用间接免疫荧光法对福建部分沿海地区1703人进行了嗜人 T 细胞病毒Ⅰ型(HTLV-Ⅰ)抗体测定。HTLV-Ⅰ的抗体阳性率为2.3%,其中白血病患者的抗体阳性率(71%)显著高于其他疾病患者(2.7%)和健康献血员(0.6%)。表明了该地区 HTLV-Ⅰ感染率明...用间接免疫荧光法对福建部分沿海地区1703人进行了嗜人 T 细胞病毒Ⅰ型(HTLV-Ⅰ)抗体测定。HTLV-Ⅰ的抗体阳性率为2.3%,其中白血病患者的抗体阳性率(71%)显著高于其他疾病患者(2.7%)和健康献血员(0.6%)。表明了该地区 HTLV-Ⅰ感染率明显高于国内其他地区的报道。部分病毒携带者的体征和实验室指标有明显增加。展开更多
The occurrence of massive CD4+ T cell depletion is one of the most prominent characteristics of human immunodeficiency virus type 1 (HIV-1) infection during acute phase, resulting in unrestorable destruction to the im...The occurrence of massive CD4+ T cell depletion is one of the most prominent characteristics of human immunodeficiency virus type 1 (HIV-1) infection during acute phase, resulting in unrestorable destruction to the immune system. The infected host undergoes an asymptomatic period lasting several years with low viral load and ostensibly healthy status, which is presumably due to virus-specific adaptive immune responses. In the absence of therapy, an overwhelming majority of cases develop to AIDS within 8-10 years of latent infection. In this review, we discuss the roles in AIDS pathogenesis played by massive CD4+ T lymphocytes depletion in gut-associated lymphoid tissue (GALT) during acute infection and abnormal immune activation emerging in the later part of chronic phase.展开更多
文摘用间接免疫荧光法对福建部分沿海地区1703人进行了嗜人 T 细胞病毒Ⅰ型(HTLV-Ⅰ)抗体测定。HTLV-Ⅰ的抗体阳性率为2.3%,其中白血病患者的抗体阳性率(71%)显著高于其他疾病患者(2.7%)和健康献血员(0.6%)。表明了该地区 HTLV-Ⅰ感染率明显高于国内其他地区的报道。部分病毒携带者的体征和实验室指标有明显增加。
文摘The occurrence of massive CD4+ T cell depletion is one of the most prominent characteristics of human immunodeficiency virus type 1 (HIV-1) infection during acute phase, resulting in unrestorable destruction to the immune system. The infected host undergoes an asymptomatic period lasting several years with low viral load and ostensibly healthy status, which is presumably due to virus-specific adaptive immune responses. In the absence of therapy, an overwhelming majority of cases develop to AIDS within 8-10 years of latent infection. In this review, we discuss the roles in AIDS pathogenesis played by massive CD4+ T lymphocytes depletion in gut-associated lymphoid tissue (GALT) during acute infection and abnormal immune activation emerging in the later part of chronic phase.
