目的评估症状性非急性期颅内大动脉闭塞血管内再通治疗的可行性、安全性及初步效果。方法回顾性收集2015年10月至2017年12月上海市同济医院采用血管内再通治疗的15例亚急性和慢性颅内大动脉闭塞患者临床和影像学资料,分析再通成功率、...目的评估症状性非急性期颅内大动脉闭塞血管内再通治疗的可行性、安全性及初步效果。方法回顾性收集2015年10月至2017年12月上海市同济医院采用血管内再通治疗的15例亚急性和慢性颅内大动脉闭塞患者临床和影像学资料,分析再通成功率、围手术期并发症及随访结果。结果15例患者中13例(86.7%)成功再通。术中发生末梢栓塞事件7例(症状性3例,无症状性4例),血管夹层1例,术后出现支架取栓相关脑出血1例。术后所有患者均存活,未发生高灌注综合征。出院时13例成功再通患者中12例症状好转,1例无明显改善;2例再通失败患者中1例症状恶化,1例无明显改善。术后13例获血管造影随访平均5.8个月,1例并发夹层再通失败患者病变段再闭塞,12例成功再通患者中1例支架内再狭窄,其余11例均无血流动力学意义上再狭窄。14例获临床随访平均5.6个月,12例成功再通患者中除1例支架内狭窄再发短暂性脑缺血发作(TIA)外,均无再发卒中及TIA,90 d改良Rankin量表(m RS)评分示功能良好;2例再通失败患者90 d m RS评分示功能恶化。结论严格筛选患者基础上采取血管内开通术治疗非急性期颅内大动脉闭塞是可行、安全的,近期内能改善患者脑缺血症状,降低卒中再发率,但远期疗效有待长期随访证实。展开更多
目的:探讨不同病因所致的大血管闭塞性脑卒中患者在亚急性期磁敏感血管征(susceptibility vessel sign,SVS)的表现。方法:选择北京大学第一医院神经内科病房2017年12月—2019年8月收治的经磁共振血管成像、CT血管造影或数字减影血管造...目的:探讨不同病因所致的大血管闭塞性脑卒中患者在亚急性期磁敏感血管征(susceptibility vessel sign,SVS)的表现。方法:选择北京大学第一医院神经内科病房2017年12月—2019年8月收治的经磁共振血管成像、CT血管造影或数字减影血管造影证实存在颅内大血管闭塞,且在发病第3~14天接受磁敏感加权成像(susceptibility-weighted imaging,SWI)检查的卒中患者进行回顾性分析,对比心源性栓塞(cardioembolism,CE)和大动脉粥样硬化性卒中(large artery atherosclerosis,LAA)患者的SVS征出现情况。结果:共有51例患者进入分析,其中女19例、男32例,平均年龄(63.04±11.23)岁。两组患者在性别、高血压、糖尿病、冠心病、高脂血症、吸烟、入院美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分间差异均无统计学意义。与LAA组相比,CE组患者年龄更大,合并房颤的比例更高,差异有统计学意义(P<0.05)。共有30例患者表现为SVS征阳性,心源性栓塞组患者SVS征阳性率为30%,显著低于大动脉粥样硬化性卒中患者(65.9%),两组间差异有统计学意义(P=0.039)。在敏感度测试中仅纳入SWI检查时间在卒中后第7~14天的患者,两组间SVS征阳性率的差异仍有统计学意义(0 vs.72.7%,P=0.006)。以有无房颤分组,合并房颤的卒中患者SVS征阳性率为25%,显著低于无房颤的卒中患者(65.1%),两组间差异有统计学意义(P=0.043)。结论:大动脉闭塞性脑卒中发病的亚急性期,心源性栓塞患者的SVS征阳性率低于LAA亚型的卒中患者;SVS征在卒中不同亚型鉴别中的作用尚需要进一步大样本的病例研究来验证。展开更多
在急性ST段抬高型心肌梗死(STEMI)患者的直接经皮冠状动脉介入治疗(PCI)中,非梗死血管的慢性完全闭塞(chronic total occlusion,CT0)病变并不少见。CT0病变一般是指冠状动脉闭塞至少3个月以上的病变。急性STEMI患者非梗死相关血管合并CT...在急性ST段抬高型心肌梗死(STEMI)患者的直接经皮冠状动脉介入治疗(PCI)中,非梗死血管的慢性完全闭塞(chronic total occlusion,CT0)病变并不少见。CT0病变一般是指冠状动脉闭塞至少3个月以上的病变。急性STEMI患者非梗死相关血管合并CT0所占的比例大约为10%左右[1]。国外研究认为慢性闭塞病变是STEMI患者住院期间预后不良的独立的预测因素[2],发现STEMI合并CT0患者冠状动脉病变重,病死率高。本研究回顾性分析合并CT0的STEMI临床特点和影响患者临床预后的危险因素,从而指导临床工作。展开更多
Background: Coronary angiographies performed during acute coronary syndrome show different coronary morphologies-vessel occlusions, thrombi and various types of stenoses. In a few cases of acute coronary syndrome, ang...Background: Coronary angiographies performed during acute coronary syndrome show different coronary morphologies-vessel occlusions, thrombi and various types of stenoses. In a few cases of acute coronary syndrome, angiography reveals normal coronary arteries. It is the purpose of this study to analyze this specific subset of patients who presented with an acute coronary syndrome but had a normal coronary angiogram with respect to the preangiographic diagnostics, risk stratification and clinical follow-up. Methods and results: A total of 897 coronary angiographies were performed as an emergency procedure in our institution. The majority of patients(n=821) presented with coronary artery disease and the majority was treated by mechanical revascularization(86.3%). In 76 patients(8.5%), no coronary artery stenosis was documented. However, according to the preangiographic risk stratification, coronary artery disease was expected in these patients. Observations documented angiographically included coronary spasms(6.6%) and muscle bridges(5.3%). During a mean follow-up of 11.2±6.4 months, one patient developed an acute myocardial infarction requiring coronary intervention. All other patients were free of any cardiac event. Conclusions: In summary, we have to consider that coronary angiography may not always detect the cause of myocardial ischemia in every patient. There is a small group of patients with normal coronary angiograms during acute coronary syndrome. Additional diagnostic procedures like intravascular ultrasound(IVUS) or the assessment of intracoronary physiological parameters may increase the diagnostic value of angiography.展开更多
文摘目的评估症状性非急性期颅内大动脉闭塞血管内再通治疗的可行性、安全性及初步效果。方法回顾性收集2015年10月至2017年12月上海市同济医院采用血管内再通治疗的15例亚急性和慢性颅内大动脉闭塞患者临床和影像学资料,分析再通成功率、围手术期并发症及随访结果。结果15例患者中13例(86.7%)成功再通。术中发生末梢栓塞事件7例(症状性3例,无症状性4例),血管夹层1例,术后出现支架取栓相关脑出血1例。术后所有患者均存活,未发生高灌注综合征。出院时13例成功再通患者中12例症状好转,1例无明显改善;2例再通失败患者中1例症状恶化,1例无明显改善。术后13例获血管造影随访平均5.8个月,1例并发夹层再通失败患者病变段再闭塞,12例成功再通患者中1例支架内再狭窄,其余11例均无血流动力学意义上再狭窄。14例获临床随访平均5.6个月,12例成功再通患者中除1例支架内狭窄再发短暂性脑缺血发作(TIA)外,均无再发卒中及TIA,90 d改良Rankin量表(m RS)评分示功能良好;2例再通失败患者90 d m RS评分示功能恶化。结论严格筛选患者基础上采取血管内开通术治疗非急性期颅内大动脉闭塞是可行、安全的,近期内能改善患者脑缺血症状,降低卒中再发率,但远期疗效有待长期随访证实。
文摘目的:探讨不同病因所致的大血管闭塞性脑卒中患者在亚急性期磁敏感血管征(susceptibility vessel sign,SVS)的表现。方法:选择北京大学第一医院神经内科病房2017年12月—2019年8月收治的经磁共振血管成像、CT血管造影或数字减影血管造影证实存在颅内大血管闭塞,且在发病第3~14天接受磁敏感加权成像(susceptibility-weighted imaging,SWI)检查的卒中患者进行回顾性分析,对比心源性栓塞(cardioembolism,CE)和大动脉粥样硬化性卒中(large artery atherosclerosis,LAA)患者的SVS征出现情况。结果:共有51例患者进入分析,其中女19例、男32例,平均年龄(63.04±11.23)岁。两组患者在性别、高血压、糖尿病、冠心病、高脂血症、吸烟、入院美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分间差异均无统计学意义。与LAA组相比,CE组患者年龄更大,合并房颤的比例更高,差异有统计学意义(P<0.05)。共有30例患者表现为SVS征阳性,心源性栓塞组患者SVS征阳性率为30%,显著低于大动脉粥样硬化性卒中患者(65.9%),两组间差异有统计学意义(P=0.039)。在敏感度测试中仅纳入SWI检查时间在卒中后第7~14天的患者,两组间SVS征阳性率的差异仍有统计学意义(0 vs.72.7%,P=0.006)。以有无房颤分组,合并房颤的卒中患者SVS征阳性率为25%,显著低于无房颤的卒中患者(65.1%),两组间差异有统计学意义(P=0.043)。结论:大动脉闭塞性脑卒中发病的亚急性期,心源性栓塞患者的SVS征阳性率低于LAA亚型的卒中患者;SVS征在卒中不同亚型鉴别中的作用尚需要进一步大样本的病例研究来验证。
文摘在急性ST段抬高型心肌梗死(STEMI)患者的直接经皮冠状动脉介入治疗(PCI)中,非梗死血管的慢性完全闭塞(chronic total occlusion,CT0)病变并不少见。CT0病变一般是指冠状动脉闭塞至少3个月以上的病变。急性STEMI患者非梗死相关血管合并CT0所占的比例大约为10%左右[1]。国外研究认为慢性闭塞病变是STEMI患者住院期间预后不良的独立的预测因素[2],发现STEMI合并CT0患者冠状动脉病变重,病死率高。本研究回顾性分析合并CT0的STEMI临床特点和影响患者临床预后的危险因素,从而指导临床工作。
文摘Background: Coronary angiographies performed during acute coronary syndrome show different coronary morphologies-vessel occlusions, thrombi and various types of stenoses. In a few cases of acute coronary syndrome, angiography reveals normal coronary arteries. It is the purpose of this study to analyze this specific subset of patients who presented with an acute coronary syndrome but had a normal coronary angiogram with respect to the preangiographic diagnostics, risk stratification and clinical follow-up. Methods and results: A total of 897 coronary angiographies were performed as an emergency procedure in our institution. The majority of patients(n=821) presented with coronary artery disease and the majority was treated by mechanical revascularization(86.3%). In 76 patients(8.5%), no coronary artery stenosis was documented. However, according to the preangiographic risk stratification, coronary artery disease was expected in these patients. Observations documented angiographically included coronary spasms(6.6%) and muscle bridges(5.3%). During a mean follow-up of 11.2±6.4 months, one patient developed an acute myocardial infarction requiring coronary intervention. All other patients were free of any cardiac event. Conclusions: In summary, we have to consider that coronary angiography may not always detect the cause of myocardial ischemia in every patient. There is a small group of patients with normal coronary angiograms during acute coronary syndrome. Additional diagnostic procedures like intravascular ultrasound(IVUS) or the assessment of intracoronary physiological parameters may increase the diagnostic value of angiography.
