浅议代记村总帐做法的利弊

浅议代记村总帐做法的利弊侯玉旌，郁松近年来，江苏东海县的一些乡镇采取了由乡镇经管站代记村总帐的办法，旨在通过代记总帐，严把村级财务关，加强和规范农村财务管理工作。笔者通过调查研究，认为代记村总帐对加强农村财务管理既有有利的一面，同时，确也存在某些弊端...

用系统论还《水浒》作者施耐庵的本来面目

白驹施耐庵即《水浒》作者这个结论,我们已在《张士诚—张荣—宋江—白驹施耐庵即〈水浒〉作者刍论》和《再论白驹施耐庵即〈水浒〉作者》诸文中,多方面加以论证。只是那些文章着重于考证和论辩,着眼于某一具体文物史料的考订,某一具体论点的研析,侧重于微观,未能与宏观很好结合。

Pharmacokinetics of exendin-4 in Wistar rats

To characterize the preclinical pharmacokinetics, tissue distribution and excretion profiles of exendin-4 in healthy Wistar rats were studied. Exendin-4 was radioiodinated by the IODOGEN （1,3,4,6-tetrachloro-3 alpha, 6 alphadiphenylglucoluril） method. Pharrnacokinetic properties of ^125I-exendin-4 were examined after a single s.c. and i.v. injection, respectively. Tissue distri- bution and urinary, fecal, and biliary excretion patterns of ^125I-exendin-4 were also investigated following a single s.c. injection. Exendin-4 was rapidly distributed and cleared with t1/2 of （0.48 ± 0.03） h after a single i.v. injection. Following a single s.c. administration, exendin-4 exhibited rapid and considerable absorption with Tmax of （0.25± 0.02） h and declined with the elimination t1/2 of（1.28± 0.14） h. The absolute bioavailability was （65.5 ± 10.2） %. The radioactivity was widely distributed and rapidly diminished in most tissues. The kidney contained the highest radioactivity and the distribution of ^125I-exendin-4 to the brain was minimal. The major elimination route was urinary excretion. The pharmacokinetic properties of exendin-4 obtained from the present study closely matched those reported in previous studies in rats. Pharmacokinetics profiles of exendin-4 in rats are warranted for the design of future clinical trials.

Effect of Sn substitution and heat treatment on microstructure and microhardness of Co_(38)Ni_(34)Al_(28-x)Sn_x magnetic shape memory alloys

Sn was used to replace Al in Co38Ni34Al28 alloy. The microstructure and microhardness of Co38Ni34Al28-xSnx （x=0, 1, 2, 3） magnetic shape memory alloys were investigated at different heat treatment temperatures （1373 K, 1473 K, and 1573 K） for 2 h. The results show that more Sn substitution reduces the content of γ-phase and a partial phase of martensite can be obtained in Co38Ni34Al28-xSnx （x=1, 2, 3） alloys after treatment at 1573 K for 2 h. The maximum martensite phase appears when 2% Al is substituted by Sn. The reverse martensitic transformation temperature of Co38Ni34Al28-xSnx alloys increases at x=1 and 2, then decreases as x=3. As the content of Sn and the temperature increase, the microhardness will increase.

Infliximab in pediatric inflammatory bowel disease rapidly decreases fecal calprotectin levels

AIM: To study the response to infliximab in pediatric inflammatory bowel disease (IBD), as reflected in fecal calprotectin levels. METHODS: Thirty-six pediatric patients with IBD [23 Crohn's disease (CD), 13 ulcerative colitis (UC); median age 14 years] were treated with infliximab. Fecal calprotectin was measured at baseline, and 2 and 6 wk after therapy, and compared to blood inflammatory markers. Maintenance medication was unaltered until the third infusion but glucocorticoids were tapered off if the patient was doing well. RESULTS: At introduction of infliximab, median fecal calprotectin level was 1150 μg/g (range 54-6032 μg/g). By week 2, the fecal calprotectin level had declined to amedian 261 μg/g (P < 0.001). In 37% of the patients, fecal calprotectin was normal (< 100 μg/g) at 2 wk. By week 6, there was no additional improvement in the fecal calprotectin level (median 345 μg/g). In 22% of the patients, fecal calprotectin levels increased by week 6 to pretreatment levels or above, suggesting no response (or a loss of early response). Thus, in CD, the proportion of non-responsive patients by week 6 seemed lower, because only 9% showed no improvement in their fecal calprotectin level when compared to the respective figure of 46% of the UC patients (P < 0.05). CONCLUSION: When treated with infliximab, fecal calprotectin levels reflecting intestinal inflammation normalized rapidly in one third of pediatric patients suggesting complete mucosal healing.

《历代三宝记》的史学、文献学价值及校理与研究

《历代三宝记》为隋费长房所撰,书成于开皇十七年(597)。它不仅是研究佛教经录、佛教史的重要著作,也是研究隋以前政治史、思想史、佛经翻译史等方面的重要参考资料。虽然该书具有极高的史学价值和文献学价值,在历代的重要藏经中均有收录,且在近代以来的目录学专著或佛教史专著中屡次提及,但至今尚未有单行本问世,故有必要对其进行校点,整理出一个比较好的版本,以推动国内外学界对该书的关注,有效改善目前的研究现状。

Re-examining the Past： Elements of Postmodern Memory in Toni Morrison＇s Love

Toni Morrison＇s fiction may arguably be characterized as postmodern discourse on memory, history and culture. In her novels, the Nobel laureate frequently returns to the past to search for answers to the questions she poses about African American realities in the contemporary United States. In doing so, Morrison often creates alternative histories or, more specifically, a usable past----one that allows her to engage in a literary （re-）construction of the Black historical and cultural material which traditional histories have chosen to ignore or disremember. Therefore, as a present-day writer of African American descent, Morrison attempts to reassemble all the fragmentary historical and cultural accounts available to her as a novelist and narrate them in the form of a convincing story. With regard to the above considerations, this article seeks to discuss some of the mechanisms employed by Morrison for weaving her postmodern, memory-filled narrative on the example of her eighth novel, Love （2003）. In particular, the analysis focuses on the book＇s central figure, Bill Cosey, and his Southern ocean-side resort--both seen against the backdrop of the pre- and post-World War II racist America, followed by the 1960s decade of the Civil Rights Movement. Finally, it is also demonstrated how the author＇s use of split narrative as well as the ＂I＂ narrator-cum-character technique contribute to recounting in retrospect Love＇s main, historicized story---one viewed and judged from a present-time perspective.

Feasibility analysis of two identity-based proxy ring signature schemes

Recently, proxy ring signature schemes have been shown to be useful in various applications, such as electronic polling, electronic payment, etc. Although many proxy ring signature schemes have been pro-posed, there are only two identity-based proxy ring signature schemes have been proposed until now, i. e., Cheng＇s scheme and Lang＇s scheme. It＇s unlucky that the two identity-based proxy ring signature schemes are unfeasible. This paper points out the reasons why the two identity-based proxy ring signature schemes are unfeasible. In order to design feasible and efficient identity-based proxy ring signature schemes from bilinear pairings, we have to search for other methods.

Lithium improves memory by decreasing A-beta production and tau phosphorylation in rats chronically exposed to aluminum

Objective: To investigate the effects of lithium on cognitive function and metabolism of Amyloid-beta Protein Precursor (APP) and tau phosphorylation in rats chronically exposed to aluminum. Methods: Twenty-four chronically aluminum-exposed rats were randomly divided into 2 groups: a lithium-treatment group and a non-treatment group (n=12 per group). Lithium chloride was administered to the lithium-treatment group via gastric gavage daily for 6 weeks (200 mg/kg·d LiCl), while the non-treatment group was administered the same volume of sodium chloride by the same means. An additional control group (n=12) received no intervention. Memory function was evaluated by the Morris water maze test. Aβ was measured by immunohistochemical staining, while total APP, phosphorylated-tau protein, CDK5 and PP2A were determined by Western Blotting. Results: (1) Compared to the non-treatment group, the lithium-treatment group had a significantly shorter mean escape latency and a lower proportion of random navigation pattern in the spatial probe test (P<0.05). After the platform was taken away, the rats in the lithium-treatment group crossed the platform quadrant significantly more and stayed longer in the platform quadrant than those in the non-treatment group (P<0.05). (2) The number of Aβ positive neurons in the hippocampus and cortex was significantly less in the lithium-treatment group than in the non-treatment group (P<0.05), but the content of APP was not different between groups (P=0.730). (3) Phosphorylation of tau protein decreased significantly in the lithium-treatment group than that in the non-treatment group (P<0.05). The content of CDK5 in the lithium-treatment group was significantly less than that in the non-treatment group in the cortex and hippocampus, while there was no difference in the content of PP2A between the 2 groups. The expression of CDK5 was significantly correlated with phosphorylated tau (r=0.871, P=0.024) in the lithium-treatment group. Conclusion: Lithium may improve memory function in rats chronically exposed to aluminum by decreasing both the production of Aβ and tau phosphorylation, with the latter results from inhibiting expression of CDK5.

Test Calibration of the Paleoclimatic Proxy Data with Chinese Historical Records

The calibration of paleoclimate proxies is one of the key problems in the study of paleoclimate at present. Historical documentary records of climate are suitable for calibration on dating and the climatic implication of the proxy data in a climatological sense. A test calibration on correcting the Delingha tree ring precipitation series using Chinese historical documentary records shows that among the 44 extreme dry cases in 1401 1950 AD, 42 cases （or 95.5%） are believable. Thus the long series of Delingha rings-denoted precipitation is highly reliable. Another test to validate the monsoon intensity proxy data based on the Zhanjiang Huguangyan sediments using historical records indicates that the years of Lake Maar Ti content series-designated winter monsoon intensities are entirely opposite to historical documents- depicted years of harsh winters in 800-900 AD. As a result, serious doubt is raised about the climatic implication of this paleo-monsoon proxy series.

Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients

AIM: To investigate the relationship of changes in expression of marker genes in functional categories or molecular networks comprising one functional category or multiple categories in progression of hepatic fibrosis in hepatitis C (HCV) patients. METHODS: Marker genes were initially identified using DNA microarray data from a rat liver fibrosis model. The expression level of each fibrosis associated marker gene was analyzed using reverse transcription-polymerase chain reaction (RT-PCR) in clinical biopsy specimens from HCV-positive patients (n = 61). Analysis of changes in expression patterns and interactions of marker genes in functional categories was used to assess the biological mechanism of fibrosis. RESULTS: The profile data showed several biological changes associated with progression of hepatic fibrosis. Clustered genes in functional categories showed sequential changes in expression. Several sets of clustered genes, including those related to the extracellular matrix (ECM), inflammation, lipid metabolism, steroid metabolism, and some transcription factors important for hepatic biology showed expression changes in the immediate early phase (F1/F2) of fibrosis. Genes associated with aromatic amino acid (AA) metabolism, sulfur-containing AA metabolism and insulin/ Wnt signaling showed expression changes in the middle phase (F2/F3), and some genes related to glucose metabolism showed altered expression in the late phase of fibrosis (F3/F4). Therefore, molecular networks showing serial changes in gene expression are present in liver fibrosis progression in hepatitis C patients. CONCLUSION: Analysis of gene expression profiles from a perspective of functional categories or molecular networks provides an understanding of disease and suggests new diagnostic methods. Selected marker genes have potential utility for biological identification of advanced fibrosis.

Yan Shigu, linguist of the Tang Dynasty

Yan Shigu, a famous linguist, scribe and historian of the Tang Dynasty, is most famous as a linguist. Since he has no monograph on linguistics, his main thoughts lie in books like Han Shu Zhu. His achievements in linguistics make a big difference in the history of Chinese linguistics.

Fluid Flow Optimization on Semiautomatic Code Marker Base

This paper describes optimization process of nozzle cup based on a device for contactless code marking to rough and contaminated surfaces--semiautomatic code marker. During tests using the CFD （computational fluid dynamics） software different geometry of nozzle cups were compared by such parameters as pressure, velocity and direction of flow. Goal of digital experiments was to find sprayer nozzle geometry that can keep stream of paint in diameter of 10 mm on 10-20 mm distance. Main problem is to avoid low-pressure regions around the stream. The optimal geometry of nozzle cup is designed to get adjusted code dimensions on given distance

Adverse Events Clustering with NAT2 Slow Metabolisers following Deparasitization in Children in Bangolan, NWR Cameroon

Inter individual differences in the metabolism of antimalarials could be due to polymorphism of NAT2 gene. The authors determined the genotypic frequencies of single nucleotide polymorphism （SNP） of NAT2 gene and it＇s implication in antimalarial treatment during a vitamin A and zinc supplementation intervention in children aged 6 to 24 months. Children were deparasitized with artesunate-amodiaquine （ASAQ）-toddler 50/135 mg. Pharmacovigilance was done for 40 days, adverse events recorded and blood was spotted on filter paper for DNA extraction by chelex method. PCR-RFLP was performed with restriction enzymes KpnI, TaqI, and BamHl for detection of SNPs of NAT2. Allelic frequencies and phenotypes were compared between participants with or without adverse drug events. The prevalence of fast, slow and intermediate acetylators was 55%, 30% and 11% respectively. There was a significant association （P = 0.035） between NAT2 slow acetylators （and susceptibility to develop skin rash. No significant difference was observed between fast and slow acetylators and susceptibility to develop fever, anorexia, cough and common cold. Slow acetylators were more susceptible, （P = 0.011） to develop any adverse event The NAT2 slow acetylator phenotype was the most predominant and individuals with this phenotype were more significantly susceptible to develop adverse events to ASAQ.

Effect of Batroxobin on Expression of Neural Cell Adhesion Molecule in Temporal Infarction Rats and Spatial Learning and Memory Disorder

The effect of Batroxobin expression of neural cell adhesion molecule (NCAM) in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemical methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats and at the same time NCAM expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of NCAM immune reactive cells of Batroxobin-treated rats was more than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats and the regulation of the expression of NCAM is probably related to the neuroprotective mechanism.

Preparation, Characterization and Pharmacokinetics of Fluorescence Labeled Propylene Glycol Alginate Sodium Sulfate

A rapid and sensitive fluorescence labeling method was developed and validated for the microanalysis of a sulfated polysaccharide drug,namely propylene glycol alginate sodium sulfate(PSS), in rat plasma. Fluorescein isothiocyanate(FITC) was selected to label PSS, and 1, 6-diaminohexane was used to link PSS and FITC in order to prepare FITC-labeled PSS(F-PSS) through a reductive amination reaction. F-PSS was identified by UV-Vis, FT-IR and 1H-NMR spectrum. The cell stability and cytotoxicity of F-PSS were tested in Madin-Darby canine kidney(MDCK) cells. The results indicated that the labeling efficiency of F-PSS was 0.522% ± 0.0248% and the absolute bioavailability was 8.39%. F-PSS was stable in MDCK cells without obvious cytotoxicity. The method was sensitive and reliable; it showed a good linearity, precision, recovery and stability. The FITC labeling method can be applied to investigating the absorption and metabolism of PSS and other polysaccharides in biological samples.

Special Marking of 3D Networks＇ Points for the Monitoring of Modern Constructions

In order to monitor the deformations of modern constructions a local 3D network was usually being established at the surrounding area. The centering error, of both the instrument and targets, causes significant uncertainties in the determination of the x, y, z coordinates of the network＇s points. In order to assure precise centering for both the instrument and targets, not only for the accessible but also for the inaccessible network＇s points, a prototype way of marking is being implied. A special semi-permanent portable metallic stand （Photo 1） was manufactured for marking the accessible points. The stand provides forced instrument centering of the order of_＋0, lmm. It is light enough to carry, it accelerates and facilitates the centering and leveling of the instrument as well as it eliminates the time needed for the measurements. The applied laboratory checks in order to certify the suitability of its use and the provided accuracy are being described. For the inaccessible points special targets were used. The targets were put in permanent attachments （Photos 7-8）, which were also manufactured. Useful conclusions were drawn when these special accessories were used in to a 3D network, which was established for the monitoring of a new football stadium. Two measurement phases were carried out. The first one is with the stadium empty and the second one is when it was crowded （about 32000 people） during a significant football match.

Pharmacokinetics and Biodegradation Performance of a Hydroxypropyl Chitosan Derivative

Hydroxypropyl chitosan(HP-chitosan) has been shown to have promising applications in a wide range of areas due to its biocompatibility, biodegradability and various biological activities, especially in the biomedical and pharmaceutical fields. However, it is not yet known about its pharmacokinetics and biodegradation performance, which are crucial for its clinical applications. In order to lay a foundation for its further applications and exploitations, here we carried out fluorescence intensity and GPC analyses to determine the pharmacokinetics mode of fluorescein isothiocyanate-labeled HP-chitosan(FITC-HP-chitosan) and its biodegradability. The results showed that after intraperitoneal administration at a dose of 10 mg per rat, FITC-HP-chitosan could be absorbed rapidly and distributed to liver, kidney and spleen through blood. It was indicated that FITC-HP-chitosan could be utilized effectively, and 88.47% of the FITC-HP-chitosan could be excreted by urine within 11 days with a molecular weight less than 10 k Da. Moreover, our data indicated that there was an obvious degradation process occurred in liver(< 10 k Da at 24 h). In summary, HP-chitosan has excellent bioavailability and biodegradability, suggesting the potential applications of hydroxypropyl-modified chitosan as materials in drug delivery, tissue engineering and biomedical area.

A Postmodern Study of Doris Lessing＇s The Golden Notebook in the Light of Jean-Francois Lyotard＇s Ideas

In the first two-thirds of The Golden Notebook （1962）, the theme of the crack-up or breakdown is elaborated in the novels representation of national and global politics. Soviet-inspired communism, European colonialism and emperialism, Britain society, and national liberation struggles in the Third World are disintegrating, collapsing, crumbling, and fragmenting, under the pressures both internal and external. The last third of the novel relocates the crack-up in the person, [...], of Anna herself. In this paper, the author attempts to show that L The Golden Notebook on the central theme of ＂Breakdown, Fragmentation, and Disintegration＂, essing has written which shows that sometimes when people ＂crack-up＂, it is a way of self-healing. This theme finds an expression in the novel and this paper shows how Anna Wulf, the protagonist, tries to deal with her inner self-divisions, what part is played by each of Anna＇s four notebooks in her struggle to integrate her fragmented inner world and personality, what enables the notebooks to come together in the golden notebook at the end of the novel, and finally, how about her relationships to others, especially to Saul Green, contribute to her ＂crack-up＂ and ＂self-healing＂