The removal of protein bound substances from blood is of therapeutic interest for drug intoxications,renal and liver failure,and so on.Current methods using hemoperfusion over adsorbents or plasma exchange are effecti...The removal of protein bound substances from blood is of therapeutic interest for drug intoxications,renal and liver failure,and so on.Current methods using hemoperfusion over adsorbents or plasma exchange are effective but not specific enough.This work presents a new procedure in which an albumin (BSA) filled porous asymmetric membrane with a high permeable flux is prepared and used for the removal of lipophilic toxins (unconjugated bilirubin) from blood.The transport mechanism of the membrane to remove protein bound toxins is analysed.The transport characteristics of the BSA filled membrane are tested by using aqueous BSA solution containing unconjugated bilirubin as simulated blood in a diffusion cell.In addition,some factors affecting transport rate are discussed.It concludes that the present method provides a theoretical basis for treatment of acute liver failure as well as acute or chronic intoxications with alburnin bound toxins.展开更多
文摘The removal of protein bound substances from blood is of therapeutic interest for drug intoxications,renal and liver failure,and so on.Current methods using hemoperfusion over adsorbents or plasma exchange are effective but not specific enough.This work presents a new procedure in which an albumin (BSA) filled porous asymmetric membrane with a high permeable flux is prepared and used for the removal of lipophilic toxins (unconjugated bilirubin) from blood.The transport mechanism of the membrane to remove protein bound toxins is analysed.The transport characteristics of the BSA filled membrane are tested by using aqueous BSA solution containing unconjugated bilirubin as simulated blood in a diffusion cell.In addition,some factors affecting transport rate are discussed.It concludes that the present method provides a theoretical basis for treatment of acute liver failure as well as acute or chronic intoxications with alburnin bound toxins.
