《绿野仙踪》(The Wonderful Wizard of Oz)是TIKCASTLEY美国作家莱曼·弗兰克·鲍姆创作的儿童文学作品,讲述了勇敢、善良的小姑娘多萝茜的历险故事。多BLUE萝茜和叔叔、婢住在堪萨斯州的一个农场里。一天,龙卷风来袭,叔叔、...《绿野仙踪》(The Wonderful Wizard of Oz)是TIKCASTLEY美国作家莱曼·弗兰克·鲍姆创作的儿童文学作品,讲述了勇敢、善良的小姑娘多萝茜的历险故事。多BLUE萝茜和叔叔、婢住在堪萨斯州的一个农场里。一天,龙卷风来袭,叔叔、和其他人都躲进旋风地洞,可怜的多萝茜连同叔叔的木头房子一起被龙卷风抛向空中。龙卷风停下来后,多萝茜走出木头房子,发现自己身处一个叫奥兹的矮人国里。由于木头房子掉下来时正好砸死了祸害奥兹国的东方魔女,多萝茜便在奥兹国受到了热烈的欢迎,备受尊崇。展开更多
Objective： To investigate the association between the mutations in lipoprotein lipase gene and hypertriglyceridemia （HTG）. Methods： The lipoprotein lipase （LPL） gene was screened for mutations in 386 Chinese sub...Objective： To investigate the association between the mutations in lipoprotein lipase gene and hypertriglyceridemia （HTG）. Methods： The lipoprotein lipase （LPL） gene was screened for mutations in 386 Chinese subjects with （108 cases in the HTG group） or without HTG （278 cases in the control group）, by single-strand conformation polymorphism （SSCP） analysis and DNA sequencing. Results： One novel silent mutation L103L, one missense mutation P207L, three splicing mutations Int3/3＇ -ass/C（-6）→T, and the common S447X polymorphism has been identified in the whole coding region and exon-intron junctions of the LPL gene were examined. Heterozygous P207L found in the HTG group was the first case reported in Asia and subsequently another P207L heterozygote was found in the proband＇s family, all of which suggested that P207L was one of the causes of familial combined hyperlipidemia, but was not so prevalent as that in French Canadian. Int3/3＇-ass/C（-6）→T was found in both groups in the present study although it was regarded as a pathogenic variant to HTG earlier on. Moreover about the beneficial polymorphism S447X, there was also some supportive evidence that the levels of triglycerides （TG） in S447X carriers were significantly lower than noncarders in the subjects without HTG. Conclusions： The association between the LPL variants and HTG is quite complicated and versatile, genotyping of LPL in a larger-scale screening should be necessary and justifiable.展开更多
Anthropogenic aluminum cycle in China was analyzed by the aluminum flow diagram based on the life cycle of aluminum products. The whole anthropogenic aluminum cycle consists of four stages： alumina and aluminum produ...Anthropogenic aluminum cycle in China was analyzed by the aluminum flow diagram based on the life cycle of aluminum products. The whole anthropogenic aluminum cycle consists of four stages： alumina and aluminum production, fabrication and manufacture, use and reclamation. Based on the investigation on the 2003-2007 aluminum cycles in China, a number of changes can be found. For instance, resources self-support ratio （RSR） in alumina production dropped from 95.42%to 55.50%, while RSR in the aluminum production increased from 52.45%to 79.25%. However, RSR in the Chinese aluminum industry leveled off at 50%in the period of 2003-2007. The respective use ratios of domestic and imported aluminum scrap in the aluminum industry of 2007 were 5.38% and 9.40%. In contrast, both the net imported Al-containing resources and the lost quantity of Al-containing materials in aluminum cycle increased during the same period, as well as the net increased quantity of Al-containing materials in social stock and recycled Al-scrap. Proposals for promoting aluminum cycle were put forward. The import/export policy and reducing the loss of Al-containing materials for the aluminum industry in China in the future were discussed.展开更多
Previous research on gene expression analysis and association tests have suggested that RELN is a risk gene for schizophrenia in world populations.Based on the reported down-regulation of RELN in schizophrenia patient...Previous research on gene expression analysis and association tests have suggested that RELN is a risk gene for schizophrenia in world populations.Based on the reported down-regulation of RELN in schizophrenia patients compared with normal subjects,we speculated that variants in the RELN promoter region may confer risk for schizophrenia.In this study,we investigated the associations of three SNPs in the promoter region of RELN with schizophrenia in a case-control sample from southwestern China（940 cases and 13 69 controls）.The results suggested that none of the SNPs showed significant associations in our sample,indicating the risk variants for schizophrenia in RELN may not be located in the promoter region.We also performed meta-analysis by combining our data with previously reported data on the Chinese population with a total sample size of 2 843 individuals,and the result remained nonsignificant.Collectively,our results suggested variants in the RELN promoter may not harbor risk SNPs associated with schizophrenia in the Chinese population.展开更多
文摘《绿野仙踪》(The Wonderful Wizard of Oz)是TIKCASTLEY美国作家莱曼·弗兰克·鲍姆创作的儿童文学作品,讲述了勇敢、善良的小姑娘多萝茜的历险故事。多BLUE萝茜和叔叔、婢住在堪萨斯州的一个农场里。一天,龙卷风来袭,叔叔、和其他人都躲进旋风地洞,可怜的多萝茜连同叔叔的木头房子一起被龙卷风抛向空中。龙卷风停下来后,多萝茜走出木头房子,发现自己身处一个叫奥兹的矮人国里。由于木头房子掉下来时正好砸死了祸害奥兹国的东方魔女,多萝茜便在奥兹国受到了热烈的欢迎,备受尊崇。
基金This work was supported by the Grant from Tianjin Municipal Natural Science Foundations (No. 033607311).
文摘Objective： To investigate the association between the mutations in lipoprotein lipase gene and hypertriglyceridemia （HTG）. Methods： The lipoprotein lipase （LPL） gene was screened for mutations in 386 Chinese subjects with （108 cases in the HTG group） or without HTG （278 cases in the control group）, by single-strand conformation polymorphism （SSCP） analysis and DNA sequencing. Results： One novel silent mutation L103L, one missense mutation P207L, three splicing mutations Int3/3＇ -ass/C（-6）→T, and the common S447X polymorphism has been identified in the whole coding region and exon-intron junctions of the LPL gene were examined. Heterozygous P207L found in the HTG group was the first case reported in Asia and subsequently another P207L heterozygote was found in the proband＇s family, all of which suggested that P207L was one of the causes of familial combined hyperlipidemia, but was not so prevalent as that in French Canadian. Int3/3＇-ass/C（-6）→T was found in both groups in the present study although it was regarded as a pathogenic variant to HTG earlier on. Moreover about the beneficial polymorphism S447X, there was also some supportive evidence that the levels of triglycerides （TG） in S447X carriers were significantly lower than noncarders in the subjects without HTG. Conclusions： The association between the LPL variants and HTG is quite complicated and versatile, genotyping of LPL in a larger-scale screening should be necessary and justifiable.
基金Projects (71003018,71373003) supported by the National Natural Science Foundation of ChinaProjects (N110402003,N120302004) supported by the Fundamental Research Funds for the Central Universities,ChinaProject (13YJCZH172) supported by the Ministry of Education of China of Humanities and Social Sciences
文摘Anthropogenic aluminum cycle in China was analyzed by the aluminum flow diagram based on the life cycle of aluminum products. The whole anthropogenic aluminum cycle consists of four stages： alumina and aluminum production, fabrication and manufacture, use and reclamation. Based on the investigation on the 2003-2007 aluminum cycles in China, a number of changes can be found. For instance, resources self-support ratio （RSR） in alumina production dropped from 95.42%to 55.50%, while RSR in the aluminum production increased from 52.45%to 79.25%. However, RSR in the Chinese aluminum industry leveled off at 50%in the period of 2003-2007. The respective use ratios of domestic and imported aluminum scrap in the aluminum industry of 2007 were 5.38% and 9.40%. In contrast, both the net imported Al-containing resources and the lost quantity of Al-containing materials in aluminum cycle increased during the same period, as well as the net increased quantity of Al-containing materials in social stock and recycled Al-scrap. Proposals for promoting aluminum cycle were put forward. The import/export policy and reducing the loss of Al-containing materials for the aluminum industry in China in the future were discussed.
文摘Previous research on gene expression analysis and association tests have suggested that RELN is a risk gene for schizophrenia in world populations.Based on the reported down-regulation of RELN in schizophrenia patients compared with normal subjects,we speculated that variants in the RELN promoter region may confer risk for schizophrenia.In this study,we investigated the associations of three SNPs in the promoter region of RELN with schizophrenia in a case-control sample from southwestern China（940 cases and 13 69 controls）.The results suggested that none of the SNPs showed significant associations in our sample,indicating the risk variants for schizophrenia in RELN may not be located in the promoter region.We also performed meta-analysis by combining our data with previously reported data on the Chinese population with a total sample size of 2 843 individuals,and the result remained nonsignificant.Collectively,our results suggested variants in the RELN promoter may not harbor risk SNPs associated with schizophrenia in the Chinese population.
