Objective: The inicidence of miscarriage is correlated with maternal age. The majority of miscarriages are chromosomally abnormal. The purpose of this study was to determine in a large population of infertility patien...Objective: The inicidence of miscarriage is correlated with maternal age. The majority of miscarriages are chromosomally abnormal. The purpose of this study was to determine in a large population of infertility patients (>2000 cycles) if preimplantation genetic diagnosis (PGD) reduced the rate of spontaneous abortions. Design: Multicenter retrospective controlled study. Setting: One hundred IVF centers referring samples to a reference PGD laboratory. Patient(s): Infertile women. Intervention(s): The spontaneous abortion rate after PGD was retrospectively compared to non- PGD cycles from the 2002 American Society for Reproductive Medicine- Society for Assisted Reproduction Technology report on IVF cycles. Main Outcome Measure(s): Spontaneous abortions and trisomic offspring rates. Result(s): The study included 2,279 cycles of PGD. The pregnancy rate per retrieval was 26.7% (average age 39.6). The mean pregnancy loss for the PGD group (0.167) was significantly lower than for the general IVF group (0.215) (P < .001). After PGD, the spontaneous abortion rate was 14.1% for ages 35- 40, and 22.2% for women over 40, compared to 19.4% (P=.03) and 40.6% (P < .001), respectively, in controls. The clinical error rate of PGD (1.2% ) was significantly lower than expected (4.7% ) (P < .001). Conclusion(s): The data suggests that PGD significantly reduces the risk of spontaneous abortions in women undergoing IVF and PGD, particularly in women over 40. In addition, PGD may also reduce the risk of trisomic offspring.展开更多
2021年6月,上海交通大学医学院附属仁济医院生殖医学中心、上海市辅助生殖与优生重点实验室孙刚教授团队在Clinical and Translational Medicine杂志在线发表了分娩启动最新研究成果,发现转录增强子结合蛋白(CEBPδ)在人的分娩启动中具...2021年6月,上海交通大学医学院附属仁济医院生殖医学中心、上海市辅助生殖与优生重点实验室孙刚教授团队在Clinical and Translational Medicine杂志在线发表了分娩启动最新研究成果,发现转录增强子结合蛋白(CEBPδ)在人的分娩启动中具有关键作用,为早产防治提供了新策略。该成果首次发现能够驱动胎膜激活相关重要事件的共同转录因子CEBPδ,抑制该转录因子通路的激活有望为阻断分娩启动提供新的药物靶标,从而为早产防治提供新的干预手段。展开更多
文摘Objective: The inicidence of miscarriage is correlated with maternal age. The majority of miscarriages are chromosomally abnormal. The purpose of this study was to determine in a large population of infertility patients (>2000 cycles) if preimplantation genetic diagnosis (PGD) reduced the rate of spontaneous abortions. Design: Multicenter retrospective controlled study. Setting: One hundred IVF centers referring samples to a reference PGD laboratory. Patient(s): Infertile women. Intervention(s): The spontaneous abortion rate after PGD was retrospectively compared to non- PGD cycles from the 2002 American Society for Reproductive Medicine- Society for Assisted Reproduction Technology report on IVF cycles. Main Outcome Measure(s): Spontaneous abortions and trisomic offspring rates. Result(s): The study included 2,279 cycles of PGD. The pregnancy rate per retrieval was 26.7% (average age 39.6). The mean pregnancy loss for the PGD group (0.167) was significantly lower than for the general IVF group (0.215) (P < .001). After PGD, the spontaneous abortion rate was 14.1% for ages 35- 40, and 22.2% for women over 40, compared to 19.4% (P=.03) and 40.6% (P < .001), respectively, in controls. The clinical error rate of PGD (1.2% ) was significantly lower than expected (4.7% ) (P < .001). Conclusion(s): The data suggests that PGD significantly reduces the risk of spontaneous abortions in women undergoing IVF and PGD, particularly in women over 40. In addition, PGD may also reduce the risk of trisomic offspring.
文摘2021年6月,上海交通大学医学院附属仁济医院生殖医学中心、上海市辅助生殖与优生重点实验室孙刚教授团队在Clinical and Translational Medicine杂志在线发表了分娩启动最新研究成果,发现转录增强子结合蛋白(CEBPδ)在人的分娩启动中具有关键作用,为早产防治提供了新策略。该成果首次发现能够驱动胎膜激活相关重要事件的共同转录因子CEBPδ,抑制该转录因子通路的激活有望为阻断分娩启动提供新的药物靶标,从而为早产防治提供新的干预手段。
