The metastable state and nucleation kinetics of clindamycin phosphate (CP) in cooling crystallization were studied by metastable zone width (MZW) method and induction time method. By correlating the MZW experimental r...The metastable state and nucleation kinetics of clindamycin phosphate (CP) in cooling crystallization were studied by metastable zone width (MZW) method and induction time method. By correlating the MZW experimental results with temperature, agitation rate and cooling rate, it is found that the correlation result shows good agreement with the change trend of MZW. The critical nucleation parameters were evaluated based on the classical theory of nucleation; both the interfacial tension and the radius of critical nucleus increased with the decrease of relative supersaturation. The effect of supersaturation on the nucleation rate was analyzed. It is indicated that the new phase formation of CP is governed by mononuclear mechanism.展开更多
The coupling between system and reservoir is considered to be linear in the coordinates of the bath but nonlinear in the system's coordinate. A dissipative threshold is observed at finite temperatures due to nonli...The coupling between system and reservoir is considered to be linear in the coordinates of the bath but nonlinear in the system's coordinate. A dissipative threshold is observed at finite temperatures due to nonlinear dissipation. The quantum decay rate of a metastable state including higher-order expanded terms of the coupling form function is proposed, which can be strongly decreased at finite temperatures when the quantum dissipative threshold is added to the saddle point of the potential.展开更多
This article studied on five elements system and set general and strict model expectations combining with Traditional Chinese Medicine Zang-fu organs theory,in which absolute stable state,conditional stable state or t...This article studied on five elements system and set general and strict model expectations combining with Traditional Chinese Medicine Zang-fu organs theory,in which absolute stable state,conditional stable state or transient stability and instability in mathematical models were corresponding to human healthy state,sub-healthy state(pathological plateau phase) and health deterioration state respectively.Model parameters were set up according to the mutual generation and restriction relations among five elements.The dynamic model of Five-Elements System was built,of which impulse responses were corresponding to human response under TCM treatment.Analyses of initial value and excitation response were conducted by numerical simulation and results turned out to meet the requirements of general model expectation:five elements system dynamic model had self-organization function;there existed only one non-global stable point and instability region in the five-dimensional space consisting of variables,in which instability was corresponding to pathological deterioration;system stable region was an unbounded domain and it included the stable sub-regions of special straight line-type,ray-type and line segment-type.Among those ray-types,some contained "Regression Peak" were classed as conditional stable regions while others as absolute ones.The existence of this peak indicates that our body must exceed a "Regression Threshold" when transiting from sub-healthy state(pathological plateau phase) to healthy state through self-regulation mechanism.Impulse excitation can reduce certain threshold and then increase the system health level,which is complied with the operating principle of Five-Elements System and the empirical rule of TCM clinical practice.This model has revealed qualitatively the inherent movement law of Five-Elements System and thus provides a new analysis tool for basic theoretical study on TCM.展开更多
基金Supported by the Program of Introducing Talents of Discipline to Universities (No. B06006)
文摘The metastable state and nucleation kinetics of clindamycin phosphate (CP) in cooling crystallization were studied by metastable zone width (MZW) method and induction time method. By correlating the MZW experimental results with temperature, agitation rate and cooling rate, it is found that the correlation result shows good agreement with the change trend of MZW. The critical nucleation parameters were evaluated based on the classical theory of nucleation; both the interfacial tension and the radius of critical nucleus increased with the decrease of relative supersaturation. The effect of supersaturation on the nucleation rate was analyzed. It is indicated that the new phase formation of CP is governed by mononuclear mechanism.
文摘The coupling between system and reservoir is considered to be linear in the coordinates of the bath but nonlinear in the system's coordinate. A dissipative threshold is observed at finite temperatures due to nonlinear dissipation. The quantum decay rate of a metastable state including higher-order expanded terms of the coupling form function is proposed, which can be strongly decreased at finite temperatures when the quantum dissipative threshold is added to the saddle point of the potential.
基金supported by the National Basic Research Program of China (973 Program, No. 2006CB504509)the Science Foundation of Shanghai Municipal Commission of Science and Technology (No. 2007DZ19722, 2008DZ19733000, 2009DZ1974303)+1 种基金the Doctoral Fund of Ministry of Education of China (No. 200802461152)the Fudan Young Teacher's Research Foundation (No. 09FQ07)
文摘This article studied on five elements system and set general and strict model expectations combining with Traditional Chinese Medicine Zang-fu organs theory,in which absolute stable state,conditional stable state or transient stability and instability in mathematical models were corresponding to human healthy state,sub-healthy state(pathological plateau phase) and health deterioration state respectively.Model parameters were set up according to the mutual generation and restriction relations among five elements.The dynamic model of Five-Elements System was built,of which impulse responses were corresponding to human response under TCM treatment.Analyses of initial value and excitation response were conducted by numerical simulation and results turned out to meet the requirements of general model expectation:five elements system dynamic model had self-organization function;there existed only one non-global stable point and instability region in the five-dimensional space consisting of variables,in which instability was corresponding to pathological deterioration;system stable region was an unbounded domain and it included the stable sub-regions of special straight line-type,ray-type and line segment-type.Among those ray-types,some contained "Regression Peak" were classed as conditional stable regions while others as absolute ones.The existence of this peak indicates that our body must exceed a "Regression Threshold" when transiting from sub-healthy state(pathological plateau phase) to healthy state through self-regulation mechanism.Impulse excitation can reduce certain threshold and then increase the system health level,which is complied with the operating principle of Five-Elements System and the empirical rule of TCM clinical practice.This model has revealed qualitatively the inherent movement law of Five-Elements System and thus provides a new analysis tool for basic theoretical study on TCM.
