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Ⅰ型变态反应疾病中特异性IgE变应原引起的单一致敏和多重致敏的变应原分布特征研究 被引量:5
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作者 沈红艳 邓演超 +2 位作者 徐湛 刘虹 李全双 《现代检验医学杂志》 CAS 2018年第4期100-103,共4页
目的研究Ⅰ型变态反应疾病中特异性IgE(specific IgE,sIgE)变应原在单一致敏和多重致敏中的分布特征。方法选取2014年10月~2017年9月徐州市医学科学研究所确诊的Ⅰ型变态反应疾病患者767例作为研究对象,免疫印迹法检测患者血清中19种变... 目的研究Ⅰ型变态反应疾病中特异性IgE(specific IgE,sIgE)变应原在单一致敏和多重致敏中的分布特征。方法选取2014年10月~2017年9月徐州市医学科学研究所确诊的Ⅰ型变态反应疾病患者767例作为研究对象,免疫印迹法检测患者血清中19种变应原sIgE,分析单一致敏和多重致敏比例、sIgE变应原在单一致敏和多重致敏中的阳性率及分布。结果 sIgE变应原引起的单一致敏和多重致敏分别为414例(53.98%)和353例(46.02%),户尘螨和混合霉菌在单一致敏和多重致敏中的分布接近(49.0%vs 51.0%和43.4%vs 56.6%),并且在不同数量变应原致敏的多重致敏中阳性率相对稳定,其他17种变应原75%~100%分布在多重致敏中,阳性率随致敏变应原种类增加而增高。单一致敏中最主要变应原为户尘螨(64.8%)和混合霉菌(19.0%),其次是牛奶(3.9%)和蟑螂(2.2%)。多重致敏中各变应原阳性率均高于单一致敏,差异均有统计学意义(χ~2=5.598~137.2,均P<0.05),在种属相近的变应原之间呈现出高度一致的阳性现象。结论Ⅰ型变态反应疾病中单一致敏和多重致敏的sIgE变应原分布有显著差异,多重致敏中可能存在广泛的交叉致敏。 展开更多
关键词 变应原 单一致 多重致 交叉
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气体传感器阵列 被引量:13
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作者 于梅芳 王士卿 《传感器技术》 CSCD 1995年第2期6-9,16,共5页
从气体传感器选择性和多功能化两个重要指标出发,指出气体传感器阵列与微处理机相结合,并通过模式识别技术,不仅能够解决交叉敏问题,提高器件的选择性,而且能够实现多功能化。
关键词 交叉敏 传感器阵列 模式识别 气体传感器阵列
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基于人工神经网络的气体定性分析方法
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作者 高峰 崔金宝 +1 位作者 曲建岭 王艺兵 《青岛大学学报(工程技术版)》 CAS 2000年第1期6-9,共4页
提出将气体传感器阵列与前馈神经网络模式识别技术相结合 ,解决气体传感器的“交叉敏”问题 ,从而完成气体的定性、定量分析 ;针对常规 BP算法的缺点 ,构造了基于自适应调整步长和加动量因子的改进 BP算法用于前馈神经网络的训练 ;通过... 提出将气体传感器阵列与前馈神经网络模式识别技术相结合 ,解决气体传感器的“交叉敏”问题 ,从而完成气体的定性、定量分析 ;针对常规 BP算法的缺点 ,构造了基于自适应调整步长和加动量因子的改进 BP算法用于前馈神经网络的训练 ;通过实验对 H2 、CH4 、CO等三种气体进行了识别 。 展开更多
关键词 交叉敏 交馈神经网络 气体传感器阵列 定性分析
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焊接船体接头设计指南(一)
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作者 章霞 《现代焊接》 2006年第2期20-23,共4页
第一批全焊船在第二次世界大战之前建造。4000多艘焊接船在二战期间建成。有些船在结构上出现了重大失误,有脆性裂纹。这种问题在“自由号”轮船上尤为突出。政府和船舶行业立即就该问题展开了广泛的调查研究。大多数主要问题不是甲板... 第一批全焊船在第二次世界大战之前建造。4000多艘焊接船在二战期间建成。有些船在结构上出现了重大失误,有脆性裂纹。这种问题在“自由号”轮船上尤为突出。政府和船舶行业立即就该问题展开了广泛的调查研究。大多数主要问题不是甲板、底壳的结构交叉敏锐区焊缝有缺陷,就是结构横截面发生一些其它突变。 展开更多
关键词 船体 设计指南 焊接 第二次世界大战 接头 二战期间 脆性裂纹 船舶行业 结构 交叉敏
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复合疫苗佐剂促进蛋白抗原通过交叉提呈和交叉致敏诱生CD8^+CTL反应的研究 被引量:1
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作者 王美菊 刘颖 +3 位作者 罗兴 杨春亭 于三科 许洪林 《中国生物制品学杂志》 CAS CSCD 2012年第9期1085-1090,共6页
目的研究CpG寡聚脱氧核苷酸(CpG-oligodeoxynucleotides,CpG-ODN)与A(lOH)3或Montanide ISA720等组成的复合佐剂在小鼠体内促进蛋白抗原通过交叉提呈和交叉致敏诱生CD8+CTL反应的能力。方法以鸡卵清蛋白(Ovalbumin,OVA)为抗原,分别以CpG... 目的研究CpG寡聚脱氧核苷酸(CpG-oligodeoxynucleotides,CpG-ODN)与A(lOH)3或Montanide ISA720等组成的复合佐剂在小鼠体内促进蛋白抗原通过交叉提呈和交叉致敏诱生CD8+CTL反应的能力。方法以鸡卵清蛋白(Ovalbumin,OVA)为抗原,分别以CpG X1、A(l OH)(3即Alum)、Montanide ISA720、CpG X1+Alum和CpG X1+Montanide ISA720为疫苗佐剂,分别于0和4周经肌肉注射免疫C57BL/6小鼠,体积均为100μl,分别含20μg OVA、20μg CpG X1、74μl Montanide ISA720和/或100μg Alum。通过胞内细胞因子染色和体内CTL杀伤试验评价不同佐剂对细胞免疫应答的影响,通过表达OVA的黑色素瘤和李斯特菌攻击模型评价不同佐剂在免疫预防和免疫治疗中的作用。结果与OVA组相比,A(lOH)3本身不能有效诱生小鼠的细胞免疫应答;CpG X1或Montanide ISA720单独使用能够在一定程度上增强抗原特异性CD8+T细胞的IFNγ分泌和CTL活性,但不增强抗原特异性CD4+T细胞反应。两种复合佐剂具有比单佐剂更强的细胞免疫佐剂效应,其中CpG X1+MontanideISA720只能增强抗原特异性CD4+和CD8+T细胞的IFNγ分泌,而CpG X1+Alum不仅能够增强抗原特异性CD4+和CD8+T细胞的IFNγ分泌,还能够增强CD8+CTL的杀伤活性。在黑色素瘤和李斯特菌攻击模型中,CpG X1+Alum佐剂显示出良好的预防和治疗效果。结论 CpG X1与A(lOH)3组成的复合佐剂能够有效促进蛋白抗原通过交叉提呈和交叉致敏诱生功能性CD8+CTL反应。 展开更多
关键词 佐剂 蛋白抗原 交叉提呈 交叉 CD8+CTL反应
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Method of correlation function for analyzing cross-sensitivity of strain and temperature in fiber grating sensors
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作者 HAN Gui-hua ZHANG Wei-gang 《Optoelectronics Letters》 EI 2007年第3期195-198,共4页
A novel method of correlation function for analyzing cross-sensitivity between strain and temperature is reported for the first time in this paper. Using the new method,the correlative characteristics between strain a... A novel method of correlation function for analyzing cross-sensitivity between strain and temperature is reported for the first time in this paper. Using the new method,the correlative characteristics between strain and temperature of fiber Bragg grating sensors are studied both theoretically and experimentally The experimental results accord with the theoretical calculations. 展开更多
关键词 纤维光栅传感器 应变 温度 交叉敏感问题 相关函数法
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Cross-sensitivity of Fiber Grating Solved by FFP Triangle Notch Filter 被引量:4
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作者 GONGXian-feng WANGChang-song +1 位作者 CHENSheng-ping LIJia-fang 《Semiconductor Photonics and Technology》 CAS 2004年第2期108-112,共5页
Employing a fiber Fabry-Perot (FFP) interferometer has been considered as a triangle notch filter to demodulate the wavelength of fiber Bragg grating (FBG) sensor.The single parameter of strain has been demodulated,an... Employing a fiber Fabry-Perot (FFP) interferometer has been considered as a triangle notch filter to demodulate the wavelength of fiber Bragg grating (FBG) sensor.The single parameter of strain has been demodulated,and the cross-sensitivity influence of temperature has been eliminated.The principle of this method is simple and easy to be implemented,and has been used to design a 30 t fiber grating weightbridge successfully.The maximal temperature drift error of the weightbridge is 4 με,which means that the full scale error is 8‰. The result reveals that the accuracy is high enough to be used in measurement. 展开更多
关键词 CROSS-SENSITIVITY FFP Weightbridge
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背根神经节P2X3受体在结肠炎诱导的膀胱过度活动中的作用 被引量:2
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作者 杨杨 张恒帅 +6 位作者 陆渠东 刘鑫 高晔 樊毅 朱景振 董兴有 李龙坤 《第三军医大学学报》 CAS CSCD 北大核心 2021年第3期195-201,共7页
目的通过三硝基苯磺酸(2,4,6-trinitrobenzene sulfonic acid,TNBS)灌肠方式建立大鼠结肠炎模型,探讨背根神经节(dorsal root ganglion,DRG)中P2X3受体在结肠炎诱导的膀胱排尿功能障碍中的作用。方法按随机数字表法将雌性SD大鼠分为3组... 目的通过三硝基苯磺酸(2,4,6-trinitrobenzene sulfonic acid,TNBS)灌肠方式建立大鼠结肠炎模型,探讨背根神经节(dorsal root ganglion,DRG)中P2X3受体在结肠炎诱导的膀胱排尿功能障碍中的作用。方法按随机数字表法将雌性SD大鼠分为3组:对照组、TNBS-3d组和TNBS-7d组。对照组用生理盐水灌肠,后2组分别用50%TNBS乙醇溶液(100 mg/kg)诱导大鼠结肠炎,灌肠3 d或7 d后采用HE染色或尼氏染色分别观察大鼠结肠和膀胱的组织病理变化,应用膀胱测压技术检测大鼠膀胱的排尿功能,免疫荧光染色检测DRG中P2X3受体的表达情况,鞘内注射P2X3抑制剂A-317491观察P2X3受体在结肠诱导的膀胱排尿功能障碍中的作用。结果TNBS诱导结肠炎后,大鼠结肠表现出黏膜充血水肿,炎性细胞浸润。大鼠膀胱未见明显组织病理学改变,但肥大细胞浸润增多。与对照组相比,TNBS-3d组的大鼠表现出明显的膀胱过度活动,其中膀胱排尿间隔缩短(P<0.01)和最大排尿压增加(P<0.01)。与对照组相比,TNBS-7d组的大鼠主要表现为膀胱排尿间隔缩短(P<0.01),最大排尿压无明显变化。与对照组相比,TNBS-3d组和TNBS-7d组的大鼠DRG中P2X3阳性神经元数量均明显增加(P<0.01),鞘内注射A-317491能显著延长TNBS-3d组和TNBS-7d组大鼠的膀胱排尿间隔(P<0.01),同时显著降低TNBS-3d组大鼠的最大排尿压(P<0.05),但TNBS-7d组大鼠的最大排尿压无明显影响。结论DRG中P2X3受体在结肠炎诱导的膀胱过度活动起着重要作用,鞘内注射P2X3抑制剂能明显改善膀胱的排尿功能障碍。 展开更多
关键词 P2X3 结肠炎 膀胱过度活动 肠膀胱交叉
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Signal timing optimization model based on dual-ring phase scheme for roundabout 被引量:4
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作者 马万经 谢涵洲 +2 位作者 白玉 赵靖 杨晓光 《Journal of Central South University》 SCIE EI CAS 2013年第2期563-571,共9页
A signal optimization model for roundabout was control concept were used to eliminate the conflict points proposed based on dual-ring scheme and two stop lines for left turns and weaving sections at a roundabout. A cy... A signal optimization model for roundabout was control concept were used to eliminate the conflict points proposed based on dual-ring scheme and two stop lines for left turns and weaving sections at a roundabout. A cycle length minimization problem was considered to generate optimal signal timings for roundabout, and a set of constraints to ensure feasibility and safety of the resulting optimal signal settings were proposed. Extensive experimental analyses in comparison with signalized intersection reveal that the proposed model is quite promising for application in design of roundabout signals, and the minimum cycle length can decrease from 186 s to 79 s while the capacity increases from 8 682 pcu/h to 9 011 pcu/h under high demand scenario. Sensitivity analysis with respect to the system performance show that the lane assignment plan, number of circulatory lanes and left turn ratio are three critical factors which have dominate impacts on performance of signalized roundabout 展开更多
关键词 signalized roundabout dual-ring phase single timing optimization left-turn movement
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Study of Isolated Contact Temperature Monitoring System Based on Optical Wireless Sensing Technology 被引量:2
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作者 Weibing GAN Youfa WANG 《Photonic Sensors》 SCIE EI CAS 2014年第2期108-112,共5页
In view of the high voltage, the strong magnetic field environment of the high-voltage switchgear, the system based on the optical wireless sensing technology, realizes the isolated contact temperature monitoring of t... In view of the high voltage, the strong magnetic field environment of the high-voltage switchgear, the system based on the optical wireless sensing technology, realizes the isolated contact temperature monitoring of the high-voltage switchgear. In this scheme, the good thermal conductivity and insulation ceramic materials were selected as the outer jacket material sensing probe, and the program had a good solution to the problem of high and low voltage isolation; The combination of the optical fiber composite insulators for wireless sensing, not only solves the problem of high voltage insulation, but also avoids the "creeping" phenomenon due to dust. The package of the structure and reasonable installation solves the cross sensitivity of strain. The application showed that the precision of temperature measurement of the system could reach ± 0.5 ℃ and could work in a variety of harsh environments. It could improve the reliability of the operation of the electrical equipment significantly and has considerable practical value for the whole power system. 展开更多
关键词 Fiber grating temperature sensor composite insulator high-voltage switchgear isolated contact
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Theoretical study on cross sensitivity of fiber Bragg grating sensor affected by double and triple external variables 被引量:1
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作者 罗彬彬 赵明富 +3 位作者 王少飞 周晓军 黄德翼 曹雪梅 《Optoelectronics Letters》 EI 2011年第5期358-362,共5页
In this work, the theoretical model of FBG when it is affected by double external variables (temperature and transverse pressure) and triple external variables (temperature, axial strain and transverse pressure) is de... In this work, the theoretical model of FBG when it is affected by double external variables (temperature and transverse pressure) and triple external variables (temperature, axial strain and transverse pressure) is deduced, respectively. The simulated results show that the properties of cross sensitivity would change in a certain regulation with the external effects and fiber parameters. At the same time, some valuable suggestions about how to improve the measurement accuracy are put forward as well. 展开更多
关键词 Fiber Bragg gratings
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A tension insensitive PbS fiber temperature sensor based on Sagnac interferometer
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作者 付兴虎 张江鹏 +4 位作者 杨凯丽 董艳华 文建湘 付广伟 毕卫红 《Optoelectronics Letters》 EI 2017年第2期135-137,共3页
In this paper, a tension insensitive Pb S fiber temperature sensor based on Sagnac interferometer is proposed and demonstrated. The sensing mechanism of tension and temperature is analyzed. The relationships between t... In this paper, a tension insensitive Pb S fiber temperature sensor based on Sagnac interferometer is proposed and demonstrated. The sensing mechanism of tension and temperature is analyzed. The relationships between the interference spectrum, temperature and tension are analyzed, respectively. The experimental temperature range is 36—70 °C. The experimental results show that the interference spectrum is red shifted, and its sensitivity is 53.89 pm/°C. In tension experiment, the tension range is 0—1 400 με. The experimental results show that there is no wavelength shift in the interference spectrum. The sensor is immune to tension cross-sensitivity compared with other sensors. It can be used for temperature testing in aerospace, chemistry and pharmacy. 展开更多
关键词 interferometer insensitive pharmacy aerospace shifted temper schematic Bragg grating coupler
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