In the moral philosophy of the late Stoa, there is a significant turn to the recognition of non-violence values. Starting from the point where the philosophers of the Ancient and the Middle Stoa acknowledge man＇s rel...In the moral philosophy of the late Stoa, there is a significant turn to the recognition of non-violence values. Starting from the point where the philosophers of the Ancient and the Middle Stoa acknowledge man＇s relation with the Cosmos and with each human being separately, the Stoics of Rome （namely, Seneca, Marcus Aurelius, Epictetus, but even Cicero who fosters many of the earlier Stoic ethical views） enrich the content of this theorization by offering an expansion of the concept of the Greek philanthropy. Through the practical means of individual correction, which leads to the therapy of passions, the stoic sage returns to society in order to emancipate the human being and to ensure that man will recover his ontological dignity. This effort is grounded on benevolent and mild action, which aims to correct rather than to discipline in a punitive way. It is their contribution to philosophy that the author aims to discuss in connection with the recording of their thought on issues directly related with a non-violent and eudaimonistic way of life in the context of social peace.展开更多
The author found the text and poem writing had not always been correspondent to his personal experience through observation and reading. The poets really meant that their own poems could not express his suffering when...The author found the text and poem writing had not always been correspondent to his personal experience through observation and reading. The poets really meant that their own poems could not express his suffering when he said he had been afraid that he could not match his suffering. People often think the rich experieuce is the key to the depth of writing, but the truth is not like that. The author concluded that the content of poem shall keep certain gap with the ethic meaning through research on the experience and writing of the great poets and give an ontological questioning and then he can embody common humanity and emotion without blank teaching. A poet shall be in face of the difficulty of writing and learn to handle with the challenge of difficulty, and then the difficulty can be transferred into skill of writing,展开更多
Ontological negation advance the third kind of relationship between human and nature, ＂Equity Between Human and Nature＂, which different from either ＂Western antagonism＂ or ＂Chinese traditional integration＂. Hum...Ontological negation advance the third kind of relationship between human and nature, ＂Equity Between Human and Nature＂, which different from either ＂Western antagonism＂ or ＂Chinese traditional integration＂. Human and Nature divided but equivalent, based on the limitation of Antagonism and Oneness Between Human and Nature, as well as the Fact and empirical discovery of equity between human and hature＂. This third point of view is expected to bring a creative and productive separation and ＂a new harmony＂ which keeps those two different types of the worlds mutual, respectful and equal.展开更多
The intellectual heritage of modernity needs rethinking. It is marked by radical humanism and implied by the ideas of Descartes and Kant above all, which introduces an unbridgeable gap between animals and human perso...The intellectual heritage of modernity needs rethinking. It is marked by radical humanism and implied by the ideas of Descartes and Kant above all, which introduces an unbridgeable gap between animals and human persons （nonhuman and human animals）. Intuitive sensibility to the question of the welfare of nonhuman animals meets a theoretical ally in the rapidly growing knowledge on their subjectivity and makes us pose a questions about their ontological status. This context arouses a possibility of a turn to personalist ethics, yet not to its anthropocentric version implied by Kant, but to personalism conceived of as an instance of value ethics as exemplified by Antonio Rosmini and Karol Wojtyta （John Paul II）.展开更多
The proposed paper focuses on art as a form of cultural expression and it presents data based on ethnographic information of famous Pakistani musical theatres in Lahore, Province of Punjab. Most description of the per...The proposed paper focuses on art as a form of cultural expression and it presents data based on ethnographic information of famous Pakistani musical theatres in Lahore, Province of Punjab. Most description of the performing arts is written by men with an exclusive male perspective. Little or no attempt has been made to explore women lives in performing theatre apart from their assigned role as physical crowd-pullers. This study presents how symbols are used to communicate, as each member of theatre community uses entire repertoire to convey messages, manual gesticulations, body gestures, facial expressions, dance patterns, a particular dress etc. at the cultural level. The central idea of this study is how artists use the body in performance to imagine and enact culture, values, humor, selfhood, and the complex relations among them. It discusses their real backstage life experiences and problems faced as well how and what type of contact they maintain with their audience and admirers. What are their moral values and what kind of social dilemmas they face, how the sexuality of theatre women is being controlled, their fears emotions, distress of theatre women etc. are the major research questions. In short, this anthropological inquiry takes into account all relevant social, cultural, political, economic, and religious dimensions of performing art.展开更多
In recent years,the assessment of proprioceptive function has received increased attention in clinical and motor skill research.This is not surprising given the growing body of scientific evidence on the importance of...In recent years,the assessment of proprioceptive function has received increased attention in clinical and motor skill research.This is not surprising given the growing body of scientific evidence on the importance of proprioceptive information for controlling nearly all facets of human movement;from standing to performing highly skilled movement patterns展开更多
In this paper, I examine Apple Founder Steve Job＇s final words ＂Oh wow. Oh wow. Oh wow＂ as uttered to his half-Sister Mona Simpson as a framework to explore how pre-experiential linguistic, social, and ontological ...In this paper, I examine Apple Founder Steve Job＇s final words ＂Oh wow. Oh wow. Oh wow＂ as uttered to his half-Sister Mona Simpson as a framework to explore how pre-experiential linguistic, social, and ontological patterns shape and construct consciousness and expressions at the final moment of death. Final words of passage provide society with insight into the experience of being human in the transition from life to death, both in their limitations and in their potential for providing a continuous fluidity of transformation. Understanding how these final words are transconceptual experiences will encourage us to reflect on alternative interpretative possibilities sensitive to ontological and logical contexts of death and dying providing a holistic alternative framework which is more congruent with individual spiritual needs.展开更多
Every day we experience relationships with artefacts, which describe material objects made by humans in order to reach a goal and exploit the human feature to plan ahead. Artefacts bring together cognitive evolution a...Every day we experience relationships with artefacts, which describe material objects made by humans in order to reach a goal and exploit the human feature to plan ahead. Artefacts bring together cognitive evolution and technical enhancement. Although artefacts are conceived as technical, we are now facing a relationship with Information Technology （IT） artefacts. IT artefacts include both hardware and software, as a two-sided entity. The definition of IT artefact corresponds with the Saussurean linguistic sign： a two-sided entity constituted by the signifier （hardware） and the signified （software）. I claim that IT artefacts share this ontological trait with the linguistic sign. I will show that IT artefacts are the result of design and planning, while language--which is an institution--is not the fabrication of one human but linked to collective human activity.展开更多
This short paper aims to critically analyze a contemporary Taiwan Residents film, The Fourth Portrait, directed by Meng-Hung Chung, from the perspective of Delenzian theories. In Deleuze＇s two books on cinema, the di...This short paper aims to critically analyze a contemporary Taiwan Residents film, The Fourth Portrait, directed by Meng-Hung Chung, from the perspective of Delenzian theories. In Deleuze＇s two books on cinema, the discussion of images demonstrates the entangled juxtaposition of the three levels： brain-thought, cinema-screen, and world-images that compose the cinematic consciousness. Through the interacted movement-images and time-images, the film unfolds the storyline within the aesthetic pleasure of poetic sentiment that gradually leads the audience to learn that a wandering boy, Hsiao-Hsiang, after the death of his father, has had several adventurous encounters that gradually expose the secrecy of his traumatic family： His birth mother has no decent job and his step-father has killed his own brother. This broken family has been haunted by the shared guilt and the undead memory as Derrida famously claims that hauntology precedes ontology. As the past coexists with the present, Deleuze analyzes the concept of I, with a central fracture in its pure form of the past demonstrating an ontological enigma that remains forever a secret. When the director uses the four portraits to indicate the four important events of this wandering boy, he deliberately leaves empty the fourth portrait, the self-portrait of the boy; it remains as an incomplete piece which symbolizes an enigma of his own life. It shows certain constitutive unnamable forces acting within the boy that seduces him forever to painfully misrecognize himself.展开更多
We previously demonstrated that matrine could inhibit the proliferating, migrating, as well as invading processes of both PC-3 and DU145 cells. However, the underlying molecular mechanisms have not yet been clearly de...We previously demonstrated that matrine could inhibit the proliferating, migrating, as well as invading processes of both PC-3 and DU145 cells. However, the underlying molecular mechanisms have not yet been clearly defined. In this study, using various techniques such as high throughput sequencing technology, bioinformatics, quantitative real-time PCR, and immunoblot analysis,we aimed to understand whether matrine serves as a novel regulator of FOXO and PI3K-AKT signaling pathway. DU145 and PC-3 cell lines were cultured for 24 h in vitro. Cells were treated with either matrine or control serum for 48 h, followed by extraction of total RNA. The RNA was sequenced using HiSeq 2500 high-throughput sequencing platform (Illumina). A gene library was established and quality analysis of read data carried out. Integrated database from the website DAVID was used to analyze Gene Ontology (GO), and Kyoto encyclopedia of genes and genomes (KEGG) pathway of differential genes was used for pathway analysis, screening for fold differences of more than two times. The FOXO and PI3K-AKT signaling pathways were screened, and expression levels of mRNA and core protein detected by real-time PCR and immunoblotting, respectively. High throughput sequencing and GO analysis revealed that differentially expressed genes before and after treatment played an important role in cell metabolic process, growth process, anatomical structure formation, cellular component organization, and biological regulation. KEGG signal pathway analysis revealed that FOXO and PI3K-AKT signal pathways had a significant difference between before and after matrine-treated androgen-independent prostate cancer cells PC-3 and DU145. Real-time PCR showed that matrine treatment led to a significant increase in the expression levels of FOXO1A, FOXO3A, FOXO4, and FOXO6 in DU145 and PC-3 cells (P<0.01 or P<0.05), whereas the PI3K expression levels decreased (P<0.01). Similarly, immunoblotting revealed a significant increase (P<0.05) in the expression levels of FOXO1A FOXO3A, FOXO4, and FOXO6 in both PC-3 and DU145 cells, whereas PI3K expression levels decreased (P<0.05). Matrine had a broad regulating effect on the mRNA expression profiles of both PC-3 and DU145 cells. Matrine may inhibit cell proliferation, migration, as well as invasion, and induce apoptosis in both PC-3 and DU145 cells through FOXO and PI3K-AKT signaling pathways. Matrine could therefore be used as a complementary drug to present chemotherapeutic agents, for treating androgen-independent prostate cancer.展开更多
Identification of disease-causing genes among a large number of candidates is a fundamental challenge in human disease studies.However,it is still time-consuming and laborious to determine the real disease-causing gen...Identification of disease-causing genes among a large number of candidates is a fundamental challenge in human disease studies.However,it is still time-consuming and laborious to determine the real disease-causing genes by biological experiments.With the advances of the high-throughput techniques,a large number of protein-protein interactions have been produced.Therefore,to address this issue,several methods based on protein interaction network have been proposed.In this paper,we propose a shortest path-based algorithm,named SPranker,to prioritize disease-causing genes in protein interaction networks.Considering the fact that diseases with similar phenotypes are generally caused by functionally related genes,we further propose an improved algorithm SPGOranker by integrating the semantic similarity of gene ontology(GO)annotations.SPGOranker not only considers the topological similarity between protein pairs in a protein interaction network but also takes their functional similarity into account.The proposed algorithms SPranker and SPGOranker were applied to 1598 known orphan disease-causing genes from 172 orphan diseases and compared with three state-of-the-art approaches,ICN,VS and RWR.The experimental results show that SPranker and SPGOranker outperform ICN,VS,and RWR for the prioritization of orphan disease-causing genes.Importantly,for the case study of severe combined immunodeficiency,SPranker and SPGOranker predict several novel causal genes.展开更多
文摘In the moral philosophy of the late Stoa, there is a significant turn to the recognition of non-violence values. Starting from the point where the philosophers of the Ancient and the Middle Stoa acknowledge man＇s relation with the Cosmos and with each human being separately, the Stoics of Rome （namely, Seneca, Marcus Aurelius, Epictetus, but even Cicero who fosters many of the earlier Stoic ethical views） enrich the content of this theorization by offering an expansion of the concept of the Greek philanthropy. Through the practical means of individual correction, which leads to the therapy of passions, the stoic sage returns to society in order to emancipate the human being and to ensure that man will recover his ontological dignity. This effort is grounded on benevolent and mild action, which aims to correct rather than to discipline in a punitive way. It is their contribution to philosophy that the author aims to discuss in connection with the recording of their thought on issues directly related with a non-violent and eudaimonistic way of life in the context of social peace.
文摘The author found the text and poem writing had not always been correspondent to his personal experience through observation and reading. The poets really meant that their own poems could not express his suffering when he said he had been afraid that he could not match his suffering. People often think the rich experieuce is the key to the depth of writing, but the truth is not like that. The author concluded that the content of poem shall keep certain gap with the ethic meaning through research on the experience and writing of the great poets and give an ontological questioning and then he can embody common humanity and emotion without blank teaching. A poet shall be in face of the difficulty of writing and learn to handle with the challenge of difficulty, and then the difficulty can be transferred into skill of writing,
文摘Ontological negation advance the third kind of relationship between human and nature, ＂Equity Between Human and Nature＂, which different from either ＂Western antagonism＂ or ＂Chinese traditional integration＂. Human and Nature divided but equivalent, based on the limitation of Antagonism and Oneness Between Human and Nature, as well as the Fact and empirical discovery of equity between human and hature＂. This third point of view is expected to bring a creative and productive separation and ＂a new harmony＂ which keeps those two different types of the worlds mutual, respectful and equal.
文摘The intellectual heritage of modernity needs rethinking. It is marked by radical humanism and implied by the ideas of Descartes and Kant above all, which introduces an unbridgeable gap between animals and human persons （nonhuman and human animals）. Intuitive sensibility to the question of the welfare of nonhuman animals meets a theoretical ally in the rapidly growing knowledge on their subjectivity and makes us pose a questions about their ontological status. This context arouses a possibility of a turn to personalist ethics, yet not to its anthropocentric version implied by Kant, but to personalism conceived of as an instance of value ethics as exemplified by Antonio Rosmini and Karol Wojtyta （John Paul II）.
文摘The proposed paper focuses on art as a form of cultural expression and it presents data based on ethnographic information of famous Pakistani musical theatres in Lahore, Province of Punjab. Most description of the performing arts is written by men with an exclusive male perspective. Little or no attempt has been made to explore women lives in performing theatre apart from their assigned role as physical crowd-pullers. This study presents how symbols are used to communicate, as each member of theatre community uses entire repertoire to convey messages, manual gesticulations, body gestures, facial expressions, dance patterns, a particular dress etc. at the cultural level. The central idea of this study is how artists use the body in performance to imagine and enact culture, values, humor, selfhood, and the complex relations among them. It discusses their real backstage life experiences and problems faced as well how and what type of contact they maintain with their audience and admirers. What are their moral values and what kind of social dilemmas they face, how the sexuality of theatre women is being controlled, their fears emotions, distress of theatre women etc. are the major research questions. In short, this anthropological inquiry takes into account all relevant social, cultural, political, economic, and religious dimensions of performing art.
基金supported by the Deutsche Forschungsgemeinschaft (No.KR 4595/1-1)
文摘In recent years,the assessment of proprioceptive function has received increased attention in clinical and motor skill research.This is not surprising given the growing body of scientific evidence on the importance of proprioceptive information for controlling nearly all facets of human movement;from standing to performing highly skilled movement patterns
文摘In this paper, I examine Apple Founder Steve Job＇s final words ＂Oh wow. Oh wow. Oh wow＂ as uttered to his half-Sister Mona Simpson as a framework to explore how pre-experiential linguistic, social, and ontological patterns shape and construct consciousness and expressions at the final moment of death. Final words of passage provide society with insight into the experience of being human in the transition from life to death, both in their limitations and in their potential for providing a continuous fluidity of transformation. Understanding how these final words are transconceptual experiences will encourage us to reflect on alternative interpretative possibilities sensitive to ontological and logical contexts of death and dying providing a holistic alternative framework which is more congruent with individual spiritual needs.
文摘Every day we experience relationships with artefacts, which describe material objects made by humans in order to reach a goal and exploit the human feature to plan ahead. Artefacts bring together cognitive evolution and technical enhancement. Although artefacts are conceived as technical, we are now facing a relationship with Information Technology （IT） artefacts. IT artefacts include both hardware and software, as a two-sided entity. The definition of IT artefact corresponds with the Saussurean linguistic sign： a two-sided entity constituted by the signifier （hardware） and the signified （software）. I claim that IT artefacts share this ontological trait with the linguistic sign. I will show that IT artefacts are the result of design and planning, while language--which is an institution--is not the fabrication of one human but linked to collective human activity.
文摘This short paper aims to critically analyze a contemporary Taiwan Residents film, The Fourth Portrait, directed by Meng-Hung Chung, from the perspective of Delenzian theories. In Deleuze＇s two books on cinema, the discussion of images demonstrates the entangled juxtaposition of the three levels： brain-thought, cinema-screen, and world-images that compose the cinematic consciousness. Through the interacted movement-images and time-images, the film unfolds the storyline within the aesthetic pleasure of poetic sentiment that gradually leads the audience to learn that a wandering boy, Hsiao-Hsiang, after the death of his father, has had several adventurous encounters that gradually expose the secrecy of his traumatic family： His birth mother has no decent job and his step-father has killed his own brother. This broken family has been haunted by the shared guilt and the undead memory as Derrida famously claims that hauntology precedes ontology. As the past coexists with the present, Deleuze analyzes the concept of I, with a central fracture in its pure form of the past demonstrating an ontological enigma that remains forever a secret. When the director uses the four portraits to indicate the four important events of this wandering boy, he deliberately leaves empty the fourth portrait, the self-portrait of the boy; it remains as an incomplete piece which symbolizes an enigma of his own life. It shows certain constitutive unnamable forces acting within the boy that seduces him forever to painfully misrecognize himself.
基金supported by the National Natural Science Foundation of China (81472382)the National Natural Science Foundation of China for Young Scientists (81101947)+3 种基金the Guangdong Province Natural Science Foundation (2014A030313079)the Fundamental Research Funds for the Central Universities (14ykpy19)Guangdong Province Science and Technology for Social Development Project (2013B021800107)Guangzhou City in 2015 scientific research projects (7415600066401 to Hai Huang)
文摘We previously demonstrated that matrine could inhibit the proliferating, migrating, as well as invading processes of both PC-3 and DU145 cells. However, the underlying molecular mechanisms have not yet been clearly defined. In this study, using various techniques such as high throughput sequencing technology, bioinformatics, quantitative real-time PCR, and immunoblot analysis,we aimed to understand whether matrine serves as a novel regulator of FOXO and PI3K-AKT signaling pathway. DU145 and PC-3 cell lines were cultured for 24 h in vitro. Cells were treated with either matrine or control serum for 48 h, followed by extraction of total RNA. The RNA was sequenced using HiSeq 2500 high-throughput sequencing platform (Illumina). A gene library was established and quality analysis of read data carried out. Integrated database from the website DAVID was used to analyze Gene Ontology (GO), and Kyoto encyclopedia of genes and genomes (KEGG) pathway of differential genes was used for pathway analysis, screening for fold differences of more than two times. The FOXO and PI3K-AKT signaling pathways were screened, and expression levels of mRNA and core protein detected by real-time PCR and immunoblotting, respectively. High throughput sequencing and GO analysis revealed that differentially expressed genes before and after treatment played an important role in cell metabolic process, growth process, anatomical structure formation, cellular component organization, and biological regulation. KEGG signal pathway analysis revealed that FOXO and PI3K-AKT signal pathways had a significant difference between before and after matrine-treated androgen-independent prostate cancer cells PC-3 and DU145. Real-time PCR showed that matrine treatment led to a significant increase in the expression levels of FOXO1A, FOXO3A, FOXO4, and FOXO6 in DU145 and PC-3 cells (P<0.01 or P<0.05), whereas the PI3K expression levels decreased (P<0.01). Similarly, immunoblotting revealed a significant increase (P<0.05) in the expression levels of FOXO1A FOXO3A, FOXO4, and FOXO6 in both PC-3 and DU145 cells, whereas PI3K expression levels decreased (P<0.05). Matrine had a broad regulating effect on the mRNA expression profiles of both PC-3 and DU145 cells. Matrine may inhibit cell proliferation, migration, as well as invasion, and induce apoptosis in both PC-3 and DU145 cells through FOXO and PI3K-AKT signaling pathways. Matrine could therefore be used as a complementary drug to present chemotherapeutic agents, for treating androgen-independent prostate cancer.
基金supported in part by the National Natural Science Foundation of China(61370024,61428209,61232001)Program for New Century Excellent Talents in University(NCET-12-0547)
文摘Identification of disease-causing genes among a large number of candidates is a fundamental challenge in human disease studies.However,it is still time-consuming and laborious to determine the real disease-causing genes by biological experiments.With the advances of the high-throughput techniques,a large number of protein-protein interactions have been produced.Therefore,to address this issue,several methods based on protein interaction network have been proposed.In this paper,we propose a shortest path-based algorithm,named SPranker,to prioritize disease-causing genes in protein interaction networks.Considering the fact that diseases with similar phenotypes are generally caused by functionally related genes,we further propose an improved algorithm SPGOranker by integrating the semantic similarity of gene ontology(GO)annotations.SPGOranker not only considers the topological similarity between protein pairs in a protein interaction network but also takes their functional similarity into account.The proposed algorithms SPranker and SPGOranker were applied to 1598 known orphan disease-causing genes from 172 orphan diseases and compared with three state-of-the-art approaches,ICN,VS and RWR.The experimental results show that SPranker and SPGOranker outperform ICN,VS,and RWR for the prioritization of orphan disease-causing genes.Importantly,for the case study of severe combined immunodeficiency,SPranker and SPGOranker predict several novel causal genes.
