Due to lack of appreciation of the complexities of the interactions between nature and nurture, claims for the rapid improvements in medical care following the human genome project have been exaggerated. Although some...Due to lack of appreciation of the complexities of the interactions between nature and nurture, claims for the rapid improvements in medical care following the human genome project have been exaggerated. Although some progress has been made in certain fields, the full scope of genomic medicine may not be realised for many years.展开更多
Along with the completion of HGP （human genome project）, huge amounts of genetic data constantly emerge. Research suggests that genes are not in independent existence and the expression of a gene will promote or inh...Along with the completion of HGP （human genome project）, huge amounts of genetic data constantly emerge. Research suggests that genes are not in independent existence and the expression of a gene will promote or inhibit the expression of another gene; if the expression of a gene makes the biochemical environment of ceils changed, the expression of a series of genes will be affected. In order to get a better understanding of the relationship between genes, all sorts of gene regulatory network models have been established by scientists. In this paper, a variety of gene regulatory networks are first introduced according to the process of this subject research, and then the most basic network （i.e. Boolean network） is emphatically analyzed, and then a new method （i.e. Boolean network based on the theory of circuit） to describe Boolean network is drawn forth. After the shortcomings of the Boolean network proposed in the past are analyzed, a simulation circuit Boolean model is established using EDA technology in order to improve the Boolean network.展开更多
The development of cancer is a pathological process involving multiple environmental carcinogenic factors and genetic alterations.For decades,cancer researchers have focused on genomic and transcriptomic analyses.The ...The development of cancer is a pathological process involving multiple environmental carcinogenic factors and genetic alterations.For decades,cancer researchers have focused on genomic and transcriptomic analyses.The completion of the Human Genome Project has opened the door to the post-genome era and oncoproteomics.Proteins play a critical role in tumorigenesis and influence the differences between normal cells and malignant cells.This report proposes the concept that cancer is a proteomic disease.This concept is based on examining protein expression profiles,post-translational modifications,and protein-protein interactions in carcinogenesis using recent advances in comparative,functional and structural proteomics.This approach provides a new way of viewing carcinogenesis,presents new clues in biomarker discovery for cancer diagnosis and therapy,and reveals important scientific findings and their significance to clinical applications.展开更多
The Human Genome Project was launched at the end of the 1980s.Since then,the cloning and identification of functional genes has been a major focus of research across the world.In China too,the potentially profound imp...The Human Genome Project was launched at the end of the 1980s.Since then,the cloning and identification of functional genes has been a major focus of research across the world.In China too,the potentially profound impact of such studies on the life sciences and on human health was realized,and relevant studies were initiated in the 1990s.To advance China's involvement in the Human Genome Project,in the mid-1990s,Committee of Experts in Biology from National High Technology Research and Development Program of China(863 Program) proposed the "two 1%" goal.This goal envisaged China contributing 1% of the total sequencing work,and cloning and identifying 1% of the total human functional genes.Over the past 20 years,tremendous achievement has been accomplished by Chinese scientists.It is well known that scientists in China finished the 1% of sequencing work of the Human Genome Project,whereas,there is no comprehensive report about "whether China had finished cloning and identifying 1% of human functional genes".In the present study,the GenBank database at the National Center of Biotechnology Information,the PubMed search tool,and the patent database of the State Intellectual Property Office,China,were used to retrieve entries based on two screening standards:(i) Were the newly cloned and identified genes first reported by Chinese scientists?(ii) Were the Chinese scientists awarded the gene sequence patent? Entries were retrieved from the databases up to the cut-off date of 30 June 2011 and the obtained data were analyzed further.The results showed that 589 new human functional genes were first reported by Chinese scientists and 159 gene sequences were patented(http:gene.fudan.sh.cn/introduction/database/chinagene/chinagene.html).This study systematically summarizes China's contributions to human functional genomics research and answers the question "has China finished cloning and identifying 1% of human functional genes?" in the affirmative.展开更多
文摘Due to lack of appreciation of the complexities of the interactions between nature and nurture, claims for the rapid improvements in medical care following the human genome project have been exaggerated. Although some progress has been made in certain fields, the full scope of genomic medicine may not be realised for many years.
文摘Along with the completion of HGP （human genome project）, huge amounts of genetic data constantly emerge. Research suggests that genes are not in independent existence and the expression of a gene will promote or inhibit the expression of another gene; if the expression of a gene makes the biochemical environment of ceils changed, the expression of a series of genes will be affected. In order to get a better understanding of the relationship between genes, all sorts of gene regulatory network models have been established by scientists. In this paper, a variety of gene regulatory networks are first introduced according to the process of this subject research, and then the most basic network （i.e. Boolean network） is emphatically analyzed, and then a new method （i.e. Boolean network based on the theory of circuit） to describe Boolean network is drawn forth. After the shortcomings of the Boolean network proposed in the past are analyzed, a simulation circuit Boolean model is established using EDA technology in order to improve the Boolean network.
基金supported by the National Basic Research Program of China (Grant Nos.2001CB510207 and 2011CB910704)the National Natural Science Foundation of China (Grant Nos.30800419,30973289 and 30972970)+1 种基金Science and Technology Foundation of Hengyang (Grant No.2010kj10)grants for Outstanding Scholars of New Era from Ministry of Education of China (Grant No.NCET-07-0861)
文摘The development of cancer is a pathological process involving multiple environmental carcinogenic factors and genetic alterations.For decades,cancer researchers have focused on genomic and transcriptomic analyses.The completion of the Human Genome Project has opened the door to the post-genome era and oncoproteomics.Proteins play a critical role in tumorigenesis and influence the differences between normal cells and malignant cells.This report proposes the concept that cancer is a proteomic disease.This concept is based on examining protein expression profiles,post-translational modifications,and protein-protein interactions in carcinogenesis using recent advances in comparative,functional and structural proteomics.This approach provides a new way of viewing carcinogenesis,presents new clues in biomarker discovery for cancer diagnosis and therapy,and reveals important scientific findings and their significance to clinical applications.
基金supported by the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (Grant No. 30024001)the National Basic Research Program of China (Grant No. 2004CB518605)+1 种基金the Major National Science and Technology Program of China (Grant No. 2008ZX10002-020)the National High Technology Research and Development Program of China (Grant Nos. 2006AA020501 and 2001AA221081)
文摘The Human Genome Project was launched at the end of the 1980s.Since then,the cloning and identification of functional genes has been a major focus of research across the world.In China too,the potentially profound impact of such studies on the life sciences and on human health was realized,and relevant studies were initiated in the 1990s.To advance China's involvement in the Human Genome Project,in the mid-1990s,Committee of Experts in Biology from National High Technology Research and Development Program of China(863 Program) proposed the "two 1%" goal.This goal envisaged China contributing 1% of the total sequencing work,and cloning and identifying 1% of the total human functional genes.Over the past 20 years,tremendous achievement has been accomplished by Chinese scientists.It is well known that scientists in China finished the 1% of sequencing work of the Human Genome Project,whereas,there is no comprehensive report about "whether China had finished cloning and identifying 1% of human functional genes".In the present study,the GenBank database at the National Center of Biotechnology Information,the PubMed search tool,and the patent database of the State Intellectual Property Office,China,were used to retrieve entries based on two screening standards:(i) Were the newly cloned and identified genes first reported by Chinese scientists?(ii) Were the Chinese scientists awarded the gene sequence patent? Entries were retrieved from the databases up to the cut-off date of 30 June 2011 and the obtained data were analyzed further.The results showed that 589 new human functional genes were first reported by Chinese scientists and 159 gene sequences were patented(http:gene.fudan.sh.cn/introduction/database/chinagene/chinagene.html).This study systematically summarizes China's contributions to human functional genomics research and answers the question "has China finished cloning and identifying 1% of human functional genes?" in the affirmative.
