市场化养老模式研究——上海市亲和源老年社区个案及启示

20世纪70年代,中国迫于巨大的人口压力开始实行严格的计划生育政策。这一政策的实施,一方面使巨大的人口规模得到了有效控制,取得了举世瞩目的成就,另一方面也使得中国老年型社会在经济社会尚不发达的情况下先期而至。从未来经济社会发展情况和人口发展趋势来看,传统养老模式将面临前所未有的压力,甚至陷入无法超越的困境。在这种情况下,寻求新的养老模式成为学术界和政府共同关注的问题,而上海市亲和源老年社区以市场化运营方式对养老问题所做的探索,无疑给人们带来了诸多启示。这是一种有可能从个案走向模式的案例,它可能成为解决中国未来养老问题的一条重要途径。

医养结合模式的新探索——以亲和源老年公寓为例

医养结合是在全球人口老龄化、高龄化、失能化的挑战下提出的一种新的养老模式,也是中国养老服务行业发展的新方向。本研究梳理了日本、德国和美国等世界老龄化水平较高的国家在医养结合实践中的基本经验和模式,并反思中国医养结合实践中存在的不同问题。最后,本研究以上海亲和源老年公寓作为研究对象,将其医养结合模式的实践进行研究,总结出相应的经验,完善医养结合衔接机制和服务体系,进而解决老年人迫切需求的医养问题,为中国医养结合实践提供经验和借鉴。

养老改变生活——亲和源养老模式探究

亲和源会员制老年社区将"机构养老"与"居家养老"完美结合,真正体现了在社区内"居家养老"的精髓。在老龄化社会问题严峻,养老模式面临变革的今天,亲和源会员制养老社区的探索与实践无疑有着特殊的意义。当然,亲和源的养老服务模式诞生不久,也一直在探索之中,它的发展前景还是十分看好的。

Method and Progress of the Research on Virus Affinity Peptide

With the continuous progress on affinity peptide research, it has become more and more popular in pharmacology and medicine. lt is promising to study these viruses affinity peptide to treat infectious diseases. And the analysis on the virus affinity peptide with high selectivity and high sensitivity could provide valuable means for disease detection, treatment as wel as the study on the molecular mechanism of virus affinity peptide. Therefore, we reviewed the bioinformatics pre-diction technologies of computer simulation, molecular docking and homology model-ing, as wel as the research method on analyzing and screening virus affinity pep-tide, such as Phage display technology.

Molecular dynamics simulation of the interactions between EHD1 EH domain and multiple peptides

Objective： To provide essential information for peptide inhibitor design, the interactions of Eps15 homology domain of Eps15 homology domain-containing protein 1 （EHD1 EH domain） with three peptides containing NPF （asparagine-proline-phenylalanine）, DPF （aspartic acid-proline-phenylalanine）, and GPF （glycine-proline-phenylalanine） motifs were deciphered at the atomic level. The binding affinities and the underlying structure basis were investigated. Methods： Molecular dynamics （MD） simulations were performed on EHD1 EH domain/peptide complexes for 60 ns using the GROMACS package. The binding free energies were calculated and decomposed by molecular mechanics/ generalized Born surface area （MM/GBSA） method using the AMBER package. The alanine scanning was performed to evaluate the binding hot spot residues using FoldX software. Results： The different binding affinities for the three peptides were affected dominantly by van der Waals interactions. Intermolecular hydrogen bonds provide the struc- tural basis of contributions of van der Waals interactions of the flanking residues to the binding. Conclusions： van der Waals interactions should be the main consideration when we design peptide inhibitors of EHD1 EH domain with high affinities. The ability to form intermolecular hydrogen bonds with protein residues can be used as the factor for choosing the flanking residues.

Plant pharmacophylogeny:past,present and future

The concept of“pharmacophylogeny”was proposed by Peigen Xiao in the 1980s based on long-term studies of Chinese researchers since ancient times and especially the 1950s.The complicated relationships and connectivity between kinship of medicinal plants,their chemical profiles and therapeutic utilities are consistent goals of pharmacophylogeny studies,which benefit innovative drug R&D.In the present work,we reviewed the origin and a brief history of research in this field,as well as the status quo and recent progress of pharmacophylogeny.The concept“pharmacophylogenomics”is put forward to represent the expanding utility of pharmacophylogeny in botanical drug R&D.Pharmacophylogeny and pharmacophylogenomics are the synthesis of multiple disciplines,such as chemotaxonomy,plant morphology,plant biochemistry/molecular biology and omics,etc.Medicinal plants within the same phylogenetic groups may have the same or similar therapeutic compounds/effects,thus forming the core of pharmacophylogeny,which is the scientific law summed up from practice and applied to practice after refining and sublimation.In the past,pharmacophylogeny plays a big role in looking for alternative resources of imported drugs in China.At present,it continues to play an active role in expanding medicinal plant resources,quality control/identification of herbal medicines,as well as predicting the chemical constituents or active ingredients of herbal medicine and the identification and determination of chemical constituents.In the ongoing future,it will play a bigger role in the search for new drugs,sorting out,summarizing,and improving herbal medicine experiences,thus boosting the sustainable conservation and utilization of traditional/natural medicinal resources.