Agricultural system is very complex since it deals with large data situation which comes from a number of factors. A lot of techniques and approaches have been used to identify any interactions between factors that af...Agricultural system is very complex since it deals with large data situation which comes from a number of factors. A lot of techniques and approaches have been used to identify any interactions between factors that affecting yields with the crop performances. The application of neural network to the task of solving non-linear and complex systems is promising. This paper presents a review on the use of artificial neural network （ANN） in predicting crop yield using various crop performance factors. General overview on the application of ANN and the basic concept of neural network architecture are also presented. From the literature, it has been shown that ANN provides better interpretation of crop variability compared to the other methods.展开更多
Statistical classification methods are frequently applied to analyze metabolomics data, especially from medicinal plants. Combined with variable selection techniques, we are able to identify marker candidates, which c...Statistical classification methods are frequently applied to analyze metabolomics data, especially from medicinal plants. Combined with variable selection techniques, we are able to identify marker candidates, which can be used to discriminate the group to which unknown subjects belong. After preprocessing, such as outlier checking, normalization, missing value imputation and transformation, we then mainly utilized four novel classification methods： RF （random forest）, NSC （nearest shrunken centroid）, PLS-DA （partial least square discriminant analysis） and SAM （significant analysis ofmicroarrays）. Each method has its own device to measure the importance of single metabolite, so that, it is probable to choose highly ranked metabolites, which show the best prediction accuracy. Adapting above strategy, we have successfully analyzed several kinds of metabolomics data including Panax ginseng, Lespedeza species, Anemarrhean asphodeloides and Gastrodia elata.展开更多
As a valuable resource for drug discovery, natural products remain largely unexplored. The cheminformatics analysis of natural product databases could help us know better about natural products, providing valuable inf...As a valuable resource for drug discovery, natural products remain largely unexplored. The cheminformatics analysis of natural product databases could help us know better about natural products, providing valuable information in drug design. In this study, we collected an in-home natural product library consisting of more than 220 000 molecules. The results showed that natural products were distributed more diversely than synthetic compounds and approved drugs in chemical space, and natural products still possessed better scaffold diversity. Besides, natural product scaffolds had more potential in some specific indications, such as antiarthritic, antihypertensive, antiallergic and analgesic. However, the utilization rate of natural product scaffolds is relatively low, especially in terms of potential indications. Therefore, we recommend the greater use of natural products while designing lead libraries.展开更多
文摘Agricultural system is very complex since it deals with large data situation which comes from a number of factors. A lot of techniques and approaches have been used to identify any interactions between factors that affecting yields with the crop performances. The application of neural network to the task of solving non-linear and complex systems is promising. This paper presents a review on the use of artificial neural network （ANN） in predicting crop yield using various crop performance factors. General overview on the application of ANN and the basic concept of neural network architecture are also presented. From the literature, it has been shown that ANN provides better interpretation of crop variability compared to the other methods.
文摘Statistical classification methods are frequently applied to analyze metabolomics data, especially from medicinal plants. Combined with variable selection techniques, we are able to identify marker candidates, which can be used to discriminate the group to which unknown subjects belong. After preprocessing, such as outlier checking, normalization, missing value imputation and transformation, we then mainly utilized four novel classification methods： RF （random forest）, NSC （nearest shrunken centroid）, PLS-DA （partial least square discriminant analysis） and SAM （significant analysis ofmicroarrays）. Each method has its own device to measure the importance of single metabolite, so that, it is probable to choose highly ranked metabolites, which show the best prediction accuracy. Adapting above strategy, we have successfully analyzed several kinds of metabolomics data including Panax ginseng, Lespedeza species, Anemarrhean asphodeloides and Gastrodia elata.
基金The National Natural Science Foundation of China(Grant No.21572010B020601)
文摘As a valuable resource for drug discovery, natural products remain largely unexplored. The cheminformatics analysis of natural product databases could help us know better about natural products, providing valuable information in drug design. In this study, we collected an in-home natural product library consisting of more than 220 000 molecules. The results showed that natural products were distributed more diversely than synthetic compounds and approved drugs in chemical space, and natural products still possessed better scaffold diversity. Besides, natural product scaffolds had more potential in some specific indications, such as antiarthritic, antihypertensive, antiallergic and analgesic. However, the utilization rate of natural product scaffolds is relatively low, especially in terms of potential indications. Therefore, we recommend the greater use of natural products while designing lead libraries.
