In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known t...In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known that the clinical features of metabolic diseases can manifest themselves with very different characteristics and escape early detection. Also, it is well known that the prognosis of many metabolic diseases is excellent if diagnosed and treated early. In this editorial we briefly summarized two groups of inherited metabolic diseases, the defects of cholesterol biosynthesis and those of bile acids. Both groups show variable clinical manifestations but some clinical signs and symptoms are common in both the defects of cholesterol and bile acids. The differential diagnosis can be made analyzing sterol profiles in blood and/or bile acids in blood and urine by chromatographic techniques(GC-MS and LC-MS/MS). Several defects of both biosynthetic pathways are treatable so early diagnosis is crucial. Unfortunately their diagnosis is made too late, due either to the clinical heterogeneity of the syndromes(severe, mild and very mild) that to the scarcity of scientific dissemination of these rare diseases. Therefore, the delay in diagnosis leads the patient to the medical observation when the disease has produced irreversible damages to the body. Here, we highlighted simple clinical and laboratory descriptions that can potentially make you to suspect a defect in cholesterol biosynthesis and/or bile acids, as well, we suggest appropriate request of the laboratory tests that along with common clinical features can help to diagnose these defects.展开更多
Inflammatory bowel disease(IBD)is a heterogeneous group of chronic diseases with a rising prevalence in the pediatric population,and up to 25%of IBD patients are diagnosed before 18 years of age.Adolescents with IBD t...Inflammatory bowel disease(IBD)is a heterogeneous group of chronic diseases with a rising prevalence in the pediatric population,and up to 25%of IBD patients are diagnosed before 18 years of age.Adolescents with IBD tend to have more severe and extensive disease and eventually require graduation from pediatric care toadult services.The transition of patients from pediatric to adult gastroenterologists requires careful preparation and coordination,with involvement of all key players to ensure proper collaboration of care and avoid interruption in care.This can be challenging and associated with gaps in delivery of care.The pediatric and adult health paradigms have inherent differences between health care models,as well as health care priorities in IBD.The readiness of the young adult also influences this transition of care,with often times other overlaps in life events,such as school,financial independence and moving away from home.These patients are therefore at higher risk for poorer clinical disease outcomes.The aim of this paper is to review concepts pertinent to transition of care of young adults with IBD to adult care,and provides resources appropriate for an IBD pediatric to adult transition of care model.展开更多
This study explores the potential risks associated with the 65 U.S.-based commercial nuclear power plants and the distribution of those risks among the populations of both their respective host communities and of the ...This study explores the potential risks associated with the 65 U.S.-based commercial nuclear power plants and the distribution of those risks among the populations of both their respective host communities and of the communities located in outlying areas. First, it starts by examining the racial/ethnic composition of the host community populations, as well as the disparities in socioeconomic status that exist, if any, between the host communities and communities located in outlying areas.Second, it utilizes two independent-sample T tests to identify any differences in the sociodemographic compositions of the two areas. Third, it explores regional demographic trends by looking at the percent change in demographic variables in the host communities and communities located in outlying areas in 1990–2000 and2000–2010. Findings reveal that during the past two decades more people were exposed to the risks as population living in the host communities increased.展开更多
In the wireless power transfer system for freely moving biomedical implants,the receiving unit was generally inefficient for the reason that its design parameters including the receiving coil's dimension and recei...In the wireless power transfer system for freely moving biomedical implants,the receiving unit was generally inefficient for the reason that its design parameters including the receiving coil's dimension and receiving circuits' topology were always determined by experiments.In order to build the relationship between these parameters and the total transfer efficiency,this paper developed a novel efficiency model based on the impedance model of the coil and the circuit model of the receiving circuits.According to the design constraints,the optimal design parameters in the worst case were derived.The results indicate that the combination of the two-layered receiving coil and half-bridge rectifier has more advantages in size,efficiency and safety,which is preferred in the receiving unit.Additionally,when the load resistance increases,the optimal turn number of the receiving coil basically keeps constant and the corresponding transmitting current and total efficiency decrease.For 100 Ω load,the transmitting current and total efficiency in the worst case were measured to be 5.30 A and 1.45% respectively,which are much better than the published results.In general,our work provides an efficient method to determine the design parameters of the wireless power transfer system for freely moving biomedical implants.展开更多
文摘In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known that the clinical features of metabolic diseases can manifest themselves with very different characteristics and escape early detection. Also, it is well known that the prognosis of many metabolic diseases is excellent if diagnosed and treated early. In this editorial we briefly summarized two groups of inherited metabolic diseases, the defects of cholesterol biosynthesis and those of bile acids. Both groups show variable clinical manifestations but some clinical signs and symptoms are common in both the defects of cholesterol and bile acids. The differential diagnosis can be made analyzing sterol profiles in blood and/or bile acids in blood and urine by chromatographic techniques(GC-MS and LC-MS/MS). Several defects of both biosynthetic pathways are treatable so early diagnosis is crucial. Unfortunately their diagnosis is made too late, due either to the clinical heterogeneity of the syndromes(severe, mild and very mild) that to the scarcity of scientific dissemination of these rare diseases. Therefore, the delay in diagnosis leads the patient to the medical observation when the disease has produced irreversible damages to the body. Here, we highlighted simple clinical and laboratory descriptions that can potentially make you to suspect a defect in cholesterol biosynthesis and/or bile acids, as well, we suggest appropriate request of the laboratory tests that along with common clinical features can help to diagnose these defects.
文摘Inflammatory bowel disease(IBD)is a heterogeneous group of chronic diseases with a rising prevalence in the pediatric population,and up to 25%of IBD patients are diagnosed before 18 years of age.Adolescents with IBD tend to have more severe and extensive disease and eventually require graduation from pediatric care toadult services.The transition of patients from pediatric to adult gastroenterologists requires careful preparation and coordination,with involvement of all key players to ensure proper collaboration of care and avoid interruption in care.This can be challenging and associated with gaps in delivery of care.The pediatric and adult health paradigms have inherent differences between health care models,as well as health care priorities in IBD.The readiness of the young adult also influences this transition of care,with often times other overlaps in life events,such as school,financial independence and moving away from home.These patients are therefore at higher risk for poorer clinical disease outcomes.The aim of this paper is to review concepts pertinent to transition of care of young adults with IBD to adult care,and provides resources appropriate for an IBD pediatric to adult transition of care model.
文摘This study explores the potential risks associated with the 65 U.S.-based commercial nuclear power plants and the distribution of those risks among the populations of both their respective host communities and of the communities located in outlying areas. First, it starts by examining the racial/ethnic composition of the host community populations, as well as the disparities in socioeconomic status that exist, if any, between the host communities and communities located in outlying areas.Second, it utilizes two independent-sample T tests to identify any differences in the sociodemographic compositions of the two areas. Third, it explores regional demographic trends by looking at the percent change in demographic variables in the host communities and communities located in outlying areas in 1990–2000 and2000–2010. Findings reveal that during the past two decades more people were exposed to the risks as population living in the host communities increased.
基金supported by the National Natural Science Foundation of China(Grant No.61473281)the National Sciences and Technology Support Project(Grant No.2015BAI01B13)State Key Laboratory of Robotics Self-plan Project(Grant No.2016-Z06)
文摘In the wireless power transfer system for freely moving biomedical implants,the receiving unit was generally inefficient for the reason that its design parameters including the receiving coil's dimension and receiving circuits' topology were always determined by experiments.In order to build the relationship between these parameters and the total transfer efficiency,this paper developed a novel efficiency model based on the impedance model of the coil and the circuit model of the receiving circuits.According to the design constraints,the optimal design parameters in the worst case were derived.The results indicate that the combination of the two-layered receiving coil and half-bridge rectifier has more advantages in size,efficiency and safety,which is preferred in the receiving unit.Additionally,when the load resistance increases,the optimal turn number of the receiving coil basically keeps constant and the corresponding transmitting current and total efficiency decrease.For 100 Ω load,the transmitting current and total efficiency in the worst case were measured to be 5.30 A and 1.45% respectively,which are much better than the published results.In general,our work provides an efficient method to determine the design parameters of the wireless power transfer system for freely moving biomedical implants.