Objective Category-specific recognition and naming deficits have been observed in a variety of patient populations. However, the category-specific cortices for naming famous faces, animals and man-made objects remain ...Objective Category-specific recognition and naming deficits have been observed in a variety of patient populations. However, the category-specific cortices for naming famous faces, animals and man-made objects remain controversial. The present study aimed to study the specific areas involved in naming pictures of these 3 categories using functional magnetic resonance imaging. Methods Functional images were analyzed using statistical parametric mapping and the 3 different contrasts were evaluated using t statistics by comparing the naming tasks to their baselines.The contrast images were entered into a random-effects group level analysis.The results were reported in Montreal Neurological Institute co-ordinates,and anatomical regions were identified using an automated anatomical labeling method with XJview 8.Results Naming famous faces caused more activation in the bilateral head of the hippocampus and amygdala with significant left dominance. Bilateral activation of pars triangularis and pars opercularis in the naming of famous faces was also revealed. Naming animals evoked greater responses in the left supplementary motor area, while naming man-made objects evoked more in the left premotor area,left pars orbitalis and right supplementary motor area. The extent of bilateral fusiform gyri activation by naming man-made objects was much larger than that by naming of famous faces or animals.Even in the overlapping sites of activation,some differences among the categories were found for activation in the fusiform gyri.Conclusion The cortices involved in the naming process vary with the naming of famous faces,animals and man-made objects.This finding suggests that different categories of pictures should be used during intra-operative language mapping to generate a broader map of language function, in order to minimize the incidence of false-negative stimulation and permanent post-operative deficits.展开更多
Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins’biological functions.During the last decade,proteomics in China has grown much faster than oth...Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins’biological functions.During the last decade,proteomics in China has grown much faster than other research fields in life sciences.At the beginning of the second decade of the 21st century,the rapid development of high-resolution and high-speed mass spectrometry makes proteomics a powerful tool to study the mechanisms underlying physiological/pathological processes in organisms.This article provides a brief overview of proteomics technology development and representative scientific progress of the Human Liver Proteome Project in China over the past three years.展开更多
As one of the leading figures in latter years of the Guangfuhui alliance, Li Xiehe＇s devotion to the revolution had a considerable impact on the growth and flourishing of the revolutionary force. During the Xinhai Re...As one of the leading figures in latter years of the Guangfuhui alliance, Li Xiehe＇s devotion to the revolution had a considerable impact on the growth and flourishing of the revolutionary force. During the Xinhai Revolution, his leadership as the Commander-in-Chief and collaborative efforts with Chen Qimei and other military leaders in restoring Shanghai, re-establishing the Restoration Army to assist rebellious actions in Nanjing and Wuhan, as well as their determination to march northward contributed greatly to the collapse of the Qing government. In its founding years of the Republic, Li retreated from the glory of his political success. Instead of winning him the due respect, however, his well-intentioned and humble act went tarnished by his later forced membership of the Chouanhui, a highly controversial topic in the literature. Adopting the relationship between the Tong- menghui and the Guangfuhui as a point of departure, this paper presents a thorough re-analysis of related historical accounts and various preoccupations surrounding Li, and assumed motivations of his political decisions, so as to reconstruct a truthful image of the debated historical figure.展开更多
Since the creation of intelligent creatures,we are no longer the puppets of the creator.For thousands of years,people have been thinking about the nature and the future of ourselves,and reconstruction of the process o...Since the creation of intelligent creatures,we are no longer the puppets of the creator.For thousands of years,people have been thinking about the nature and the future of ourselves,and reconstruction of the process of life has become the ultimate dream for us.In 1951,William Harvey,a British scientist,elaborated the theory of the structure and function of embryos for the first time in his book'the reproduction of animals',which established the foundation for people to explore the process and the mechanism of embryonic development.展开更多
基金supported bythe Foundation of Science and Technology Program of Guangdong Province,China(No.2008A030201021)the Natural Science Foundation of Guangdong Province,China(No.10151001002000010)
文摘Objective Category-specific recognition and naming deficits have been observed in a variety of patient populations. However, the category-specific cortices for naming famous faces, animals and man-made objects remain controversial. The present study aimed to study the specific areas involved in naming pictures of these 3 categories using functional magnetic resonance imaging. Methods Functional images were analyzed using statistical parametric mapping and the 3 different contrasts were evaluated using t statistics by comparing the naming tasks to their baselines.The contrast images were entered into a random-effects group level analysis.The results were reported in Montreal Neurological Institute co-ordinates,and anatomical regions were identified using an automated anatomical labeling method with XJview 8.Results Naming famous faces caused more activation in the bilateral head of the hippocampus and amygdala with significant left dominance. Bilateral activation of pars triangularis and pars opercularis in the naming of famous faces was also revealed. Naming animals evoked greater responses in the left supplementary motor area, while naming man-made objects evoked more in the left premotor area,left pars orbitalis and right supplementary motor area. The extent of bilateral fusiform gyri activation by naming man-made objects was much larger than that by naming of famous faces or animals.Even in the overlapping sites of activation,some differences among the categories were found for activation in the fusiform gyri.Conclusion The cortices involved in the naming process vary with the naming of famous faces,animals and man-made objects.This finding suggests that different categories of pictures should be used during intra-operative language mapping to generate a broader map of language function, in order to minimize the incidence of false-negative stimulation and permanent post-operative deficits.
基金funded by the Chinese National Basic Research Program grants(2011CB910600,2013CB911201)to Xu Ping and Li Ning respectivelythe grants of National Natural Science Foundation of China(31070673,31170780)to Xu Ping
文摘Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins’biological functions.During the last decade,proteomics in China has grown much faster than other research fields in life sciences.At the beginning of the second decade of the 21st century,the rapid development of high-resolution and high-speed mass spectrometry makes proteomics a powerful tool to study the mechanisms underlying physiological/pathological processes in organisms.This article provides a brief overview of proteomics technology development and representative scientific progress of the Human Liver Proteome Project in China over the past three years.
文摘As one of the leading figures in latter years of the Guangfuhui alliance, Li Xiehe＇s devotion to the revolution had a considerable impact on the growth and flourishing of the revolutionary force. During the Xinhai Revolution, his leadership as the Commander-in-Chief and collaborative efforts with Chen Qimei and other military leaders in restoring Shanghai, re-establishing the Restoration Army to assist rebellious actions in Nanjing and Wuhan, as well as their determination to march northward contributed greatly to the collapse of the Qing government. In its founding years of the Republic, Li retreated from the glory of his political success. Instead of winning him the due respect, however, his well-intentioned and humble act went tarnished by his later forced membership of the Chouanhui, a highly controversial topic in the literature. Adopting the relationship between the Tong- menghui and the Guangfuhui as a point of departure, this paper presents a thorough re-analysis of related historical accounts and various preoccupations surrounding Li, and assumed motivations of his political decisions, so as to reconstruct a truthful image of the debated historical figure.
基金supported by the National Nature Science of China(3147127791649202)National key R&D program of China(2016YFA0500901)
文摘Since the creation of intelligent creatures,we are no longer the puppets of the creator.For thousands of years,people have been thinking about the nature and the future of ourselves,and reconstruction of the process of life has become the ultimate dream for us.In 1951,William Harvey,a British scientist,elaborated the theory of the structure and function of embryos for the first time in his book'the reproduction of animals',which established the foundation for people to explore the process and the mechanism of embryonic development.
