A complete geometric nonlinear formulation for rigid-flexible coupling dynamics of a flexible beam undergoing large overall motion was proposed based on virtual work principle, in which all the high-order terms relate...A complete geometric nonlinear formulation for rigid-flexible coupling dynamics of a flexible beam undergoing large overall motion was proposed based on virtual work principle, in which all the high-order terms related to coupling deformation were included in dynamic equations. Simulation examples of the flexible beam with prescribed rotation and free rotation were investigated. Numerical results show that the use of the first-order approximation coupling (FOAC) model may lead to a significant error when the flexible beam experiences large deformation or large deformation velocity. However, the correct solutions can always be obtained by using the present complete model. The difference in essence between this model and the FOAC model is revealed. These coupling high-order terms, which are ignored in FOAC model, have a remarkable effect on the dynamic behavior of the flexible body. Therefore, these terms should be included for the rigid-flexible dynamic modeling and analysis of flexible body undergoing motions with high speed.展开更多
AIM: Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk. Our objective was to investigate the possible association between p53Arg72Pro polymorphism and susceptibility to hepatoc...AIM: Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk. Our objective was to investigate the possible association between p53Arg72Pro polymorphism and susceptibility to hepatocellular carcinoma (HCC) among Chinese population.METHODS: The p53 Arg72Pro genotypes were determined by PCR-based restriction fragment length polymorphism (RFLP) analysis in 507 HCC cases and 541 controls. Odds ratios (ORs) for HCC and 95% confidence intervals (CIs)from unconditional logistic regression models were used to evaluate relative risks. Potential risk factors were included in the logistic regression models as covariates in the multivariate analyses on genotype and HCC.RESULTS: The frequencies for Pro and Arg alleles were 44.5%, 55.5% in HCC cases, and 40.3% and 59.7% in controls, respectively. The Pro allele was significantly associated with the presence of HCC (P = 0.05) and had a higher risk for HCC (OR = 1.19, 95% CI 1.00-1.41) as compared with the Arg allele. After adjusted for potential risk factors, Arg/Pro heterozygotes had an 1.21-fold increased risk (95% CI 0.82-1.78, P = 0.34) of HCC compared with Arg homozygotes, whereas the risk for Pro homozygotes was 1.79 (95% CI 1.06-3.01, P = 0.03) times higher than that for Arg homozygotes. Pro-allele carriers had a higher relative risk of HCC than the Arg-only carriers (adjusted OR = 1.33, 95% CI 0.92-1.92, P = 0.13), although the difference was not statistically significant.CONCLUSION: Homozygosity for Pro of p53 Arg72Pro is potentially one of the genetic risk factors for HCC in Chinese population. The p53 Arg72Pro polymorphism may be used as a stratification marker in screening individuals at a high risk of HCC.展开更多
The substantive characteristics of the connotation of ＂State＂ include two parts： （I） the relatively perpetual and impersonalized political system; （II） the ductility of organization forms within the space and p...The substantive characteristics of the connotation of ＂State＂ include two parts： （I） the relatively perpetual and impersonalized political system; （II） the ductility of organization forms within the space and politics. And the later part is the absolute attribute of this connotation while the former part tends to show with different forms. Therefore, it is more suitable for the former one to be the objective for study on the evolution process of the connotation of ＂State＂ at different stages. Based on this understanding, the author discusses the specific political system at different stages and the relatively perpetual and impersonalized methods for the realization of the system, then tries to define the connotation of the early state, ancient state and modem state in Chinese history.展开更多
Extended cognition is the thesis that vehicles realizing cognitive systems can possibly extend beyond traditional boundaries of brain, skin, or skull. It is a popular thesis because of its counterintuitive consequence...Extended cognition is the thesis that vehicles realizing cognitive systems can possibly extend beyond traditional boundaries of brain, skin, or skull. It is a popular thesis because of its counterintuitive consequence that coupled systems of vehicles of very different entities could form a realizer of one cognitive systems. Popular examples consist of human-handy-systems or human-notebook-systems, and it is a thesis that could non-dogmatically decide what individuates the realizers of cognitive systems. But the thesis is in need for individuation-criteria： How could we individuate a coupled system of different systems of vehicles？ We inspect some of the usually handled candidates for individuation-criteria and argue that in principal there will be no successful candidate due to methodological problems. We aim to show this by using a cookbook theory of extended cognition and add different types of candidates. No candidate is non-arbitrary or non-intrinsic, which leads the proponent to the forced selection between arbitrary or intrinsic candidates. We argue that without criteria, the talk about extended cognition is a bottomless pit that should only serve as an example for bottomless theory-building.展开更多
With the continuous development of human civilization, modem design has also made great progress. The design thinking tends more to adapting to human self-demand, in order to achieve the purpose of serving for people...With the continuous development of human civilization, modem design has also made great progress. The design thinking tends more to adapting to human self-demand, in order to achieve the purpose of serving for people＇ s daily life. Therefore, the humanized design concept of modem society is proposed, and in many fields, the humanized design thinking has become mature. This paper mainly takes systematic and overall analysis of the application of humanized design thinking in ceramic modeling, in order to provide relevant reference for the majority of peers.展开更多
基金Project(10772113) supported by the National Natural Science Foundation of China
文摘A complete geometric nonlinear formulation for rigid-flexible coupling dynamics of a flexible beam undergoing large overall motion was proposed based on virtual work principle, in which all the high-order terms related to coupling deformation were included in dynamic equations. Simulation examples of the flexible beam with prescribed rotation and free rotation were investigated. Numerical results show that the use of the first-order approximation coupling (FOAC) model may lead to a significant error when the flexible beam experiences large deformation or large deformation velocity. However, the correct solutions can always be obtained by using the present complete model. The difference in essence between this model and the FOAC model is revealed. These coupling high-order terms, which are ignored in FOAC model, have a remarkable effect on the dynamic behavior of the flexible body. Therefore, these terms should be included for the rigid-flexible dynamic modeling and analysis of flexible body undergoing motions with high speed.
基金Supported by the National Natural Science Foundation of China,No. 30370645, by the Hundred Leading Scientists Program of the Public Health Sector of Shanghai, No, 98BR007
文摘AIM: Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk. Our objective was to investigate the possible association between p53Arg72Pro polymorphism and susceptibility to hepatocellular carcinoma (HCC) among Chinese population.METHODS: The p53 Arg72Pro genotypes were determined by PCR-based restriction fragment length polymorphism (RFLP) analysis in 507 HCC cases and 541 controls. Odds ratios (ORs) for HCC and 95% confidence intervals (CIs)from unconditional logistic regression models were used to evaluate relative risks. Potential risk factors were included in the logistic regression models as covariates in the multivariate analyses on genotype and HCC.RESULTS: The frequencies for Pro and Arg alleles were 44.5%, 55.5% in HCC cases, and 40.3% and 59.7% in controls, respectively. The Pro allele was significantly associated with the presence of HCC (P = 0.05) and had a higher risk for HCC (OR = 1.19, 95% CI 1.00-1.41) as compared with the Arg allele. After adjusted for potential risk factors, Arg/Pro heterozygotes had an 1.21-fold increased risk (95% CI 0.82-1.78, P = 0.34) of HCC compared with Arg homozygotes, whereas the risk for Pro homozygotes was 1.79 (95% CI 1.06-3.01, P = 0.03) times higher than that for Arg homozygotes. Pro-allele carriers had a higher relative risk of HCC than the Arg-only carriers (adjusted OR = 1.33, 95% CI 0.92-1.92, P = 0.13), although the difference was not statistically significant.CONCLUSION: Homozygosity for Pro of p53 Arg72Pro is potentially one of the genetic risk factors for HCC in Chinese population. The p53 Arg72Pro polymorphism may be used as a stratification marker in screening individuals at a high risk of HCC.
文摘The substantive characteristics of the connotation of ＂State＂ include two parts： （I） the relatively perpetual and impersonalized political system; （II） the ductility of organization forms within the space and politics. And the later part is the absolute attribute of this connotation while the former part tends to show with different forms. Therefore, it is more suitable for the former one to be the objective for study on the evolution process of the connotation of ＂State＂ at different stages. Based on this understanding, the author discusses the specific political system at different stages and the relatively perpetual and impersonalized methods for the realization of the system, then tries to define the connotation of the early state, ancient state and modem state in Chinese history.
文摘Extended cognition is the thesis that vehicles realizing cognitive systems can possibly extend beyond traditional boundaries of brain, skin, or skull. It is a popular thesis because of its counterintuitive consequence that coupled systems of vehicles of very different entities could form a realizer of one cognitive systems. Popular examples consist of human-handy-systems or human-notebook-systems, and it is a thesis that could non-dogmatically decide what individuates the realizers of cognitive systems. But the thesis is in need for individuation-criteria： How could we individuate a coupled system of different systems of vehicles？ We inspect some of the usually handled candidates for individuation-criteria and argue that in principal there will be no successful candidate due to methodological problems. We aim to show this by using a cookbook theory of extended cognition and add different types of candidates. No candidate is non-arbitrary or non-intrinsic, which leads the proponent to the forced selection between arbitrary or intrinsic candidates. We argue that without criteria, the talk about extended cognition is a bottomless pit that should only serve as an example for bottomless theory-building.
文摘With the continuous development of human civilization, modem design has also made great progress. The design thinking tends more to adapting to human self-demand, in order to achieve the purpose of serving for people＇ s daily life. Therefore, the humanized design concept of modem society is proposed, and in many fields, the humanized design thinking has become mature. This paper mainly takes systematic and overall analysis of the application of humanized design thinking in ceramic modeling, in order to provide relevant reference for the majority of peers.
