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P2X7R在肺动脉高压患者肺组织及人肺动脉内皮细胞中的表达 被引量:1
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作者 王莉 赵旭 +1 位作者 王亮 倪秀芹 《解剖科学进展》 2019年第1期91-93,97,共4页
目的研究肺动脉高压患者与人肺动脉内皮细胞中P2X7受体(P2X7R)的表达变化,探讨P2X7R是否参与肺动脉高压发病。方法人的肺组织来源于黑龙江省医院,其中对照组取自右下肺叶球形性变实施肺叶切除患者的肺组织,病变组取自患有特发性肺动脉... 目的研究肺动脉高压患者与人肺动脉内皮细胞中P2X7受体(P2X7R)的表达变化,探讨P2X7R是否参与肺动脉高压发病。方法人的肺组织来源于黑龙江省医院,其中对照组取自右下肺叶球形性变实施肺叶切除患者的肺组织,病变组取自患有特发性肺动脉高压尸检患者的肺组织,应用免疫印迹及实时定量PCR技术检测P2X7R的表达变化。人肺动脉内皮细胞系给予缺氧处理后,采用免疫印记技术检测P2X7R的表达变化。结果原发性肺动脉高压患者肺组织P2X7R蛋白及mRNA表达水平均较对照组明显增高。缺氧组肺动脉内皮细胞P2X7R蛋白的表达水平较常氧对照组明显增高。结论 P2X7R可能参与肺动脉高压发病过程。 展开更多
关键词 P2X7受体 人肺动脉高压 肺动脉内皮细胞
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Which prognostic factors should be used in pulmonary arterial hypertension in elderly patients? 被引量:2
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作者 Bahri Akdeniz 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2017年第1期28-34,共7页
In recent times, the prevalence of pulmonary arterial hypertension creased prevalence of hypertension, diabetes, obesity, arterial stiffness, (PAH) is more commonly seen among elderly populations. The inas well as d... In recent times, the prevalence of pulmonary arterial hypertension creased prevalence of hypertension, diabetes, obesity, arterial stiffness, (PAH) is more commonly seen among elderly populations. The inas well as diastolic dysfunction, may cause endothelial dysfunction and affect pulmonary vasculature. Furthermore, older patients have certain differences in clinical characteristics and outcomes. In this article the special characteristics of aging in PAH patients have been reviewed, while the risk predictors of elderly patients are also discussed. 展开更多
关键词 PROGNOSIS Pulmonary hypertension The elderly
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