亚洲玉米螟性信息素的简便合成

以廉价的1,12-十二碳二醇为起始原料,经单边溴代、乙酰化、氧化吡啶氧化和Wittig反应,以36.6%的总收率合成了亚洲玉米螟性信息素(Z/E)-12-十四碳烯醇乙酸酯(Z/E,89/11),接着将顺反异构体混合物在亚硝酸钠和硝酸体系中经构型转化得到顺反比例为17/83的12-十四碳烯醇乙酸酯。产物通过红外光谱、核磁共振光谱数据确证,并采用气相色谱确定了顺反异构体的比例。该方法简单、易操作,而且总产率相对高于文献报道。

人民币成为亚洲储备性货币现状研究

人民币初步具备了区域性货币的条件，但由于其现有国际货币地位低下、影响力不足，人民币在相当长的时间内将处于国际货币竞争格局的弱势地位，要使人民币成为亚洲主要储备性货币，我国必须首先加强自身的轻济实力，这是一国货币国际化的基础；其次，必须考虑和亚洲尤其是东亚形成更紧密经贸关系，在东亚金融合作中，我国应该发挥主导作用；最后，必须完善我国的资本市场和金融市场结构，形成由市场决定的汇率及利率机制。

亚洲传播研究的蓬勃发展与未来:中国视角与日本视角(上)

中国学者与日本学者就"亚洲传播研究的蓬勃发展及未来"这一问题进行对话,其中的问题包括:亚洲传播研究蓬勃发展的情况如何?为什么亚洲传播研究者尚未终止欧洲中心传播范式的统治?亚洲传播研究的目的与意义何在?哪些亚洲本土文化概念可以为亚洲传播理论的发展做出贡献?如何评价亚洲传播研究?

亚洲传播研究的蓬勃发展与未来:中国视角与日本视角(下)

中国学者与日本学者就"亚洲传播研究的蓬勃发展及未来"这一问题进行对话,其中的问题包括:亚洲传播研究蓬勃发展的情况如何?为什么亚洲传播研究者尚未终止欧洲中心传播范式的统治?亚洲传播研究的目的与意义何在?哪些亚洲本土文化概念可以为亚洲传播理论的发展做出贡献?如何评价亚洲传播研究?

Progress on Sex Pheromone Synthesis of Asian Corn Borer, Ostrinia furnacalis (Guenee)

The progress on the components identification, synthesis methods （syn- thetic strategy of carbon chain increasing and synthetic strategy of carbon chain de- creasing） of Asian corn borer （Ostrinia fumacalis （Guenee）） sex pheromone was reviewed, which will provide a reference for the control of Asian corn borer.

Clinical features of aortic dissection associated with Takayasu＇s arteritis

Takayasu＇s arteritis （TA） is a chronic and nonspecific in- flammatory vessel disease that involves the aorta and its major branches. TA results in stenosis, occlusion or aneu- rysmal degeneration of large arteries pathologically. Al- though TA is an unusual disease, it is more commonly ob- served to occur in Asian females compared to the general population worldwide. Aortic dissection is a very rare com- plication of TA, and only a limited number of TA cases presenting with aortic dissection have been published so far.

Female breast cancer in Vietnam: a comparison across Asian specific regions

Breast cancer is one of the most commonly diagnosed malignancies and the leading cause of cancer death of women over the world. A large number of females with breast cancer in Vietnam and other Southeast Asian(SEA) countries present at an early age with more aggressive tumors compared with women in Australia. Despite experiencing a low incidence rate, the increasing incidence rate among SEA countries exceeds that of the Westernized world. Changes in reproductive factors, environmental exposures, and lifestyle are the possible causes of this trend. However, limited evidence shows that these factors are associated with breast cancer in the Vietnamese population. Breast cancer incidence rates within Vietnam are not uniform and appear to be dependent on geographic location. Findings from this review have important implications for breast cancer control and treatment in Vietnam. A good understanding of the morphology of the breast and the type and nature of breast cancers presenting in Vietnam is required to facilitate the introduction of an effective national breast screening program.

Non-alcoholic fatty liver disease may not be a severe disease at presentation among Asian Indians

AIM： To evaluate the clinical and biochemical profile of patients with non alcoholic fatty liver disease （NAFLD） and to assess their histological severity at presentation.METHODS： Consecutive patients presenting to the liver clinic of All India Institute of Medical Sciences （AIIMS） with raised transaminases to at least 1.5 times upper limit of normal, and histologically confirmed non-alcoholic fatty liver disease were included. Patients who had significant alcohol intake or positive markers of other liver diseases or who were taking drugs known to produce fatty liver were excluded. The clinical, biochemical and histological profile of this group was studied. RESULTS： Fifty-one patients with NAFLD formed the study population. Their median age and BMI were 34（17-58） years and 26.7（21.3-32.5） kg/m^2 respectively and 46 （90.1%） were males. The majority of the patients had mild inflammation, either grade 1 [32 （63%）] or grade 2 [16 （31%）] and only 3 （6%） patients had severe （grade 3） inflammation. Twenty-three （45%）, 19 （37%）, 8（16%） and 1（2%） patient had stage 0, 1, 2 and 3 fibrosis respectively on index biopsy and none had cirrhosis. On univariate analysis, triglyceride levels more than 150 mg % （OR = 7.1; 95% CI： 1.6-31.5, P = 0.002） and AST ALT ratio 〉 1 （OR = 14.3; 95% CI： 1.4-678.5, P = 0.008） were associated with high grades of inflammation and none was associated with advanced fibrosis. On multivariate logistic regression analysis, hypertriglyceridemia 〉150 mg% was the only factor independently associated with presence of high grade of inflammation （OR = 1.6; 95% CI： 1.3-22.7, P =0.02）, while none was associated with advanced fibrosis. Triglyceride levels correlated positively with inflammatory grade （r = 0.412; P = 0.003）. CONCLUSION： NAFLD in North Indian patients is a disease of young over-weight males, most of whom are insulin resistant and they tend to have a mild histological disease at presentation.

A comparison of the clinical, demographic and psychiatric profiles among patients with erosive and non-erosive reflux disease in a multi-ethnic Asian country

AIM:To examine the clinical spectrum of gastroesophageal reflux disease (GERD) and compare erosive (ERD) with non-erosive (NERD) in terms of clinical, demographic and psychiatric profiles. METHODS: Patients with reflux symptoms were enrolled and stratified to NERD and ERD after endoscopy (LA classification). Patients with ERD presenting with dyspepsia were included. Patients on proton pump inhibitors (PPI) or H2 receptor antagonists before endoscopy were excluded. Demographic data, Helicobacter pylori(H pylori) status and presence of minor psychiatric morbidity (based on General Health Questionnaire-28) were analyzed. RESULTS: Among 690 patients screened, 533 were eligible for analysis (male to female ratio: 3:2; Chinese: 75.4%; Malay: 9.8%; Indian: 14.8%). Clinical spectrum of GERD: N: 40.5%; A: 46%; B: 9.2%; C: 2.1%; D: 0.6%; Barrett's esophagus: 1.7%. Compared to patients with NERD, patients with ERD were significantly older (45 vs 39.4 years), more likely to be male (64.4% vs 53.7%), tended to smoke (19.6% vs 9.7%), less likely to have minor psychiatric morbidity (26.4 vs 46.7%) and were more likely to respond to PPI (79.7 vs 66.8%). There was also a trend towards a higher BMI (24.5 vs 23.5). Race, alcohol consumption and H pylori status were not significant. On multivariate analysis, age and presence of minor psychiatric morbidity remained with significant differences. CONCLUSION: The majority of patients who have typical symptoms of GERD have NERD or mild erosive reflux disease. Compared to patients with erosive reflux disease, patients with NERD were younger and had a higher prevalence of minor psychiatric morbidity.

Plastic-Flow Waves (“Slow-Waves") and Seismic Activity in Central-Eastern Asia

The results inferred from experiments with analogue models carried out previously have shown that two types of plastic-flow waves, “fast-waves" and “slow-waves", are induced in the lower lithosphere (including the lower crust and lithospheric mantle) under driving at plate boundaries and both of them are viscous gravity waves formed by the superposition of major and subsidiary waves. The major waves are similar to solitary waves and the subsidiary waves are traveling waves. The plastic-flow waves in the lower lithosphere control seismic activities in the overlying seismogenic layer and result in the distribution of earthquakes along the wave-crest belts. “Fast-waves" propagated with velocities of orders of magnitude of 100～102km/a have been verified by wave-controlled earthquake migration, showing the “decade waves" and “century waves" with the average periods of 10.8 and 93.4 a, respectively, which originate from the Himalayan driving boundary. According to the recognition of the patterns of the belt-like distribution of strong earthquakes with M S≥7.0, it is indicated further in this paper that the “slow-waves" with velocities of orders of magnitude of 100～101 m/a also originated under compression from the Himalayan driving boundary. Strong earthquakes with M S≥7.0 are controlled mainly by subsidiary waves, because the major waves with a duration of up to 106 a for each disturbance cannot result in the accumulation of enough energy for strong earthquakes due to the relaxation of the upper crust. The subsidiary waves propagate with an average wave length of 445 km, velocities of 0.81～2.80 m/a and periods of 0.16～0.55 Ma. The wave-generating time at the Himalayan driving boundary is about 1.34～4.59 Ma before present for the “slow-waves", corresponding to the stage from the Mid Pliocene to the Mid Early-Pleistocene and being identical with one of the major tectonic episodes of the Himalayan tectonic movement. It is shown from the recognition of the wave-controlled belts of strong earthquakes that two optimal patterns of wave-crest belts originated simultaneously from the eastern and western segments of the Himalayan arc, respectively. The overlap of wave-crest belts of these two systems is responsible for the relative concentration of energy and forms the seismic-energy-background zones for strong earthquakes with M S≥7.0.

FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus

AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE～TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan～ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV.

ASIAN JOURNAL OF ANDROLOGY Information for Authors

The Asian Journal of Andrology is the official publication of the Asian Society of Andrology, and is sponsored by the Shanghai Institute of Materia Medica, Chinese Academy of Sciences. The Journal has been included in 11 international indexing systems, including BIOSIS, CAB Abstracts, CAB Health, Chemical Abstracts, Current Contents/Clinical Medicine, EMBASE, Index Medicus, MEDLINE, PASCAL, Research Alert, and SCI Expanded. The Impact Factor is 1.096 and the Journal ranks third among international andrology journals.

Spontaneous diffuse vasospasm simultaneously found at left main trunk, left anterior descending, left circumflex and right coronary arteries

Coronary artery spasm （CAS） is found not only in Asian but also in white patients. CAS can lead to angina pecto- ris, myocardial infarction, ventricular arrhythmias and sud- den cardiac death. But CAS diagnosis is not necessarily easy, and it also remains highly challenging to therapy and prevention. We present a spontaneous extensive-CAS case with typical clinical features of acute myocardial infarction, despite the regular vasodilator treatment.

What's new about inflammatory bowel diseases in 2011

Inflammatory bowel diseases (IBD) are chronic disorders of the intestine with increasing incidence in Europe, Northern America and asiatic countries such as china. Thus, we have putted together these topic highlight articles to give insights into the current understanding of IBD pathogenesis, diagnostics and treatment.

Seismogram Analysis and Fitting of Three Earthquakes,West Papua,Recorded at Stations ENH and KMI,China

The S wave velocity structure of the earth below Eastern Southeast Asia has been investigated by analyzing the seismogram from surface wave to multiple depth waves in the time domain and three Cartesian components simultaneously.The wave passes across the front area of subduction zone between the Philippine plate and the Asian plate.The main data are waveform comparisons,instead of the arrival times.The synthetic seismogram is calculated using the GEMINI method.The synthetic seismogram constructed by PREMAN global earth model deviates greatly from the measured one.To solve this problem,corrections are needed for the β speed structure.Corrections cover the gradient change of β_h,which turns from negative to positive in upper mantle layers as in the PREMAN,change of earth crust depth and change of zero order coefficients of β velocity function in all earth mantle layers.So,the fitting is obtained,as well as the arrival time or the waveform of Love and Rayleigh surface waves,the S wave and the repetitive depth waves ScS_2 and ScS_3.This result reveals that the Southeast Asia,being stretched due to tectonic release,has a mantle in some parts with negative anomaly of S wave velocity and vertical anisotropy in all earth mantle layers.

Incidence and mortality of female breast cancer in the AsiaPacific region

Objective: To provide an overview of the incidence and mortality of female breast cancer for countries in the Asia-Pacific region.Methods: Statistical information about breast cancer was obtained from publicly available cancer registry and mortality databases(such as GLOBOCAN), and supplemented with data requested from individual cancer registries. Rates were directly age-standardised to the Segi World Standard population and trends were analysed using joinpoint models.Results: Breast cancer was the most common type of cancer among females in the region, accounting for 18% of all cases in 2012, and was the fourth most common cause of cancer-related deaths(9%). Although incidence rates remain much higher in New Zealand and Australia, rapid rises in recent years were observed in several Asian countries. Large increases in breast cancer mortality rates also occurred in many areas, particularly Malaysia and Thailand, in contrast to stabilising trends in Hong Kong and Singapore, while decreases have been recorded in Australia and New Zealand. Mortality trends tended to be more favourable for women aged under 50 compared to those who were 50 years or older. Conclusion: It is anticipated that incidence rates of breast cancer in developing countries throughout the Asia-Pacific region will continue to increase. Early detection and access to optimal treatment are the keys to reducing breast cancerrelated mortality, but cultural and economic obstacles persist. Consequently, the challenge is to customise breast cancer control initiatives to the particular needs of each country to ensure the best possible outcomes.

Protective effects of Asian green vegetables against oxidant induced cytotoxicity

AIM： To evaluate the antioxidant and phase II detoxification enzyme inducing ability of green leaf vegetables consumed in Asia.METHODS： The antioxidant properties of six commonly consumed Asian vegetables were determined using the ABTS, DPPH, deoxyribose, PR bleaching and ironascorbate induced lipid peroxidation assay. Induce of phase II detoxification enzymes was also determined for each respective vegetable extract. Protection against authentic ONOO- and HOCl mediated cytotoxicity in human colon HCT116 cells was determined using the MTT 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrasodium bromide） viability assay.RESULTS： All of the extracts derived from green leaf vegetables exhibited antioxidant properties, while also having cytoprotective effects against ONOO- and HOCI mediated cytotoxicity. In addition, evaluation of the phase II enzyme inducing ability of each extract, as assessed by quinone reductase and glutathione- S-transferase activities, showed significant variation between the vegetables analyzed.CONCLUSION： Green leaf vegetables are potential sources of antioxidants and phase II detoxification enzyme inducers in the Asian diet. It is likely that consumption of such vegetables is a major source of beneficial phytochemical constituents that may protect against colonic damage.

寻找亚洲:2010—2020年亚洲电影研究图谱——知识脉络、前沿热点与研究趋势

在2010—2020这十年的亚洲电影研究中,寻找亚洲成为海内外学者观照亚洲电影的普遍线索。中国学者的亚洲电影研究具有一条贯穿始终的主轴,即亚洲电影主体性建构,海外学者的亚洲电影研究则依循一条由异域奇观的他者想象向全球权力结构的文化博弈转变的轴线。学术话语体系则表现为由旧有的中心—边缘结构向多元文化博弈演进,风靡的亚洲热潮与电影工业奇观是学术话语体系变化的重要原因,而以理论旅行为根基的流动的历史话语建构将成为亚洲电影研究学术话语体系的新去向。未来亚洲电影研究趋势或将涵盖疫情下亚洲电影的裂变与重生、旧概念的复兴与新解、学术集群与多学科的交叉融合,且东亚学者将依旧是主体身份建构的核心力量。

亚洲电影理论：世界电影与亚洲电影

本文试图对“亚洲电影”概念的合理性以及“亚洲电影”作为一种电影理论范式的重要性进行全面辩护。就其本质而言,“亚洲电影”既不能被个别重要国家的电影所代表,也不能被单纯地视为“世界电影”的一部分。相反,亚洲电影理论能够成为对抗西方电影中心论以及国别电影狭隘性的新型范式,它兼具本土性和跨文化性双重特征,能够从多元政治、语言、文化中梳理出一种“亚洲性”的电影经验品质,从而为“亚洲电影”作为一种严肃且可靠的学术概念奠定了前提。

朴槿惠政府东北亚和平合作构想的具体化和改进方向

2013年2月上台的朴槿惠政府提出了一项新的外交政策,即"东北亚和平合作构想",并在国内外进行广泛宣传和研究。"东北亚和平合作构想"为了解决包括区域外国家美国在内的,东北亚区域内各国间的"亚洲悖论",以非传统安全领域的"软安全"问题为中心,开展多边对话机制,并致力于最终形成一个东北亚安全共同体。但该构想尚处于理论起步阶段,对合作(安全)议题、区域范围(参与对象国)、行为主体、国际机制(制度化)、推进战略等问题没有具体界定,距离政策化也还有一段距离。其间朴槿惠总统(政府)向美国和中国介绍了"东北亚和平合作构想",但仅得到美国的消极理解和中国原则上的支持,并没有得到对该构想的实质和具体内容的理解和支持。"东北亚和平合作构想"应要进一步具体化、理论化,以此来得到东北亚各国一致认同且可实践的国际合作体制。