AIM: To describe molecules or genes interaction between hepatitis B viruses (HBV) and host, for understanding how virus' and host's genes and molecules are networked to form a biological system and for perceiv...AIM: To describe molecules or genes interaction between hepatitis B viruses (HBV) and host, for understanding how virus' and host's genes and molecules are networked to form a biological system and for perceiving mechanism of HBV infection.METHODS: The knowledge of HBV infection-related reactions was organized into various kinds of pathways with carefully drawn graphs in HBVPathDB. Pathway information is stored with relational database management system (DBMS), which is currently the most efficient way to manage large amounts of data and query is implemented with powerful Structured Query Language (SQL). The search engine is written using Personal Home Page (PHP) with SQL embedded and web retrieval interface is developed for searching with Hypertext Markup Language (HTML).RESULTS: We present the first version of HBVPathDB,which is a HBV infection-related molecular interaction network database composed of 306 pathways with 1050molecules involved. With carefully drawn graphs, pathway information stored in HBVPathDB can be browsed in an intuitive way. We develop an easy-to-use interface for flexible accesses to the details of database. Convenient software is implemented to query and browse the pathway information of HBVPathDB. Four search page layout options-category search, gene search, description search,unitized search-are supported by the search engine ofthe database. The database is freely available at http://www.bio-inf, net/HBVPathDB/HBV/.CONCLUSION: The conventional perspective HBVPathDB have already contained a considerable amount of pathway information with HBV infection related, which is suitable for in-depth analysis of molecular interaction network of virus and host. HBVPathDB integrates pathway data-sets with convenient software for query, browsing,visualization, that provides users more opportunity to identify regulatory key molecules as potential drug targets and to explore the possible mechanism of HBV infection based on gene expression datasets.展开更多
Greening Internet is an important issue now, which studies the way to reduce the increas- ing energy expenditure. Our work focuses on the network infrastructure and considers its energy awareness in traffic routing. W...Greening Internet is an important issue now, which studies the way to reduce the increas- ing energy expenditure. Our work focuses on the network infrastructure and considers its energy awareness in traffic routing. We formulate the model by traffic engineering to achieve link rate a- daption, and also predict traffic matrices to pre- serve network stability. However, we realize that there is a tradeoff between network performance and energy efficiency, which is an obvious issue as Internet grows larger and larger. An essential cause is the huge traffic, and thus we try to fred its so- lution from a novel architecture called Named Data Networking （NDN） which tent in edge routers and can flexibly cache con- decrease the backbone traffic. We combine our methods with NDN, and finally improve both the network performance and the energy efficiency. Our work shows that it is effective, necessary and feasible to consider green- ing idea in the design of future Internet.展开更多
With the advancements in wireless sensor networks, Internet of Vehicles(IOV) has shown great potential in aiding to ease traffic congestion. In IOV, vehicles can easily exchange information with other vehicles and inf...With the advancements in wireless sensor networks, Internet of Vehicles(IOV) has shown great potential in aiding to ease traffic congestion. In IOV, vehicles can easily exchange information with other vehicles and infrastructures, thus, the development of IOV will greatly improve vehicles safety, promote green information consumption and have a profound impact on many industries. The purpose of this paper is to promote the innovation and development of IOV. Firstly, this paper presents general requirements of IOV such as guidelines, basic principles, and the goal of development. Secondly, we analyze critical applications, crucial support, and business model to promote the industrial development of IOV. Finally, this paper proposes some safeguard measures to further promote the development of IOV.展开更多
Aiming at the significance of the energy controls of wireless sensor networks, an economical energy consumption algorithm for wireless communicating in Wireless Sensor Networks (WSN) is presented. Based on the algorit...Aiming at the significance of the energy controls of wireless sensor networks, an economical energy consumption algorithm for wireless communicating in Wireless Sensor Networks (WSN) is presented. Based on the algorithm, the maximal system throughput of WSN is analyzed, and the upper bound of throughput of WSN is proposed and proved. Some numerical simulations are conducted and analyzed. The conclusions include that the transmitting radius of sensor node and the parameters of the energy cost function have significant influence upon the throughput, but the monitoring region radius has little influence. For the same transmitting distance, the more the hopping of information trans- mitting, the better the throughput of WSN. On the other hand, for the energy optimization of the whole WSN, the trade-off problem between the throughput capacity and the relay nodes is proposed, and the specific expression of relay hops that minimized the energy consumptions and the maximal throughput of WSN under the specific situation is derived.展开更多
WSN has been developing from traditional environment monitoring applications to the ubiquitous information services such as the Congestion-oriented Intelligent Transportation System （ColTS）. However, the mobility of...WSN has been developing from traditional environment monitoring applications to the ubiquitous information services such as the Congestion-oriented Intelligent Transportation System （ColTS）. However, the mobility of nodes makes data dissemination a hard nut to crack. In this paper, we propose MSDD, a multiple mobile sinks data dissemination mechanism for solving the dissemination problem. The main ideas of MSDD are constructing a two-tier grid structure by a designated sink, exploiting a hierarchical monitoring mechanism, and employing a global agent to track the sink locations in order to make the emergencies reported to the sinks immediately, In addition, MSDD supports the query-driven data dissemination. Being compared with TTDD, MSDD is theoretically proved to have less communication overhead. We also validate MSDD outperforms TTDD in reliability and the emergency delivery latency bv simulations.展开更多
Two-way packet exchange synchronization scheme has been widely used in wireless sensor networks. However, due to the fact that its synchronization error accumulates rapidly over hop count, its applications are greatly...Two-way packet exchange synchronization scheme has been widely used in wireless sensor networks. However, due to the fact that its synchronization error accumulates rapidly over hop count, its applications are greatly restricted. In this paper, the factors that cause the accumulation of synchronization error over hop count are investigated. Theoretical analysis shows that two factors including the clock drift and the asymmetry of two-way packet exchange, have distinct influences on synchronization error between two adjacent nodes. Further, the clock frequency order along synchronization path is found to be vital to the accumulation of synchronization error. The above three factors jointly determine the accumulation of synchronization error over hop count in wireless network. Theoretic results are also verified by three fine-grained experiments on wireless sensor network testbed. The conclusions can be used to decrease synchronization error for large-scale wireless network by careful network deployment.展开更多
This paper conducts research on the algorithm to improve the location of Wireless Sensor Network （WSN） in Intelligent Transportation System （ITS）. The localization algorithm introduced an improved RSSI vehicle loc...This paper conducts research on the algorithm to improve the location of Wireless Sensor Network （WSN） in Intelligent Transportation System （ITS）. The localization algorithm introduced an improved RSSI vehicle localization algorithm based on multi-path effect and Gaussian white noise. The localization results under different values of Gaussian white noise and different density of beacon nodes are analyzes, and Kalman filtering algorithm is introduced to reduce the influence of signal noise. Finally, a simulation model of ITS is developed to test the algorithm based on mixed noise and Kalman filtering algorithm, which is used to simulate the localization of real vehicles. The simulation shows the algorithm has effect to improve location accuracy and to application展开更多
Channel parameters estimation in an orthogonal for the receiver station is a multi-dimensional （MD） frequency division multiple access （OFDMA） system optimization problem, because every user node has a separate lo...Channel parameters estimation in an orthogonal for the receiver station is a multi-dimensional （MD） frequency division multiple access （OFDMA） system optimization problem, because every user node has a separate local oscillator and every transmitter to receiver link has individual carrier frequency offset （CFO） and channel impulse response （CIR） parameters. In order to reduce the computational complexity for MD optimization, a time domain CFOs and CIRs estimation algorithm over the OFDMA based wireless multimedia sensor networks （WMSN） is proposed in this paper. In this algorithm, the receiver station can decouple the signal from every node by correlation based on specially designed training sequences, so that the MD optimization problem is simplified to an 1-D optimal problem. It is proved that the multiple CFOs can be identified from the correlation result using the phase shift of the consecutive training se- quences. Based on the CFOs estimation result, the CIRs can then he estimated according to the minimum mean square error （MMSE） criterion. The theoretic analysis and simulation results show that the proposed algorithm can effectively decouple the signal from different user nodes and the bit error rate （BER） per- formance curves are close to the ideal estimation when the user number is not large.展开更多
基金Supported by the grant of the National High Technology R and D Program of China No. 2002AA231051the grant of the Science and Technology Program of Zhejiang Province No. 011103001
文摘AIM: To describe molecules or genes interaction between hepatitis B viruses (HBV) and host, for understanding how virus' and host's genes and molecules are networked to form a biological system and for perceiving mechanism of HBV infection.METHODS: The knowledge of HBV infection-related reactions was organized into various kinds of pathways with carefully drawn graphs in HBVPathDB. Pathway information is stored with relational database management system (DBMS), which is currently the most efficient way to manage large amounts of data and query is implemented with powerful Structured Query Language (SQL). The search engine is written using Personal Home Page (PHP) with SQL embedded and web retrieval interface is developed for searching with Hypertext Markup Language (HTML).RESULTS: We present the first version of HBVPathDB,which is a HBV infection-related molecular interaction network database composed of 306 pathways with 1050molecules involved. With carefully drawn graphs, pathway information stored in HBVPathDB can be browsed in an intuitive way. We develop an easy-to-use interface for flexible accesses to the details of database. Convenient software is implemented to query and browse the pathway information of HBVPathDB. Four search page layout options-category search, gene search, description search,unitized search-are supported by the search engine ofthe database. The database is freely available at http://www.bio-inf, net/HBVPathDB/HBV/.CONCLUSION: The conventional perspective HBVPathDB have already contained a considerable amount of pathway information with HBV infection related, which is suitable for in-depth analysis of molecular interaction network of virus and host. HBVPathDB integrates pathway data-sets with convenient software for query, browsing,visualization, that provides users more opportunity to identify regulatory key molecules as potential drug targets and to explore the possible mechanism of HBV infection based on gene expression datasets.
基金This work was supported by the National Key Basic Re- search Program of China under Grant No. 2011 CB302702 the National Natural Science Foundation of China under Grants No. 61132001, No. 61120106008, No. 61070187, No. 60970133, No. 61003225 the Beijing Nova Program.
文摘Greening Internet is an important issue now, which studies the way to reduce the increas- ing energy expenditure. Our work focuses on the network infrastructure and considers its energy awareness in traffic routing. We formulate the model by traffic engineering to achieve link rate a- daption, and also predict traffic matrices to pre- serve network stability. However, we realize that there is a tradeoff between network performance and energy efficiency, which is an obvious issue as Internet grows larger and larger. An essential cause is the huge traffic, and thus we try to fred its so- lution from a novel architecture called Named Data Networking （NDN） which tent in edge routers and can flexibly cache con- decrease the backbone traffic. We combine our methods with NDN, and finally improve both the network performance and the energy efficiency. Our work shows that it is effective, necessary and feasible to consider green- ing idea in the design of future Internet.
文摘With the advancements in wireless sensor networks, Internet of Vehicles(IOV) has shown great potential in aiding to ease traffic congestion. In IOV, vehicles can easily exchange information with other vehicles and infrastructures, thus, the development of IOV will greatly improve vehicles safety, promote green information consumption and have a profound impact on many industries. The purpose of this paper is to promote the innovation and development of IOV. Firstly, this paper presents general requirements of IOV such as guidelines, basic principles, and the goal of development. Secondly, we analyze critical applications, crucial support, and business model to promote the industrial development of IOV. Finally, this paper proposes some safeguard measures to further promote the development of IOV.
文摘Aiming at the significance of the energy controls of wireless sensor networks, an economical energy consumption algorithm for wireless communicating in Wireless Sensor Networks (WSN) is presented. Based on the algorithm, the maximal system throughput of WSN is analyzed, and the upper bound of throughput of WSN is proposed and proved. Some numerical simulations are conducted and analyzed. The conclusions include that the transmitting radius of sensor node and the parameters of the energy cost function have significant influence upon the throughput, but the monitoring region radius has little influence. For the same transmitting distance, the more the hopping of information trans- mitting, the better the throughput of WSN. On the other hand, for the energy optimization of the whole WSN, the trade-off problem between the throughput capacity and the relay nodes is proposed, and the specific expression of relay hops that minimized the energy consumptions and the maximal throughput of WSN under the specific situation is derived.
基金This work was supported in part by China National Natural Science Foundation under Grant 61271185,and the Fundamental Research Funds for the Central Universities
文摘WSN has been developing from traditional environment monitoring applications to the ubiquitous information services such as the Congestion-oriented Intelligent Transportation System （ColTS）. However, the mobility of nodes makes data dissemination a hard nut to crack. In this paper, we propose MSDD, a multiple mobile sinks data dissemination mechanism for solving the dissemination problem. The main ideas of MSDD are constructing a two-tier grid structure by a designated sink, exploiting a hierarchical monitoring mechanism, and employing a global agent to track the sink locations in order to make the emergencies reported to the sinks immediately, In addition, MSDD supports the query-driven data dissemination. Being compared with TTDD, MSDD is theoretically proved to have less communication overhead. We also validate MSDD outperforms TTDD in reliability and the emergency delivery latency bv simulations.
基金Supported by the National Natural Science Foundation of China （61003307, 61173132, 60803159）,the Basic Disciplines Research Foundation of China University of Petroleum, Beijing （JCXK-2010-01）, Key Laboratory of Computer System and Architecture, ICT,CAS（ICT-ARCH200901）, and the Open Laboratory for the Internet Fundamental Technology, China Intemet Network Information Center（2012-N03）
文摘Two-way packet exchange synchronization scheme has been widely used in wireless sensor networks. However, due to the fact that its synchronization error accumulates rapidly over hop count, its applications are greatly restricted. In this paper, the factors that cause the accumulation of synchronization error over hop count are investigated. Theoretical analysis shows that two factors including the clock drift and the asymmetry of two-way packet exchange, have distinct influences on synchronization error between two adjacent nodes. Further, the clock frequency order along synchronization path is found to be vital to the accumulation of synchronization error. The above three factors jointly determine the accumulation of synchronization error over hop count in wireless network. Theoretic results are also verified by three fine-grained experiments on wireless sensor network testbed. The conclusions can be used to decrease synchronization error for large-scale wireless network by careful network deployment.
文摘This paper conducts research on the algorithm to improve the location of Wireless Sensor Network （WSN） in Intelligent Transportation System （ITS）. The localization algorithm introduced an improved RSSI vehicle localization algorithm based on multi-path effect and Gaussian white noise. The localization results under different values of Gaussian white noise and different density of beacon nodes are analyzes, and Kalman filtering algorithm is introduced to reduce the influence of signal noise. Finally, a simulation model of ITS is developed to test the algorithm based on mixed noise and Kalman filtering algorithm, which is used to simulate the localization of real vehicles. The simulation shows the algorithm has effect to improve location accuracy and to application
基金supported by the National High Technology Research and Development Programme of China(No.2006AA01Z216)
文摘Channel parameters estimation in an orthogonal for the receiver station is a multi-dimensional （MD） frequency division multiple access （OFDMA） system optimization problem, because every user node has a separate local oscillator and every transmitter to receiver link has individual carrier frequency offset （CFO） and channel impulse response （CIR） parameters. In order to reduce the computational complexity for MD optimization, a time domain CFOs and CIRs estimation algorithm over the OFDMA based wireless multimedia sensor networks （WMSN） is proposed in this paper. In this algorithm, the receiver station can decouple the signal from every node by correlation based on specially designed training sequences, so that the MD optimization problem is simplified to an 1-D optimal problem. It is proved that the multiple CFOs can be identified from the correlation result using the phase shift of the consecutive training se- quences. Based on the CFOs estimation result, the CIRs can then he estimated according to the minimum mean square error （MMSE） criterion. The theoretic analysis and simulation results show that the proposed algorithm can effectively decouple the signal from different user nodes and the bit error rate （BER） per- formance curves are close to the ideal estimation when the user number is not large.
