Tetronate antibiotics, a growing family of natural products featuring a characteristic tetronic acid moiety, are of importance and of particular interest for their typical structures, especially the spirotetronate str...Tetronate antibiotics, a growing family of natural products featuring a characteristic tetronic acid moiety, are of importance and of particular interest for their typical structures, especially the spirotetronate structure, and corresponding versatile biolog- ical activities. Considerable efforts have persistently performed since the first tetronate was isolated, to elucidate the biosyn- thesis of natural tetronate products, by isotope-labeled feeding experiments, genetical characterization of biosynthetic gene clusters, and biochemical reconstitution of key enzymatic catalyzed reactions. Accordingly, the biosynthesis of spirotetronates has been gradually determined, including biosynthesis of a polyketide-derived backbone for spirotetronate aglycone, incorpo- ration of a glycerol-derived three-carbon unit into tetronic acid moiety, formation of mature aglycone via Diels-AIder-like re- action, and decorations of aglycone with various deoxysugar moieties. In this paper, the biosynthetic investigations of natural tetronates are well documented and a common biosynthetic route for this group of natural products is summarized accordingly.展开更多
基金supported by the Research Fund for the Doctoral Program of Higher Education of Chinathe Research and Development Program of Hubei Province,and the China Postdoctoral Science Foundation(2012M521461)
文摘Tetronate antibiotics, a growing family of natural products featuring a characteristic tetronic acid moiety, are of importance and of particular interest for their typical structures, especially the spirotetronate structure, and corresponding versatile biolog- ical activities. Considerable efforts have persistently performed since the first tetronate was isolated, to elucidate the biosyn- thesis of natural tetronate products, by isotope-labeled feeding experiments, genetical characterization of biosynthetic gene clusters, and biochemical reconstitution of key enzymatic catalyzed reactions. Accordingly, the biosynthesis of spirotetronates has been gradually determined, including biosynthesis of a polyketide-derived backbone for spirotetronate aglycone, incorpo- ration of a glycerol-derived three-carbon unit into tetronic acid moiety, formation of mature aglycone via Diels-AIder-like re- action, and decorations of aglycone with various deoxysugar moieties. In this paper, the biosynthetic investigations of natural tetronates are well documented and a common biosynthetic route for this group of natural products is summarized accordingly.
