磁共振加速器计划系统测量仿真人模体照射野外剂量准确性评估

目的评估磁共振加速器(MR-Linac)Monaco计划系统(TPS)的快速蒙特卡罗模拟算法对照射野外剂量计算的准确性。方法使用光释光剂量计分别测量仿真人模体在头、胸、腹盆3个部位分别接受相同处方剂量规则野照射后,体表20个、体内5个检查点的辐射剂量。每个部位计划重复照射5次,测量结果取平均值,并与Monaco TPS的计算剂量值进行比较。拟合照射野外辐射剂量与靶区等中心距离反比函数,并描绘TPS计算误差随靶区等中心距离变化的分布特征。结果25个检查点中实测最高为离胸部靶区距离最近的甲状腺体表剂量,约为处方剂量的1.45%。不同部位照射过程中测得模体体表及体内辐射剂量在距靶区中心10~90 cm内遵循指数函数递减关系。与光释光剂量计测量数据相比,Monaco TPS在照射野外2%~5%剂量线范围内低估检查点剂量0~35%,在0~2%剂量线范围内高估检查点剂量0~270%。结论Monaco TPS快速蒙特卡罗算法计算MR-Linac照射野外剂量在5%以下剂量线范围内与实测剂量存在偏差,且随照射野外距离增加而增大。

中子实验中新型软组织替代物与水的比较研究

目的 :研制一种适用于中子实验的液体软组织当量材料 ,并观察拟人模体 (简称人模体 )受中子照射后器官内2 4Na比活度产额与水 (常用的当量液 )的差异。方法 :查阅 1 .8万多种化合物 ,进行比较、组合计算和密度试验 ,确定当量液的原料和配比。分别用组织当量液和水作软组织替代物进行 2个实验 :一个是使用人模体实验 ,比较心、脑、肺和肝内2 4Na生成量的差异 ;另一个是使用长方体进行体内中子入射方向2 4Na生成量的相对分布实验。结果 :2个实验表明 ,在相同的中子照射条件下 ,人模体的软组织用组织当量液和水替代 ,使2 4Na比活度产额产生显著差异。结论 :在用2 4Na比活度确定照射剂量的中子实验中 ,使用组织当量液方便可行 ,人模体软组织当量液不能用水代替。

Human tracking in camera network with non-overlapping FOVs

An adaptive human tracking method across spatially separated surveillance cameras with non-overlapping fields of views （FOVs） is proposed. The method relies on the two cues of the human appearance model and spatio-temporal information between cameras. For the human appearance model, an HSV color histogram is extracted from different human body parts （head, torso, and legs）, then a weighted algorithm is used to compute the similarity distance of two people. Finally, a similarity sorting algorithm with two thresholds is exploited to find the correspondence. The spatio- temporal information is established in the learning phase and is updated incrementally according to the latest correspondence. The experimental results prove that the proposed human tracking method is effective without requiring camera calibration and it becomes more accurate over time as new observations are accumulated.

应用热释光剂量计研究放疗中热塑膜对体表吸收剂量的影响

目的探讨应用LiF(Mg、Cu、P)热释光剂量计(TLD)测量2种不同照射方式下热塑膜对固体水或Alderson Rando仿真人模体体表吸收剂量的影响,为临床治疗提供参考。方法首先应用6MV-X射线筛选出符合临床测量要求的TLD,然后应用筛选好的TLD测量2种不同照射技术下的固体水或仿真人模体体表相对吸收剂量:(1)采用源皮距(SSD)=100 cm垂野照射技术时固体水模体体表相对吸收剂量,其中一组无热塑膜覆盖,另一组覆盖热塑膜;(2)采用容积旋转调强(VMAT)技术照射时仿真人模体体表相对吸收剂量,其中一组无热塑膜覆盖,另一组覆盖热塑膜。分别比较2种照射技术下热塑膜对体表相对吸收剂量的影响。结果在SSD=100重野照射技术条件下,无热塑膜与有热塑膜覆盖固体水模体体表相对吸收剂量分别为108.67、138.60 cGy,两者比较差异有统计学意义(P<0.001),热塑膜能够提高27.5%的体表相对吸收剂量;在VAMT照射技术条件下,无热塑膜与有热塑膜覆盖仿真人模体体表相对吸收剂量分别为98.83、154.95 cGy,两者比较差异有统计学意义(P<0.001),热塑膜能够提高56.8%的体表相对吸收剂量。结论2种不同照射技术下覆盖热塑膜都会增加模体体表吸收剂量,在临床治疗中应引起重视。

Pharmacokinetics of 20(R)-Ginsenoside Rg3 in Human Volunteers

Objective: To study the pharmacokinetics of 20(R)-Ginsenoside Rg3 in the human body. Methods: High-performance liquid chromatography-ultraviolet detection method was used in this study. Results: The pharmacokinetics of Ginsenoside Rg3 in 14 healthy volunteers were investigated. After a single oral dose of 3.2 mg.g-1 Ginsenoside Rg3 in 8 male volunteers, the plasma concentration-time course fitted in well with a two-compartment open model, with the following pharmacokinetic parameters: Tmax 0.660.10 h, Cmax 166 ngmL-1, T1/2a 0.460.12 h, T1/2b 4.91.1 h, T1/2(Ka) 0.280.04 h, AUC0-∞ 7726 ngmL-1h, respectively. No kinetic analysis was made after an oral dose of 0.8 mg.g-1 Rg3 in other 6 volunteers because of the low concentration, but there was a good correlation between Cmax and dosage of the two groups. Conclusion: The absorption of Rg3 was rapid in the human body, and its elimination was rapid too after oral administration of Ginsenoside Rg3. The pharmacokinetic results shows that it exhibited the first-order kinetic characteristics.

Ultrafast Energy Transfer in Artificial Antenna Molecule Measured by Transient Fluorescence Spectroscopy

We have reported previously the ultrafast energy transfer process with a time constant of 0.8 ps from a monomeric to a dimeric subunit within a perylenetetracarboxylic diimide trimer, which was derived indirectly from a model fitting into the transient absorption experimental data. Here we present a direct ultrafast fluorescence quenching measurement by employing fs time-resolved transient fluorescence spectroscopy based on noncollinear optical parametric amplification technique. The rapid decay of the monomer＇s emission due to energy transfer was observed directly with a time constant of about 0.82 ps, in good agreement with the previous result.

Relationship between trawl selectivity and fish body size in a simulated population

Trawl is a main fishing gear in Chinese fishery,capturing large fish and letting small ones at large.However,long-term use of trawl would result in changes of phenotypic traits of the fish stocks,such as smaller size-at-age and earlier age-at-maturation.In this study,we simulated a fish population with size characteristics of trawl fishing and the population produces one generation of offspring and lives for one year,used trawl to exploit the simulated fish population,and captured individuals by body size.We evaluated the impact of the changes on selectivity parameters,such as selective range and the length at 50% retention.Under fishing pressure,we specified the selectivity parameters,and determined that smaller selection rates and greater length at 50% retention were associated with an increased tendency towards miniaturization.

Optimal Seat Suspension Design Using Genetic Algorithms

The linear seat suspension is considered due to the low cost consideration therefore, the optimal linear seat suspension design method can be used for this purpose. In this paper, the design of a passive vehicle seat suspension system was handled in the framework of linear optimization. The variance of the dynamic load resulting from the vibrating vehicle operating at a constant speed was used as the performance measure of a suspension system. Using 4-DOF human body model developed by Abbas et al., with linear seat suspension and coupled with half car model. A genetic algorithm is applied to solve the linear optimization problem. The optimal design parameters of the seat suspension systems obtained are kse = 3 012.5 N/m and cse = 1 210.4 N.s/m, respectively.

Use of 3-D magnetic resonance electrical impedance tomography in detecting human cerebral stroke: a simulation study

We have developed a new three dimensional (3-D) conductivity imaging approach and have used it to detect human brain conductivity changes corresponding to acute cerebral stroke. The proposed Magnetic Resonance Electrical Impedance Tomography (MREIT) approach is based on the J-Substitution algorithm and is expanded to imaging 3-D subject conductivity distribution changes. Computer simulation studies have been conducted to evaluate the present MREIT imaging approach. Simulations of both types of cerebral stroke, hemorrhagic stroke and ischemic stroke, were performed on a four-sphere head model. Simulation results showed that the correlation coefficient (CC) and relative error (RE) between target and estimated conductivity distributions were 0.9245±0.0068 and 8.9997%±0.0084%, for hemorrhagic stroke, and 0.6748±0.0197 and 8.8986%±0.0089%, for ischemic stroke, when the SNR (signal-to-noise radio) of added GWN (Gaussian White Noise) was 40. The convergence characteristic was also evaluated according to the changes of CC and RE with different iteration numbers. The CC increases and RE decreases monotonously with the increasing number of iterations. The present simulation results show the feasibility of the proposed 3-D MREIT approach in hemorrhagic and ischemic stroke detection and suggest that the method may become a useful alternative in clinical diagnosis of acute cerebral stroke in humans.

Simplified propulsive model for biomimetic robot fish and its experimental validation

As a combination of bio-mechanism and engineering technology, robot fish has become a multidisci- plinary research that mainly involves both hydrodynamics-based control and actuation technology. This paper presents a simplified propulsive model for carangiform propulsion, which is a swimming mode suitable for high speed and high efficiency. The carangiform motion is modeled as an N-joint nscillating mechanism that is composed of two basic components： the streamlined fish body represented by a planar spline curve and its hmate caudal tail by an oscillating foil. The speed of fish＇s straight swimming is adjusted by modulating the joint＇s oscillating frequency, and its orientation is tuned by different joint＇s deflection. The results from actual experiment showed that the proposed simplified propulsive model could be a viable eandidate for application in aquatic： swimming vehicles.

Generation of human/rat xenograft animal model for the study of human donor stem cell behaviors in vivo

AIM： TO accurately and realistically elucidate human stem cell behaviors in vivo and the fundamental mechanisms controlling human stem cell fates in vivo, which is urgently required in regenerative medicine and treatments for some human diseases, a surrogate human-rat chimera model was developed. METHODS： Human-rat chimeras were achieved by in utero transplanting low-density mononuclear cells from human umbilical cord blood into the fetal rats at 9-11 d of gestation, and subsequently, a variety of methods, including flow cytometry, PCR as well as immunohistochemical assay, were used to test the human donor contribution in the recipients. RESULTS： Of 29 live-born recipients, 19 had the presence of human CD45^＋ cells in peripheral blood （PB） detected by flow cytometry, while PCR analysis on genomic DNA from 11 different adult tissues showed that 14 selected from flow cytometry-positive 19 animals possessed of donor-derived human cell engraftment in multiple tissues （i.e. liver, spleen, thymus, heart, kidney, blood, lung, muscle, gut and skin） examined at the time of tissue collection, as confirmed by detecting human 132- microglobulin expression using immunohistochemistry. Tn this xenogeneic system, the engrafted donor-derived human cells persisted in multiple tissues for at least 6 mo after birth. Moreover, transplanted human donor cells underwent site-specific differentiation into CK18-positive human cells in chimeric liver and CEHS-positive human cells in chimeric spleen and thymus of recipients. CONCLUSION： Taken together, these findings suggest that we successfully developed human-rat chimeras, in which xenogeneic human cells exist up to 6 mo later. This humanized small animal model, which offers an in vivo environment more closely resembling to the situations in human, provides an invaluable and effective approach for in vivo investigating human stem cell behaviors, and further in vivo examining fundamental mechanisms controlling human stem cell fates in the future. The potential for new advances in our better understanding the living biological systems in human provided by investigators in humanized animals will remain promising.

Human Body Modeling and Posture Simulating Based on 3D Surface Scan Data

This paper presents a new approach for modeling the human body by considering the motion state and the shape of whole body. The body model consists of a skeleton kinematic model and a surface model. The former is used to determine the posture of the body,and the latter is used to generate the body shape according to the given posture. The body surface is reconstructed with multi-segment B-spline surfaces based on the 3D scan data from a real human body.Using only a few joints parameters and the original surface scan data, the various body postures and the shape can be generated easily. The model has a strong potential of being used for ergonomic design,garment design, virtual reality environment, as well as creating human animation, etc.

Human skeleton proportions from monocular data

This paper introduces a novel method for estimating the skeleton proportions of a human figure from monocular data. The proposed system will first automatically extract the key frames and recover the perspective camera model from the 2D data. The human skeleton proportions are then estimated from the key frames using the recovered camera model without posture re- construction. The proposed method is tested to be simple, fast and produce satisfactory results for the input data. The human model with estimated proportions can be used in future research involving human body modeling or human motion reconstruction.

Quantum theory-based physical model of the human body in TCM

In the study,a quantum resonant cavity model based on wave-particle duality was proposed for the explanation of the dynamic processes of essence,vigor,and spirit in the human body in traditional Chinese medicine(TCM).It is assumed that there is a macro human order parameter(wave function),and its dynamics are governed by a macro potential field reflecting influences from heaven,earth,and society,and satisfy the generalized Schrodinger equation.This proposed model was applied in the study to interpret basic concepts of human body in TCM,with an aim to unfold the TCM development in the future.

Using computed tomography scans to develop an ex-vivo gastric model

The objective of this research was to use abdominal computed tomography (CT) scans to non-invasively quantify anthropometrical data of the human stomach and to concomitantly create an anatomically correct and distensible ex-vivo gastric model. Thirty-three abdominal CT scans of human subjects were obtained and were imported into reconstruction software to generate 3D models of the stomachs. Anthropometrical data such as gastric wall thickness, gastric surface area and gastric volume were subsequently quantified. A representative 3D computer model was exported into a selective laser sintering (SLS) rapid prototyping machine to create an anatomically correct solid gastric model. Subsequently, a replica wax template of the SLS model was created. A negative mould was offset around the wax template such that the offset distance was equivalent to that of the gastric wall thickness. A silicone with similar mechanical properties to the human stomach was poured into the offset. The lost wax manufacturing technique was employed to create a hollow distensible stomach model. 3D computer gastric models were generated from the CT scans. A hollow distensible silicone ex-vivo gastric model with similar compliance to that of the human stomach was created. The anthropometrical data indicated that there is no significant relationship between BMI and gastric surface area or gastric volume. There were inter- and intra-group differences between groups with respect to gastric wall thickness. This study demonstrates that abdominal CT scans can be used to both non-invasively determine gastric anthropometrical data as well as create realistic ex-vivo stomach models.

Gastric stimulation for weight loss

The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight loss.Behavior and lifestyle therapy are safe treatments for obesity in the short term,but the durability of the weight loss is limited.Although promising obesity drugs are in development,the currently available drugs lack efficacy or have unacceptable side effects.Surgery leads to long-term weight loss,but it is associated with morbidity and mortality.Gastric electrical stimulation(GES) has received increasing attention as a potential tool for treating obesity and gastrointestinal dysmotility disorders.GES is a promising,minimally invasive,safe,and effective method for treating obesity.External gastric pacing is aimed at alteration of the motility of the gastrointestinal tract in a way that will alter absorption due to alteration of transit time.In addition,data from animal models and preliminary data from human trials suggest a role for the gut-brain axis in the mechanism of GES.This may involve alteration of secretion of hormones associated with hunger or satiety.Patient selection for gastric stimulation therapy seems to be an important determinant of the treatment's outcome.Here,we review the current status,potential mechanisms of action,and possible future applications of gastric stimulation for obesity.

Establishment of a three-dimensional finite element model for gunshot wounds to the human mandible

Objective:To investigate the feasibility of a finite element model as an ideal research tool for human maxillofacial gunshot wounds.Methods:Mandible CT scan data on the Chinese Visible Human were imported into MIMICS software to obtain the surface mesh of the mandible.Then,these surface-meshed models were imported into ANSA software for automatic net generation.Elements and nodes were partitioned on the basis of the mesh to obtain a three-dimensional finite element model for the mandible with every internal parameter consistent with those of our previously developed model in the pig mandible.The finite element model was imported into LS-DYNA for computation.Finally,the LS-POST was used to complete the simulation and the measurements.Results:A three-dimensional finite element model was successfully established for gunshot wounds in the human mandible.The stress distribution and the degree of injury were simulated dynamically for shots from two types of projectiles in the mandible at one entry angle and at three impact velocities.Conclusion:Three-dimensional finite element models will become ideal research tools for treatment of ballistic wounds of the human maxillofacial region.Using this human mandibular model as a foundation,we will be able to successfully develop three-dimensional finite element models for human maxillofacial gunshot wounds.

Motion estimation of elastic articulated objects from image contours

A new method of elastic articulated objects (human bodies) modeling was presented based on a new conic curve. The model includes 3D object deformable curves which can represent the deformation of human occluding contours. The deformation of human occluding contour can be represented by adjusting only four deformation parameters for each limb. Then, the 3D deformation parameters are determined by corresponding 2D contours from a sequence of stereo images. The algorithm presented in this paper includes deformable conic curve parameters determination and the plane, 3D conic curve lying on, parameter determination.

Population sizes and group characteristics of Siberian Crane(Leucogeranus leucogeranus) and Hooded Crane(Grus monacha) in Poyang Lake Wetland

Both the Siberian Crane(Leucogeranus leucogeranus) and Hooded Crane(Grus monacha) have limited population sizes and are considered endangered by domestic Chinese and international agencies.To document the current size of their respective populations and characterize their groups,between October 2012 and April 2013 we undertook fieldwork at four nature reserve areas within the Poyang Lake wetlands.We divided Poyanghu National Nature Reserve(PYH) into the Wucheng(PWC) and Hengfeng areas(PHF),because each are each located in different counties.Our fieldwork showed that the Siberian Crane occurred mainly in PYH(364 in the PHF,158 in the PWC) and the Nanjishan Wetland National Nature Reserve(NJS,with 200 individuals).The Hooded Crane was mainly distributed in PYH(302 in the PHF and 154 in the PWC).Family groups accounted for more than 50% of the total number of groups among both species,with Hooded Cranes forming more family groups than Siberian Cranes.Typically,these groups were formed of two adults with one offspring(Siberian Crane),and two adults with two offspring(Hooded Crane),with the mean family group size of the Siberian Crane and Hooded Crane being respectively 2.65±0.53(n=43) and 3.09±0.86(n=47) individuals per group.The mean collective group size of the Siberian Crane and Hooded Crane included 28.09±24.94(n=23) and 28.94±27.97(n=16) individuals per group,respectively,with the proportion of juveniles among Hooded Cranes being more than double that seen among the Siberian Cranes.

Chinese Fuzzy Ontology Mapping Based on Support Vector Machine

Taking into account that fuzzy ontology mapping has wide application and cannot be dealt with in many fields at present,a Chinese fuzzy ontology model and a method for Chinese fuzzy ontology mapping are proposed.The mapping discovery between two ontologies is achieved by computing the similarity between the concepts of two ontologies.Every concept consists of four features of concept name,property,instance and structure.First,the algorithms of calculating four individual similarities corresponding to the four features are given.Secondly,the similarity vectors consisting of four weighted individual similarities are built,and the weights are the linear function of harmony and reliability.The similarity vector is used to represent the similarity relation between two concepts which belong to different fuzzy ontolgoies.Lastly,Support Vector Machine(SVM) is used to get the mapping concept pairs by the similarity vectors.Experiment results are satisfactory.