Katherine Mansfield is a world famous woman master of short stories in English literature. Her stories are sensitive revelations of human behaiour in quite ordinary situations, through which we can glimpse a powerful ...Katherine Mansfield is a world famous woman master of short stories in English literature. Her stories are sensitive revelations of human behaiour in quite ordinary situations, through which we can glimpse a powerful and sometimes cruelly pessimistic view of life. Miss Brill is one of her short stories published in her collection of stories entitled The Garden Party and Other Stories （2007）, describing an afternoon in the life of a middle-aged spinster who visits the public park on a weekly basis, leading to her reassessment of her view of the world and the secular reality. Short as it is, it is really worth carful analysis and appreciation. This paper will mainly deal with the theme--alienation that the story conveys in two aspects： some obvious alienate elments in Miss Brill, in which some background information is provided; some less obvious alienation in Miss Brill, in which a detailed analysis is made into the story to reveal its alienation.展开更多
In the development of human civilization, plant has been closely attached to human beings, and also been endowed with rich cultural imagery. However, ascribed to the differences between Chinese and English cultures, p...In the development of human civilization, plant has been closely attached to human beings, and also been endowed with rich cultural imagery. However, ascribed to the differences between Chinese and English cultures, plant of the same kind exhibits similar, distinct or vacant characteristics. This paper adopts comparison method so as to compare and to analyze the differences and similarities of cultural connotation contained in plant emerging in Treasure Island （a representative of western adventure literature） and The Swordsman （a representative of Chinese martial arts literature） and roles plant plays in a certain chapter, or the whole story. The literature study presents a general knowledge of research theories in this field and cultural background. Moreover, the induction method integrates and summarizes the prior analyses and researches. Reasons underlying those cultural differences are also expounded, including legend and folklore, literature works and convention and custom. The conclusion is that analyzing the cultural connotation of plant is of significance for understanding the corresponding cultural differences as well as appreciating adventure and martial arts literature.展开更多
The protein prenylation is one of the essential post-translational protein modifications, which extensively exists in the eukaryocyte. It includes protein farnesylation and geranylgeranylation, using farnesyl pyrophos...The protein prenylation is one of the essential post-translational protein modifications, which extensively exists in the eukaryocyte. It includes protein farnesylation and geranylgeranylation, using farnesyl pyrophosphate(FPP) or geranylgeranyl pyrophosphate(GGPP) as the substrate, respectively. The prenylation occurs by covalent addition of these two types of isoprenoids to cysteine residues at or near the carboxyl terminus of the proteins that possess Caa X motif, such as Ras small GTPase family. The attachment of hydrophobic prenyl groups can anchor the proteins to intracellular membranes and trigger downstream cell signaling pathway. Geranylgeranyl biphosphate synthase(GGPPS) catalyzes the synthesis of 20-carbon GGPP from 15-carbon FPP. The abnormal expression of this enzyme will affect the relative content of FPP and GGPP, and thus disrupts the balance between protein farnesylation and geranylgeranylation, which participates into various aspects of cellular physiology and pathology. In this paper, we mainly review the property of this important protein post-translational modification and research progress in its regulation of cigarette smoke induced pulmonary disease, adipocyte insulin sensitivity, the inflammation response of Sertoli cells, the hepatic lipogenesis and the cardiac hypertrophy.展开更多
文摘Katherine Mansfield is a world famous woman master of short stories in English literature. Her stories are sensitive revelations of human behaiour in quite ordinary situations, through which we can glimpse a powerful and sometimes cruelly pessimistic view of life. Miss Brill is one of her short stories published in her collection of stories entitled The Garden Party and Other Stories （2007）, describing an afternoon in the life of a middle-aged spinster who visits the public park on a weekly basis, leading to her reassessment of her view of the world and the secular reality. Short as it is, it is really worth carful analysis and appreciation. This paper will mainly deal with the theme--alienation that the story conveys in two aspects： some obvious alienate elments in Miss Brill, in which some background information is provided; some less obvious alienation in Miss Brill, in which a detailed analysis is made into the story to reveal its alienation.
文摘In the development of human civilization, plant has been closely attached to human beings, and also been endowed with rich cultural imagery. However, ascribed to the differences between Chinese and English cultures, plant of the same kind exhibits similar, distinct or vacant characteristics. This paper adopts comparison method so as to compare and to analyze the differences and similarities of cultural connotation contained in plant emerging in Treasure Island （a representative of western adventure literature） and The Swordsman （a representative of Chinese martial arts literature） and roles plant plays in a certain chapter, or the whole story. The literature study presents a general knowledge of research theories in this field and cultural background. Moreover, the induction method integrates and summarizes the prior analyses and researches. Reasons underlying those cultural differences are also expounded, including legend and folklore, literature works and convention and custom. The conclusion is that analyzing the cultural connotation of plant is of significance for understanding the corresponding cultural differences as well as appreciating adventure and martial arts literature.
基金supported by the National Basic Research Program of China(2012CB524900,2009CB918703)National Natural Science Foundation of China(31271540,30671086)awarded to Li Chao Jun
文摘The protein prenylation is one of the essential post-translational protein modifications, which extensively exists in the eukaryocyte. It includes protein farnesylation and geranylgeranylation, using farnesyl pyrophosphate(FPP) or geranylgeranyl pyrophosphate(GGPP) as the substrate, respectively. The prenylation occurs by covalent addition of these two types of isoprenoids to cysteine residues at or near the carboxyl terminus of the proteins that possess Caa X motif, such as Ras small GTPase family. The attachment of hydrophobic prenyl groups can anchor the proteins to intracellular membranes and trigger downstream cell signaling pathway. Geranylgeranyl biphosphate synthase(GGPPS) catalyzes the synthesis of 20-carbon GGPP from 15-carbon FPP. The abnormal expression of this enzyme will affect the relative content of FPP and GGPP, and thus disrupts the balance between protein farnesylation and geranylgeranylation, which participates into various aspects of cellular physiology and pathology. In this paper, we mainly review the property of this important protein post-translational modification and research progress in its regulation of cigarette smoke induced pulmonary disease, adipocyte insulin sensitivity, the inflammation response of Sertoli cells, the hepatic lipogenesis and the cardiac hypertrophy.
