In order to reduce energy consumption and protect the human survival environment, the lightweight has became the development trend of the world automobile industry. On the premise of ensuring the strength, safety and ...In order to reduce energy consumption and protect the human survival environment, the lightweight has became the development trend of the world automobile industry. On the premise of ensuring the strength, safety and driving performance of the car, the major car enterprises try to reduce the curb weight of the ear, fuel consumption and emissions. Not only a lot of new technologies and new products have been generated, but also joint vehicle development process and computer aided engineering （CAE） analysis technology have been developed. Since the entry into the ＂Au- tomobile Lightweight Technology Innovation Strategic Alliance＂ in Dec. 2007, Geely Group has been focusing on light- weight construction of vehicle and key assemblies in every stage of the vehicle product development. Among vehicles ap- peared on the market and in research, it has presented continuously better performance. The paper describes application examples and successful experience of CAE simulation analysis and performance optimization during the lightweight de- sign and development of a self-developed model of Geely, and looks forward to the prospects for the development of lightweight of Geely vehicle.展开更多
Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the resul...Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the result of traditional molecular biological approaches that are relatively inefficient in elucidating underlying molecular mechanism. To improve the efficacy of animal models, a technological breakthrough is required. The growing availability and application of the high-throughput methods make systematic comparisons between human and animal models easier to perform. In the present study, we introduce the concept of the comparative systems biology, which we define as "comparisons of biological systems in different states or species used to achieve an integrated understanding of life forms with all their characteristic complexity of interactions at multiple levels". Furthermore, we discuss the applications of RNA-seq and ChIP-seq technologies to comparative systems biology between human and animal models and assess the potential applications for this approach in the future studies.展开更多
基金Supporting Program of the"Twelfth Five-year Plan"for Sci & Tech Research of China(No. 2011BAG03B02No.2011BAG03B06)
文摘In order to reduce energy consumption and protect the human survival environment, the lightweight has became the development trend of the world automobile industry. On the premise of ensuring the strength, safety and driving performance of the car, the major car enterprises try to reduce the curb weight of the ear, fuel consumption and emissions. Not only a lot of new technologies and new products have been generated, but also joint vehicle development process and computer aided engineering （CAE） analysis technology have been developed. Since the entry into the ＂Au- tomobile Lightweight Technology Innovation Strategic Alliance＂ in Dec. 2007, Geely Group has been focusing on light- weight construction of vehicle and key assemblies in every stage of the vehicle product development. Among vehicles ap- peared on the market and in research, it has presented continuously better performance. The paper describes application examples and successful experience of CAE simulation analysis and performance optimization during the lightweight de- sign and development of a self-developed model of Geely, and looks forward to the prospects for the development of lightweight of Geely vehicle.
基金supported by the National Natural Science Foundation of China (31123005)the Chinese Academy of Sciences (Y002731071)the National Basic Research Program of China (2009CB941300)
文摘Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the result of traditional molecular biological approaches that are relatively inefficient in elucidating underlying molecular mechanism. To improve the efficacy of animal models, a technological breakthrough is required. The growing availability and application of the high-throughput methods make systematic comparisons between human and animal models easier to perform. In the present study, we introduce the concept of the comparative systems biology, which we define as "comparisons of biological systems in different states or species used to achieve an integrated understanding of life forms with all their characteristic complexity of interactions at multiple levels". Furthermore, we discuss the applications of RNA-seq and ChIP-seq technologies to comparative systems biology between human and animal models and assess the potential applications for this approach in the future studies.
