期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
LncRNA-HOTAIRM1下调对Jurkat细胞增殖、凋亡及KIT/AKT通路的影响
1
作者 李玉茹 燕文敬 +1 位作者 蔡力力 邓新立 《中国实验血液学杂志》 CAS CSCD 北大核心 2021年第4期1123-1128,共6页
目的:观察长链非编码-HOX反义基因间RNA髓样1(LncRNA-HOTAIRM1)下调对人白血病T淋巴细胞Jurkat增殖及凋亡的影响,并初步探讨其作用机理。方法:体外培养Jurkat细胞,随机分为对照组、HOTAIRM1siRNA-NC组、HOTAIRM1 siRNA组;利用实时荧光定... 目的:观察长链非编码-HOX反义基因间RNA髓样1(LncRNA-HOTAIRM1)下调对人白血病T淋巴细胞Jurkat增殖及凋亡的影响,并初步探讨其作用机理。方法:体外培养Jurkat细胞,随机分为对照组、HOTAIRM1siRNA-NC组、HOTAIRM1 siRNA组;利用实时荧光定量PCR法检测转染后各组Jurkat细胞LncRNA-HOTAIRM1mRNA、KIT受体酪氨酸激酶(KIT) mRNA、丝氨酸-苏氨酸激酶(AKT) mRNA的表达情况;采用CCK-8法检测各组Jurkat细胞的增殖情况;利用Annexin V-FITC/PI双染法检测各组Jurkat细胞的凋亡情况;采用蛋白印迹分析法检测KIT、AKT、p-KIT、p-AKT、B淋巴细胞瘤-2基因(BCL-2)及半胱氨酸天冬氨酸酶3(Caspase-3)蛋白表达的情况。结果:与对照组和HOTAIRM1 siRNA-NC组相比,HOTAIRM1 siRNA组Jurkat细胞LncRNA-HOTAIRM1 mRNA表达水平、细胞存活率、KIT mRNA、AKT mRNA、p-KIT、p-AKT及BCL-2蛋白表达水平均显著降低(P<0.05),Cleared Caspase-3蛋白表达水平、Jurkat细胞凋亡率显著升高(P<0.05)。结论:LncRNA-HOTAIRM1可能通过KIT/AKT信号通路,抑制Jurkat细胞增殖并诱导其凋亡。 展开更多
关键词 LncRNA-HOtAIRM1 人白血病t淋巴细胞 KIt/AKt通路 凋亡
下载PDF
Adult T-cell leukemia/lymphoma presenting multiple lymphomatous polyposis 被引量:1
2
作者 Akira Hokama Takeaki Tomoyose +8 位作者 Yu-ichi Yamamoto Takako Watanabe Tetsuo Hirata Fukunori Kinjo Seiya Kato Koichi Ohshima Hiroshi Uezato Nobuyuki Takasu Jiro Fujita 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第42期6584-6588,共5页
Multiple lymphomatous polyposis (MLP) is an unusual form of non-Hodgkin's lymphoma characterized by polyps throughout the gastrointestinal tract. It has been reported that most MLP are observed in cases with mantl... Multiple lymphomatous polyposis (MLP) is an unusual form of non-Hodgkin's lymphoma characterized by polyps throughout the gastrointestinal tract. It has been reported that most MLP are observed in cases with mantle cell lymphoma of B-cell type. We herein present a case of a 66-year-old man with adult T-cell leukemia/lymphoma (ATLL). Colonoscopy revealed MLP throughout the colon and histopathological findings of ATLL cell infiltration. The patient died despite combination of chemotherapy. The literature of manifestations of colonic involvement of ATLL isreviewed and the importance of endoscopic evaluation to differentiate ATLL intestinal lesions from opportunistic infectious enterocolitis is discussed. 展开更多
关键词 Adult t-cell leukemia/lymphoma Multiplelymphomatous polyposis Human t-cell lymphotropicvirus type 1 Strongyloides stercora/is COLONOSCOPY
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部