良性前列腺增生(benign prostate hyperplasia, BPH)是世界范围内泌尿系统常见疾病.下尿路症状严重BPH患者需要手术治疗.目前临床上常采用经尿道前列腺切除术(transurethral resection of the prostate,TURP)治疗BPH[1].但是TURP术后可...良性前列腺增生(benign prostate hyperplasia, BPH)是世界范围内泌尿系统常见疾病.下尿路症状严重BPH患者需要手术治疗.目前临床上常采用经尿道前列腺切除术(transurethral resection of the prostate,TURP)治疗BPH[1].但是TURP术后可发生一些并发症,比如勃起功能障碍(erectile dys-function,ED)[2].展开更多
Nonalcoholic fatty liver disease (NAPLD) is consistently associated with features of the metabolic syndrome, a condition carrying a high risk of cardiovascular events. We measured the vasodilatory response of the brac...Nonalcoholic fatty liver disease (NAPLD) is consistently associated with features of the metabolic syndrome, a condition carrying a high risk of cardiovascular events. We measured the vasodilatory response of the brachial artery in response to ischemia (a test of endothelial function) (FMV) as well as cardiovascular risk profile in 52 NAPLD cases and 28 age-and sex-matched controls. The 10-year risk of coronary events was calculated according to the Framingham equation and the scores derived from the PROCAM study and NCEP-ATP III proposals. FMV was 6.33% ± 5.93% in NAFLD versus 12.22% ± 5.05% in controls (P < .0001), and higher in pure fatty liver (9.93% ) compared with nonalcoholic steatohepatitis (4.94% ) (P = .010). No differences were observed in flow-independent vasodilation (response to sublingual nitroglycerin). Percent FMV was negatively associated with insulin resistance (homeostasis model assessment) in the whole population (r = - 0.243; P = .030). In logistic regression analysis, NAFLD was associated with a percent FMV in the lower fertile (OR, 6.7; 95% CI, 1.26- 36.1), after adjustment for age, sex, body mass index, and insulin resistance. Among NAFLD patients, low FMV was associated with nonalcoholic steatohepatitis (adjusted OR, 6.8; 95% CI, 1.2- 40.2). The 10-year probability of cardiovascular events was moderately increased in NAFLD, and particularly in nonalcoholic steatohepatitis. In conclusion, our study provides evidence of endothelial dysfunction and increased risk of cardiovascular events in NAFLD. The risk of advanced liver disease is well recognized in NAFLD patients, but the large majority of cases might experience cardiovascular disease in the long term, indirectly limiting the burden of liver failure.展开更多
文摘良性前列腺增生(benign prostate hyperplasia, BPH)是世界范围内泌尿系统常见疾病.下尿路症状严重BPH患者需要手术治疗.目前临床上常采用经尿道前列腺切除术(transurethral resection of the prostate,TURP)治疗BPH[1].但是TURP术后可发生一些并发症,比如勃起功能障碍(erectile dys-function,ED)[2].
文摘Nonalcoholic fatty liver disease (NAPLD) is consistently associated with features of the metabolic syndrome, a condition carrying a high risk of cardiovascular events. We measured the vasodilatory response of the brachial artery in response to ischemia (a test of endothelial function) (FMV) as well as cardiovascular risk profile in 52 NAPLD cases and 28 age-and sex-matched controls. The 10-year risk of coronary events was calculated according to the Framingham equation and the scores derived from the PROCAM study and NCEP-ATP III proposals. FMV was 6.33% ± 5.93% in NAFLD versus 12.22% ± 5.05% in controls (P < .0001), and higher in pure fatty liver (9.93% ) compared with nonalcoholic steatohepatitis (4.94% ) (P = .010). No differences were observed in flow-independent vasodilation (response to sublingual nitroglycerin). Percent FMV was negatively associated with insulin resistance (homeostasis model assessment) in the whole population (r = - 0.243; P = .030). In logistic regression analysis, NAFLD was associated with a percent FMV in the lower fertile (OR, 6.7; 95% CI, 1.26- 36.1), after adjustment for age, sex, body mass index, and insulin resistance. Among NAFLD patients, low FMV was associated with nonalcoholic steatohepatitis (adjusted OR, 6.8; 95% CI, 1.2- 40.2). The 10-year probability of cardiovascular events was moderately increased in NAFLD, and particularly in nonalcoholic steatohepatitis. In conclusion, our study provides evidence of endothelial dysfunction and increased risk of cardiovascular events in NAFLD. The risk of advanced liver disease is well recognized in NAFLD patients, but the large majority of cases might experience cardiovascular disease in the long term, indirectly limiting the burden of liver failure.
