Cu） and aluminum （AI） can induce various adverse health effects in humans and animals. However, the effects of these metals on the gut mic...Oral exposure to toxic metals such as cadmium （Cd）, lead （Pb）, copper （Cu） and aluminum （AI） can induce various adverse health effects in humans and animals. However, the effects of these metals on the gut microbiota have received limited attention. The present study demonstrated that long-term toxic metal exposure altered the intestinal microbiota of mice in a metal-specific and time-dependent manner. Subchronic oral Cu exposure for eight weeks caused a profound decline in gut microbial diversity in mice, whereas no significant changes were observed in groups treated with other metals. Cd exposure signif- icantly increased the relative abundances of organisms from the genera Alistipes and Odoribacter and caused marked decreases in Mollicutes and unclassified Ruminococcaceae. Pb exposure significantly decreased the abundances of eight genera： unclassified and uncultured Ruminococcaceae, unclassified Lachnospiraceae, Ruminiclostridium_9, Rikenellaceae_RCg_gut group, Oscillibacter, Anaerotruncus and Lachnoclostridium. Cu exposure affected abundances of the genera Alistipes, Bacteroides, Ruminococcaceae_UCG-014, AUobaculum, Mollicutes_RF9_norank, Rikenellaceae_RCg gut_group, Ruminococcaceae_unclassified and Turicibacter. A1 exposure increased the abundance of Odoribacter and decreased that of Anaerotruncus. Exposure to any metal for eight weeks significantly decreased the abun- dance of Akkermansia. These results provide a new understanding regarding the role of toxic metals in the pathogenesis of intestinal and systemic disorders in the host within the gut microbiota framework.展开更多
文摘Copper alloyed with various compositions of nickel and tin were cast into molds under argon atmosphere.The cast rods were homogenized,solution heat treated,followed by aging for different time duration.The specimens were characterized for microstructure and tested for microhardness and wear rate.A hybrid model with a linear function and radial basis function was developed to analyze the influence of nickel,tin,and aging time on the microhardness and tribological behavior of copper-nickel-sin alloy system.The results indicate that increase in the composition of nickel and tin increases the microhardness and decreases the wear rate of the alloy.The increase in the concentration of nickel and tin decreases the peak aging time of the alloy system.
基金supported by the National Natural Science Foundation of China Key Program(31530056)National Natural Science Foundation of China(31601452)+3 种基金the General Financial Grant from the China Postdoctoral Science Foundation(2016M590412)the Natural Science Foundation of Jiangsu Province(BK20160175)the General Financial Grant from the Jiangsu Postdoctoral Science Foundation(1601113C)BBSRC Newton Fund Joint Centre Award
文摘Oral exposure to toxic metals such as cadmium （Cd）, lead （Pb）, copper （Cu） and aluminum （AI） can induce various adverse health effects in humans and animals. However, the effects of these metals on the gut microbiota have received limited attention. The present study demonstrated that long-term toxic metal exposure altered the intestinal microbiota of mice in a metal-specific and time-dependent manner. Subchronic oral Cu exposure for eight weeks caused a profound decline in gut microbial diversity in mice, whereas no significant changes were observed in groups treated with other metals. Cd exposure signif- icantly increased the relative abundances of organisms from the genera Alistipes and Odoribacter and caused marked decreases in Mollicutes and unclassified Ruminococcaceae. Pb exposure significantly decreased the abundances of eight genera： unclassified and uncultured Ruminococcaceae, unclassified Lachnospiraceae, Ruminiclostridium_9, Rikenellaceae_RCg_gut group, Oscillibacter, Anaerotruncus and Lachnoclostridium. Cu exposure affected abundances of the genera Alistipes, Bacteroides, Ruminococcaceae_UCG-014, AUobaculum, Mollicutes_RF9_norank, Rikenellaceae_RCg gut_group, Ruminococcaceae_unclassified and Turicibacter. A1 exposure increased the abundance of Odoribacter and decreased that of Anaerotruncus. Exposure to any metal for eight weeks significantly decreased the abun- dance of Akkermansia. These results provide a new understanding regarding the role of toxic metals in the pathogenesis of intestinal and systemic disorders in the host within the gut microbiota framework.
