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端粒和端粒酶在生殖领域的研究进展 被引量:2
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作者 杜坤 董悦芝 周飞京 《中华生殖与避孕杂志》 CAS CSCD 北大核心 2020年第5期434-438,共5页
端粒是染色体末端的DNA-蛋白质复合体,端粒的长度决定了细胞的寿命;端粒酶是具有延长端粒长度的逆转录酶。外周血白细胞及人类生殖系细胞中都有端粒及端粒酶活性的表达。研究显示端粒及端粒酶活性与胚胎发育异常及不孕不育有关,明确端... 端粒是染色体末端的DNA-蛋白质复合体,端粒的长度决定了细胞的寿命;端粒酶是具有延长端粒长度的逆转录酶。外周血白细胞及人类生殖系细胞中都有端粒及端粒酶活性的表达。研究显示端粒及端粒酶活性与胚胎发育异常及不孕不育有关,明确端粒、端粒酶与不孕不育的关系可为一些疾病的治疗带来指导意义。本文就端粒及端粒酶在生殖领域研究进展方面作一综述。 展开更多
关键词 端粒 端粒酶 人类生殖系细胞 外周血白细胞 不孕不育
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Experiments that led to the first gene-edited babies: the ethical failings and the urgent need for better governance 被引量:12
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作者 Jing-ru LI Simon WALKER +1 位作者 Jing-bao NIE Xin-qing ZHANG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2019年第1期32-38,共7页
The rapid developments of science and technology in China over recent decades, particularly in biomedical research, have brought forward serious challenges regarding ethical governance. Recently, Jian-kui HE, a Chines... The rapid developments of science and technology in China over recent decades, particularly in biomedical research, have brought forward serious challenges regarding ethical governance. Recently, Jian-kui HE, a Chinese scientist, claimed to have "created" the first gene-edited babies, designed to be naturally immune to the human immunodeficiency virus(HIV). The news immediately triggered widespread criticism, denouncement, and debate over the scientific and ethical legitimacy of HE’s genetic experiments. China’s guidelines and regulations have banned germline genome editing on human embryos for clinical use because of scientific and ethical concerns, in accordance with the international consensus. HE’s human experimentation has not only violated these Chinese regulations, but also breached other ethical and regulatory norms. These include questionable scientific value, unreasonable risk-benefit ratio, illegitimate ethics review, invalid informed consent, and regulatory misconduct. This series of ethical failings of HE and his team reveal the institutional failure of the current ethics governance system which largely depends on scientist’s self-regulation. The incident highlights the need for urgent improvement of ethics governance at all levels, the enforcement of technical and ethical guidelines, and the establishment of laws relating to such bioethical issues. 展开更多
关键词 Jian-kui HE Human germline gene editing Human immunodeficiency virus (HIV) Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 Ethical review
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