With the continuous development of society and culture,clothing is not just to make people feel warn. Production, design, and continuous innovation of appare aim to make clothing serve people better, satisfy the deman...With the continuous development of society and culture,clothing is not just to make people feel warn. Production, design, and continuous innovation of appare aim to make clothing serve people better, satisfy the demand of more people, and let people feel more comfortable, safer, more hygienic and more convenient. People would have more scientific and effective way in dominating his own clothing style, making clothes serving for people.展开更多
Enterprise Management Innovation has been a topic of concern to the business community and holds the same opinions to adhere to corporate management for innovation, but how to make companies management innovation beco...Enterprise Management Innovation has been a topic of concern to the business community and holds the same opinions to adhere to corporate management for innovation, but how to make companies management innovation becomes the business people must face. I believe that： enterprise management innovation is the innovation of the modem enterprise system, enterprise management innovation is necessary not only to establish modem corporate governance institutions, but also to establish a sound management system. Based on this idea, the purpose of this paper is to explore the enterprise management innovation, a true reflection of the necessity and creative approach to business management innovation. Through analysis, the enterprise management innovation is the scientific concept of development of specific applications in the field of enterprise management. Enterprise management innovation is the development of internal demand point of view, hoping to be helpful for Chinese enterprises to occupy a place in the fierce competition in the international market.展开更多
To establish scientific and effective performance management system is one of the important tasks of establishing a modem enterprise human resources management. Based on modern management concept of human resources, t...To establish scientific and effective performance management system is one of the important tasks of establishing a modem enterprise human resources management. Based on modern management concept of human resources, this thesis discusses how the newly set-up Chinese private high-tech manufacturing enterprise effectively import performance management system, design and implement the system and put it into application. With application of performance management related theory, the thesis analyzes the characteristics of current stage of enterprise development, designs the construction process of performance management system, and illustrates the detailed implementation method.展开更多
Absolute commitment to reduce the impact of greenhouse gas emissions while increasing fuel efficiency and power density requires further enhancement of prime mover characteristics and special coatings, but mostly requ...Absolute commitment to reduce the impact of greenhouse gas emissions while increasing fuel efficiency and power density requires further enhancement of prime mover characteristics and special coatings, but mostly requires compliance with EEDI （energy efficiency design index） measures. For the container shipping industry this represents significant increases in fuel costs that can be mitigated above all by reduction of power demand, that is, of ship frictional resistance. In this respect, this paper discusses advantages attainable by application of the ACS （air cavity system） technology on the basis of recent KSRC （Krylov State Research Centre） studies Savings in operating costs yielded by the enhanced propulsion performance for ships fitted with this system are illustrated by a case study of a containership.展开更多
Graphene possesses unique physical and chemical properties, which have inspired a wide range of potential biomedical applications. However, little is known about the adverse effects of graphene on the human body and e...Graphene possesses unique physical and chemical properties, which have inspired a wide range of potential biomedical applications. However, little is known about the adverse effects of graphene on the human body and ecological environment. The purpose of our work is to make assessment on the toxicity of graphene oxide (GO) against human cell line (human bone marrow neuroblastoma cell line and human epithelial carcinoma cell line) and zebrafish (Danio rerio) by comparing the toxic effects of GO with its sister, multi-walled carbon nanotubes (MWNTs). The results show that GO has a moderate toxicity to organisms since it can induce minor (about 20%) cell growth inhibition and slight hatching delay of zebrafish embryos at a dosage of 50 mg/L, but did not result in significant increase of apoptosis in embryo, while MWNTs exhibit acute toxicity leading to a strong inhibition of cell proliferation and serious morphological defects in developing embryos even at relatively low concentration of 25 mg/L. The distinctive toxicity of GO and MWNTs should be ascribed to the different models of interaction between nanomaterials and organisms, which arises from the different geometric structures of nanomaterials. Collectively, our work suggests that GO does actual toxicity to organisms posing potential environmental risks and the result is also shedding light on the geometrical structure-dependent toxicity of graphitic nanomaterials.展开更多
Ferulic acid(FA) is an active component of herbal medicines. One of the best documented activities of FA is its antioxidant property. Moreover, FA exerts antiallergic, anti-inflammatory, and hepatoprotective effects. ...Ferulic acid(FA) is an active component of herbal medicines. One of the best documented activities of FA is its antioxidant property. Moreover, FA exerts antiallergic, anti-inflammatory, and hepatoprotective effects. However, the metabolic pathways of FA in humans remain unclear. To identify whether human CYP or UGT enzymes are involved in the metabolism of FA, reaction phenotyping of FA was conducted using major CYP-selective chemical inhibitors together with individual CYP and UGT Supersomes. The CYPand/or UGT-mediated metabolism kinetics were examined simultaneously or individually. Relative activity factor and total normalized rate approaches were used to assess the relative contributions of each major human CYPs towards the FA metabolism. Incubations of FA with human liver microsomes(HLM) displayed NADPH-and UDPGA-dependent metabolism with multiple CYP and UGT isoforms involved. CYPs and UGTs contributed equally to the metabolism of FA in HLM. Although CYP1 A2 and CYP3 A4 appeared to be the major contributors in the CYP-mediated clearance, their contributions to the overall clearance are still minor(< 25%). As a constitute of many food and herbs, FA poses low drug-drug interaction risk when co-administrated with other herbs or conventional medicines because multiple phase I and phase II enzymes are involved in its metabolism.展开更多
文摘With the continuous development of society and culture,clothing is not just to make people feel warn. Production, design, and continuous innovation of appare aim to make clothing serve people better, satisfy the demand of more people, and let people feel more comfortable, safer, more hygienic and more convenient. People would have more scientific and effective way in dominating his own clothing style, making clothes serving for people.
文摘Enterprise Management Innovation has been a topic of concern to the business community and holds the same opinions to adhere to corporate management for innovation, but how to make companies management innovation becomes the business people must face. I believe that： enterprise management innovation is the innovation of the modem enterprise system, enterprise management innovation is necessary not only to establish modem corporate governance institutions, but also to establish a sound management system. Based on this idea, the purpose of this paper is to explore the enterprise management innovation, a true reflection of the necessity and creative approach to business management innovation. Through analysis, the enterprise management innovation is the scientific concept of development of specific applications in the field of enterprise management. Enterprise management innovation is the development of internal demand point of view, hoping to be helpful for Chinese enterprises to occupy a place in the fierce competition in the international market.
文摘To establish scientific and effective performance management system is one of the important tasks of establishing a modem enterprise human resources management. Based on modern management concept of human resources, this thesis discusses how the newly set-up Chinese private high-tech manufacturing enterprise effectively import performance management system, design and implement the system and put it into application. With application of performance management related theory, the thesis analyzes the characteristics of current stage of enterprise development, designs the construction process of performance management system, and illustrates the detailed implementation method.
文摘Absolute commitment to reduce the impact of greenhouse gas emissions while increasing fuel efficiency and power density requires further enhancement of prime mover characteristics and special coatings, but mostly requires compliance with EEDI （energy efficiency design index） measures. For the container shipping industry this represents significant increases in fuel costs that can be mitigated above all by reduction of power demand, that is, of ship frictional resistance. In this respect, this paper discusses advantages attainable by application of the ACS （air cavity system） technology on the basis of recent KSRC （Krylov State Research Centre） studies Savings in operating costs yielded by the enhanced propulsion performance for ships fitted with this system are illustrated by a case study of a containership.
基金supported by the National Natural Science Foundation of China (21035005)the Doctoral Program Foundation of Institutions of Higher Education of China (20115301120002)the Natural Science Foundation of Yunnan Province of China (2011FB007)
文摘Graphene possesses unique physical and chemical properties, which have inspired a wide range of potential biomedical applications. However, little is known about the adverse effects of graphene on the human body and ecological environment. The purpose of our work is to make assessment on the toxicity of graphene oxide (GO) against human cell line (human bone marrow neuroblastoma cell line and human epithelial carcinoma cell line) and zebrafish (Danio rerio) by comparing the toxic effects of GO with its sister, multi-walled carbon nanotubes (MWNTs). The results show that GO has a moderate toxicity to organisms since it can induce minor (about 20%) cell growth inhibition and slight hatching delay of zebrafish embryos at a dosage of 50 mg/L, but did not result in significant increase of apoptosis in embryo, while MWNTs exhibit acute toxicity leading to a strong inhibition of cell proliferation and serious morphological defects in developing embryos even at relatively low concentration of 25 mg/L. The distinctive toxicity of GO and MWNTs should be ascribed to the different models of interaction between nanomaterials and organisms, which arises from the different geometric structures of nanomaterials. Collectively, our work suggests that GO does actual toxicity to organisms posing potential environmental risks and the result is also shedding light on the geometrical structure-dependent toxicity of graphitic nanomaterials.
基金supported by Chinese National Science & Technology Major Special Project on Major New Drug Innovation(Nos.2008ZXJ09006001 and 2015ZX09J15104)National Natural Science Foundation of China(No.81130067)
文摘Ferulic acid(FA) is an active component of herbal medicines. One of the best documented activities of FA is its antioxidant property. Moreover, FA exerts antiallergic, anti-inflammatory, and hepatoprotective effects. However, the metabolic pathways of FA in humans remain unclear. To identify whether human CYP or UGT enzymes are involved in the metabolism of FA, reaction phenotyping of FA was conducted using major CYP-selective chemical inhibitors together with individual CYP and UGT Supersomes. The CYPand/or UGT-mediated metabolism kinetics were examined simultaneously or individually. Relative activity factor and total normalized rate approaches were used to assess the relative contributions of each major human CYPs towards the FA metabolism. Incubations of FA with human liver microsomes(HLM) displayed NADPH-and UDPGA-dependent metabolism with multiple CYP and UGT isoforms involved. CYPs and UGTs contributed equally to the metabolism of FA in HLM. Although CYP1 A2 and CYP3 A4 appeared to be the major contributors in the CYP-mediated clearance, their contributions to the overall clearance are still minor(< 25%). As a constitute of many food and herbs, FA poses low drug-drug interaction risk when co-administrated with other herbs or conventional medicines because multiple phase I and phase II enzymes are involved in its metabolism.
