Carbon emissions and water use are two major kinds of human activities. To reveal whether these two activities can modify the hydrological cycle and climate system in China, we conducted two sets of numerical experime...Carbon emissions and water use are two major kinds of human activities. To reveal whether these two activities can modify the hydrological cycle and climate system in China, we conducted two sets of numerical experiments using regional climate model RegCM4. In the first experiment used to study the climatic responses to human carbon emissions, the model were configured over entire China because the impacts of carbon emissions can be detected across the whole country. Results from the first experiment revealed that near-surface air temperature may significantly increase from 2007 to 2059 at a rate exceeding 0.1 ~C per decade in most areas across the country; southwestern and southeastern China also showed increasing trends in summer precipitation, with rates exceeding 10 mm per decade over the same period. In summer, only northern China showed an increasing trend of evapotranspiration, with increase rates ranging from 1 to 5 mm per decade; in winter, increase rates ranging from 1 to 5 mm per decade were observed in most regions. These effects are believed to be caused by global warming from human carbon emissions. In the second experiment used to study the effects of human water use, the model were configured over a limited region-- Haihe River Basin in the northern China, because compared with the human carbon emissions, the effects of human water use are much more local and regional, and the Haihe River Basin is the most typical region in China that suffers from both intensive human groundwater exploitation and surface water diversion. We incorporated a scheme of human water regulation into RegCM4 and conducted the second experiment. Model outputs showed that the groundwater table severely declined by -10 m in 1971-2000 through human groundwater over- exploitation in the basin; in fact, current conditions are so extreme that even reducing the pumping rate by half cannot eliminate the ground- water depletion cones observed in the area. Other hydrological and climatic elements, such as soil moisture, runoff generation, air humidity, precipitation, wind field, and soil and air temperature, were also significantly affected by anthropogenic water withdrawal and consumption, although these effects could be mitigated by reducing the amount of water drawn for extraction and application.展开更多
Human cytosolic NADP-1DH （IDH1） has recently been found to be involved in tumorigenesis. Notably, the tumorderived IDH1 mutations identified so far mainly occur at Arg132, and mutation R132H is the most prevalent on...Human cytosolic NADP-1DH （IDH1） has recently been found to be involved in tumorigenesis. Notably, the tumorderived IDH1 mutations identified so far mainly occur at Arg132, and mutation R132H is the most prevalent one. This mutation impairs the oxidative IDH activity of the enzyme, but renders a new reduction function of converting a-ketoglutarate （aKG） to 2-hydroxyglutarate. Here, we report the structures of the R132H mutant IDH1 with and without isocitrate OCT） bound. The structural data together with mutagenesis and biochemical data reveal a previ- ously undefined initial ICT-binding state and demonstrate that IDH activity requires a conformational change to a closed pre-transition state. Arg132 plays multiple functional roles in the catalytic reaction; in particular, the R132H mutation hinders the conformational changes from the initial ICT-binding state to the pre-transition state, leading to the impairment of the IDH activity. Our results describe for the first time that there is an intermediate conformation that corresponds to an initial ICT-binding state and that the R132H mutation can trap the enzyme in this conforma- tion, therefore shedding fight on the molecular mechanism of the ＂off switch＂ of the potentially tumor-suppressive IDH activity. Furthermore, we proved the necessity of Tyr139 for the gained aKG reduction activity and propose that Tyr139 may play a vital role by compensating the increased negative charge on the C2 atom of aKG during the trans- fer of a hydride anion from NADPH to aKG, which provides new insights into the mechanism of the ＂on switch＂ of the hypothetically oncogenic reduction activity of IDH1 by this mutation.展开更多
In order to reduce energy consumption and protect the human survival environment, the lightweight has became the development trend of the world automobile industry. On the premise of ensuring the strength, safety and ...In order to reduce energy consumption and protect the human survival environment, the lightweight has became the development trend of the world automobile industry. On the premise of ensuring the strength, safety and driving performance of the car, the major car enterprises try to reduce the curb weight of the ear, fuel consumption and emissions. Not only a lot of new technologies and new products have been generated, but also joint vehicle development process and computer aided engineering （CAE） analysis technology have been developed. Since the entry into the ＂Au- tomobile Lightweight Technology Innovation Strategic Alliance＂ in Dec. 2007, Geely Group has been focusing on light- weight construction of vehicle and key assemblies in every stage of the vehicle product development. Among vehicles ap- peared on the market and in research, it has presented continuously better performance. The paper describes application examples and successful experience of CAE simulation analysis and performance optimization during the lightweight de- sign and development of a self-developed model of Geely, and looks forward to the prospects for the development of lightweight of Geely vehicle.展开更多
In the development process of human history, music and literature have their own unique characteristics, and also are closely related to each other. Both own a very long history and maintain an interdependent relation...In the development process of human history, music and literature have their own unique characteristics, and also are closely related to each other. Both own a very long history and maintain an interdependent relationship with each other. The dances accompanied by music in China＇ s primitive tribes and the lyric poetry in the ancient Greek times can be said to be the coexistence form of music and literature. Although music and literature have undergone a whole development process from a unified development to an independent development, there are links always maintained between the two art forms. In this paper, the coexistence and fusion between music and literature are specifically introduced from different aspects.展开更多
As human improve their ability to fabricate materials, alloys have evolved from simple to complex compositions, accordingly improving functions and performances,promoting the advancements of human civilization. In rec...As human improve their ability to fabricate materials, alloys have evolved from simple to complex compositions, accordingly improving functions and performances,promoting the advancements of human civilization. In recent years, high-entropy alloys（HEAs） have attracted tremendous attention in various fields. With multiple principal components, they inherently possess unique microstructures and many impressive properties, such as high strength and hardness, excellent corrosion resistance, thermal stability, fatigue,fracture, and irradiation resistance, in terms of which they overwhelm the traditional alloys. All these properties have endowed HEAs with many promising potential applications.An in-depth understanding of the essence of HEAs is important to further developing numerous HEAs with better properties and performance in the future. In this paper, we review the recent development of HEAs, and summarize their preparation methods, composition design, phase formation and microstructures, various properties, and modeling and simulation calculations. In addition, the future trends and prospects of HEAs are put forward.展开更多
文摘Carbon emissions and water use are two major kinds of human activities. To reveal whether these two activities can modify the hydrological cycle and climate system in China, we conducted two sets of numerical experiments using regional climate model RegCM4. In the first experiment used to study the climatic responses to human carbon emissions, the model were configured over entire China because the impacts of carbon emissions can be detected across the whole country. Results from the first experiment revealed that near-surface air temperature may significantly increase from 2007 to 2059 at a rate exceeding 0.1 ~C per decade in most areas across the country; southwestern and southeastern China also showed increasing trends in summer precipitation, with rates exceeding 10 mm per decade over the same period. In summer, only northern China showed an increasing trend of evapotranspiration, with increase rates ranging from 1 to 5 mm per decade; in winter, increase rates ranging from 1 to 5 mm per decade were observed in most regions. These effects are believed to be caused by global warming from human carbon emissions. In the second experiment used to study the effects of human water use, the model were configured over a limited region-- Haihe River Basin in the northern China, because compared with the human carbon emissions, the effects of human water use are much more local and regional, and the Haihe River Basin is the most typical region in China that suffers from both intensive human groundwater exploitation and surface water diversion. We incorporated a scheme of human water regulation into RegCM4 and conducted the second experiment. Model outputs showed that the groundwater table severely declined by -10 m in 1971-2000 through human groundwater over- exploitation in the basin; in fact, current conditions are so extreme that even reducing the pumping rate by half cannot eliminate the ground- water depletion cones observed in the area. Other hydrological and climatic elements, such as soil moisture, runoff generation, air humidity, precipitation, wind field, and soil and air temperature, were also significantly affected by anthropogenic water withdrawal and consumption, although these effects could be mitigated by reducing the amount of water drawn for extraction and application.
文摘Human cytosolic NADP-1DH （IDH1） has recently been found to be involved in tumorigenesis. Notably, the tumorderived IDH1 mutations identified so far mainly occur at Arg132, and mutation R132H is the most prevalent one. This mutation impairs the oxidative IDH activity of the enzyme, but renders a new reduction function of converting a-ketoglutarate （aKG） to 2-hydroxyglutarate. Here, we report the structures of the R132H mutant IDH1 with and without isocitrate OCT） bound. The structural data together with mutagenesis and biochemical data reveal a previ- ously undefined initial ICT-binding state and demonstrate that IDH activity requires a conformational change to a closed pre-transition state. Arg132 plays multiple functional roles in the catalytic reaction; in particular, the R132H mutation hinders the conformational changes from the initial ICT-binding state to the pre-transition state, leading to the impairment of the IDH activity. Our results describe for the first time that there is an intermediate conformation that corresponds to an initial ICT-binding state and that the R132H mutation can trap the enzyme in this conforma- tion, therefore shedding fight on the molecular mechanism of the ＂off switch＂ of the potentially tumor-suppressive IDH activity. Furthermore, we proved the necessity of Tyr139 for the gained aKG reduction activity and propose that Tyr139 may play a vital role by compensating the increased negative charge on the C2 atom of aKG during the trans- fer of a hydride anion from NADPH to aKG, which provides new insights into the mechanism of the ＂on switch＂ of the hypothetically oncogenic reduction activity of IDH1 by this mutation.
基金Supporting Program of the"Twelfth Five-year Plan"for Sci & Tech Research of China(No. 2011BAG03B02No.2011BAG03B06)
文摘In order to reduce energy consumption and protect the human survival environment, the lightweight has became the development trend of the world automobile industry. On the premise of ensuring the strength, safety and driving performance of the car, the major car enterprises try to reduce the curb weight of the ear, fuel consumption and emissions. Not only a lot of new technologies and new products have been generated, but also joint vehicle development process and computer aided engineering （CAE） analysis technology have been developed. Since the entry into the ＂Au- tomobile Lightweight Technology Innovation Strategic Alliance＂ in Dec. 2007, Geely Group has been focusing on light- weight construction of vehicle and key assemblies in every stage of the vehicle product development. Among vehicles ap- peared on the market and in research, it has presented continuously better performance. The paper describes application examples and successful experience of CAE simulation analysis and performance optimization during the lightweight de- sign and development of a self-developed model of Geely, and looks forward to the prospects for the development of lightweight of Geely vehicle.
文摘In the development process of human history, music and literature have their own unique characteristics, and also are closely related to each other. Both own a very long history and maintain an interdependent relationship with each other. The dances accompanied by music in China＇ s primitive tribes and the lyric poetry in the ancient Greek times can be said to be the coexistence form of music and literature. Although music and literature have undergone a whole development process from a unified development to an independent development, there are links always maintained between the two art forms. In this paper, the coexistence and fusion between music and literature are specifically introduced from different aspects.
基金supported by the National Natural Science Foundation of China (51471025 and 51671020)
文摘As human improve their ability to fabricate materials, alloys have evolved from simple to complex compositions, accordingly improving functions and performances,promoting the advancements of human civilization. In recent years, high-entropy alloys（HEAs） have attracted tremendous attention in various fields. With multiple principal components, they inherently possess unique microstructures and many impressive properties, such as high strength and hardness, excellent corrosion resistance, thermal stability, fatigue,fracture, and irradiation resistance, in terms of which they overwhelm the traditional alloys. All these properties have endowed HEAs with many promising potential applications.An in-depth understanding of the essence of HEAs is important to further developing numerous HEAs with better properties and performance in the future. In this paper, we review the recent development of HEAs, and summarize their preparation methods, composition design, phase formation and microstructures, various properties, and modeling and simulation calculations. In addition, the future trends and prospects of HEAs are put forward.
