AIM: To study the association between self-reported peptic ulcer and childhood adversities.METHODS: The Health and Social Support Study (HeS-Sup) population consisted of a stratif ied random sample drawn from the Finn...AIM: To study the association between self-reported peptic ulcer and childhood adversities.METHODS: The Health and Social Support Study (HeS-Sup) population consisted of a stratif ied random sample drawn from the Finnish Population Register in four age groups: 20-24, 30-34, 40-44 and 50-54. The survey was carried out by postal questionnaire during 1998, with a response rate of 40.0%. A follow-up questionnaire was sent during 2003 to all those who responded to the f irst. Altogether 19 626 individuals returned the follow-up questionnaire; a response rate of 75.8%. The subjects were asked whether a doctor had told them that they have or have had peptic ulcer. The analyses covered those who responded aff irmatively to both the baseline and the follow-up enquiries (n = 718). Those not re-porting a peptic ulcer in either of the two questionnaires (n = 17 677) were taken as controls. The subjects were further requested (through six questions) to think about their childhood adversities.RESULTS: The most common adversities mentioned were long-lasting financial difficulties in the family, serious conflicts in the family, and a family member seriously or chronically ill. All the adversities reported, except parental divorce, were more common among peptic ulcer patients than among controls (P values varied between < 0.001 and 0.003). Age- and sex-adjusted odds ratios (OR) of childhood adversities in the multivariate logistic analysis for self-reported pep-tic ulcer varied between 1.45 and 2.01. Adjusting for smoking, heavy drinking, stress and nonsteroidal anti-inflammatory drug use had no further influence (ORs between 1.22 and 1.73).CONCLUSION: Our findings suggest that childhood adversities maintain a connection with and have a predictive role in the development of peptic ulcer.展开更多
Holocaust memorial sites rarely tell the story of individual fates but rather give attention to the main or larger population groups that were the focus of persecution and extermination during the Nazi Germany twelve ...Holocaust memorial sites rarely tell the story of individual fates but rather give attention to the main or larger population groups that were the focus of persecution and extermination during the Nazi Germany twelve years of terror in Europe 1933-45. This essay takes a closer look at one of the most remarkable exemptions of the prevailing memory culture at Holocaust memorials： the sites and events highlighting Anne Frank and her short life in troubled times. Over the past years millions of travelers from all over the world have shown a genuine interest in learning about the life world of their young heroine thus creating what has been termed Anne Frank Tourism. In 2014, 1.2 million people visited the Anne Frank House in Amsterdam： the museum and educational center, the place in hiding where she wrote her now famous and widely read diary. Several other sites connected to the life path of Anne Frank, from her birth place in Frankfurt to the Bergen-Belsen Concentration Camp where her life prematurely ended, have also become part of the mostly young tourists＇ search for Anne Frank＇s life and legacy. With the rising popularity of Anne Frank related sites the management of some of the locales has become more problematic which is discussed in the context of a several museums, centers and historic sites. On a more general note, it is argued here that in recent years the more group oriented commemoration practices at Holocaust sites have given way to a trend of putting individual faces to the victims of the Holocaust. It was, in particular, novels, films and TV productions about the Holocaust that emphasized individual life paths and events and enticed visitation to more personalized sites. Steven Spielberg＇s popular movie Schindler＇s List, for example, contributed to ＂Schindler tourism＂, a form of special interest tourism in Krakow. More and more Holocaust memorial sites have also started to honor outstanding individuals or small groups in resistance and opposition to Nazi Germany. Examples of this are the fighters of the 1943 uprising at the Sobibor death camp and the courageous student members of the ＂White Rose＂ in Munich who stood up to the powers of the time and were executed. In the concluding part the question will be raised of what is the proper approach in the representation of the fate of the victims of Nazi Germany： A personalized approach or a greater focus on an explanation of the ideology and policies behind the rule of terror which may contribute to the visitors＇ better understanding of a complex history？展开更多
GPR54 is highly expressed in the central nervous system and plays a crucial role in pubertal development. However, GRP54 is also expressed in the immune system, implying possible immunoregulatory functions. Here we in...GPR54 is highly expressed in the central nervous system and plays a crucial role in pubertal development. However, GRP54 is also expressed in the immune system, implying possible immunoregulatory functions. Here we investigated the role of GPR54 in T cell and immune tolerance. GPR54 deficiency led to an enlarged thymus, an increased number of thymocytes, and altered thymic micro-architecture starting around puberty, indicating GPR54 function in T-cell development through its regulatory effect on the gonadal system. However, flow cytometry revealed a significant reduction in the peripheral regulatory T cell population and a moderate decrease in CD4 single-positive thymocytes in prepubertal Gpr54^(-/-) mice. These phenotypes were confirmed in chimeric mice with GPR54 deficient bone marrow-derived cells. In addition, we found elevated T cell activation in peripheral and thymic T cells in Gpr54^(-/-) mice. When intact mice were immunized with myelin oligodendrocyte glycoprotein, a more severe experimental autoimmune encephalomyelitis(EAE) developed in the Gpr54^(-/-) mice. Interestingly, aggravated EAE disease was also manifested in castrated and bone marrow chimeric Gpr54^(-/-) mice compared to the respective wild-type control,suggesting a defect in self-tolerance resulting from GPR54 deletion through a mechanism that bypassed sex hormones. These findings demonstrate a novel role for GPR54 in regulating self-tolerant immunity in a sex hormone independent manner.展开更多
文摘AIM: To study the association between self-reported peptic ulcer and childhood adversities.METHODS: The Health and Social Support Study (HeS-Sup) population consisted of a stratif ied random sample drawn from the Finnish Population Register in four age groups: 20-24, 30-34, 40-44 and 50-54. The survey was carried out by postal questionnaire during 1998, with a response rate of 40.0%. A follow-up questionnaire was sent during 2003 to all those who responded to the f irst. Altogether 19 626 individuals returned the follow-up questionnaire; a response rate of 75.8%. The subjects were asked whether a doctor had told them that they have or have had peptic ulcer. The analyses covered those who responded aff irmatively to both the baseline and the follow-up enquiries (n = 718). Those not re-porting a peptic ulcer in either of the two questionnaires (n = 17 677) were taken as controls. The subjects were further requested (through six questions) to think about their childhood adversities.RESULTS: The most common adversities mentioned were long-lasting financial difficulties in the family, serious conflicts in the family, and a family member seriously or chronically ill. All the adversities reported, except parental divorce, were more common among peptic ulcer patients than among controls (P values varied between < 0.001 and 0.003). Age- and sex-adjusted odds ratios (OR) of childhood adversities in the multivariate logistic analysis for self-reported pep-tic ulcer varied between 1.45 and 2.01. Adjusting for smoking, heavy drinking, stress and nonsteroidal anti-inflammatory drug use had no further influence (ORs between 1.22 and 1.73).CONCLUSION: Our findings suggest that childhood adversities maintain a connection with and have a predictive role in the development of peptic ulcer.
文摘Holocaust memorial sites rarely tell the story of individual fates but rather give attention to the main or larger population groups that were the focus of persecution and extermination during the Nazi Germany twelve years of terror in Europe 1933-45. This essay takes a closer look at one of the most remarkable exemptions of the prevailing memory culture at Holocaust memorials： the sites and events highlighting Anne Frank and her short life in troubled times. Over the past years millions of travelers from all over the world have shown a genuine interest in learning about the life world of their young heroine thus creating what has been termed Anne Frank Tourism. In 2014, 1.2 million people visited the Anne Frank House in Amsterdam： the museum and educational center, the place in hiding where she wrote her now famous and widely read diary. Several other sites connected to the life path of Anne Frank, from her birth place in Frankfurt to the Bergen-Belsen Concentration Camp where her life prematurely ended, have also become part of the mostly young tourists＇ search for Anne Frank＇s life and legacy. With the rising popularity of Anne Frank related sites the management of some of the locales has become more problematic which is discussed in the context of a several museums, centers and historic sites. On a more general note, it is argued here that in recent years the more group oriented commemoration practices at Holocaust sites have given way to a trend of putting individual faces to the victims of the Holocaust. It was, in particular, novels, films and TV productions about the Holocaust that emphasized individual life paths and events and enticed visitation to more personalized sites. Steven Spielberg＇s popular movie Schindler＇s List, for example, contributed to ＂Schindler tourism＂, a form of special interest tourism in Krakow. More and more Holocaust memorial sites have also started to honor outstanding individuals or small groups in resistance and opposition to Nazi Germany. Examples of this are the fighters of the 1943 uprising at the Sobibor death camp and the courageous student members of the ＂White Rose＂ in Munich who stood up to the powers of the time and were executed. In the concluding part the question will be raised of what is the proper approach in the representation of the fate of the victims of Nazi Germany： A personalized approach or a greater focus on an explanation of the ideology and policies behind the rule of terror which may contribute to the visitors＇ better understanding of a complex history？
基金supported by the National Natural Science Foundation of China(31271468)the Science and Technology Commission of Shanghai Municipality(12ZR1408700)
文摘GPR54 is highly expressed in the central nervous system and plays a crucial role in pubertal development. However, GRP54 is also expressed in the immune system, implying possible immunoregulatory functions. Here we investigated the role of GPR54 in T cell and immune tolerance. GPR54 deficiency led to an enlarged thymus, an increased number of thymocytes, and altered thymic micro-architecture starting around puberty, indicating GPR54 function in T-cell development through its regulatory effect on the gonadal system. However, flow cytometry revealed a significant reduction in the peripheral regulatory T cell population and a moderate decrease in CD4 single-positive thymocytes in prepubertal Gpr54^(-/-) mice. These phenotypes were confirmed in chimeric mice with GPR54 deficient bone marrow-derived cells. In addition, we found elevated T cell activation in peripheral and thymic T cells in Gpr54^(-/-) mice. When intact mice were immunized with myelin oligodendrocyte glycoprotein, a more severe experimental autoimmune encephalomyelitis(EAE) developed in the Gpr54^(-/-) mice. Interestingly, aggravated EAE disease was also manifested in castrated and bone marrow chimeric Gpr54^(-/-) mice compared to the respective wild-type control,suggesting a defect in self-tolerance resulting from GPR54 deletion through a mechanism that bypassed sex hormones. These findings demonstrate a novel role for GPR54 in regulating self-tolerant immunity in a sex hormone independent manner.
