AIM:To investigate the prevalence and physicians' detection rate of depressive and anxiety disorders in gastrointestinal(GI)outpatients across China. METHODS:A hospital-based cross-sectional survey was conducted i...AIM:To investigate the prevalence and physicians' detection rate of depressive and anxiety disorders in gastrointestinal(GI)outpatients across China. METHODS:A hospital-based cross-sectional survey was conducted in the GI outpatient departments of 13 general hospitals.A total of 1995 GI outpatients were recruited and screened with the Hospital Anxiety and Depression Scale(HADS).The physicians of the GI departments performed routine clinical diagnosis and management without knowing the HADS score results.Subjects with HADS scores≥8 were subsequently interviewed by psychiatrists using the Mini International Neuropsy-chiatric Interview(MINI)to make further diagnoses. RESULTS:There were 1059 patients with HADS score ≥8 and 674(63.64%)of them undertook the MINI interview by psychiatrists.Based on the criteria of Diagnostic and Statistical Manual of Mental Disorders (4th edition),the adjusted current prevalence for depressive disorders,anxiety disorders,and comorbidity of both disorders in the GI outpatients was 14.39%, 9.42%and 4.66%,respectively.Prevalence of depressive disorders with suicidal problems[suicide attempt or suicide-related ideation prior or current;module C (suicide)of MINI score≥1]was 5.84%in women and 1.64%in men.The GI physicians'detection rate of depressive and anxiety disorders accounted for 4.14%. CONCLUSION:While the prevalence of depressive and anxiety disorders is high in Chinese GI outpatients, the detection rate of depressive and anxiety disorders by physicians is low.展开更多
Understanding of the habitat range of threatened Himalayan medicinal plants which are declining in their abundance due to high anthropogenic disturbances is essential for developing conservation strategies and agrotec...Understanding of the habitat range of threatened Himalayan medicinal plants which are declining in their abundance due to high anthropogenic disturbances is essential for developing conservation strategies and agrotechnologies for cultivation. In this communication, we have discussed the habitat range of two alpine medicinal plants, Aconitum naviculare (Bruehl) Stapf and Neopicrorhiza scrophulariiflora (Pennel) Hong in a trans-Himalayan dry valley of central Nepal, Manang district. They are the most prioritized medicinal plants of the study area in terms of ethnomedicinal uses. A. naviculare occurs on warm and dry south facing slopes between 4090-4650 m asl along with sclerophyllous and thorny alpine scrubs, while N. scrophulariiflora is exclusively found on cool and moist north facing slope between 4000 and 4400 m asl where adequate water is available from snow melt to create a suitable habitat for this wetland dependent species. The soil in rooting zone of the two plants differs significantly in organic carbon (OC), organic matter (OM), total nitrogen (N) and carbon to nitrogen (C/N) ratio. Due to cool and moist condition of N. scrophulariiflora habitat, accumulation of soil OC is higher, but soil N content is lower probably due to slow release from litter, higher leaching loss and greater retention in perennial live biomass of the plant. The C/N ratio of soil is more suitable in A. navuculare habitat than that of N scrophulariiflora for N supply. Warm and sunny site with N rich soil can be suitable for cultivation ofA. naviculare, while moist and cool site with organic soil for N. scrophulariiflora. The populations of both the plants are fragmented and small. Due to collection by human and trampling damage by livestock, the population of A. naviculare was found absent in open areas in five of the six sampling sites and it was confined only within the bushes of alpine scrubs. For N. serophulariiflora, high probability of complete receding of small glaeiers may be a new threat in future to its habitat. The information about habitat conditions, together with the information from other areas, ean be useful to identify potential habitats and plan for cultivation or domestication of the two medieinal plants.展开更多
The present paper reviews the UN important efforts to promote global sustainable development in the chronological order since UN Conference on Human Environment in 1972, and ana- lyzes the progress and gap. The result...The present paper reviews the UN important efforts to promote global sustainable development in the chronological order since UN Conference on Human Environment in 1972, and ana- lyzes the progress and gap. The results show that the UN system has made great efforts for global sustainable development since the UN Conference on Human Environment, especially since UN Conference on Environment and Development, promoted the for- mation of important consensus and multilateral internhtional con- ventions on many fields, boosted the development of partnership in the field of sustainable development, and accelerated actions for sustainable development of many countries and regions. However, at present, the progress made is still far below the level required, prominently reflected in the slow progress toward the millen-nium development goals, the difficulties in negotiations in the field of environment and development, insufficient fulfillment of international agreements and conventions, and undesirable effects of partnership in the field of sustainable development. Based on these, the paper puts forward four suggestions for UN Conference on Sustainable Development in 2012(Rio+20): (1) to revitalize the "spirit of Rio" and accelerate the implementation of existing politi- cal commitments; (2) to make new political commitments focusing on climate change and other major global challenges under the Rio principles; (3) to lay out a blueprint of green economy under the Rio principles; and (4) to promote South-South cooperation as the focus of international cooperation.展开更多
The urban developments have been carried out by only professionals for a long time because of efficiency and safety. However, most residents are ordinary people. Therefore, it is necessary to change the awareness of s...The urban developments have been carried out by only professionals for a long time because of efficiency and safety. However, most residents are ordinary people. Therefore, it is necessary to change the awareness of sustainable living environments, not only on the construction side but also the residents. In recent years, the number of cases of residents' participation in planning, maintaining, and repairing increased. However, sometimes youths and children, who might spend a lifetime longer than adults in a city after the developments have been done, are not included in this "Residents". Conceming youth and children's participation, CFC (child friendly city) is one of the good practices for sustainable development. It was launched by UNICEF (United Nations Intemational Children's Emergency Fund) and UN-Habitat in the Habitat II in 1996. City governments, especially in European countries, started to view CFC as their key concept for preservation and/or sustainable development. CFC means not only being "Children" friendly but also "All people" friendly. Various effects have been reported since the Historic Cities/districts included CFC in their city planning as a common concept, especially in education, community re-development, and operation and maintenance by the community. It is expected that better city planning in preservation and sustainable development can be achieved by adding CFC concept. In this research, an ideal way of city planning involving resident participation and the possibility in the future are analyzed based on case studies. Then a strategy of sustainable development and community planning involving youth and children's participation is proposed.展开更多
Objectives To evaluate the association between a KCNQ 1 mutation, R259H, and short QT syndrome (SQTS) and to explore the elec- trophysiological mechanisms underlying their association. Methods We performed genetic s...Objectives To evaluate the association between a KCNQ 1 mutation, R259H, and short QT syndrome (SQTS) and to explore the elec- trophysiological mechanisms underlying their association. Methods We performed genetic screening of SQTS genes in 25 probands and their family members (63 patients). We used direct sequencing to screen the exons and intron-exon boundaries of candidate genes that en- code ion channels which contribute to the repolarization of the ventricular action potential, including KCNQI, KCNH2, KCNE1, KCNE2, KCNJ2, CACNAlc, CACNB2b and CACNA2D1. In one of the 25 SQTS probands screened, we discovered a KCNQ1 mutation, R259H. We cloned R259H and transiently expressed it in HEK-293 cells; then, currents were recorded using whole cell patch clamp techniques. Results R259H-KCNQ 1 showed significantly increased current density, which was approximately 3-fold larger than that of wild type (WT) after a depolarizing pulse at 1 s. The steady state voltage dependence of the activation and inactivation did not show significant differences between the WT and R259H mutation (P 〉 0.05), whereas the time constant of deactivation was markedly prolonged in the mutant compared with the WT in terms of the test potentials, which indicated that the deactivation of R259H was markedly slower than that of the WT. These results suggested that the R259H mutation can effectively increase the slowly activated delayed rectifier potassium current (Irs) in phase 3 of the cardiac action potential, which may be an infrequent cause of QT interval shortening. Conclusions R259H is a gain-of-function muta- tion of the KCNQ1 channel that is responsible for SQTS2. This is the first time that the R259H mutation was detected in Chinese people.展开更多
Background:Most of previous studies aimed to estimate the effect of nurse staffing on quality of acute hospital care have used stochastic methods and their results are mixed.Objective:To measure the magnitude of effec...Background:Most of previous studies aimed to estimate the effect of nurse staffing on quality of acute hospital care have used stochastic methods and their results are mixed.Objective:To measure the magnitude of effect of nurse-staffing level on increasing quality of acute care services in long-run.Data:The number of practicing nurses'density per 1000 population as the proxy of nurse-staffing level and three Health Care Quality Indicators(HCQI)included 30-day mortality per 100 patients based on acute myocardial infarction(MORTAMIO),hemorrhagic stroke(MORTHSTO)and ischemic stroke(MORTISTO)were collected as a part of ongoing project by OECD.org in panels of 26 OECD countries over 2005-2015 period.Method:Panel data analysis.Results:There were committed relationships from nurse-staffing level to the enhancement of HCQI i.e.1%increase in nurse-staffing level would reduce the rates of patient mortality based on MORTAMIO,MORTHSTO and MORTISTO by 0.65%,0.60%and 0.80%,respectively.Furthermore,the role of nursestaffing level in increasing overall HCQI were simulated at the highest level in Sweden(-3.53),Denmark(-3.31),Canada(-2.59),Netherlands(-2.33),Finland(-2.09),Switzerland(-1.72),Australia(-1.64)and United States(-1.53).Conclusion:A higher proportion of nurses-staffing level is associated with higher quality of acute care services in OECD countries.Also,the nursing characteristics of Sweden,Denmark,Canada,Netherlands,Finland,Switzerland,Australia and United States would be good patterns for other countries to maximize nursing outcomes in the care of patients with acute and life-threatening conditions by reducing the risk of complication,mortality and adverse clinical outcomes.展开更多
During the Cold War,China’s diplomacy failed to treat the Arab states as a whole.It was not until the end of the Cold War that China established diplomatic relations with all 22 Arab states.Since then,a multilateral ...During the Cold War,China’s diplomacy failed to treat the Arab states as a whole.It was not until the end of the Cold War that China established diplomatic relations with all 22 Arab states.Since then,a multilateral cooperation mechanism between China and Arab states has come into existence and become steadily developed.In 2004,the China-Arab States Cooperation Forum was established.In 2010,China and the Arab states announced the establishment of a strategic cooperative relationship.After the Gulf War,the Arab world entered a period of fragmentation and division.The situation deteriorated after the drastic changes in the Middle East in 2011,to the point of entering an era of granulation.The ability of The League of Arab States to operate as a single international actor has been greatly impaired.In the era of the fragmentation of the Arab world,the mechanism of multilateral cooperation between China and the Arab States has developed in spite of these great difficulties.In future,the role and function of the multilateral mechanism of cooperation between China and the Arab states needs to be clarified,and efficiency needs to be improved based on the existing mechanisms.展开更多
Reviewing the past, traditional Chinese medicine (TCM) in the 20th century experienced vicissitude. Since the founding the People's Republic of China, especially for the past twenty years, traditional Chinese medi...Reviewing the past, traditional Chinese medicine (TCM) in the 20th century experienced vicissitude. Since the founding the People's Republic of China, especially for the past twenty years, traditional Chinese medicine undertaking, full of vigor and vitality, has made an unprecedented development in China. The legal status and scientific status of traditional Chinese medicine and pharmacology have already been established. The medical system of traditional Chinese medicine, which is composed of traditional Chinese medicine hospitals, ethnic minority medicine hospitals, integration of traditional and western medicine hospitals and comprehensive hospitals, is playing an important role in preventing, treating diseases and enhancing people's health level. The system of production and circulation for traditional Chinese medicine has basically guaranteed the people's demand for Chinese medicine, with the principles of producing medicinal materials as basis, taking Chinese medicine industry as pillar and Chinese medicine as link. Remarkable achievements have been scored in the research of TCM development as well as research of TCM basic theory and clinical treatment. A number of scientific and technological results have been transformed into productive forces. TCM education has formed a rational pattern based on inheriting traditional way of transmission from master to disciple as well as taking the university and college education as the main part. Minority medical science has been further explored and sorted out; the level of medical treatment, teaching and scientific research for ethnic minority medicines has been improved. As the contingent of integrated traditional and western medicine is growing steadily, medical treatment system, scientific research system and teaching system for integrated traditional and western medicine takes shape progressively. International exchange and cooperation on traditional Chinese medicine has been greatly promoted. Various forms of cooperative relations on the TCM medical treatment, teaching and scientific research have been established between China and many other countries and regions in the world. With the increasing influence of TCM in the world, the accomplishment of traditional Chinese medicine in the 20th century has attracted world attention.展开更多
Background The vasovagal reflex syndrome (VVRS) is common in the patiems undergoing percutaneous coronary intervemion (PCI) However, prediction and prevention of the risk for the VVRS have not been completely fulf...Background The vasovagal reflex syndrome (VVRS) is common in the patiems undergoing percutaneous coronary intervemion (PCI) However, prediction and prevention of the risk for the VVRS have not been completely fulfilled. This study was conducted to develop a Risk Prediction Score Model to identify the determinants of VVRS in a large Chinese population cohort receiving PCI. Methods From the hos- pital electronic medical database, we idemified 3550 patients who received PCI (78.0% males, mean age 60 years) in Chinese PLA General Hospital from January 1, 2000 to August 30, 2016. The multivariate analysis and receiver operating characteristic 01OC) analysis were performed. Results The adverse events of VVRS in the patients were significantly increased after PCI procedure than before the operation (all P 〈 0.001). The rate of VVRS [95% confidence interval (CI)] in patients receiving PCI was 4.5% (4.1%-5.6%). Compared to the patients suffering no VVRS, incidence of VVRS involved the following factors, namely female gender, primary PCI, hypertension, over two stems im- plantation in the left anterior descending (LAD), and the femoral puncture site. The multivariate analysis suggested that they were independ- ent risk factors for predicting the incidence of VVRS (all P 〈 0.001). We developed a risk prediction score model for VVRS. ROC analysis showed that the risk prediction score model was effectively predictive of the incidence of VVRS in patients receiving PCI (c-statistic 0.76, 95% CI: 0.72-0.79, P 〈 0.001). There were decreased evems of VVRS in the patients receiving PCI whose diastolic blood pressure dropped by more than 30 mmHg and heart rate reduced by 10 times per minute (AUC: 0.84, 95% CI: 0.81-0.87, P 〈 0.001). Conclusion The risk prediction score is quite efficient in predicting the incidence of VVRS in patients receiving PCI. In which, the following factors may be in- volved, the femoral puncture site, female gender, hypertension, primary PCI, and over 2 stents implanted in LAD.展开更多
Background A considerable proportion of elderly patients with symptomatic severe heart valve disease are treated conservatively de- spite clear indications for surgical intervention. However, little is known about how...Background A considerable proportion of elderly patients with symptomatic severe heart valve disease are treated conservatively de- spite clear indications for surgical intervention. However, little is known about how advanced age and comorbidities affect treatment deci-sion-making and therapeutic outcomes. Methods Patients (n = 234, mean age: 78.5 ± 3.7 years) with symptomatic severe heart valve dis- ease hospitalized in our center were included. One hundred and fifty-one patients (65%) were treated surgically (surgical group) and 83 (35%) were treated conservatively (conservative group). Factors that affected therapeutic decision-making and treatment outcomes were investi- gated and long-term survival was explored. Results Isolated aortic valve disease, female sex, chronic renal insufficiency, aged _〉 80 years, pneumonia, and emergent status were independent factors associated with therapeutic decision-making. In-hospital mortality for the surgical group was 5.3% (8/151). Three patients (3.6%) in the conservative group died during initial hospitalization. Low cardiac output syndrome and chronic renal insufficiency were identified as predictors of in-hospital mortality in the surgical group. Conservative treatment was identi- fied as the single risk factor for late death in the entire study population. The surgical group had better 5-year (77.2% vs. 45.4%, P 〈 0.0001) and 10-year (34.5% vs. 8.9%, P 〈 0.0001) survival rates than the conservative group, even when adjusted by propensity score-matched analysis. Conclusions Advanced age and geriatric comorbidities profoundly affect treatment decision-making for severe heart valve disease. Valve surgery in the elderly was not only safe but was also associated with good long-term survival while conservative treatment was unfavorable for patients with symptomatic severe valve disease.展开更多
The paper analyses the market of Arabian countries, and Sino-Arab trade, and technology relations. In the recent years, Sino-Arab trade, investment, engineering contracting, Project Contracting, and technology coop...The paper analyses the market of Arabian countries, and Sino-Arab trade, and technology relations. In the recent years, Sino-Arab trade, investment, engineering contracting, Project Contracting, and technology cooperation developed very quickly. The paper also gives some recommendations to enhance Sino-Arab trade and technology relations.展开更多
Our country rural area has carried out broad practice on new model system of rural cooperative medical services, and the rural new medical treatment system has developed quickly. However, there are still many problems...Our country rural area has carried out broad practice on new model system of rural cooperative medical services, and the rural new medical treatment system has developed quickly. However, there are still many problems which needs us to solve. This article will analysis its present situation, problems and reasons, then give some suggestions to solve these problems. The new rural cooperative medical system has made great achievements since its implementation, which is a radical reform of the traditional medical systen. Lcd by thc govcmmcnt, trying to solve the majority of the Chinese population of the peasant groups to see the doctor difficult and expensive medical problems, and effectively protect the vital interests of farmers, so that people=oriented, establish and improve the rural medical service system. This paper analyzes the status quo of the new rural cooperative medical system, puts forward the problems, finds the reasons, and puts forward the corresponding countermeasures on the basis of this.展开更多
THIS year marks the 10th anniversary of the establishment of diplomatic relations between the People’s Republic of China and the Commonwealth of Dominica.China’s1.3 billion-strong population dwarfs Dominica’s less ...THIS year marks the 10th anniversary of the establishment of diplomatic relations between the People’s Republic of China and the Commonwealth of Dominica.China’s1.3 billion-strong population dwarfs Dominica’s less than 100,000 inhabitants.However,the two countries share a common understanding of equality and mutual benefit and have developed bilateral relations noticeably over the past 10 years,witnessed by achievements ranging from high-level visits and meetings between leaders to fruitful cooperation in political,展开更多
Judging by the general pattern of human civilization, ecological civilization is not a simple negation of industrial civilization. Given China's unique national conditions and uneven process of industrialization, it ...Judging by the general pattern of human civilization, ecological civilization is not a simple negation of industrial civilization. Given China's unique national conditions and uneven process of industrialization, it is inappropriate to separate eeological civilization from industrial civilization. Instead, government should identify the common ground between industrial civilization and ecological civilization, fully utilize material wealth, technology means and organizational system of industrial civilization of the world, leave the freedom of imagination and practices for creating the new-type industrial civilization to businesses and the public, continuously strengthen the material foundation of China's ecological civilization, with a view to supporting the development of ecological civilization with high-quality real economy and achieving the integrated development of industrial civilization and ecological civilization while expediting the new-type industrialization and delivering the benefits of industrialization to 1.3 billion Chinese people.展开更多
ON August 6,Navi Pillay,the United Nations High Commissioner for Human Rights,urged Japan to produce a comprehensive,impartial and lasting resolution on the issue of wartime sexual slavery,the so-called"comfort w...ON August 6,Navi Pillay,the United Nations High Commissioner for Human Rights,urged Japan to produce a comprehensive,impartial and lasting resolution on the issue of wartime sexual slavery,the so-called"comfort women."She lamented a report released by the Japanese government on June 20that said it"was not possible to confirm that women were forcefully recruited."In appealing to Japan,Pillay recognized that such a statement would cause tremendous agony to those female victims.展开更多
Objective The predictive value of the metabolic syndrome (MetS) for mortality from all-cause and cardiovascular disease (CVD) in the Chinese population is unclear. The aim of this present study was to compare MetS...Objective The predictive value of the metabolic syndrome (MetS) for mortality from all-cause and cardiovascular disease (CVD) in the Chinese population is unclear. The aim of this present study was to compare MetS with its individual components as predictors of mortality in Chinese elderly adults. Methods A cohort of 1,535 subjects (994 men and 541 women) aged 50 years or older was selected from employees of a machinery factory in 1994 and followed until 2009. Cox models were used to estimate the hazard ratios (HRs) predicted by MetS according to the harmonized defmition and by its individual components. Results The baseline prevalence of MetS was 28.0% in men and 48.4% in women. During a median follow-up of 15 years, 414 deaths occurred, of these, 153 participants died from CVD. Adjusted for age and gender, the HRs of mortality from all-cause and CVD in participants with MetS were 1.47 (95% confidence interval (CI): 1.20-1.80) and 1.96 (95%CI: 1.42-2.72), respectively, compared with those without MetS. Non-significant higher risk of CVD mortality was seen in those with one or two individual components (HR = 1.22, 95%CI: 0.59-2.50; fir = 1.82, 95%CI: 0.91-3.64, respectively), while a substantially higher risk of CVD mortality only appeared in those with 3, 4, or 5 components (H_R = 2.81-3.72), compared with those with no components. On evaluating the MetS components individually, we found that, independent of MetS, only hypertension and impaired glucose predicted higher mortality. Conclusions The number of positive MetS components seems no more informative than classifying (dichotomous) MetS for CVD risks assessment in this Chinese cohort.展开更多
基金Supported by The former Wyeth Pharmaceutical Co.,Ltd., Madison,NJ,United States
文摘AIM:To investigate the prevalence and physicians' detection rate of depressive and anxiety disorders in gastrointestinal(GI)outpatients across China. METHODS:A hospital-based cross-sectional survey was conducted in the GI outpatient departments of 13 general hospitals.A total of 1995 GI outpatients were recruited and screened with the Hospital Anxiety and Depression Scale(HADS).The physicians of the GI departments performed routine clinical diagnosis and management without knowing the HADS score results.Subjects with HADS scores≥8 were subsequently interviewed by psychiatrists using the Mini International Neuropsy-chiatric Interview(MINI)to make further diagnoses. RESULTS:There were 1059 patients with HADS score ≥8 and 674(63.64%)of them undertook the MINI interview by psychiatrists.Based on the criteria of Diagnostic and Statistical Manual of Mental Disorders (4th edition),the adjusted current prevalence for depressive disorders,anxiety disorders,and comorbidity of both disorders in the GI outpatients was 14.39%, 9.42%and 4.66%,respectively.Prevalence of depressive disorders with suicidal problems[suicide attempt or suicide-related ideation prior or current;module C (suicide)of MINI score≥1]was 5.84%in women and 1.64%in men.The GI physicians'detection rate of depressive and anxiety disorders accounted for 4.14%. CONCLUSION:While the prevalence of depressive and anxiety disorders is high in Chinese GI outpatients, the detection rate of depressive and anxiety disorders by physicians is low.
文摘Understanding of the habitat range of threatened Himalayan medicinal plants which are declining in their abundance due to high anthropogenic disturbances is essential for developing conservation strategies and agrotechnologies for cultivation. In this communication, we have discussed the habitat range of two alpine medicinal plants, Aconitum naviculare (Bruehl) Stapf and Neopicrorhiza scrophulariiflora (Pennel) Hong in a trans-Himalayan dry valley of central Nepal, Manang district. They are the most prioritized medicinal plants of the study area in terms of ethnomedicinal uses. A. naviculare occurs on warm and dry south facing slopes between 4090-4650 m asl along with sclerophyllous and thorny alpine scrubs, while N. scrophulariiflora is exclusively found on cool and moist north facing slope between 4000 and 4400 m asl where adequate water is available from snow melt to create a suitable habitat for this wetland dependent species. The soil in rooting zone of the two plants differs significantly in organic carbon (OC), organic matter (OM), total nitrogen (N) and carbon to nitrogen (C/N) ratio. Due to cool and moist condition of N. scrophulariiflora habitat, accumulation of soil OC is higher, but soil N content is lower probably due to slow release from litter, higher leaching loss and greater retention in perennial live biomass of the plant. The C/N ratio of soil is more suitable in A. navuculare habitat than that of N scrophulariiflora for N supply. Warm and sunny site with N rich soil can be suitable for cultivation ofA. naviculare, while moist and cool site with organic soil for N. scrophulariiflora. The populations of both the plants are fragmented and small. Due to collection by human and trampling damage by livestock, the population of A. naviculare was found absent in open areas in five of the six sampling sites and it was confined only within the bushes of alpine scrubs. For N. serophulariiflora, high probability of complete receding of small glaeiers may be a new threat in future to its habitat. The information about habitat conditions, together with the information from other areas, ean be useful to identify potential habitats and plan for cultivation or domestication of the two medieinal plants.
文摘The present paper reviews the UN important efforts to promote global sustainable development in the chronological order since UN Conference on Human Environment in 1972, and ana- lyzes the progress and gap. The results show that the UN system has made great efforts for global sustainable development since the UN Conference on Human Environment, especially since UN Conference on Environment and Development, promoted the for- mation of important consensus and multilateral internhtional con- ventions on many fields, boosted the development of partnership in the field of sustainable development, and accelerated actions for sustainable development of many countries and regions. However, at present, the progress made is still far below the level required, prominently reflected in the slow progress toward the millen-nium development goals, the difficulties in negotiations in the field of environment and development, insufficient fulfillment of international agreements and conventions, and undesirable effects of partnership in the field of sustainable development. Based on these, the paper puts forward four suggestions for UN Conference on Sustainable Development in 2012(Rio+20): (1) to revitalize the "spirit of Rio" and accelerate the implementation of existing politi- cal commitments; (2) to make new political commitments focusing on climate change and other major global challenges under the Rio principles; (3) to lay out a blueprint of green economy under the Rio principles; and (4) to promote South-South cooperation as the focus of international cooperation.
文摘The urban developments have been carried out by only professionals for a long time because of efficiency and safety. However, most residents are ordinary people. Therefore, it is necessary to change the awareness of sustainable living environments, not only on the construction side but also the residents. In recent years, the number of cases of residents' participation in planning, maintaining, and repairing increased. However, sometimes youths and children, who might spend a lifetime longer than adults in a city after the developments have been done, are not included in this "Residents". Conceming youth and children's participation, CFC (child friendly city) is one of the good practices for sustainable development. It was launched by UNICEF (United Nations Intemational Children's Emergency Fund) and UN-Habitat in the Habitat II in 1996. City governments, especially in European countries, started to view CFC as their key concept for preservation and/or sustainable development. CFC means not only being "Children" friendly but also "All people" friendly. Various effects have been reported since the Historic Cities/districts included CFC in their city planning as a common concept, especially in education, community re-development, and operation and maintenance by the community. It is expected that better city planning in preservation and sustainable development can be achieved by adding CFC concept. In this research, an ideal way of city planning involving resident participation and the possibility in the future are analyzed based on case studies. Then a strategy of sustainable development and community planning involving youth and children's participation is proposed.
基金grants obtained from the National Natural Science Foundation of China (No.: 81170177, 81030002) and science and Technology De- partment of Gansu Province Project (145RJZ104).
文摘Objectives To evaluate the association between a KCNQ 1 mutation, R259H, and short QT syndrome (SQTS) and to explore the elec- trophysiological mechanisms underlying their association. Methods We performed genetic screening of SQTS genes in 25 probands and their family members (63 patients). We used direct sequencing to screen the exons and intron-exon boundaries of candidate genes that en- code ion channels which contribute to the repolarization of the ventricular action potential, including KCNQI, KCNH2, KCNE1, KCNE2, KCNJ2, CACNAlc, CACNB2b and CACNA2D1. In one of the 25 SQTS probands screened, we discovered a KCNQ1 mutation, R259H. We cloned R259H and transiently expressed it in HEK-293 cells; then, currents were recorded using whole cell patch clamp techniques. Results R259H-KCNQ 1 showed significantly increased current density, which was approximately 3-fold larger than that of wild type (WT) after a depolarizing pulse at 1 s. The steady state voltage dependence of the activation and inactivation did not show significant differences between the WT and R259H mutation (P 〉 0.05), whereas the time constant of deactivation was markedly prolonged in the mutant compared with the WT in terms of the test potentials, which indicated that the deactivation of R259H was markedly slower than that of the WT. These results suggested that the R259H mutation can effectively increase the slowly activated delayed rectifier potassium current (Irs) in phase 3 of the cardiac action potential, which may be an infrequent cause of QT interval shortening. Conclusions R259H is a gain-of-function muta- tion of the KCNQ1 channel that is responsible for SQTS2. This is the first time that the R259H mutation was detected in Chinese people.
文摘Background:Most of previous studies aimed to estimate the effect of nurse staffing on quality of acute hospital care have used stochastic methods and their results are mixed.Objective:To measure the magnitude of effect of nurse-staffing level on increasing quality of acute care services in long-run.Data:The number of practicing nurses'density per 1000 population as the proxy of nurse-staffing level and three Health Care Quality Indicators(HCQI)included 30-day mortality per 100 patients based on acute myocardial infarction(MORTAMIO),hemorrhagic stroke(MORTHSTO)and ischemic stroke(MORTISTO)were collected as a part of ongoing project by OECD.org in panels of 26 OECD countries over 2005-2015 period.Method:Panel data analysis.Results:There were committed relationships from nurse-staffing level to the enhancement of HCQI i.e.1%increase in nurse-staffing level would reduce the rates of patient mortality based on MORTAMIO,MORTHSTO and MORTISTO by 0.65%,0.60%and 0.80%,respectively.Furthermore,the role of nursestaffing level in increasing overall HCQI were simulated at the highest level in Sweden(-3.53),Denmark(-3.31),Canada(-2.59),Netherlands(-2.33),Finland(-2.09),Switzerland(-1.72),Australia(-1.64)and United States(-1.53).Conclusion:A higher proportion of nurses-staffing level is associated with higher quality of acute care services in OECD countries.Also,the nursing characteristics of Sweden,Denmark,Canada,Netherlands,Finland,Switzerland,Australia and United States would be good patterns for other countries to maximize nursing outcomes in the care of patients with acute and life-threatening conditions by reducing the risk of complication,mortality and adverse clinical outcomes.
文摘During the Cold War,China’s diplomacy failed to treat the Arab states as a whole.It was not until the end of the Cold War that China established diplomatic relations with all 22 Arab states.Since then,a multilateral cooperation mechanism between China and Arab states has come into existence and become steadily developed.In 2004,the China-Arab States Cooperation Forum was established.In 2010,China and the Arab states announced the establishment of a strategic cooperative relationship.After the Gulf War,the Arab world entered a period of fragmentation and division.The situation deteriorated after the drastic changes in the Middle East in 2011,to the point of entering an era of granulation.The ability of The League of Arab States to operate as a single international actor has been greatly impaired.In the era of the fragmentation of the Arab world,the mechanism of multilateral cooperation between China and the Arab States has developed in spite of these great difficulties.In future,the role and function of the multilateral mechanism of cooperation between China and the Arab states needs to be clarified,and efficiency needs to be improved based on the existing mechanisms.
文摘Reviewing the past, traditional Chinese medicine (TCM) in the 20th century experienced vicissitude. Since the founding the People's Republic of China, especially for the past twenty years, traditional Chinese medicine undertaking, full of vigor and vitality, has made an unprecedented development in China. The legal status and scientific status of traditional Chinese medicine and pharmacology have already been established. The medical system of traditional Chinese medicine, which is composed of traditional Chinese medicine hospitals, ethnic minority medicine hospitals, integration of traditional and western medicine hospitals and comprehensive hospitals, is playing an important role in preventing, treating diseases and enhancing people's health level. The system of production and circulation for traditional Chinese medicine has basically guaranteed the people's demand for Chinese medicine, with the principles of producing medicinal materials as basis, taking Chinese medicine industry as pillar and Chinese medicine as link. Remarkable achievements have been scored in the research of TCM development as well as research of TCM basic theory and clinical treatment. A number of scientific and technological results have been transformed into productive forces. TCM education has formed a rational pattern based on inheriting traditional way of transmission from master to disciple as well as taking the university and college education as the main part. Minority medical science has been further explored and sorted out; the level of medical treatment, teaching and scientific research for ethnic minority medicines has been improved. As the contingent of integrated traditional and western medicine is growing steadily, medical treatment system, scientific research system and teaching system for integrated traditional and western medicine takes shape progressively. International exchange and cooperation on traditional Chinese medicine has been greatly promoted. Various forms of cooperative relations on the TCM medical treatment, teaching and scientific research have been established between China and many other countries and regions in the world. With the increasing influence of TCM in the world, the accomplishment of traditional Chinese medicine in the 20th century has attracted world attention.
文摘Background The vasovagal reflex syndrome (VVRS) is common in the patiems undergoing percutaneous coronary intervemion (PCI) However, prediction and prevention of the risk for the VVRS have not been completely fulfilled. This study was conducted to develop a Risk Prediction Score Model to identify the determinants of VVRS in a large Chinese population cohort receiving PCI. Methods From the hos- pital electronic medical database, we idemified 3550 patients who received PCI (78.0% males, mean age 60 years) in Chinese PLA General Hospital from January 1, 2000 to August 30, 2016. The multivariate analysis and receiver operating characteristic 01OC) analysis were performed. Results The adverse events of VVRS in the patients were significantly increased after PCI procedure than before the operation (all P 〈 0.001). The rate of VVRS [95% confidence interval (CI)] in patients receiving PCI was 4.5% (4.1%-5.6%). Compared to the patients suffering no VVRS, incidence of VVRS involved the following factors, namely female gender, primary PCI, hypertension, over two stems im- plantation in the left anterior descending (LAD), and the femoral puncture site. The multivariate analysis suggested that they were independ- ent risk factors for predicting the incidence of VVRS (all P 〈 0.001). We developed a risk prediction score model for VVRS. ROC analysis showed that the risk prediction score model was effectively predictive of the incidence of VVRS in patients receiving PCI (c-statistic 0.76, 95% CI: 0.72-0.79, P 〈 0.001). There were decreased evems of VVRS in the patients receiving PCI whose diastolic blood pressure dropped by more than 30 mmHg and heart rate reduced by 10 times per minute (AUC: 0.84, 95% CI: 0.81-0.87, P 〈 0.001). Conclusion The risk prediction score is quite efficient in predicting the incidence of VVRS in patients receiving PCI. In which, the following factors may be in- volved, the femoral puncture site, female gender, hypertension, primary PCI, and over 2 stents implanted in LAD.
文摘Background A considerable proportion of elderly patients with symptomatic severe heart valve disease are treated conservatively de- spite clear indications for surgical intervention. However, little is known about how advanced age and comorbidities affect treatment deci-sion-making and therapeutic outcomes. Methods Patients (n = 234, mean age: 78.5 ± 3.7 years) with symptomatic severe heart valve dis- ease hospitalized in our center were included. One hundred and fifty-one patients (65%) were treated surgically (surgical group) and 83 (35%) were treated conservatively (conservative group). Factors that affected therapeutic decision-making and treatment outcomes were investi- gated and long-term survival was explored. Results Isolated aortic valve disease, female sex, chronic renal insufficiency, aged _〉 80 years, pneumonia, and emergent status were independent factors associated with therapeutic decision-making. In-hospital mortality for the surgical group was 5.3% (8/151). Three patients (3.6%) in the conservative group died during initial hospitalization. Low cardiac output syndrome and chronic renal insufficiency were identified as predictors of in-hospital mortality in the surgical group. Conservative treatment was identi- fied as the single risk factor for late death in the entire study population. The surgical group had better 5-year (77.2% vs. 45.4%, P 〈 0.0001) and 10-year (34.5% vs. 8.9%, P 〈 0.0001) survival rates than the conservative group, even when adjusted by propensity score-matched analysis. Conclusions Advanced age and geriatric comorbidities profoundly affect treatment decision-making for severe heart valve disease. Valve surgery in the elderly was not only safe but was also associated with good long-term survival while conservative treatment was unfavorable for patients with symptomatic severe valve disease.
文摘The paper analyses the market of Arabian countries, and Sino-Arab trade, and technology relations. In the recent years, Sino-Arab trade, investment, engineering contracting, Project Contracting, and technology cooperation developed very quickly. The paper also gives some recommendations to enhance Sino-Arab trade and technology relations.
文摘Our country rural area has carried out broad practice on new model system of rural cooperative medical services, and the rural new medical treatment system has developed quickly. However, there are still many problems which needs us to solve. This article will analysis its present situation, problems and reasons, then give some suggestions to solve these problems. The new rural cooperative medical system has made great achievements since its implementation, which is a radical reform of the traditional medical systen. Lcd by thc govcmmcnt, trying to solve the majority of the Chinese population of the peasant groups to see the doctor difficult and expensive medical problems, and effectively protect the vital interests of farmers, so that people=oriented, establish and improve the rural medical service system. This paper analyzes the status quo of the new rural cooperative medical system, puts forward the problems, finds the reasons, and puts forward the corresponding countermeasures on the basis of this.
文摘THIS year marks the 10th anniversary of the establishment of diplomatic relations between the People’s Republic of China and the Commonwealth of Dominica.China’s1.3 billion-strong population dwarfs Dominica’s less than 100,000 inhabitants.However,the two countries share a common understanding of equality and mutual benefit and have developed bilateral relations noticeably over the past 10 years,witnessed by achievements ranging from high-level visits and meetings between leaders to fruitful cooperation in political,
文摘Judging by the general pattern of human civilization, ecological civilization is not a simple negation of industrial civilization. Given China's unique national conditions and uneven process of industrialization, it is inappropriate to separate eeological civilization from industrial civilization. Instead, government should identify the common ground between industrial civilization and ecological civilization, fully utilize material wealth, technology means and organizational system of industrial civilization of the world, leave the freedom of imagination and practices for creating the new-type industrial civilization to businesses and the public, continuously strengthen the material foundation of China's ecological civilization, with a view to supporting the development of ecological civilization with high-quality real economy and achieving the integrated development of industrial civilization and ecological civilization while expediting the new-type industrialization and delivering the benefits of industrialization to 1.3 billion Chinese people.
文摘ON August 6,Navi Pillay,the United Nations High Commissioner for Human Rights,urged Japan to produce a comprehensive,impartial and lasting resolution on the issue of wartime sexual slavery,the so-called"comfort women."She lamented a report released by the Japanese government on June 20that said it"was not possible to confirm that women were forcefully recruited."In appealing to Japan,Pillay recognized that such a statement would cause tremendous agony to those female victims.
基金This study was supported by the National Natural Science Foundation of China,Ministry of Science and Technology of China,National Department Public Benefit Research Foundation by Ministry of Health of China
文摘Objective The predictive value of the metabolic syndrome (MetS) for mortality from all-cause and cardiovascular disease (CVD) in the Chinese population is unclear. The aim of this present study was to compare MetS with its individual components as predictors of mortality in Chinese elderly adults. Methods A cohort of 1,535 subjects (994 men and 541 women) aged 50 years or older was selected from employees of a machinery factory in 1994 and followed until 2009. Cox models were used to estimate the hazard ratios (HRs) predicted by MetS according to the harmonized defmition and by its individual components. Results The baseline prevalence of MetS was 28.0% in men and 48.4% in women. During a median follow-up of 15 years, 414 deaths occurred, of these, 153 participants died from CVD. Adjusted for age and gender, the HRs of mortality from all-cause and CVD in participants with MetS were 1.47 (95% confidence interval (CI): 1.20-1.80) and 1.96 (95%CI: 1.42-2.72), respectively, compared with those without MetS. Non-significant higher risk of CVD mortality was seen in those with one or two individual components (HR = 1.22, 95%CI: 0.59-2.50; fir = 1.82, 95%CI: 0.91-3.64, respectively), while a substantially higher risk of CVD mortality only appeared in those with 3, 4, or 5 components (H_R = 2.81-3.72), compared with those with no components. On evaluating the MetS components individually, we found that, independent of MetS, only hypertension and impaired glucose predicted higher mortality. Conclusions The number of positive MetS components seems no more informative than classifying (dichotomous) MetS for CVD risks assessment in this Chinese cohort.