脂肪组织(AT)的 CT 测量技术是目前准确性和可重复性最高的人体 AT 测量技术。有关该技术的方法已在“人体脂肪组织(AT)的 CT 测量”一文中详述(见本刊上期)。本文讨论目前该技术的应用及价值。一、正常人体 AT 分布的研究(一)人体 AT ...脂肪组织(AT)的 CT 测量技术是目前准确性和可重复性最高的人体 AT 测量技术。有关该技术的方法已在“人体脂肪组织(AT)的 CT 测量”一文中详述(见本刊上期)。本文讨论目前该技术的应用及价值。一、正常人体 AT 分布的研究(一)人体 AT 分布的一般规律 Baum-gartner 等曾根据96例正常男女的 CT展开更多
Caveolin-2,a protein about 20 kD,is a major component of the inner surface of caveolae,small invaginations of the plasma membrane.Similar with caveolin-1 and caveolin-3,it serves as a protein marker of caveolae.Caveol...Caveolin-2,a protein about 20 kD,is a major component of the inner surface of caveolae,small invaginations of the plasma membrane.Similar with caveolin-1 and caveolin-3,it serves as a protein marker of caveolae.Caveolin-1 and-2 are located next to each other at 7q31.1 on human chromosome,the proteins encoded are co-localized and form a stable hetero-oligomeric complex,distributing similarly in tissue and cultured cells.Caveolin-3 is located on different chromosomes but confirmed to interact with caveolin-2.Caveolin-2 is similar to caveolin-1 in many respects but differs from the latter in functional domains,especially in G-protein binding domain and caveolin scaffolding domain.The mRNAs of both caveolin-1 and caveolin-2 are most abundantly expressed in white adipose tissue and are induced during differentiation of 3T3-L1 cells to adipocytes.Caveolin-2-deficinet mice demonstrate clear pulmonary defects,with little or no change in caveolin-1 expression and caveolae formation,suggesting that caveolin-2 plays a selective role in lung functions.Caveolin-2 is also involved in lipid metabolism and human cancers.展开更多
文摘脂肪组织(AT)的 CT 测量技术是目前准确性和可重复性最高的人体 AT 测量技术。有关该技术的方法已在“人体脂肪组织(AT)的 CT 测量”一文中详述(见本刊上期)。本文讨论目前该技术的应用及价值。一、正常人体 AT 分布的研究(一)人体 AT 分布的一般规律 Baum-gartner 等曾根据96例正常男女的 CT
基金Supported by National Basic Research Program of China (973 Program) (2004CB518602,2006CB503909)National High Technology Research and Development Program of China (863 Program) (2009AA02Z192)
文摘Caveolin-2,a protein about 20 kD,is a major component of the inner surface of caveolae,small invaginations of the plasma membrane.Similar with caveolin-1 and caveolin-3,it serves as a protein marker of caveolae.Caveolin-1 and-2 are located next to each other at 7q31.1 on human chromosome,the proteins encoded are co-localized and form a stable hetero-oligomeric complex,distributing similarly in tissue and cultured cells.Caveolin-3 is located on different chromosomes but confirmed to interact with caveolin-2.Caveolin-2 is similar to caveolin-1 in many respects but differs from the latter in functional domains,especially in G-protein binding domain and caveolin scaffolding domain.The mRNAs of both caveolin-1 and caveolin-2 are most abundantly expressed in white adipose tissue and are induced during differentiation of 3T3-L1 cells to adipocytes.Caveolin-2-deficinet mice demonstrate clear pulmonary defects,with little or no change in caveolin-1 expression and caveolae formation,suggesting that caveolin-2 plays a selective role in lung functions.Caveolin-2 is also involved in lipid metabolism and human cancers.
