Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins’biological functions.During the last decade,proteomics in China has grown much faster than oth...Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins’biological functions.During the last decade,proteomics in China has grown much faster than other research fields in life sciences.At the beginning of the second decade of the 21st century,the rapid development of high-resolution and high-speed mass spectrometry makes proteomics a powerful tool to study the mechanisms underlying physiological/pathological processes in organisms.This article provides a brief overview of proteomics technology development and representative scientific progress of the Human Liver Proteome Project in China over the past three years.展开更多
The uterus is an indispensable organ for the development of a new life in eutherian mammals.The female mammalian reproductive capacity diminishes with age.In this respect,the senescence of uterine endometrium is convi...The uterus is an indispensable organ for the development of a new life in eutherian mammals.The female mammalian reproductive capacity diminishes with age.In this respect,the senescence of uterine endometrium is convinced to contribute to this failure.This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models.A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans.展开更多
Since the creation of intelligent creatures,we are no longer the puppets of the creator.For thousands of years,people have been thinking about the nature and the future of ourselves,and reconstruction of the process o...Since the creation of intelligent creatures,we are no longer the puppets of the creator.For thousands of years,people have been thinking about the nature and the future of ourselves,and reconstruction of the process of life has become the ultimate dream for us.In 1951,William Harvey,a British scientist,elaborated the theory of the structure and function of embryos for the first time in his book'the reproduction of animals',which established the foundation for people to explore the process and the mechanism of embryonic development.展开更多
基金funded by the Chinese National Basic Research Program grants(2011CB910600,2013CB911201)to Xu Ping and Li Ning respectivelythe grants of National Natural Science Foundation of China(31070673,31170780)to Xu Ping
文摘Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins’biological functions.During the last decade,proteomics in China has grown much faster than other research fields in life sciences.At the beginning of the second decade of the 21st century,the rapid development of high-resolution and high-speed mass spectrometry makes proteomics a powerful tool to study the mechanisms underlying physiological/pathological processes in organisms.This article provides a brief overview of proteomics technology development and representative scientific progress of the Human Liver Proteome Project in China over the past three years.
基金supported by the National Basic Research Program of China (Grant Nos. 2011CB944401 and 2010CB945002)the National Natural Science Foundation of China(Grant Nos. 30825015 and 81130009)
文摘The uterus is an indispensable organ for the development of a new life in eutherian mammals.The female mammalian reproductive capacity diminishes with age.In this respect,the senescence of uterine endometrium is convinced to contribute to this failure.This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models.A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans.
基金supported by the National Nature Science of China(3147127791649202)National key R&D program of China(2016YFA0500901)
文摘Since the creation of intelligent creatures,we are no longer the puppets of the creator.For thousands of years,people have been thinking about the nature and the future of ourselves,and reconstruction of the process of life has become the ultimate dream for us.In 1951,William Harvey,a British scientist,elaborated the theory of the structure and function of embryos for the first time in his book'the reproduction of animals',which established the foundation for people to explore the process and the mechanism of embryonic development.
