The male writers＇ intuitive gift and superb insight describe feminine characters, feminine nature, femaleness, and femininity. In the 19th century, the study of the character logical portrait and cultural traits asso...The male writers＇ intuitive gift and superb insight describe feminine characters, feminine nature, femaleness, and femininity. In the 19th century, the study of the character logical portrait and cultural traits associated with femininity enunciated feminists＇ discourse to justify vindication of rights as regards women＇s cultural anxiety, political identification, and aesthetic experimentation. Similarly, the women writers＇ imaginative powers characterize women＇s emotions either reflecting shrinking subjectivity or elaborating notion of voluntary subjectivity as regards their experiences and existence, their passions and sensations, and their self and life. The 20th century women＇s writings raised inquiry against presentation of gendered self, performance of gender, gender discontent as regards with their sex and gender, which are assigned at birth as well as also for the alignment of biological sex, sexuality, gender identity, and gender roles. In this paper, the study of the four selected novels such as The Scarlet Letter, Tess of the D ＇Urbervilles, Emma, Surfacing, and Inner Line shows how circumstances, strata of time, and externalities of others objectify woman and her domestic space; how a woman perceives her deprivation as regards her own image which seems nobody to herself due to the sense of low perception; in what way sexual difference and gender-specific practices and ideology enforce woman to chide herself in the given environment and surroundings of legal codifications, moral prescriptions, and medical prognostications. The analyses of the novels draw how woman＇s experience as living subject in the vital dimension of human existence and utopian image of human fellowship is potentially undone by way of sexual exploitation, dismemberment, and embodiment. What kind of vulnerable moments force woman to withdraw from her body and fi＇om her essence is the center of concern in this paper？ While discussing the feminists＇ culture and ethics in their works, the focus is on the essentialized notion of gender-specific discrimination as well as on the frustrating double-consciousness that characterizes the cultural position of the other.展开更多
To examine the importance of kin selection in shaping human societies, this study analyzed the kinship system practiced in traditional China for two millennia and teased apart its underlying genetic and other, presuma...To examine the importance of kin selection in shaping human societies, this study analyzed the kinship system practiced in traditional China for two millennia and teased apart its underlying genetic and other, presumably cultural, components. The results demonstrate that, in the traditional patrilineal Chinese family, both genetic relatedness and the cultural factor of generation were important in determining kinship status for male agnates （genetically related relatives）. For female agnates, however, only genetic relatedness was important. Another surprising finding was that the influence of gender was not as important as genetic relatedness. The most interesting finding in this study, however, was that kin selection and culture （i.e., seniority in generation and age） played vastly different roles in different lineages in the Chinese family： for collateral （indirect） agnates, genetic relatedness was the most important factor in determining their kinship status, but for lineal （direct） agnates, its importance was overridden by seniority in generation and age, a cultural factor. Several other bio-cultural factors also explained a considerable amount of variance in kinship status. Since kinship profoundly affected, and was often the foundation of, the legal and social systems in dynastic China, kin selection, while its strength may differ remarkably between lineal and collateral relatives, could act as a selective force in Chinese families展开更多
The aim of this study is to explore potential pathogenicity of Mycoplasma penetrans, and to investigate whether M. penetrans lipid-associated membrane proteins （LAMPs） could induce human monocytic cell line （THP- 1...The aim of this study is to explore potential pathogenicity of Mycoplasma penetrans, and to investigate whether M. penetrans lipid-associated membrane proteins （LAMPs） could induce human monocytic cell line （THP- 1 ） to produce some proinflammatory cytokines in vitro, including interleukin- 1β （ IL- 1β）, tumor necrosis factor alpha （TNF-α）, and IL-8. THP-1 was stimulated with different concentrations of M.penetrans LAMPs and at different time to analyze the production of human IL-1β, TNF-α and IL-8. The protein levels of human IL-1β, TNF-α and IL-8 were measured by enzyme-linked immunoadsorbent assay （ELISA） and the mRNA levels of these proinflammatory cytokines were detected by reverse transcriptase-PCR （RT-PCR）. It was demonstrated in the present study that the production of IL-1β, TNF-α and IL-8 increased in dose- and time-dependent manner after stimulation with M. penetrans LAMPs in THP-1 cells. M. penetrans LAMPs also induced the expression of IL-1β, TNF-α and IL-8 mRNA. The production of IL-1β, TNF-α and IL-8 and the expression of mRNA were down-regulated by pyrrolidine dithiocarbamate （PDTC）. This study demonstrated that M. penetrans LAMPs can induce the production of proinflammatory cytokines in human monocytic cells in vitro, thus suggesting that it may be an important etiological factor.展开更多
文摘The male writers＇ intuitive gift and superb insight describe feminine characters, feminine nature, femaleness, and femininity. In the 19th century, the study of the character logical portrait and cultural traits associated with femininity enunciated feminists＇ discourse to justify vindication of rights as regards women＇s cultural anxiety, political identification, and aesthetic experimentation. Similarly, the women writers＇ imaginative powers characterize women＇s emotions either reflecting shrinking subjectivity or elaborating notion of voluntary subjectivity as regards their experiences and existence, their passions and sensations, and their self and life. The 20th century women＇s writings raised inquiry against presentation of gendered self, performance of gender, gender discontent as regards with their sex and gender, which are assigned at birth as well as also for the alignment of biological sex, sexuality, gender identity, and gender roles. In this paper, the study of the four selected novels such as The Scarlet Letter, Tess of the D ＇Urbervilles, Emma, Surfacing, and Inner Line shows how circumstances, strata of time, and externalities of others objectify woman and her domestic space; how a woman perceives her deprivation as regards her own image which seems nobody to herself due to the sense of low perception; in what way sexual difference and gender-specific practices and ideology enforce woman to chide herself in the given environment and surroundings of legal codifications, moral prescriptions, and medical prognostications. The analyses of the novels draw how woman＇s experience as living subject in the vital dimension of human existence and utopian image of human fellowship is potentially undone by way of sexual exploitation, dismemberment, and embodiment. What kind of vulnerable moments force woman to withdraw from her body and fi＇om her essence is the center of concern in this paper？ While discussing the feminists＇ culture and ethics in their works, the focus is on the essentialized notion of gender-specific discrimination as well as on the frustrating double-consciousness that characterizes the cultural position of the other.
文摘To examine the importance of kin selection in shaping human societies, this study analyzed the kinship system practiced in traditional China for two millennia and teased apart its underlying genetic and other, presumably cultural, components. The results demonstrate that, in the traditional patrilineal Chinese family, both genetic relatedness and the cultural factor of generation were important in determining kinship status for male agnates （genetically related relatives）. For female agnates, however, only genetic relatedness was important. Another surprising finding was that the influence of gender was not as important as genetic relatedness. The most interesting finding in this study, however, was that kin selection and culture （i.e., seniority in generation and age） played vastly different roles in different lineages in the Chinese family： for collateral （indirect） agnates, genetic relatedness was the most important factor in determining their kinship status, but for lineal （direct） agnates, its importance was overridden by seniority in generation and age, a cultural factor. Several other bio-cultural factors also explained a considerable amount of variance in kinship status. Since kinship profoundly affected, and was often the foundation of, the legal and social systems in dynastic China, kin selection, while its strength may differ remarkably between lineal and collateral relatives, could act as a selective force in Chinese families
基金This study is supported by Natural Science Foundation of Hunan Province （No. 06JJ5044） a Grant from Hunan Province Department of Health （No. B2005-089）.
文摘The aim of this study is to explore potential pathogenicity of Mycoplasma penetrans, and to investigate whether M. penetrans lipid-associated membrane proteins （LAMPs） could induce human monocytic cell line （THP- 1 ） to produce some proinflammatory cytokines in vitro, including interleukin- 1β （ IL- 1β）, tumor necrosis factor alpha （TNF-α）, and IL-8. THP-1 was stimulated with different concentrations of M.penetrans LAMPs and at different time to analyze the production of human IL-1β, TNF-α and IL-8. The protein levels of human IL-1β, TNF-α and IL-8 were measured by enzyme-linked immunoadsorbent assay （ELISA） and the mRNA levels of these proinflammatory cytokines were detected by reverse transcriptase-PCR （RT-PCR）. It was demonstrated in the present study that the production of IL-1β, TNF-α and IL-8 increased in dose- and time-dependent manner after stimulation with M. penetrans LAMPs in THP-1 cells. M. penetrans LAMPs also induced the expression of IL-1β, TNF-α and IL-8 mRNA. The production of IL-1β, TNF-α and IL-8 and the expression of mRNA were down-regulated by pyrrolidine dithiocarbamate （PDTC）. This study demonstrated that M. penetrans LAMPs can induce the production of proinflammatory cytokines in human monocytic cells in vitro, thus suggesting that it may be an important etiological factor.
文摘目的探索蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)和国际人类免疫缺陷病毒痴呆量表(international human immunodeficiency virus dementia scale,IHDS)筛查人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染男男同性性行为者(men who have sex with men,MSM)无症状认知功能损伤(asymptomatic neurocognitive impairment,ANI)和人类免疫缺陷病毒相关性痴呆(human immunodeficiency virus-associated dementia,HAD)的效能。方法根据排除标准纳入2016年12月至2018年12月在沈阳中国医科大学附属第一医院就诊的HIV感染MSM 210例和自愿咨询检测的HIV阴性MSM 84例。分别采用MoCA和IHDS对HIV感染MSM和HIV阴性MSM进行横断面认知功能评估,分析各量表在ANI和HAD中的筛查效能。统计学分析采用t检验、单因素方差分析、χ2检验。结果HIV阳性MSM的MoCA和IHDS总分[(26.04±3.41)分和(11.15±1.44)分]均低于HIV阴性MSM[(27.58±1.85)分和(11.67±0.52)分],差异均有统计学意义(t=-4.970、-4.542,均P<0.01)。不同认知功能的HIV感染者MoCA、IHDS总分差异均有统计学意义(F=117.982、49.291,均P<0.05),MoCA<26分、IHDS≤10分所占比例差异均有统计学意义(χ2=115.917、70.155,均P<0.05)。ANI筛查中,MoCA以<26分为阈值,灵敏度为79%,特异度为91%,约登指数为0.70;IHDS以≤11分为阈值,灵敏度为74%,特异度为75%,约登指数为0.49。HAD筛查中,MoCA以<24分为阈值,灵敏度为88%,特异度为87%,约登指数为0.75;IHDS以≤10分为阈值,灵敏度为68%,特异度为87%,约登指数为0.55。结论MoCA比IHDS更适用于HIV感染MSM认知功能障碍的筛查,对于不同程度认知功能障碍应采用不同分数阈值。
