做中国天主教跨世纪的新一代接班人

做中国天主教跨世纪的新一代接班人张洪波修生各位领导，各位神长，主内兄弟姐妹们：在中国天主教爱国会成立４０周年之际，我谨代表中国天主教新一代１７００余名修道生，向中国天主教爱国会表示衷心的祝贺！向在爱国爱教的事业中做出巨大贡献的老一辈神长教友致以崇高的...

基于智能代接的电话助手App设计

设计了以智能代接为核心的电话助手App,后端技术基于语音听写、实时语音转写、离线语音合成技术,实现智能代接听、语音文字双向转化、骚然电话精准拦截功能,有效解决电话交流中的问题。

四代接力照料孤老的“文明世家

在经济特区汕头,传颂着一个一家四代人接力义务照料双目失明孤寡老人纪清梅的感人故事.这就是今年2月28日被中共汕头市委、市人民政府授予“文明世家”的纪婵蕊一家.

Iterative receivers for SFBC-OFDM systems with adaptive training scheme

This paper considers the design of iterative receivers for space-frequencyblock-coded orthogonal frequency division multiplexing (SFBC-OFDM) systems in unknown wirelessdispersive fading channels. An iterative joint channel estimation and symbol detection algorithm isderived. In the algorithm, the channel estimator performs alternately in two modes. During thetraining mode, the channel state information (CSI) is obtained by a discrete-Fourier-transform-basedchannel estimator and the noise variance and covariance matrix of the channel response is estimatedby the proposed method. In the data transmission mode, the CSI and transmitted data is obtainediteratively. In order to suppress the error propagation caused by a random error in identifyingsymbols, a simple error propagation detection criterion is proposed and an adaptive training schemeis applied to suppress the error propagation. Both theoretical analysis and simulation results showthat this algorithm gives better bit-error-rate performance and saves the overhead of OFDM systems.

程控交换机特服功能的开发及其应用

程控交换机有丰富的特服功能及特点,可为工作带来很多的便利。依据普遍使用的Hicom390型程控交换机为例,作者介绍了这种交换机多种特服功能的实现及其应用。

办公室人员接电话的技巧

电话,是一个组织同外界联系、接收信息的主要渠道。办公室人员在接电话时如能给对方留下美好的印象,获得对方的好感,对树立组织的形象有极其重要的作用。接电话看似小事,其实有一定的学问。 一、自我介绍与询问对方 电话铃一响,工作人员应立即接电话,首先要和蔼可亲地报出自己单位的名称,有时还须报出自己的姓名,让对方明白是否要对了电话。

满江红——寄援藏干部

无私无畏, 天高处, 多少豪杰。 登屋脊, 放眼长眺, 沸腾热血。 投身高岭故土远, 富国强边老幼别。 好男儿移花再接木, 倾碧血。

中小学教育培训市场存在问题及对策研究

针对中小学教育培训市场存在的问题及对策展开研究。认为中小学教育培训市场存在的问题包括:恶意压低培训收费;代接孩子存在隐患;伙食存在食品安全。提出的对策包括:严惩恶意压低培训收费;严厉禁止代接孩子;杜绝食品安全隐患。希望本文的研究可以进一步促进中小学教育培训市场的健康发展。

SOLSM Channel Estimation for W CDMA

Estimation of Rayleigh fading channels using time multiplexed pilot symbols in W CDMA (FDD) is considered. Method of interpolation on a second order curve using the instantaneous channel estimation of two contiguous slots based on least square method (SOLSM) is presented. It is demonstrated by computer simulations that the channel distortion on data symbols in a slot can be estimated effectively compared to the method using simple linear interpolation, and the performance of the Rake combiner is improved effectively especially in fast moving cases.

FXR： a metabolic regulator and cell protector

Farnesoid X receptor （FXR） is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid, cholesterol, lipid, and glucose metabolism. Therefore, FXR is a potential drug target for a number of metabolic disorders, especially those related to the metabolic syndrome. More recently, our group and others have extended the functions of FXR to more than metabolic regulation, which include anti-bacterial growth in intestine, liver regeneration, and hepatocarcinogenesis. These new findings suggest that FXR has much broader roles than previously thought, and also higi.light FXR as a drug target for multiple diseases. This review summarizes the basic information of FXR but focuses on its new functions.

Efficacy and safety of combined directly acting antivirals for treatment of Chinese chronic hepatitis C patients in a real-world setting

AIM To assess the efficacy and safety of combined directly acting antivirals(DAAs) for the treatment of Chinese chronic hepatitis C(CHC) patients in a real-world setting.METHODS Hospitalized CHC patients who were treated with DAAs at Peking University First Hospital between January 2015 and December 2016 were enrolled. Samples and clinical data were collected at 0 wk, 2 wk, 4 wk, 8 wk, 12 wk, or 24 wk during DAAs treatment and at 4 wk, 12 wk, and 24 wk after the end of treatment. RESULTS Fifty-four patients who underwent DAAs treatment were included in our study, of whom 83.3%(45/54) achieved rapid virological response at 2 wk after treatment initiation(RVR 2) and 94.4%(51/54)achieved sustained virological response at 24 wk after the end of treatment(SVR 24). Serum creatinine and uric acid levels at the end of treatment were significantly increased compared with baseline levels(83.6 ± 17.9 vs 88.8 ± 19.4, P 01 < 0.001; 320.8 ± 76.3 vs 354.5 ± 87.6, P 01 < 0.001), and no significant improvements were observed at 24 w after the end of treatment(83.6 ± 17.9 vs 86.8 ± 19.1, P 02 = 0.039; 320.8 ± 76.3 vs 345.9 ± 89.4, P 02 = 0.001). The total frequency of adverse events(AEs) during treatment was 33.3%(18/54), with major AEs being fatigue(16.7%), headache(7.4%), anorexia(7.4%), and insomnia(5.6%). CONCLUSION Though based in a small cohort of patients, the abnormal changes in renal function indices and relative high frequency of AEs during combined DAAs treatment should be taken as a note of caution.

Channel aware receiver for next generation wireless communication system

We consider an iterative phase synchronization scheme based on maximum a posteriori probability algorithm.In classical approaches,the phase noise estimation model considers one sample per symbol at the channel and receiver.However,information theoretic studies suggested use of more than one sample per symbol at the channel and receiver for achieving higher performance.In this article,a soft-information aided iterative receiver is derived,which uses off-the-shelf blocks for detection and demodulation by keeping the complexity of the receiver acceptable.We consider here two samples per symbols at the channel and receiver in a pragmatic paradigm.It is shown that phase noise estimation can be significantly improved at the expense of modest processing overhead.Simulation results are presented for low-density parity check coded quadrature amplitude modulations.Our results show a significant performance improvement for strong phase noise values compared to classical receiver approaches.

ITERATIVE RECEIVER FOR OFDM-SDMA SYSTEM

An iterative receiver is proposed based on the EM (Expectation-Maximization)algorithm for an OFDM-SDMA (Orthogonal Frequency Division Multiplexing-Space Division Multiple Access) system. By using a few pilots in every OFDM symbol, both channel estimation and multiuser detection can be simultaneously obtained by iteration. The computer simulation results show this receiver can track channel variations and detect multiuser symbols for different number of users under time-varying multipath channels.

ITERATIVE RECEIVER FOR OFDM SYSTEMS BASED ON SEMI-BLIND CHANNEL ESTIMATION

In this paper we propose two iterative algorithms of joint channel estimation and symbol detection for Orthogonal Frequency Division Multiplexing (OFDM) systems. In which, superimposed pilot scheme is adopted and an initial Channel State Information (CSI) is obtained by employing a first-order statistic. In each subsequent iteration, we propose two algorithms to update the CSI. The Mean Square Error (MSE) of channel estimation and Bit Error Rate (BER) performance are given and simulation results demonstrate that the iterative algorithm using method B has good perform-ance approaching the ideal condition.

Separation Properties of a New Polysiloxane-Anchored β-Cyclodextrin Derivative as Gas Chromatography Stationary Phase

A new capillary gas chromatography stationary phase, monokis (2,6 di O benzyl 3 O propyl (3’)) hexakis(2,6 di O benzyl 3 O methyl) β CD bonded polysiloxane, was synthesized. It exhibited separation abilities to disubstituted benzene isomers and some chiral solutes. It was also found that the polarity of CD derivatives can be lowered both by chemically bonding it to polysiloxane and by diluting it in polysiloxane. The separation abilities of the polysiloxane anchored CDs (SP CD) are higher than that of the unbonded CDs (S CD) and the diluted S CD at lower column temperature. Hydrosilylation reaction is one of the best methods to lower the operating temperature of CDs.

Caring for Unclean Animals in Ancient Israel： An Ecological Perspective

In view of the biblical kosher law of clean and unclean animals, the question of whether unclean animals could be reared or not in Ancient Israel becomes an ecological concern （Lev. 7：21; 11：26） for religious bodies today who still consider certain animals as unclean. A theological study of the law in the Pentateuch suggests that, in Ancient Israel, unclean animals were well catered for. Physical contact with live unclean animals did not render one unclean. Rather, uncleanness could be acquired through the touching of the carcass of clean or unclean animals （11：24-28, 38-39）. As part of their stewardship ordained by God （Gen. 1：26）, the people of Israel touched and reared/cared for unclean animals. Amongst other things, analysis of Gen. 1：26, in the Hebrew text, indicates that the primary purpose of human creation, as cosmic stewards over all creatures （including unclean animals）, is underlined. Hence, contemporary religious bodies, who still consider certain animals as unclean, should have an unfeigned care and positive attitude towards all unclean animals.

Cx31 is assembled and trafficked to cell surface by ER-Golgi pathway and degraded by proteasomal or lysosomal pathways

Gap junctions, consisting of connexins, allow the exchange of small molecules (<1 kD) between adjacent cells, thusproviding a mechanism for synchronizing the responses of groups of cells to environmental stimuli. Connexin 31 is amember of the connexin family. Mutations on connexin 31 are associated with erythrokeratodermia variabilis, hearingimpairment and peripheral neuropathy. However, the pathological mechanism for connexin 31 mutants in these diseasesare still unknown. In this study, we analyzed the assembly, trafficking and metabolism of connexin 31 in HeLa cellsstably expressing connexin 31. Calcein transfer assay showed that calcein transfer was inhibited when cells weretreated with Brefeldin A or cytochalasin D, but not when treated with nocodazole or α-glycyrrhetinic acid, suggestingthat Golgi apparatus and actin filaments, but not microtubules, are crucial to the trafficking and assembly of connexin31, as well as the formation of gap junction intercellular communication by connexin 31. Additionally, α-glycyrrhetinicacid did not effectively inhibit gap junctional intercellular communication formed by connexin 31. Pulse-chase assayrevealed that connexin 31 had a half-life of about 6 h. Moreover, Western blotting and fluorescent staining demonstratedthat in HeLa cells stably expressing connexin 31, the amount of connexin 31 was significantly increased after these cellswere treated with proteasomal or lysosomal inhibitors. These findings indicate that connexin 31 was rapidly renewed,and possibly degraded by both proteasomal and lysosomal pathways.

Cross-Layer Framework for Fine-Grained Channel Access in Next Generation High-Density Wi Fi Networks

Densely deployed Wi Fi networks will play a crucial role in providing the capacity for next generation mobile internet. However, due to increasing interference, overlapped channels in Wi Fi networks and throughput efficiency degradation, densely deployed Wi Fi networks is not a guarantee to obtain higher throughput. An emergent challenge is how to effi ciently utilize scarce spectrum resources, by matching physical layer resources to traffi c demand. In this aspect, access control allocation strategies play a pivotal role but remain too coarse-grained. As a solution, this research proposes a flexible framework for fine-grained channel width adaptation and multi-channel access in Wi Fi networks. This approach, named SFCA(Subcarrier Fine-grained Channel Access), adopts DOFDM(Discontinuous Orthogonal Frequency Division Multiplexing) at the PHY layer. It allocates the frequency resource with a subcarrier granularity, which facilitates the channel width adaptation for multi-channel access and thus brings more fl exibility and higher frequency efficiency. The MAC layer uses a frequencytime domain backoff scheme, which combines the popular time-domain BEB scheme with a frequency-domain backoff to decrease access collision, resulting in higher access probability for the contending nodes. SFCA is compared with FICA(an established access scheme)showing significant outperformance. Finally we present results for next generation 802.11 ac Wi Fi networks.

In silico prediction of phytoconstituents from Ehretia laevis targeting TNF-αin arthritis

Objective Rheumatoid arthritis(RA)is an autoimmune disease involving the synovial lining of the major joints.Current therapies have noteworthy side effects.Our study involved in silico evaluation of Ehretia laevis(E.laevis)phytoconstituents targeting tumor necrosis factor-α(TNF-α).Methods Molecular docking studies performed to investigate the binding pattern of the plant E.laevis phytoconstituents along with the crystal structure of TNF-α(PDB ID:2 AZ5)using AutoDock Vina followed by a study of interacting amino acid residues and their influence on the inhibitory potentials of the active constituents.Further the pharmacokinetic profile and toxicity screening carried out using Swiss ADME and pk CSM.Results The docked results suggest that lupeol(-9.4 kcal/mol)andα-amyrin(-9.4 kcal/mol)has best affinity towards TNF-αcompared to standard drug thalidomide(-7.4 kcal/mol).The active chemical constituents represents better interaction with the conserved catalytic residues,leading to the inhibition/blockade of the TNF-α-associated signaling pathway in RA.Furthermore,pharmacokinetics and toxicity parameters of these phytochemicals were within acceptable limits according to ADMET studies.Conclusion The binding potential of phytoconstituents targeting TNF-αshowed promising results.Nonetheless,it encourages the traditional use of E.laevis and provides vital information on drug development and clinical treatment.

Relay Scheme Based on Distributed Luby Transform Codes for InterPlaNetary Internet

Distributed Luby Transform （DLT） codes have been proposed to improve the robustness and system throughputs for multisource single-sink networks by exploiting the benefits of Network Coding （NC） at a single relay. All the proposed schemes such as the DLT and Soliton-Like Rateless Coding （SLRC） have attempted to maintain Robust Soliton Distribution （RSD） or Soliton-Like Distribution （SLD） for the output data at the relay. This rzsult in some source symbols to be discarded, thereby degrading the throughput. In this paper, we have proposed a novel method called the Full DLT （FDLT） coding scheme to be applied in the InterPlaNetary （IPN） Internet scenario comprising two sources and one relay The aim of the proposed scheme is to fully utilise the source symbols so as to reduce the overheads and improve energy efficiencies at the sources while maintaining low overhead at the relay. In addition, almost no buffer is needed in the proposed scheme so the relay can have limited storage space, and the proposed scheme is resilient to the churn rates of the nodes. The simulation results have shown that the proposed scheme outperforms the aforementioned schemes with respect to source overheads and total overhead in addition to preserving the benefits of NC and LT codes.