In the present study,we aimed to prepare Panax japonicus tablets and carry out quality inspection.Panax japonicus tablets were prepared by ultrafine pulverization-wet granulation,and quality inspection was carried out...In the present study,we aimed to prepare Panax japonicus tablets and carry out quality inspection.Panax japonicus tablets were prepared by ultrafine pulverization-wet granulation,and quality inspection was carried out according to Pharmacopoeia regulations.The plasma concentration of animals with self-made Panax japonicus tablets or ginsenoside Rg3 in single-dose intragastric administration was determined by high-performance liquid chromatography(HPLC).The pharmacokinetic parameters and relative bioavailability were calculated by DAS 2.0 software.The quality inspection of self-made Panax japonicus tablets met the requirements of Chinese Pharmacopoeia(2015 edition),and this preparation had high bioequivalence of ginsenoside Rg3.The preparation of Panax japonicus tablets was reasonable and highly qualified.Moreover,this new Panax japonicus preparation showed better profiles in oral absorption and utilization.This study provided evidence for the industrial production and clinical application of Panax japonicus tablets.展开更多
基金Postgraduate Research Innovation Program of Yangzhou University(Grant No.XKYCX18_128)
文摘In the present study,we aimed to prepare Panax japonicus tablets and carry out quality inspection.Panax japonicus tablets were prepared by ultrafine pulverization-wet granulation,and quality inspection was carried out according to Pharmacopoeia regulations.The plasma concentration of animals with self-made Panax japonicus tablets or ginsenoside Rg3 in single-dose intragastric administration was determined by high-performance liquid chromatography(HPLC).The pharmacokinetic parameters and relative bioavailability were calculated by DAS 2.0 software.The quality inspection of self-made Panax japonicus tablets met the requirements of Chinese Pharmacopoeia(2015 edition),and this preparation had high bioequivalence of ginsenoside Rg3.The preparation of Panax japonicus tablets was reasonable and highly qualified.Moreover,this new Panax japonicus preparation showed better profiles in oral absorption and utilization.This study provided evidence for the industrial production and clinical application of Panax japonicus tablets.