解毒利肺汤对成人病毒性肺炎T淋巴细胞亚群和炎症因子的影响

目的:观察解毒利肺汤对成人病毒性肺炎T淋巴细胞亚群和炎症因子的影响。方法:将纳入研究的104例成人病毒性肺炎患者抽签分为治疗组(54例)和对照组(50例),对照组在常规治疗的基础上给予利巴韦林,治疗组在对照组的基础上给予解毒利肺汤。治疗1周,观察两组T淋巴细胞亚群(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)及炎症因子(IL-6、IL-8、CRP、TNF-α)的变化。结果:治疗前,两组CD3^+、CD4^+、CD8^+和CD4^+/CD8^+水平比较差异无统计学意义(P>0.05);治疗后,两组CD3^+、CD4^+、CD4^+/CD8^+明显上升而CD8^+明显下降,差异有统计学意义(P<0.05);IL-6、IL-8、CRP、TNF-α均明显下降,差异有统计学意义(P<0.05);治疗组治疗后CD3^+、CD4^+和CD4^+/CD8^+分别为(66.47±21.24)%、(36.74±12.05)%、(1.77±0.31),显著高于对照组治疗后CD3^+、CD4^+和CD4^+/CD8^+,差异有统计学意义(P<0.05);CD8^+、IL-6、IL-8、CRP、TNF-α为(20.09±8.08)%、(20.75±10.23)ng/mL、(8.37±4.45)ng/mL、(3.67±1.48)mg/L、(22.12±9.14)ng/L,显著低于对照组治疗后CD8^+、IL-6、IL-8、CRP、TNF-α,比较差异均有统计学意义(P<0.05)。结论:解毒利肺汤具有调节病毒性肺炎患者免疫功能、抑制炎症反应的作用。

莫桑比克上利戈尼亚钽-铌稀有元素成矿带成矿规律及资源潜力

莫桑比克上利戈尼亚钽-铌稀有元素成矿带位于中南部非洲达马拉-赞比西亚巨型成矿域东段莫桑比克活动带内,已发现钽-铌稀有元素矿床、矿点149处,成矿类型均为伟晶岩型。成矿带内伟晶岩主要为泛非造山作用晚期岩浆结晶分异的产物,成岩时代为440~450 Ma和470~490 Ma,已发现的伟晶岩可划分为5条伟晶岩带,12个伟晶岩田,46个伟晶岩群,超过100个伟晶岩矿化区,与成矿关系密切的LCT(锂-铯-钽)型伟晶岩矿物分带性明显,其中Ta-Nb等成矿元素主要赋存于长石带和锂化带中。钽-铌稀有元素矿床成矿时代与伟晶岩成岩时代相同,主要集中于440~450 Ma和470~480 Ma。矿床的产出受纳玛玛逆冲推覆带、穆格巴飞来峰控制作用明显,矿体产于纳玛玛逆冲推覆带和穆格巴飞来峰边缘环状区南北两侧的EW向、NW向断裂带内的LCT型伟晶岩中,呈脉状、透镜状、板状产出。各矿区自SE→NW或SEE→NWW稀有金属矿化组合具有由简单向复杂,成矿元素种类由单一向综合方向演化的趋势,表明岩浆结晶分异程度在不断升高。结合已有资料,将上利戈尼亚稀有元素成矿带筛选出11处成矿远景区,其中重点远景区6处,一般远景区5处,对重点远景区开展了资源潜力分析,指明了找矿方向。

匈亚利油气地质特征、开发历史及油气生产的经济作用

匈亚利位于中欧东南部,喀尔巴阡盆地之中。该盆地为孤间盆地,由几个次盆地组成,其中最大且最重要的要属潘诺尼亚盆地。该盆地介于西喀尔巴阡、比哈尔、迪纳里德斯、东阿尔卑斯及南阿尔卑斯山脉之间,包括现在的全部匈牙利地区,并且认为是欧洲重要的含油气盆地。匈牙利总面积为93,000平方公里,其中77,000平方公里有利于油气聚集虽然盖层的厚度不同,但是时代较新的沉积盖层几乎都是均质的。基底可分成几个带。整个盆地由中-匈牙利构造带(线)分割形成两个完全不同的单元。纵观盆地不同地区的成因差异,可分成下列几个含油气段(“贮集岩层”)

莫桑比克上利戈尼亚地区航磁、航放异常特征及钽-铌矿找矿方向

为深化莫桑比克上利戈尼亚钽−铌稀有元素成矿带区域成矿规律研究,充分挖掘已有区域成果资料中隐含的找矿有利信息,笔者对所收集莫桑比克北部地区高精度航磁、航放测量网格数据进行转换处理,加强成矿弱信息提取,并在已有成果认识基础上开展区内地质构造的综合推断解释,分析总结区内的航磁、航放异常展布特征及与本区伟晶岩型钽−铌矿的空间对应关系,查明区内主要控矿构造−纳玛玛逆冲推覆带的分布范围和内部断裂构造展布特征。结合区内姆艾尼大型钽铌矿床航空物探综合异常特征,对全区进行类比找矿预测,圈定钽铌矿远景区5处。研究认为,该成矿带北东向延伸被F2断裂错断,南西向断距超过20 km,引起成矿有利区的整体北西转移,追索异常找矿意义重大。

短暂光辉的一生——记叙利亚现实主义画家鲁韦·凯亚利

鲁韦·凯亚利是叙利亚杰出的现实主义画家、叙利亚绘画艺术的先驱之一。鲁韦·凯亚利一生热爱祖国,辛勤工作,把艺术之根深深扎入社会生活之中,为叙利亚绘画艺术的兴起做出了重要的贡献,叙利亚人民把他视为本国绘画艺术的骄傲。

匈牙利算法理论根据证明新探

在经营管理活动中,经常会遇到如何将人、物和事作适当调配,求得人尽其才、物尽其用、事得其人的问题。如有几项工作任务要完成,恰好有几个人可以分别去完成其中的每一项,但由于任务性质和各人专长不同,因此不同的人去完成不同的任务的效率(或费用)也各不相同。那么哪些人被分配去完成哪些任务使总效率最高(或总费用最少)?这类问题称为分配问题。分配问题是管理数学中线性规划的一个重要类型。它可以用单纯形法求解,但由于其模型的特殊性,一般都采用特殊的解法——匈亚利算法。

关于核准刘亚利保荐代表人资格的批复

日信证券有限责任公司:你公司报送的《关于刘亚利注册为保荐代表人的申请报告》(日信证字[2010]074号)及相关文件收悉。根据《证券法》、《证券发行上市保荐业务管理办法》

Composition Analysis of HMW-GS in Australian Wheat Cultivars

[Objective] The aim was to provide information for the breeding of wheat in China.[Method] 64 wheat cultivars from Australia were analyzed by SDS-PAGE to determine their high molecular weight（HMW） glutenin subunit combinations.Then,the cultivars had good HMW-GS were screened.[Result] A total of nine alleles were identified at Glu-1.Glu-A1 encoded two subunits,1 and null subunit,and 1 was the major type,the frequency was 59.37%;Glu-B1 encoded five subunits,7,7＋8,7＋9,14＋15,17＋18,and 7＋8 was the major type,the frequency was 56.2%;Glu-D1 encoded two subunits,2＋12,5＋10,and 2＋12 was the major type,the frequency was 70.3%.Furthermore,12 subunit combinations were detected,and the composition of ＂1,2＋12,7＋8＂ was the major type.The quality scores of these cultivars ranged from 4 to 10,with an average of 7.4.[Conclusion] The quality of these varieties was good.

荧光标记探针原位杂交技术

荧光标记探针原位杂交技术钟梅，吕亚利，张杰，陈乐真（北京解放军总医院病理科．北京１００８５３）荧光标记原位杂交技术（Ｆｌｕｏｒｅｓｃｅｎｃｅｉｎｓｉｔｕｈｙｂｉｄｉｚａｔｉｏｎ，ＦＩＳＨ），国外曾多用于染色体异常的研究，近年来开始应用于实体肿瘤基因分...

Comparison and Analysis on Animal and Plant Quarantine of Entry Mails among China, Australia and New Zealand

With the significant increase of the number of entry mails in China, mail inspection has become more and more challenge. Australia and New Zealand are the two countries recognized as the ones with the most stringent inspection and quarantine measures in the world. The mail inspection work in China, Australia and New Zealand was compared on the aspects of mail quarantine system, inspection, quarantine treatment and punishment, based on which something worth learning and referring could be found and some suggestions were put forward, with the aim to provide theoretical basis for the animal and plant quarantine of entry mails.

Analysis of Reference Evapotranspiration Change and Its Impact Factors in Australia

[ Objective] To discuss regional response of reference evapotranspiration （ ETo ） to global climate change and its influencing factors. [Method] Penman-Monteith equation was adopted to calculate ET0 in Australia from 1998 to 2007. Spatiotemporal change characteristics were analyzed by using GIS spatial analysis tools and relationships between ETo and main climate factors were also analyzed. [ Resultsl The results showed that multi-year average ET0 increased from the east and south part to the northwest part and inland, and its distribution was consistent with climate zones. Multi-year average ETo of the whole region was 1 750 mm, obtaining minimum and maximum values in 2000 and 2002 respectively. Regional ETo decreased in the order of summer, spring, autumn and winter; January and December got the highest monthly ET0, while June got the lowest value 79.55 mm. ETo positively correlated with mean temperature and solar radiation, R2 for each were 0.83 and 0.94, while the relationship between ETo and average relative humidity was negative, and precipitation had no significant relationship with ET0. [ Conclusion] This research could provide important reference for crop water requirement study and making irrigation method for Australia.

Analysis on the Hydrochemical Characteristics of Groundwater and the Formation Reason in Wadi Bay Area of Libya

[Objective] The research aimed to analyze the formation reason of groundwater hydrochemical characteristics in the dry valley area of Wadi Bay of Libya and provide the scientific basis for the reasonable development utilization and the environmental protection of groundwater.[Method] Took Wadi Bay area（dry valley）of Libya as the example,Piper trilinear graphic representation method,the descriptive statistics,the ion ratio coefficient method and the isotope evidence were used to systematically study the special hydrochemical characteristics of shallow groundwater in the arid climate condition in Wadi Bay area of Libya.[Result] The salt content of groundwater in the area was very high,and TDS was during 3.2-8.4 g/L.The main groundwater type was Cl·SO4-Na·Ca,then was Cl·SO4-Na·Ca·Mg.The concentrations of Cl-,Na＋ and SO2-4,etc.in the groundwater in 70 km from the sea had the remarkable variation,but the concentrations of Mn2＋,Ba2＋,Si2＋,NH＋4 and NO-3 didn＇t have the same variation phenomenon.[Conclusion] The hydrochemical characteristics of shallow groundwater didn＇t relate to the dissolution infiltration reaction,the evaporation concentration effect and human activities.The major cause was the mixing effect of salt and fresh water in the invasion process of seawater.

扫描电镜用于人工器官及材料研究的几个问题

扫描电镜用于人工器官及材料研究的几个问题天津医学院电镜测试中心董亚利在人工器官及材料的研制及实验中，扫描电镜已成为使用越来普遍的重要形态研究工具。一、扫描电镜具有的特点：１．分辨率高目前扫描电镜普遍能达到的分辨率是６ｎｍ，而场发射扫描电镜的分辨率优于...

Synthesis and reversal effect of a novel N-substituted phthalimidesugar on doxorubicin resistant of human breast cancer cells

Thalidomide （α-N-phthalimido-glutarimide, TLD） is a kind of anti-angiogenic and anti-inflammatory drug, and showed effects in the treatment of several disease entities. In this study, the biological effects of a novel N-sugar substituted phthalimide （STA-35） on the regulation of multidrug resistance （MDR） to doxorubicin （ADR） were investigated. The proliferation of cancer cells was detected by a SRB assay. The activity of P-glycoprotein （P-gp） was determined by a Flow cytometry. The expression of P-gp was measured by western blotting. The results showed that STA-35 inhibited the proliferation of human breast cancer cell line MCF-7 and its ADR resistant cell line MCF-7/ADR, and the relative resistance was only 1.19. Meanwhile, STA-35 could sensitize the cytotoxicity of ADR in MCF-7/ADR cells. In addition, we found that STA-35 reduced the activity of P-gp by suppressing the P-gp expression, which was indicated by the increase in the accumulation of rhodamine 123 in MCF-7/ADR cells. These results suggested a promising application of STA-35 as the MDR reversing agent. The underlying mechanism of the effects might be attributed to the inhibition of P-gp.

Depression in patients with irritable bowel syndrome in Jos,Nigeria

AIM: To study the brain-gut interaction and the effect of behavioral or psychiatric conditions on irritable bowel syndrome (IBS) in an African population. METHODS: IBS was diagnosed using the Rome Ⅱ diagnostic criteria. The entry of each patient was confirmed following detailed explanations of the questions. Four hundred and eighteen patients were studied. Subjects satisfying the Rome Ⅱ criteria for IBS were physically examined and stool microscopy was done to identify the presence of “alarm factors”. Depression was diagnosed using the symptom-check list adapted from the Research Diagnostic Criteria (DSM-Ⅳ) of the American Psychiatric Association. RESULTS: Seventy-five (56.8%) of the 132 IBS patients were depressed whereas only 54 (20.1%) of the 268 non-IBS patients were depressed. There was a significant relationship between IBS and depression (χ2 = 54.29, Odds ratio = 5.21, 56.8 ± 8.4 vs 20.1 ± 5.2, P = 0.001). Even though constipation predominant IBS patients were more likely to be depressed, no significant relationship was found between the subtype of IBS and depression (χ2 = 0.02, OR = 0.95, P = 0.68). CONCLUSION: IBS is significantly associated with major depression but not gender and bowel subtypes of the patients. Patients with IBS need to be evaluated for depression due to the highly significant relationship between the two conditions.

Distant skeletal muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome

Intrahepatic cholangiocarcinoma is a malignant neoplasm arising from the biliary epithelium, which frequently invades adjacent organs or metastasizes to other visceral organs such as the lungs, bones, adrenals, and brain. However, distant skeletal muscle metastasis of cholangiocarcinoma has never been described before to the best of our knowledge and, furthermore, Budd-Chiari syndrome secondary to intrahepatic cholangiocarcinoma is also extremely rare. Here we present the first case overall of distant muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome. A 44-year-old man admitted to the hospital with complaints of abdominal distension, edema of both legs, back pain and anorexia of 30 d' duration. Computed tomography and ultrasonography-guided percutaneous muscle biopsy established intrahepatic cholangiocarcinoma with disseminated thrombosis from inferior vena cava to bilateral iliac and femoral veins, and multiple skeletal muscle metastases in bilateral buttock and erector spinal muscle.

Controlling Non-Point Source Pollution in Australian Agricultural Systems

The Australian farming sector is continuing to intensify, particularly within 300 km of the east and southern coastlines. In the future there will be fewer and larger farms, which will use more fertilizer, support more stock, grow more monoculture crops, and utilise more marginal soils. This is likely to increase the major environmental impacts of soil degradation, salt, nutrient and sediment contamination of waterways, and greenhouse gas emissions. Australian national water policy continues to focus on land, stream and groundwater salinity issues, although there is now a greater recognition of the importance of nitrogen and phosphorus losses from agriculture. The general philosophy of policy for dealing with non- point source pollution has been towards a voluntary rather than regulatory approach, with state and national governments supporting a range of programs to encourage sustainable agricultural practices. A catchment (watershed) based approach, through the use of integrated catchment management plans, is the primary way that non-point source pollution is addressed at the farm and local level. At an industry level, cotton, grains, meat, sugarcane and dairy amongst others, as well as the Australian fertilizer industry, have responded to non-point source issues by investing in research and development, and developing codes of practice aimed at abating these environmental impacts. Understanding the economic, social, political and cultural contexts of farming as well as the environmental impacts of agriculture are very important in determining the appropriateness of policy responses for Australian farming systems.

An Integrated GIS/RS Approach for Soil Erosion Assessment and Modeling in Syrian Coastal Soils

An integrated remote sensing (RS) and geographic information system (GIS) technique was employed to characterize the spatial distribution of the risk of soil erosion by water on Latakia district, Syria. The universal soil loss equation (USLE) was used to calculate the annual soil loss rates for Latakia soils. Mainly, remote sensing data, soil survey, land use inventory, elevation data and climatic atlases are used as resource data sets to generate USLE factor values. The results revealed that integration of GIS/RS with USLE was a practical and effective approach for monitoring soil erosion over large areas.

Nutritional status of four species of giant land snails in Nigeria

Four species of African giant land snails （Archachatina marginata （ovum ） Pfeiffer, Archachatina marginata （saturalis ） Philippi, Achatina achatina and Limicolaria spp.） were assessed for their proximate and mineral compositions aimed at establishing their nutritive values on wet weight basis. Analysis of muscle revealed that composition of crude protein varied from 18.66%±0.57% in Limicolaria spp. and 20.56%±L0.05% in Archachatina marginata （ovum） Pfeiffer; moisture content was 76.56%±0.04% in Archachatina marginata （ovum） Pfeiffer and 78.68%±0.68% in Limicolaria spp. and ash was 1.34%±0.02% in Achatina achatina and 1.44%±0.01% in Archachatina marginata （ovum） Pfeiffer. These values were statistically different from each other （P〈0.05）. Carbohydrate and fat content were generally low. Crude fibre was not detected in any of the species. The concentrations of zinc, iron, manganese, magnesium, calcium, phosphorus, sulphur, potassium and sodium in the flesh of the snails were determined. Values of iron, magnesium, calcium, phosphorus, potassium and sodium were consistently high while cobalt, copper and lead were not detected. Snails complement the required trace and minor elements needed for proper growth and development in human being, so it is recommended for regular consumption.

Application of coal mine roof rating in Chinese coal mines

The coal mine roof rating(CMRR) is a measure of roof quality or structure competency for bedded roof types typically of underground coal mines. The CMRR has been used widely in the US, South Africa,Canada and Australia. In order to investigate the application of the CMRR system in Chinese coal mines,two coal mines in China located in Panjiang Coal Field in Guizhou Province were investigated. Field data were collected which is required to calculate the CMRR value based on underground exposure. The CMRR values of 11 locations in two coal mines were calculated. The investigations demonstrated that the chance of mine roof failure is very low if the CMRR value is more than 50, given adequate support is installed in mine. It was found that the CMRR guideline are useful to preliminarily investigate stability in Panjiang Coal Field mines.