As a group of diversified frameworks, quinazolin derivatives displayed a broad field of biological functions, especially as anticancer. To investigate the quantitative structure-activity relationship, 3D-QSAR models ...As a group of diversified frameworks, quinazolin derivatives displayed a broad field of biological functions, especially as anticancer. To investigate the quantitative structure-activity relationship, 3D-QSAR models were generated with 24 quinazolin scaffold molecules. The experimental and predicted pIC50 values for both training and test set compounds showed good correlation, which proved the robustness and reliability of the generated QSAR models. The most effective CoMFA and CoMSIA were obtained with correlation coefficient2ncv r of 1.00 （both） and leave-one-out coefficient q2 of 0.61 and 0.59, respectively. The predictive abilities of CoMFA and CoMSIA were quite good with the predictive correlation coefficients （2pred r ） of 0.97 and 0.91. In addition, the statis-tic results of CoMFA and CoMSIA were used to design new quinazolin molecules.展开更多
Performance management as the core part of modem human resources management, is to ensure that the employee＇s work and the organization＇s strategic objectives to maintain consistent process. Performance management b...Performance management as the core part of modem human resources management, is to ensure that the employee＇s work and the organization＇s strategic objectives to maintain consistent process. Performance management by setting a scientific and rational organizational goals, departmental goals and individual goals for employees specified in the direction Managers to discover the work of subordinates through performance coaching communication problems exist, to provide guidance and resources to support the necessary work to subordinates, subordinates bv improving, work attitude and workin~ melhnd~ tn en^Hre~ tho renl^v~fltan nfn^r~＂ I-,;~.~;展开更多
基金financial supports from the National Natural Science Foundation of China (Nos. 50673085, 20677053)the National High-Tech Research and Development Programme of China (No. 2010AA09Z203)
文摘As a group of diversified frameworks, quinazolin derivatives displayed a broad field of biological functions, especially as anticancer. To investigate the quantitative structure-activity relationship, 3D-QSAR models were generated with 24 quinazolin scaffold molecules. The experimental and predicted pIC50 values for both training and test set compounds showed good correlation, which proved the robustness and reliability of the generated QSAR models. The most effective CoMFA and CoMSIA were obtained with correlation coefficient2ncv r of 1.00 （both） and leave-one-out coefficient q2 of 0.61 and 0.59, respectively. The predictive abilities of CoMFA and CoMSIA were quite good with the predictive correlation coefficients （2pred r ） of 0.97 and 0.91. In addition, the statis-tic results of CoMFA and CoMSIA were used to design new quinazolin molecules.
文摘Performance management as the core part of modem human resources management, is to ensure that the employee＇s work and the organization＇s strategic objectives to maintain consistent process. Performance management by setting a scientific and rational organizational goals, departmental goals and individual goals for employees specified in the direction Managers to discover the work of subordinates through performance coaching communication problems exist, to provide guidance and resources to support the necessary work to subordinates, subordinates bv improving, work attitude and workin~ melhnd~ tn en^Hre~ tho renl^v~fltan nfn^r~＂ I-,;~.~;
